WO2002076495A1 - Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität - Google Patents
Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität Download PDFInfo
- Publication number
- WO2002076495A1 WO2002076495A1 PCT/EP2002/002625 EP0202625W WO02076495A1 WO 2002076495 A1 WO2002076495 A1 WO 2002076495A1 EP 0202625 W EP0202625 W EP 0202625W WO 02076495 A1 WO02076495 A1 WO 02076495A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- insulin
- pharmaceutical formulation
- formulation according
- human insulin
- group
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 194
- 102000004877 Insulin Human genes 0.000 title claims abstract description 78
- 108090001061 Insulin Proteins 0.000 title claims abstract description 78
- 229940125396 insulin Drugs 0.000 title claims abstract description 67
- 238000002360 preparation method Methods 0.000 title claims abstract description 45
- 239000011701 zinc Substances 0.000 title claims abstract description 34
- 229910052725 zinc Inorganic materials 0.000 title claims abstract description 31
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 38
- 239000004026 insulin derivative Substances 0.000 claims abstract description 37
- 239000004094 surface-active agent Substances 0.000 claims abstract description 24
- 239000003755 preservative agent Substances 0.000 claims abstract description 13
- 239000000872 buffer Substances 0.000 claims abstract description 11
- 230000002335 preservative effect Effects 0.000 claims abstract description 8
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- 229920001184 polypeptide Polymers 0.000 claims abstract description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims description 43
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 39
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims description 38
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
- 229920001983 poloxamer Polymers 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 13
- 235000011187 glycerol Nutrition 0.000 claims description 13
- 235000002639 sodium chloride Nutrition 0.000 claims description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 12
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 12
- 229920000136 polysorbate Polymers 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 9
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 9
- 239000000600 sorbitol Substances 0.000 claims description 9
- 235000010356 sorbitol Nutrition 0.000 claims description 9
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 9
- -1 fatty acid esters Chemical class 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- 229960000281 trometamol Drugs 0.000 claims description 7
- 239000004475 Arginine Substances 0.000 claims description 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 6
- 239000000194 fatty acid Substances 0.000 claims description 6
- 229930195729 fatty acid Natural products 0.000 claims description 6
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 5
- 239000003093 cationic surfactant Substances 0.000 claims description 5
- 150000002191 fatty alcohols Chemical class 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 239000000344 soap Substances 0.000 claims description 5
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 claims description 4
- 239000007983 Tris buffer Substances 0.000 claims description 4
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 4
- 229930003836 cresol Natural products 0.000 claims description 4
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 229920005862 polyol Polymers 0.000 claims description 4
- 150000003077 polyols Chemical class 0.000 claims description 4
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 102000007327 Protamines Human genes 0.000 claims description 3
- 108010007568 Protamines Proteins 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- 235000010489 acacia gum Nutrition 0.000 claims description 3
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 3
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 claims description 3
- 150000008052 alkyl sulfonates Chemical class 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 3
- RCHHVVGSTHAVPF-ZPHPLDECSA-N apidra Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3N=CNC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CNC=N1 RCHHVVGSTHAVPF-ZPHPLDECSA-N 0.000 claims description 3
- 229960000541 cetyl alcohol Drugs 0.000 claims description 3
- 235000012000 cholesterol Nutrition 0.000 claims description 3
- 239000008121 dextrose Substances 0.000 claims description 3
- 150000002170 ethers Chemical class 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 3
- 150000002942 palmitic acid derivatives Chemical class 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 239000008389 polyethoxylated castor oil Substances 0.000 claims description 3
- 229940048914 protamine Drugs 0.000 claims description 3
- 229930182490 saponin Natural products 0.000 claims description 3
- 150000007949 saponins Chemical class 0.000 claims description 3
- 235000017709 saponins Nutrition 0.000 claims description 3
- 229940080236 sodium cetyl sulfate Drugs 0.000 claims description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 3
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 claims description 3
- NWZBFJYXRGSRGD-UHFFFAOYSA-M sodium;octadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOS([O-])(=O)=O NWZBFJYXRGSRGD-UHFFFAOYSA-M 0.000 claims description 3
- 150000005846 sugar alcohols Polymers 0.000 claims description 3
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- 108010008488 Glycylglycine Proteins 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 229920002359 Tetronic® Polymers 0.000 claims description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 2
- 239000012928 buffer substance Substances 0.000 claims description 2
- 229940043257 glycylglycine Drugs 0.000 claims description 2
- 239000000787 lecithin Substances 0.000 claims description 2
- 235000010445 lecithin Nutrition 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 239000003833 bile salt Substances 0.000 claims 1
- 229940093761 bile salts Drugs 0.000 claims 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims 1
- 229960002242 chlorocresol Drugs 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 claims 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 25
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
- 238000009472 formulation Methods 0.000 description 21
- 239000000243 solution Substances 0.000 description 20
- 238000012360 testing method Methods 0.000 description 17
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 14
- 206010012601 diabetes mellitus Diseases 0.000 description 12
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 11
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 10
- 229960000502 poloxamer Drugs 0.000 description 10
- 230000009471 action Effects 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 239000008103 glucose Substances 0.000 description 9
- 230000006641 stabilisation Effects 0.000 description 9
- 238000011105 stabilization Methods 0.000 description 9
- 235000001014 amino acid Nutrition 0.000 description 8
- 229940024606 amino acid Drugs 0.000 description 8
- 150000001413 amino acids Chemical class 0.000 description 8
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 229920001213 Polysorbate 20 Polymers 0.000 description 7
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 7
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 7
- 229940068977 polysorbate 20 Drugs 0.000 description 7
- 239000011550 stock solution Substances 0.000 description 7
- 239000013020 final formulation Substances 0.000 description 6
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 5
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 4
- 125000000539 amino acid group Chemical group 0.000 description 4
- 230000003914 insulin secretion Effects 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000539 dimer Substances 0.000 description 3
- 239000000825 pharmaceutical preparation Substances 0.000 description 3
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229940068968 polysorbate 80 Drugs 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 2
- 108010065920 Insulin Lispro Proteins 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 108010005991 Pork Regular Insulin Proteins 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 238000007385 chemical modification Methods 0.000 description 2
- 230000001934 delay Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- WNRQPCUGRUFHED-DETKDSODSA-N humalog Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(O)=O)C1=CC=C(O)C=C1.C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 WNRQPCUGRUFHED-DETKDSODSA-N 0.000 description 2
- 229960002068 insulin lispro Drugs 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000011592 zinc chloride Substances 0.000 description 2
- 235000005074 zinc chloride Nutrition 0.000 description 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 101001011741 Bos taurus Insulin Proteins 0.000 description 1
- 241001631457 Cannula Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- 108010073961 Insulin Aspart Proteins 0.000 description 1
- 108010057186 Insulin Glargine Proteins 0.000 description 1
- COCFEDIXXNGUNL-RFKWWTKHSA-N Insulin glargine Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(=O)NCC(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 COCFEDIXXNGUNL-RFKWWTKHSA-N 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 229960001230 asparagine Drugs 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- FXQJFHYFOGHZTB-UHFFFAOYSA-M carbethopendecinium bromide Chemical compound [Br-].CCCCCCCCCCCCCCC([N+](C)(C)C)C(=O)OCC FXQJFHYFOGHZTB-UHFFFAOYSA-M 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000009229 glucose formation Effects 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229960004717 insulin aspart Drugs 0.000 description 1
- 229960002869 insulin glargine Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 108010066090 neutral insulin Proteins 0.000 description 1
- VOMXSOIBEJBQNF-UTTRGDHVSA-N novorapid Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(O)=O)C1=CC=C(O)C=C1.C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 VOMXSOIBEJBQNF-UTTRGDHVSA-N 0.000 description 1
- 229940127017 oral antidiabetic Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 239000008180 pharmaceutical surfactant Substances 0.000 description 1
- 230000007180 physiological regulation Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000000930 thermomechanical effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 229940120347 zinc preparations Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Definitions
- the invention relates to stabilized pharmaceutical formulations containing a polypeptide selected from a group containing insulin (e.g. human insulin, bovine or porcine insulin), an insulin analogue, an insulin derivative, active insulin metabolites or combinations thereof; a surfactant or combinations of several surfactants and optionally a preservative or combinations of several preservatives and optionally an isotonizing agent, buffer or other auxiliaries or combinations thereof, the pharmaceutical formulation being low in zinc or free of zinc.
