WO2002072783A3 - Identification of cellular targets for biologically active molecules - Google Patents

Identification of cellular targets for biologically active molecules Download PDF

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Publication number
WO2002072783A3
WO2002072783A3 PCT/US2002/007713 US0207713W WO02072783A3 WO 2002072783 A3 WO2002072783 A3 WO 2002072783A3 US 0207713 W US0207713 W US 0207713W WO 02072783 A3 WO02072783 A3 WO 02072783A3
Authority
WO
WIPO (PCT)
Prior art keywords
identification
biologically active
active molecules
cellular targets
small molecule
Prior art date
Application number
PCT/US2002/007713
Other languages
French (fr)
Other versions
WO2002072783A2 (en
Inventor
Jeremy S Caldwell
Sumit K Chanda
Nikunj V Somia
John B Hogenesch
Michael P Cooke
Pedro Aza-Blanc
Original Assignee
Irm Llc
Jeremy S Caldwell
Sumit K Chanda
Nikunj V Somia
John B Hogenesch
Michael P Cooke
Pedro Aza-Blanc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc, Jeremy S Caldwell, Sumit K Chanda, Nikunj V Somia, John B Hogenesch, Michael P Cooke, Pedro Aza-Blanc filed Critical Irm Llc
Priority to AU2002254212A priority Critical patent/AU2002254212A1/en
Publication of WO2002072783A2 publication Critical patent/WO2002072783A2/en
Publication of WO2002072783A3 publication Critical patent/WO2002072783A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host

Abstract

A genetic screening methodology for rapid identification of candidate targets of any small molecule cellular effectors and other signals and modulators of cellular functions and pathways is provided. The effect of a small molecule or other signal on a cell is titrated by expressing within the cell cDNA that encodes a polypeptide that is the molecular target or that is responsible for directly or indirectly producing the molecular target.
PCT/US2002/007713 2001-03-12 2002-03-12 Identification of cellular targets for biologically active molecules WO2002072783A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002254212A AU2002254212A1 (en) 2001-03-12 2002-03-12 Identification of cellular targets for biologically active molecules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27526601P 2001-03-12 2001-03-12
US60/275,266 2001-03-12

Publications (2)

Publication Number Publication Date
WO2002072783A2 WO2002072783A2 (en) 2002-09-19
WO2002072783A3 true WO2002072783A3 (en) 2003-04-10

Family

ID=23051541

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/007713 WO2002072783A2 (en) 2001-03-12 2002-03-12 Identification of cellular targets for biologically active molecules

Country Status (3)

Country Link
US (1) US20030170642A1 (en)
AU (1) AU2002254212A1 (en)
WO (1) WO2002072783A2 (en)

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AU2002254212A1 (en) 2002-09-24
WO2002072783A2 (en) 2002-09-19
US20030170642A1 (en) 2003-09-11

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