- insulin e.g. human insulin, bovine or porcine insulin
- an insulin analogue e.g. human insulin, bovine or porcine insulin
- an insulin derivative e.g. human insulin, bovine or porcine insulin derivative
- active insulin metabolites or combinations thereof e.g. human insulin, bovine or porcine insulin
- a surfactant or combinations of several surfactants and optionally a preservative or combinations of several preservatives and optionally an isotonizing agent, buffer or other auxiliaries or combinations thereof e
- diabetes mellitus Around 120 million people worldwide suffer from diabetes mellitus. Among them are about 12 million type I diabetics, for whom the replacement of the missing endocrine insulin secretion is the only therapy currently possible. Those affected are dependent on insulin injections for life, usually several times a day. In contrast to type I diabetes, type II diabetes is not fundamentally deficient in insulin, but in a large number of cases, especially in the advanced stage, treatment with insulin, possibly in combination with an oral antidiabetic, is the cheapest form of therapy considered.
- the replacement of the body's own insulin secretion with exogenous, mostly subcutaneous application of insulin generally does not come close to the quality of the physiological regulation of blood glucose described above. Blood glucose is often derailed, which can be life-threatening in its most severe forms. In addition, however, elevated blood glucose levels without initial symptoms pose a significant health risk over the years.
- Late diabetic damage is micro- and macrovascular damage, which may manifest itself as retino-, nephro- or neuropathy and lead to blindness, kidney failure and the loss of extremities and is also associated with an increased risk of cardiovascular diseases. From this it can be deduced that an improved therapy for diabetes must primarily aim to keep blood glucose as narrow as possible in the physiological range. According to the concept of intensified insulin therapy, this should be achieved by injecting fast and slow-acting insulin preparations several times a day. Rapid-acting formulations are added to meals to compensate for the postprandial increase in blood glucose. Slow-acting basal insulins are intended to ensure basic insulin supply, especially at night, without leading to hypoglycemia.
- Insulin is a polypeptide of 51 amino acids, which are divided into 2 amino acid chains: the A chain with 21 amino acids and the B chain with 30 amino acids. The chains are linked by two disulfide bridges. Insulin preparations have been used for diabetes therapy for many years. Not only naturally occurring insulins are used, but recently also insulin derivatives and analogs. Insulin analogs are analogs of naturally occurring insulins, namely human insulin or animal insulins, which differ from the corresponding, otherwise identical, naturally occurring insulin by substituting at least one naturally occurring amino acid residue with other amino acid residues and / or adding / removing at least one amino acid residue. The amino acid residues added and / or replaced can also be those that do not occur naturally.
- Insulin derivatives are derivatives of naturally occurring insulin or an insulin analogue, which are obtained by chemical modification.
- the chemical modification can e.g. consist in the addition of one or more specific chemical groups to one or more amino acids.
- insulin derivatives and insulin analogues have a somewhat different effect than human insulin.
- EP 0 214 826 Insulin analogs with an accelerated onset of action are described in EP 0 214 826, EP 0 375 437 and EP 0 678 522.
- EP 0 124 826 relates inter alia to on substitutions of B27 and B28.
- EP 0 678 522 describes insulin analogs which have different amino acids, preferably proline, in position B29, but not glutamic acid.
- EP 0 375 437 comprises insulin analogs with lysine or arginine in B28, which can optionally additionally be modified in B3 and / or A21.
- EP 0 419 504 discloses insulin analogs which are active against chemical
- Modifications are protected by changing asparagine in B3 and at least one further amino acid in positions A5, A15, A18 or A21.
- WO 92/00321 describes insulin analogs in which at least one amino acid of positions B1 -B6 is replaced by lysine or arginine. According to WO 92/00321, such insulins have a prolonged action.
- the insulin preparations on the market of naturally occurring insulins for insulin substitution differ in the origin of the insulin (eg cattle, pork, human insulin) and the composition, with which the action profile (onset and duration of action) can be influenced. By combining different insulin preparations, a wide variety of activity profiles can be achieved and physiological blood sugar levels can be set. For some time now, not only the naturally occurring insulins mentioned, but also preparations of insulin derivatives or insulin analogs have been on the market which show a changed kinetics.
- modified insulins include so-called monomeric insulin analogues such as Lisulin, Insulin Aspart and HMR 1964 (Lys (B3), Glu (B29) human insulin) with a fast onset of action, and insulin glargine with a prolonged duration of action.
- monomeric insulin analogues such as Lisulin, Insulin Aspart and HMR 1964 (Lys (B3), Glu (B29) human insulin
- insulin glargine with a prolonged duration of action.
- Stabilized insulin formulations with increased long-term physical stability are particularly required for preparations that are exposed to special mechanical loads or higher temperatures. These include, for example, insulins in application systems such as pens, inhalation systems, needleless injection systems or insulin pumps. Insulin pumps are either worn on the patient's body or implanted. In both cases, the preparation of body heat and movement, as well as the pumping movement, is exposed to very high thermo-mechanical loads. Since insulin pens (disposable or reusable pens) are usually worn on the body, the same applies here. Previous preparations have only limited stability under these conditions.
- Insulin is present in neutral solution in pharmaceutical concentration in the form of stabilized zinc-containing hexamers which are made up of 3 identical dimer units (Brange et al., Diabetes Care 13: 923-954 (1990)).
- the association of insulin can be reduced.
- the insulin analogue Lispro is predominantly present as a monomer and is therefore absorbed more quickly and shows a shorter duration of action (HPT Ammon and C. Werning; antidiabetics; 2nd edition; Wiss. Verl.-Ges. Stuttgart; 2000; p. 94. f).
- the fast-acting insulin analogs which are present in the form of monomers or dimers, show a reduced stability and an increased tendency to aggregate when thermal and mechanical stress. It often manifests itself in cloudiness and precipitation of insoluble aggregates.
- insoluble aggregates can clog and clog the cannulas and hoses of the pumps. Since zinc leads to an additional stabilization of the insulin, zinc-free or low-zinc preparations of insulin and insulin analogues are particularly susceptible to instabilities.
- Adding excess zinc to a zinc-containing insulin solution can also increase stability (J. Brange et al., Diabetic Medicine, 3: 532-536, 1986).
- the influence of pH and various auxiliaries on the stability of insulin preparations has also been described in detail (J. Brange & L. Langkjaer, Acta Pharm. Nordica 4: 149-158).
- these stabilization methods are not sufficient for increased requirements (improving durability at room or body temperature and mechanical stress) or for so-called monomeric insulin analogues or fast-acting insulins that are particularly susceptible to physical stress.
- all commercial insulin preparations contain zinc, which is added to stabilize the preparation. Bakaysa et al.
- the present invention was therefore based on the object of finding zinc-free preparations for insulins and their derivatives and analogs which are notable for high stability.
- surfactants such as, for example, poloxamers or polysorbates (Tween ® )
- surfactants such as, for example, poloxamers or polysorbates (Tween ® )
- these preparations show increased stability, particularly under stress conditions. This applies to both insulin, insulin analogues, insulin derivatives or mixtures thereof.
- Insulin forms complexes with zinc ions in neutral preparations. With sufficient zinc concentration, stable hexamers are formed from 6 insulin molecules and 2 zinc ions. A zinc concentration of at least 0.4% (w / w) based on the insulin is required to develop this structure. With a preparation of 100 lU / ml insulin, this corresponds to a concentration of approx. 13 ⁇ g / ml zinc. An excess of zinc (e.g. 4 zinc ions per hexamer) significantly stabilizes the preparation against physical stress (J. Brange et al., Neutral insulin Solutions physically stabilized by the addition of Zn 2+ . Diabetic Med. 3, 532-536 (1986 )).
- Zinc-free or “low-zinc” in the sense of this application therefore means the presence of less than 0.4 percent by weight of zinc based on the insulin content of the preparation, preferably less than 0.2 percent by weight based on the insulin content.
- milliliters for a common insulin preparation with 100 units per For example, milliliters (0.6 ⁇ mol / ml) means a concentration of less than 13 ⁇ g / ml Zn ++ ions (0.2 ⁇ mol / ml), preferably less than 6.5 ⁇ g / ml Zn ⁇ ions the pharmaceutical preparation, based on an insulin concentration of 100 units / ml.
- Zinc-free content can also be achieved by adding zinc-complexing substances such as citrate or EDTA, so that insufficient zinc ions are available to form the insulin / zinc hexamer complex.
- the pharmaceutical preparations contain 60-6000 nmol / ml, preferably 240-3000 nmol / ml of an insulin, an insulin metabolite, an insulin analogue or an insulin derivative.
- Nonionic or ionic (anionic, cationic or amphoteric) surfactants can be used as surfactants.
- Pharmaceutical surfactants are particularly preferred, such as:
- Alkali, amine and alkaline earth soaps stearates, palmitates, oleates, ricinolates
- alkyl sulfates and alkyl sulfonates sodium lauryl sulfate, sodium cetyl sulfate, sodium stearyl sulfate
- natural surfactants bile acid salts, saponins, arabic gum
- cationic surfactants aluminum chloride, fatty alcohols
- Cetyl alcohol, stearyl alcohol, cholesterol partial and fatty acid esters of polyhydric alcohols such as glycerol, sorbitol and others (Span ® , Tween ® , Myrj ® , Brij ® ), Cremophor ® or poloxamers.
- the surfactants are present in the pharmaceutical composition in a concentration of 0.1 ⁇ g / ml - 10000 ⁇ g / ml, preferably 1 ⁇ g / ml - 1000 ⁇ g / ml.
- the preparation can also contain preservatives (e.g. phenol, cresol, parabens), isotonizing agents (e.g. mannitol, sorbitol, lactose, dextrose, Trehalose, sodium chloride, glycerol) contain buffer substances, salts, acids and alkalis as well as other auxiliary substances. These substances can each be present individually or as mixtures.
- preservatives e.g. phenol, cresol, parabens
- isotonizing agents e.g. mannitol, sorbitol, lactose, dextrose, Trehalose, sodium chloride, glycerol
- buffer substances e.g. mannitol, sorbitol, lactose, dextrose, Trehalose, sodium chloride, glycerol
- Glycerol, dextrose, lactose, sorbitol and mannitol are usually present in the pharmaceutical preparation in a concentration of 100-250 mM, NaCl in a concentration up to 150 mM.
- Buffer substances e.g. Phosphate, acetate, citrate, arginine, glycylglycine or TRIS (ie 2-amino-2-hydroxymethyl-1,3-propanediol) buffers and corresponding salts are present in a concentration of 5-250 mM, preferably 10-100 mM ,
- auxiliaries can include salts, arginine, protamine, or Surfing ® .
- the invention therefore relates to a pharmaceutical formulation
- a pharmaceutical formulation comprising a polypeptide selected from a group comprising insulin, an insulin analogue, an insulin derivative, an active insulin metabolite or combinations thereof; one surfactant or combinations of several surfactants; optionally one preservative or combinations of several preservatives; and optionally an isotonizing agent, buffer substances and / or further auxiliaries or combinations thereof, wherein the pharmaceutical formulation is free of or low in zinc;
- the surfactant being selected from a group comprising alkali, amine, alkaline earth soaps, alkyl sulfates, alkyl sulfonates, natural surfactants, cationic surfactants, fatty alcohols, partial and fatty acid esters of polyhydric alcohols such as glycerol and sorbitol, polyols; said soaps being selected from a group comprising stearates, palmitates, oleates, ricinolates; wherein the alkyl
- Another object of the invention is a pharmaceutical formulation as described above, in which the insulin, the insulin analogue, the active insulin metabolite and / or the insulin derivative in a concentration of 60-6000 nmol / ml, preferably in a concentration of 240-3000 nmol / ml is present (this corresponds to a concentration of 1, 4 - 35 mg / ml or 40 - 500 units / ml); in which the surfactant is present in a concentration of 0.1-10000 ⁇ g / ml, preferably in a concentration of 1-1000 ⁇ g / ml.
- Another object of the invention is a pharmaceutical formulation as stated above, in which glycerol and / or mannitol is present in a concentration of 100-250 mM, and / or chloride is preferably present in a concentration up to 150 mM.
- Another object of the invention is a pharmaceutical formulation as set out above, in which a buffer substance is present in a concentration of 5-250 mM.
- Another object of the invention is a pharmaceutical insulin formulation which contains further additives such as salts, protamine or surfing ® , which delay the release of insulin. Mixtures of such retardinsulins with the formulations described above are also included. Another object of the invention is a method for producing such pharmaceutical formulations. Another object of the invention is the use of such formulations for the treatment of diabetes mellitus. Another object of the invention is the use or addition of surfactants as a stabilizer during the manufacturing process of insulin, insulin analogues or insulin derivatives or their preparations.
- Insulin derivative, an active insulin metabolite or combinations thereof, the pH is between 2 and 12, preferably between 6 and 8.5 and particularly preferably between 7 and 7.8.
- Rotation test 5 tubes in a batch and 5 tubes in the comparison batch are subjected to a rotation test.
- the tubes are clamped in a rotator and rotated overhead at 37 ° C at 60 rpm (360 °).
- the turbidity of the preparations in the vessels is compared to turbidity standards or determined using a laboratory turbidity photometer (nephelometer) in formazin nephelometric units (FNU). The test is carried out until a turbidity value of 18 FNU is exceeded in all vessels.
- Shake test The tubes are placed on a laboratory shaker in an incubator and shaken at 30 ° C with 100 movements / min. After defined times, the turbidity value of the samples is determined using a laboratory turbidity photometer (nephelometer) in formazin nephelometric units (FNU).
- Example 1 Stabilization of HMR1964 by adding zinc in a rotation test
- Example 2 Stabilization of HMR1964 by adding polysorbate 20 (Tween ® 20) in a rotation test
- Zinc-free HMR1964 (calculated in such a way that in the finished formulation a concentration of 3,) is added to an aqueous solution containing 3.15 mg / ml m-cresol, 5 mg / ml NaCI and 6 mg / ml trometamol 5 mg / ml) and the pH is adjusted to 7.2-7.4 (measured at room temperature) with 1N hydrochloric acid / 1N NaOH. The solution is made up to the final volume with water and sterile filtered through a 0.2 ⁇ m filter. It is then filled into 5 ml injection vials and closed with caps.
- a comparison solution is prepared identically, but before filling up with water, a corresponding amount of a 0.1% Polysorbate 20 (Tween ® 20) Stock solution added so that there is a concentration of 10 ⁇ g / ml in the finished formulation.
- polysorbate 20 delays the occurrence of turbidity very significantly.
- Example 3 Stabilization of HMR1964 by adding poloxamer in a rotation test
- Zinc-free HMR1964 is added to an aqueous solution that contains 4.5 mg / ml phenol, 5 mg / ml NaCI and 6 mg / ml trometamol in the final formulation (calculated so that a concentration of 3.5 mg in the finished formulation / ml is formed) and the pH is adjusted to 7.2-7.4 (measured at room temperature) with 1N hydrochloric acid / 1N NaOH. The solution is made up to the final volume with water and sterile filtered through a 0.2 ⁇ m filter. Then it is in 5 ml
- a comparison solution is prepared identically, however, before filling up with water, a corresponding amount of a 0.1% Poloxamer 171 (eg Genapol ® ) stock solution is added, so that a concentration of 10 ⁇ g / ml results in the finished formulation. In each case 5 samples are then stressed in the rotation test and the turbidity determined after different periods. The results are shown in the table below.
- Poloxamer 171 eg Genapol ®
- Poloxamer 171 also significantly delays the appearance of cloudiness and stabilizes the preparation.
- Example 4 Stabilization of HMR1964 by adding polysorbate 20 or polysorbate 80 in the shake test
- a comparison solution is prepared identically, however, before filling up with water, an appropriate amount of a 0.1% polysorbate 20 (Tween ® 20) stock solution is added, so that there is a concentration of 10 ⁇ g / ml in the finished formulation.
- a 0.1% polysorbate 20 Teween ® 20
- the samples are shaken at 30 ° C. on a laboratory shaker (60 rpm) and the turbidity of the samples is measured after certain times. The results are shown in the table below.
- Zinc-free HMR1964 is added to an aqueous solution containing 3.3 mg / ml phenol, 5 mg / ml NaCl and 6 mg / ml trometamol in the final formulation (calculated so that a concentration of 3.5 mg / ml is formed) and the pH is adjusted to 7.2 - 7.4 (measured at room temperature) with 1 N hydrochloric acid / 1 N NaOH.
- the solution is made up to the final volume with water and sterile filtered through a 0.2 ⁇ m filter. It is then filled into 5 ml injection vials and closed with caps.
- a comparison solution is prepared identically, but before filling up with water, a corresponding amount of a 0.1% Poloxamer 171 (Genapol ® ) stock solution is added, so that the final formulation has a content of 10 ⁇ g / ml.
- a further comparison solution is prepared as described under a), but instead of poloxamer, a corresponding amount of a 0.1% zinc chloride stock solution is added to the solution before filling up with water, so that a concentration of 15 ⁇ g / ml of zinc gives.
- Zinc-free HMR1964 is added to an aqueous solution containing 3.3 mg / ml phenol, 5 mg / ml NaCl and 6 mg / ml trometamol in the final formulation (calculated so that a concentration of 3.5 mg / ml is formed) and the pH is adjusted to 7.2 - 7.4 (measured at room temperature) with 1 N hydrochloric acid / 1 N NaOH.
- the solution is made up to the final volume with water and sterile filtered through a 0.2 ⁇ m filter. It is then filled into 5 ml injection vials and closed with caps.
- a comparison solution is prepared identically, however, before filling up with water, a corresponding amount of a 0.1% Poloxamer 171 (Genapol ® ) stock solution is added, so that a concentration of 100 ⁇ g / ml results in the finished formulation.
- a corresponding amount of a 0.1% Poloxamer 171 (Genapol ® ) stock solution is added, so that a concentration of 100 ⁇ g / ml results in the finished formulation.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02729985A EP1381385B1 (de) | 2001-03-23 | 2002-03-09 | Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität |
NZ528335A NZ528335A (en) | 2001-03-23 | 2002-03-09 | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability |
HU0303596A HU228847B1 (en) | 2001-03-23 | 2002-03-09 | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability |
AT02729985T ATE497777T1 (de) | 2001-03-23 | 2002-03-09 | Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität |
AU2002302409A AU2002302409B2 (en) | 2001-03-23 | 2002-03-09 | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability |
PL362800A PL205465B1 (pl) | 2001-03-23 | 2002-03-09 | Wodny preparat farmaceutyczny o polepszonej trwałości, zawierający ludzką insulinę |
MXPA03007942A MXPA03007942A (es) | 2001-03-23 | 2002-03-09 | Preparaciones de insulina exentas de zinc y con bajo contenido de zinc, que tienen una estabilidad mejorada. |
IL15805702A IL158057A0 (en) | 2001-03-23 | 2002-03-09 | Insulin preparations, wich do not contain any zinc or only a small quantity of zinc and which have an improved stability |
MEP-2008-608A ME00408B (de) | 2001-03-23 | 2002-03-09 | Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität |
SI200230934T SI1381385T1 (sl) | 2001-03-23 | 2002-03-09 | Inzulinski pripravki, ki ne vsebujejo cinka ali so siromašni s cinkom, z izboljšano stabilnostjo |
CA2441260A CA2441260C (en) | 2001-03-23 | 2002-03-09 | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability |
KR1020037012339A KR100987311B1 (ko) | 2001-03-23 | 2002-03-09 | 아연을 전혀 포함하지 않거나 소량의 아연만을 포함한 개선된 안정성을 가지는 인슐린 제형 |
DE50214903T DE50214903D1 (de) | 2001-03-23 | 2002-03-09 | Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität |
DK02729985.8T DK1381385T3 (da) | 2001-03-23 | 2002-03-09 | Zinkfrie og zinkfattige insulinpræparater med forbedret stabilitet |
BR0208210-1 BRPI0208210B8 (pt) | 2001-03-23 | 2002-03-09 | preparação de insulina pobre em zinco e isenta de zinco com estabilidade aperfeiçoada |
JP2002575008A JP4231292B2 (ja) | 2001-03-23 | 2002-03-09 | 改善された安定性を有するいかなる量の亜鉛も含有しないかまたはほんの少量の亜鉛しか含有しないインスリン製剤 |
YU73503A RS51579B (sr) | 2001-03-23 | 2002-03-09 | Preparati insulina koji ne sadrže cink ili sadrže male količine cinka i koji imaju poboljšanu stabilnost |
NO20034125A NO326780B1 (no) | 2001-03-23 | 2003-09-16 | Insulinformulering med forbedret stabilitet samt fremgangsmate for fremstilling av slike |
IL158057A IL158057A (en) | 2001-03-23 | 2003-09-22 | Insulin preparations, which contain a surfactant and less than 0.2% zinc and a method for their preparation |
HR20030765A HRP20030765B1 (en) | 2001-03-23 | 2003-09-22 | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability |
HK04104454A HK1061521A1 (en) | 2001-03-23 | 2004-06-19 | Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10114178.5 | 2001-03-23 | ||
DE10114178A DE10114178A1 (de) | 2001-03-23 | 2001-03-23 | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002076495A1 true WO2002076495A1 (de) | 2002-10-03 |
Family
ID=7678654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/002625 WO2002076495A1 (de) | 2001-03-23 | 2002-03-09 | Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität |
Country Status (32)
Country | Link |
---|---|
US (5) | US6960561B2 (de) |
EP (2) | EP1381385B1 (de) |
JP (1) | JP4231292B2 (de) |
KR (2) | KR20100061868A (de) |
CN (1) | CN1273187C (de) |
AR (2) | AR033059A1 (de) |
AT (1) | ATE497777T1 (de) |
AU (1) | AU2002302409B2 (de) |
BR (1) | BRPI0208210B8 (de) |
CA (1) | CA2441260C (de) |
CY (2) | CY1111413T1 (de) |
DE (2) | DE10114178A1 (de) |
DK (2) | DK1381385T3 (de) |
ES (2) | ES2393180T3 (de) |
HK (1) | HK1061521A1 (de) |
HR (1) | HRP20030765B1 (de) |
HU (1) | HU228847B1 (de) |
IL (2) | IL158057A0 (de) |
ME (1) | ME00408B (de) |
MX (1) | MXPA03007942A (de) |
MY (1) | MY129417A (de) |
NO (1) | NO326780B1 (de) |
NZ (1) | NZ528335A (de) |
PE (1) | PE20020968A1 (de) |
PL (1) | PL205465B1 (de) |
PT (2) | PT2289539E (de) |
RS (1) | RS51579B (de) |
RU (1) | RU2311922C2 (de) |
SI (1) | SI1381385T1 (de) |
TW (1) | TWI301761B (de) |
WO (1) | WO2002076495A1 (de) |
ZA (1) | ZA200306637B (de) |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004039838A1 (de) * | 2002-10-29 | 2004-05-13 | Aventis Pharma Deutschland Gmbh | Kristalle von insulinanaloga und verfahren zu ihrer herstellung |
US7193035B2 (en) | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
JP2007528902A (ja) * | 2004-03-12 | 2007-10-18 | バイオデル, インコーポレイテッド | 迅速に作用する薬物送達組成物 |
JP2012519695A (ja) * | 2009-03-03 | 2012-08-30 | バイオデル, インコーポレイテッド | 迅速取込みのためのインスリン製剤 |
US8828923B2 (en) | 2003-08-05 | 2014-09-09 | Novo Nordisk A/S | Insulin derivatives |
WO2015059302A1 (en) | 2013-10-25 | 2015-04-30 | Sanofi | Stable formulation of insulin glulisine |
US9034818B2 (en) | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
US9364519B2 (en) | 2011-09-01 | 2016-06-14 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
US9408893B2 (en) | 2011-08-29 | 2016-08-09 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
US9526764B2 (en) | 2008-10-17 | 2016-12-27 | Sanofi-Aventis Deutschland Gmbh | Combination of an insulin and a GLP-1-agonist |
WO2017032797A1 (en) | 2015-08-25 | 2017-03-02 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
WO2017032795A1 (en) | 2015-08-25 | 2017-03-02 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
US9603904B2 (en) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
US9644017B2 (en) | 2008-01-09 | 2017-05-09 | Sanofi-Aventis Deutschland Gmbh | Insulin derivatives having an extremely delayed time-action profile |
US9707176B2 (en) | 2009-11-13 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
US9950039B2 (en) | 2014-12-12 | 2018-04-24 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
US9981013B2 (en) | 2010-08-30 | 2018-05-29 | Sanofi-Aventis Deutschland Gmbh | Use of AVE0010 for the treatment of diabetes mellitus type 2 |
US10029011B2 (en) | 2009-11-13 | 2018-07-24 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine |
US10092513B2 (en) | 2013-04-03 | 2018-10-09 | Sanofi | Treatment of diabetes mellitus by long-acting formulations of insulins |
US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
US10159713B2 (en) | 2015-03-18 | 2018-12-25 | Sanofi-Aventis Deutschland Gmbh | Treatment of type 2 diabetes mellitus patients |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
US10434147B2 (en) | 2015-03-13 | 2019-10-08 | Sanofi-Aventis Deutschland Gmbh | Treatment type 2 diabetes mellitus patients |
US10596229B2 (en) | 2010-10-27 | 2020-03-24 | Novo Nordisk A/S | Method of treating diabetes mellitus by administration, at specifically defined intervals, of a derivative of a naturally occurring insulin or insulin analogue, the derivative having a prolonged profile of action |
US11167035B2 (en) | 2005-12-28 | 2021-11-09 | Novo Nordisk A/S | Insulin compositions and method of making a composition |
US11278624B2 (en) | 2016-05-06 | 2022-03-22 | Arecor Limited | Formulations |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3764174B2 (ja) * | 1997-03-20 | 2006-04-05 | ノボ ノルディスク アクティーゼルスカブ | 肺用組成物において使用するための亜鉛非含有のインスリン結晶 |
DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
US20050250676A1 (en) * | 2001-11-19 | 2005-11-10 | Aventis Pharma Deutschland Gmbh | Method of activating insulin receptor substrate-2 to stimulate insulin production |
DE10227232A1 (de) * | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
WO2004096266A1 (en) * | 2003-05-02 | 2004-11-11 | Novo Nordisk A/S | Improved physical stability of insulin formulations |
EP1711220A1 (de) * | 2004-01-16 | 2006-10-18 | Biodel, Inc. | Sublinguale arzneimittelabgabevorrichtung |
CN1993113B (zh) * | 2004-02-13 | 2010-12-08 | Nod药物公司 | 包含磷酸钙纳米颗粒核心,生物分子和胆汁酸的颗粒,其生产方法,其治疗用途 |
US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
US20080096800A1 (en) * | 2004-03-12 | 2008-04-24 | Biodel, Inc. | Rapid mucosal gel or film insulin compositions |
EP1773878B1 (de) | 2004-07-19 | 2015-03-04 | Biocon Limited | Insulinoligomerkonjugate, formulierungen und anwendungen davon |
JP2006087815A (ja) * | 2004-09-27 | 2006-04-06 | Canon Inc | 噴霧方法および該方法に基づく噴霧装置 |
US20060194762A1 (en) * | 2004-12-23 | 2006-08-31 | Olaf Reer | Composition comprising an epothilone and methods for producing a composition comprising an epothilone |
US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US7713929B2 (en) | 2006-04-12 | 2010-05-11 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
MX2008013165A (es) | 2006-04-12 | 2009-01-29 | Biodel Inc | Formulaciones de combinacion de insulina de accion rapida y accion larga. |
US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
US7714025B2 (en) * | 2006-05-10 | 2010-05-11 | Arizona Biomedical Research Commission | Modified chalcone compounds as antimitotic agents |
EP2152243A2 (de) * | 2007-04-30 | 2010-02-17 | Novo Nordisk A/S | Hochkonzentrierte insulinlösungen und zusammensetzungen |
US8642532B2 (en) * | 2007-11-16 | 2014-02-04 | Guohan Yang | Excipients for protein stabilization |
WO2009075859A2 (en) * | 2007-12-11 | 2009-06-18 | Conjuchem Biotechnologies Inc. | Formulation of insulinotropic peptide conjugates |
KR101239008B1 (ko) * | 2008-03-31 | 2013-03-04 | 한양대학교 산학협력단 | 바일산 유도체 및 그의 응용 |
JP2010063762A (ja) * | 2008-09-12 | 2010-03-25 | Yoshiharu Masui | 抗菌消臭剤 |
CA2764423A1 (en) * | 2009-06-26 | 2010-12-29 | Novo Nordisk A/S | Preparation comprising insulin, nicotinamide and an amino acid |
TWI520745B (zh) * | 2009-07-06 | 2016-02-11 | 賽諾菲阿凡提斯德意志有限公司 | 含甲硫胺酸之胰島素製劑 |
CN101912600B (zh) * | 2010-01-11 | 2014-01-29 | 杨国汉 | 改善胰岛素在溶液中稳定性的方法 |
EP2771026A4 (de) | 2011-10-27 | 2015-08-05 | Univ Case Western Reserve | Ultrakonzentrierte und schnell wirkende insulinanalogformulierungen |
CA2889552C (fr) | 2012-11-13 | 2023-10-10 | Adocia | Formulation a action rapide d'insuline comprenant un compose anionique substitue |
TWI780236B (zh) | 2013-02-04 | 2022-10-11 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
CN105960249B (zh) | 2014-01-09 | 2021-03-16 | 赛诺菲 | 胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂 |
WO2015104310A1 (en) | 2014-01-09 | 2015-07-16 | Sanofi | Stabilized pharmaceutical formulations of insulin aspart |
BR112016013832A2 (pt) | 2014-01-09 | 2017-08-08 | Sanofi Sa | Uso de análogo e/ou derivado de insulina, formulação farmacêutica e processo para a preparação da mesma, kit e dispositivo médico |
AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
US10314911B2 (en) | 2014-04-08 | 2019-06-11 | Healthpartners Research & Education | Methods for protecting and treating traumatic brain injury, concussion and brain inflammation with intranasal insulin |
AR102869A1 (es) | 2014-12-16 | 2017-03-29 | Lilly Co Eli | Composiciones de insulina de rápida acción |
CA2996455A1 (en) | 2015-08-25 | 2017-03-02 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
CN105749292A (zh) * | 2016-02-29 | 2016-07-13 | 苏州市贝克生物科技有限公司 | 促进胰岛素吸收的组合物及其制备方法 |
JP7145849B2 (ja) | 2016-09-29 | 2022-10-03 | アレコル リミテッド | 新規の製剤 |
GB201707189D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
GB201707187D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
GB201707188D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
EA201992351A1 (ru) | 2017-06-01 | 2020-03-26 | Эли Лилли Энд Компани | Быстродействующие композиции инсулина |
CN112040928A (zh) | 2018-04-04 | 2020-12-04 | 艾瑞克有限公司 | 用于递送胰岛素化合物的医用输注泵系统 |
CA3094237A1 (en) | 2018-04-04 | 2019-10-10 | Arecor Limited | Medical infusion pump system for the delivery of an insulin compound |
KR20200139700A (ko) | 2018-04-04 | 2020-12-14 | 아레콜 리미티드 | 인슐린 화합물의 전달을 위한 의료용 주입 펌프 시스템 |
FR3083700B1 (fr) * | 2018-07-13 | 2021-03-12 | Adocia | Formulation thermostable d'insuline humaine a21g |
EP3883635A1 (de) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Verfahren und vorrichtungen zur behandlung einer krankheit mit biotherapeutika |
EP4049032A1 (de) | 2019-10-25 | 2022-08-31 | Cercacor Laboratories, Inc. | Indikatorverbindungen, vorrichtungen, die indikatorverbindungen umfassen, und verfahren zur herstellung und verwendung derselben |
PE20221260A1 (es) | 2019-12-11 | 2022-08-16 | Novo Nordisk As | Analogos de insulina novedosos y usos de estos |
EP3870261B1 (de) | 2019-12-13 | 2024-01-31 | Biora Therapeutics, Inc. | Einnehmbare vorrichtung zur abgabe eines therapeutischen mittels an den magen-darm-trakt |
GB202004814D0 (en) | 2020-04-01 | 2020-05-13 | Arecor Ltd | Novel formulations |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4153689A (en) * | 1975-06-13 | 1979-05-08 | Takeda Chemical Industries, Ltd. | Stable insulin preparation for nasal administration |
EP0166529A1 (de) * | 1984-05-29 | 1986-01-02 | Eli Lilly And Company | Stabilisierte Insulin-Formulierung |
EP0200383A2 (de) * | 1985-04-15 | 1986-11-05 | Eli Lilly And Company | Verfahren zur Verabreichung von Insulin |
US5506203A (en) * | 1993-06-24 | 1996-04-09 | Ab Astra | Systemic administration of a therapeutic preparation |
WO1998042749A1 (en) * | 1997-03-20 | 1998-10-01 | Novo Nordisk A/S | Zinc free insulin crystals for use in pulmonary compositions |
WO2000074736A1 (en) * | 1999-06-04 | 2000-12-14 | Delrx Pharmaceutical Corporation | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3758683A (en) | 1971-04-30 | 1973-09-11 | R Jackson | Insulin product |
US3868358A (en) * | 1971-04-30 | 1975-02-25 | Lilly Co Eli | Protamine-insulin product |
GB1527605A (en) | 1975-08-20 | 1978-10-04 | Takeda Chemical Industries Ltd | Insulin preparation for intranasal administration |
US4783441A (en) * | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
DE3064888D1 (en) | 1979-04-30 | 1983-10-27 | Hoechst Ag | Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization |
JPS55153712A (en) | 1979-05-18 | 1980-11-29 | Kao Corp | Insulin pharmaceutical preparation and its production |
DE3033127A1 (de) | 1980-09-03 | 1982-04-08 | Hoechst Ag, 6000 Frankfurt | Neue analoga des insulins |
JPS58501125A (ja) | 1981-07-17 | 1983-07-14 | ノルデイスク・インスリンラボラトリウム | 安定な水性治療性インシユリン製剤及びその製造方法 |
NL193099C (nl) | 1981-10-30 | 1998-11-03 | Novo Industri As | Gestabiliseerde insuline-oplossing. |
DE3316363A1 (de) | 1983-05-05 | 1984-11-08 | Deutsche Babcock Anlagen Ag, 4200 Oberhausen | Walzenrost fuer muellverbrennungsanlagen |
DE3326473A1 (de) * | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
DE3326472A1 (de) | 1983-07-22 | 1985-02-14 | Hoechst Ag, 6230 Frankfurt | Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus |
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
DE3327713A1 (de) | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Wasserloesliche disazoverbindungen, verfahren zu deren herstellung und ihre verwendung als farbstoffe |
US4839341A (en) * | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
ATE50502T1 (de) | 1984-06-09 | 1990-03-15 | Hoechst Ag | Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung. |
KR860001166B1 (ko) * | 1984-06-15 | 1986-08-20 | 곽성일 | 신발 결착용 구멍쇠의 제조방법 |
DE3440988A1 (de) | 1984-11-09 | 1986-07-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung |
DK113585D0 (da) | 1985-03-12 | 1985-03-12 | Novo Industri As | Nye peptider |
US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
DK347086D0 (da) | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
DE3526995A1 (de) | 1985-07-27 | 1987-02-05 | Hoechst Ag | Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung |
PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
US5496924A (en) | 1985-11-27 | 1996-03-05 | Hoechst Aktiengesellschaft | Fusion protein comprising an interleukin-2 fragment ballast portion |
DE3541856A1 (de) | 1985-11-27 | 1987-06-04 | Hoechst Ag | Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens |
CA1275922C (en) | 1985-11-28 | 1990-11-06 | Harunobu Amagase | Treatment of cancer |
DE3544295A1 (de) * | 1985-12-14 | 1987-06-19 | Bayer Ag | Thermoplastische formmassen mit hoher kriechstromfestigkeit |
PH23446A (en) * | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
ES2053723T3 (es) | 1987-02-25 | 1994-08-01 | Novo Nordisk As | Nuevos derivados de insulina. |
US5034415A (en) * | 1987-08-07 | 1991-07-23 | Century Laboratories, Inc. | Treatment of diabetes mellitus |
DE3726655A1 (de) * | 1987-08-11 | 1989-02-23 | Hoechst Ag | Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten |
DK257988D0 (da) | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
US6875589B1 (en) * | 1988-06-23 | 2005-04-05 | Hoechst Aktiengesellschaft | Mini-proinsulin, its preparation and use |
DE3827533A1 (de) * | 1988-08-13 | 1990-02-15 | Hoechst Ag | Pharmazeutische zubereitung zur behandlung des diabetes mellitus |
DE3837825A1 (de) * | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
JPH04502465A (ja) | 1988-12-23 | 1992-05-07 | ノボ ノルディスク アクティーゼルスカブ | ヒトインシュリン類似物質 |
US4994439A (en) * | 1989-01-19 | 1991-02-19 | California Biotechnology Inc. | Transmembrane formulations for drug administration |
US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
NZ232375A (en) | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
US5358857A (en) * | 1989-08-29 | 1994-10-25 | The General Hospital Corp. | Method of preparing fusion proteins |
US5397771A (en) * | 1990-05-10 | 1995-03-14 | Bechgaard International Research And Development A/S | Pharmaceutical preparation |
JP3219096B2 (ja) | 1990-05-10 | 2001-10-15 | ニコメド ファーマ エイエス | n―グリコフロール類及びn―エチレングリコール類を含有する医薬製剤 |
DK155690D0 (da) | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
DK10191D0 (da) * | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
US5932245A (en) * | 1991-12-05 | 1999-08-03 | Alfatec Pharma Gmbh | Gelatin or collagen hydrolysate containing drug formulation that provides for immediate release of nanoparticle drug compounds |
US5614219A (en) * | 1991-12-05 | 1997-03-25 | Alfatec-Pharma Gmbh | Oral administration form for peptide pharmaceutical substances, in particular insulin |
US6468959B1 (en) * | 1991-12-05 | 2002-10-22 | Alfatec-Pharm Gmbh | Peroral dosage form for peptide containing medicaments, in particular insulin |
ATE148710T1 (de) * | 1992-12-02 | 1997-02-15 | Hoechst Ag | Verfahren zur gewinnung von proinsulin mit korrekt verbundenen cystinbrücken |
AU680462B2 (en) | 1992-12-18 | 1997-07-31 | Eli Lilly And Company | Insulin analogs |
DE4400709B4 (de) * | 1993-01-13 | 2005-06-23 | Denso Corp., Kariya | Schraubenfestziehvorrichtung |
US5606203A (en) * | 1993-01-20 | 1997-02-25 | Kabushiki Kaisha Toshiba | Semiconductor device having Al-Cu wiring lines where Cu concentration is related to line width |
US5534488A (en) * | 1993-08-13 | 1996-07-09 | Eli Lilly And Company | Insulin formulation |
DE4405179A1 (de) | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
US5559094A (en) * | 1994-08-02 | 1996-09-24 | Eli Lilly And Company | AspB1 insulin analogs |
CN1157562A (zh) | 1994-09-09 | 1997-08-20 | 武田药品工业株式会社 | 含有一种肽金属盐的缓释制剂 |
US5547929A (en) * | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
US5707641A (en) | 1994-10-13 | 1998-01-13 | Pharmaderm Research & Development Ltd. | Formulations comprising therapeutically-active proteins or polypeptides |
US5824638A (en) * | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
JP2002514892A (ja) | 1995-06-08 | 2002-05-21 | コブラ セラピューティクス リミテッド | 遺伝子治療における合成ウイルス様粒子の使用 |
WO1997001331A2 (en) | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | Method of producing sustained-release preparation |
DE19545257A1 (de) * | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US5948751A (en) | 1996-06-20 | 1999-09-07 | Novo Nordisk A/S | X14-mannitol |
US5866538A (en) | 1996-06-20 | 1999-02-02 | Novo Nordisk A/S | Insulin preparations containing NaCl |
US5783556A (en) * | 1996-08-13 | 1998-07-21 | Genentech, Inc. | Formulated insulin-containing composition |
DE19707245A1 (de) * | 1997-02-25 | 1998-08-27 | Patent Treuhand Ges Fuer Elektrische Gluehlampen Mbh | Verfahren zur Herstellung einer elektrischen Glühlampe |
US6043214A (en) * | 1997-03-20 | 2000-03-28 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
US6310038B1 (en) * | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
PE79099A1 (es) | 1997-06-13 | 1999-08-24 | Lilly Co Eli | Formulaciones de insulina estables |
DE19726167B4 (de) * | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
ZA989744B (en) * | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
WO1999024015A1 (en) | 1997-11-12 | 1999-05-20 | Alza Corporation | Buffered drug formulations for transdermal electrotransport delivery |
WO1999034821A1 (en) * | 1998-01-09 | 1999-07-15 | Novo Nordisk A/S | Stabilised insulin compositions |
PT1121145E (pt) | 1998-10-16 | 2002-09-30 | Novo Nordisk As | Preparacoes de insulina contendo mentol e destinadas a administracao via pulmonar |
US6635617B1 (en) * | 1998-10-16 | 2003-10-21 | Novo Nordisk A/S | Insulin preparations for pulmonary delivery containing menthol |
ATE218364T1 (de) | 1998-10-16 | 2002-06-15 | Novo Nordisk As | Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung |
US6211144B1 (en) * | 1998-10-16 | 2001-04-03 | Novo Nordisk A/S | Stable concentrated insulin preparations for pulmonary delivery |
EP1131089B1 (de) | 1998-11-18 | 2004-02-18 | Novo Nordisk A/S | Stabile wässrige insulinzubereitungen ohne phenol und kresol |
US6489292B1 (en) * | 1998-11-18 | 2002-12-03 | Novo Nordisk A/S | Stable aqueous insulin preparations without phenol and cresol |
DE19908041A1 (de) * | 1999-02-24 | 2000-08-31 | Hoecker Hartwig | Kovalent verbrückte Insulindimere |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
JP2003503356A (ja) * | 1999-06-25 | 2003-01-28 | メドトロニック ミニメド インコーポレイテッド | 多剤糖尿病治療 |
US6309663B1 (en) * | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
KR100801588B1 (ko) | 1999-09-21 | 2008-02-05 | 스키에파마 캐나다 인코포레이티드 | 생물학적 유효 물질의 표면 변형된 미립자 조성물 |
US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
WO2001052937A1 (en) | 2000-01-24 | 2001-07-26 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
WO2001093837A2 (en) | 2000-06-08 | 2001-12-13 | Eli Lilly And Company | Protein powder for pulmonary delivery |
KR100508695B1 (ko) | 2001-02-13 | 2005-08-17 | 한국과학기술연구원 | 인슐린의 경구투여용 제형과 그의 제조방법 |
DE10114178A1 (de) * | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
CN1160122C (zh) | 2001-04-20 | 2004-08-04 | 清华大学 | 一种制备口服胰岛素油相制剂的方法 |
US20040265268A1 (en) * | 2001-08-18 | 2004-12-30 | Deepak Jain | Compositions and methods for skin rejuvenation and repair |
WO2003035028A1 (en) | 2001-10-19 | 2003-05-01 | Nektar Therapeutics | Modulating charge density to produce improvements in the characteristics of spray-dried proteins |
WO2003035051A2 (en) | 2001-10-19 | 2003-05-01 | Inhale Therapeutic Systems, Inc. | The use of proton sequestering agents in drug formulations |
US20060287221A1 (en) * | 2003-11-13 | 2006-12-21 | Novo Nordisk A/S | Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia |
-
2001
- 2001-03-23 DE DE10114178A patent/DE10114178A1/de not_active Ceased
-
2002
- 2002-03-09 PT PT10178836T patent/PT2289539E/pt unknown
- 2002-03-09 KR KR1020107011428A patent/KR20100061868A/ko not_active Application Discontinuation
- 2002-03-09 DK DK02729985.8T patent/DK1381385T3/da active
- 2002-03-09 WO PCT/EP2002/002625 patent/WO2002076495A1/de active Application Filing
- 2002-03-09 PT PT02729985T patent/PT1381385E/pt unknown
- 2002-03-09 RS YU73503A patent/RS51579B/sr unknown
- 2002-03-09 DK DK10178836.2T patent/DK2289539T3/da active
- 2002-03-09 HU HU0303596A patent/HU228847B1/hu unknown
- 2002-03-09 AT AT02729985T patent/ATE497777T1/de active
- 2002-03-09 SI SI200230934T patent/SI1381385T1/sl unknown
- 2002-03-09 MX MXPA03007942A patent/MXPA03007942A/es active IP Right Grant
- 2002-03-09 KR KR1020037012339A patent/KR100987311B1/ko active IP Right Grant
- 2002-03-09 ES ES10178836T patent/ES2393180T3/es not_active Expired - Lifetime
- 2002-03-09 JP JP2002575008A patent/JP4231292B2/ja not_active Expired - Lifetime
- 2002-03-09 ES ES02729985T patent/ES2360505T3/es not_active Expired - Lifetime
- 2002-03-09 EP EP02729985A patent/EP1381385B1/de not_active Expired - Lifetime
- 2002-03-09 CN CNB02807114XA patent/CN1273187C/zh not_active Expired - Lifetime
- 2002-03-09 NZ NZ528335A patent/NZ528335A/en not_active IP Right Cessation
- 2002-03-09 DE DE50214903T patent/DE50214903D1/de not_active Expired - Lifetime
- 2002-03-09 RU RU2003131187/15A patent/RU2311922C2/ru active
- 2002-03-09 PL PL362800A patent/PL205465B1/pl unknown
- 2002-03-09 BR BR0208210-1 patent/BRPI0208210B8/pt not_active IP Right Cessation
- 2002-03-09 IL IL15805702A patent/IL158057A0/xx unknown
- 2002-03-09 AU AU2002302409A patent/AU2002302409B2/en not_active Expired
- 2002-03-09 EP EP10178836A patent/EP2289539B1/de not_active Expired - Lifetime
- 2002-03-09 ME MEP-2008-608A patent/ME00408B/de unknown
- 2002-03-09 CA CA2441260A patent/CA2441260C/en not_active Expired - Lifetime
- 2002-03-21 TW TW091105385A patent/TWI301761B/zh not_active IP Right Cessation
- 2002-03-21 AR ARP020101020A patent/AR033059A1/es not_active Application Discontinuation
- 2002-03-22 US US10/102,862 patent/US6960561B2/en not_active Expired - Lifetime
- 2002-03-22 MY MYPI20021031A patent/MY129417A/en unknown
- 2002-03-22 PE PE2002000226A patent/PE20020968A1/es not_active Application Discontinuation
-
2003
- 2003-08-26 ZA ZA200306637A patent/ZA200306637B/xx unknown
- 2003-09-16 NO NO20034125A patent/NO326780B1/no not_active IP Right Cessation
- 2003-09-22 HR HR20030765A patent/HRP20030765B1/xx not_active IP Right Cessation
- 2003-09-22 IL IL158057A patent/IL158057A/en active IP Right Grant
-
2004
- 2004-06-19 HK HK04104454A patent/HK1061521A1/xx not_active IP Right Cessation
- 2004-12-09 US US11/007,154 patent/US7205276B2/en not_active Expired - Lifetime
- 2004-12-09 US US11/007,155 patent/US7205277B2/en not_active Expired - Lifetime
-
2007
- 2007-03-08 US US11/683,747 patent/US7452860B2/en not_active Expired - Lifetime
-
2008
- 2008-10-06 US US12/285,464 patent/US7696162B2/en not_active Expired - Lifetime
-
2011
- 2011-03-03 CY CY20111100253T patent/CY1111413T1/el unknown
-
2012
- 2012-11-08 CY CY20121101060T patent/CY1113318T1/el unknown
-
2014
- 2014-05-21 AR ARP140102020A patent/AR096376A2/es not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4153689A (en) * | 1975-06-13 | 1979-05-08 | Takeda Chemical Industries, Ltd. | Stable insulin preparation for nasal administration |
EP0166529A1 (de) * | 1984-05-29 | 1986-01-02 | Eli Lilly And Company | Stabilisierte Insulin-Formulierung |
EP0200383A2 (de) * | 1985-04-15 | 1986-11-05 | Eli Lilly And Company | Verfahren zur Verabreichung von Insulin |
US5506203A (en) * | 1993-06-24 | 1996-04-09 | Ab Astra | Systemic administration of a therapeutic preparation |
US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
WO1998042749A1 (en) * | 1997-03-20 | 1998-10-01 | Novo Nordisk A/S | Zinc free insulin crystals for use in pulmonary compositions |
WO2000074736A1 (en) * | 1999-06-04 | 2000-12-14 | Delrx Pharmaceutical Corporation | Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same |
Non-Patent Citations (2)
Title |
---|
LOUGHEED W D ET AL: "Physical stability of insulin formulations.", DIABETES. UNITED STATES MAY 1983, vol. 32, no. 5, May 1983 (1983-05-01), pages 424 - 432, XP001096187, ISSN: 0012-1797 * |
THUROW H ET AL: "Stabilisation of dissolved proteins against denaturation at hydrophobic interfaces.", DIABETOLOGIA. GERMANY, WEST AUG 1984, vol. 27, no. 2, August 1984 (1984-08-01), pages 212 - 218, XP001096189, ISSN: 0012-186X * |
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7193035B2 (en) | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
WO2004039838A1 (de) * | 2002-10-29 | 2004-05-13 | Aventis Pharma Deutschland Gmbh | Kristalle von insulinanaloga und verfahren zu ihrer herstellung |
US8828923B2 (en) | 2003-08-05 | 2014-09-09 | Novo Nordisk A/S | Insulin derivatives |
JP2007528902A (ja) * | 2004-03-12 | 2007-10-18 | バイオデル, インコーポレイテッド | 迅速に作用する薬物送達組成物 |
JP2012087153A (ja) * | 2004-03-12 | 2012-05-10 | Biodel Inc | 迅速に作用する薬物送達組成物 |
US11167035B2 (en) | 2005-12-28 | 2021-11-09 | Novo Nordisk A/S | Insulin compositions and method of making a composition |
US9034818B2 (en) | 2007-06-13 | 2015-05-19 | Novo Nordisk A/S | Pharmaceutical formulations comprising an insulin derivative |
US9644017B2 (en) | 2008-01-09 | 2017-05-09 | Sanofi-Aventis Deutschland Gmbh | Insulin derivatives having an extremely delayed time-action profile |
US10117909B2 (en) | 2008-10-17 | 2018-11-06 | Sanofi-Aventis Deutschland Gmbh | Combination of an insulin and a GLP-1 agonist |
US9526764B2 (en) | 2008-10-17 | 2016-12-27 | Sanofi-Aventis Deutschland Gmbh | Combination of an insulin and a GLP-1-agonist |
US9603904B2 (en) | 2008-10-30 | 2017-03-28 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections with less than daily injection frequency |
JP2012519695A (ja) * | 2009-03-03 | 2012-08-30 | バイオデル, インコーポレイテッド | 迅速取込みのためのインスリン製剤 |
US9707176B2 (en) | 2009-11-13 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
US10028910B2 (en) | 2009-11-13 | 2018-07-24 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1-agonist and methionine |
US10029011B2 (en) | 2009-11-13 | 2018-07-24 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine |
US9981013B2 (en) | 2010-08-30 | 2018-05-29 | Sanofi-Aventis Deutschland Gmbh | Use of AVE0010 for the treatment of diabetes mellitus type 2 |
US10596229B2 (en) | 2010-10-27 | 2020-03-24 | Novo Nordisk A/S | Method of treating diabetes mellitus by administration, at specifically defined intervals, of a derivative of a naturally occurring insulin or insulin analogue, the derivative having a prolonged profile of action |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
US9408893B2 (en) | 2011-08-29 | 2016-08-09 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
US9364519B2 (en) | 2011-09-01 | 2016-06-14 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
US9987332B2 (en) | 2011-09-01 | 2018-06-05 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
US10092513B2 (en) | 2013-04-03 | 2018-10-09 | Sanofi | Treatment of diabetes mellitus by long-acting formulations of insulins |
US11191722B2 (en) | 2013-04-03 | 2021-12-07 | Sanofi | Treatment of diabetes mellitus by long-acting formulations of insulins |
US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
US20180036411A1 (en) * | 2013-10-25 | 2018-02-08 | Sanofi | Stable Formulation of Insulin Glulisine |
US20150119323A1 (en) * | 2013-10-25 | 2015-04-30 | Sanofi | Stable Formulation of Insulin Glulisine |
WO2015059302A1 (en) | 2013-10-25 | 2015-04-30 | Sanofi | Stable formulation of insulin glulisine |
US9950039B2 (en) | 2014-12-12 | 2018-04-24 | Sanofi-Aventis Deutschland Gmbh | Insulin glargine/lixisenatide fixed ratio formulation |
US10434147B2 (en) | 2015-03-13 | 2019-10-08 | Sanofi-Aventis Deutschland Gmbh | Treatment type 2 diabetes mellitus patients |
US10159713B2 (en) | 2015-03-18 | 2018-12-25 | Sanofi-Aventis Deutschland Gmbh | Treatment of type 2 diabetes mellitus patients |
WO2017032795A1 (en) | 2015-08-25 | 2017-03-02 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
WO2017032797A1 (en) | 2015-08-25 | 2017-03-02 | Novo Nordisk A/S | Novel insulin derivatives and the medical uses hereof |
US11278624B2 (en) | 2016-05-06 | 2022-03-22 | Arecor Limited | Formulations |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2289539B1 (de) | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität | |
EP2305288B1 (de) | Saure Insulinzubereitungen mit verbesserter Stabilität | |
EP2451437B1 (de) | Wässrige insulinzubereitungen enthaltend methionin | |
EP3228320B1 (de) | Kombination von einem insulin und einem glp-1-agonisten | |
DE60034445T2 (de) | Gefriergetrocknete hgf-präparationen | |
EP2451471A1 (de) | Langsamwirkende insulinzubereitungen | |
EP2451472A1 (de) | Hitze- und schüttelstabile insulinzubereitungen | |
CH689250A5 (de) | Insulin-Analogon-Formulierungen. | |
DE102008053048A1 (de) | Kombination von einem Insulin und einem GLP-1-Agonisten | |
EP1723172B1 (de) | Erythropoietin-flüssigformulierung | |
EP2076243B9 (de) | Flüssigformulierung von g-csf | |
EP2293817B1 (de) | Stabilisierte flüssigformulierung | |
DE102008051834A1 (de) | Kombination von einem Insulin und einem GLP-1-Agonisten | |
DE102009038210A1 (de) | Kombination von einem Insulin und einem GLP-1-Agonisten |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: P-735/03 Country of ref document: YU |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 200306637 Country of ref document: ZA Ref document number: 1-2003-500785 Country of ref document: PH |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2003/007942 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002729985 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2441260 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 528335 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 158057 Country of ref document: IL Ref document number: P20030765A Country of ref document: HR Ref document number: 2002575008 Country of ref document: JP Ref document number: 2002302409 Country of ref document: AU Ref document number: 1488/CHENP/2003 Country of ref document: IN Ref document number: 1020037012339 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 02807114X Country of ref document: CN |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 2002729985 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 528335 Country of ref document: NZ |
|
WWG | Wipo information: grant in national office |
Ref document number: 528335 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020107011428 Country of ref document: KR |