WO2002067827A1 - Apparatus for and method of cooling a brain - Google Patents
Apparatus for and method of cooling a brain Download PDFInfo
- Publication number
- WO2002067827A1 WO2002067827A1 PCT/CA2002/000223 CA0200223W WO02067827A1 WO 2002067827 A1 WO2002067827 A1 WO 2002067827A1 CA 0200223 W CA0200223 W CA 0200223W WO 02067827 A1 WO02067827 A1 WO 02067827A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cooling liquid
- pads
- liquid
- temperature
- brain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/10—Cooling bags, e.g. ice-bags
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00084—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0001—Body part
- A61F2007/0002—Head or parts thereof
- A61F2007/0009—Throat or neck
- A61F2007/001—Throat only
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
- A61F2007/0056—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0226—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof adhesive, self-sticking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0231—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof hook and loop-type fastener
Definitions
- an apparatus for and a method of cooling a brain which has two hollow pads which are formed so that each is applicable exclusively to an area of a patient's neck adjoining one of carotid arteries so that when applied said hollow pads contact the areas exclusively adjacent to the carotid arteries and are spaced from one another, each of said hollow pads has a cooling liquid inlet and a cooling liquid outlet; a source of liquid; and two liquid circulating means each including one end connected to said source of liquid and another end connected to a corresponding one of said pads so that each of said liquid circulating means supplies cooling liquid from said cooling liquid source to a respective one of said pads and withdraws liquid from the same pad, whereby the cooling liquid can circulate either through one of said pads independently from the other of said pads, or the cooling liquid can circulate through the other of said pads independently from one of said pads, or the cooling liquid can circulate through both said pads, to cool either one half of the brain, or another
- It is another feature of the present invention to provide a method of cooling of a brain which includes the steps of applying each of two hollow pads exclusively to an area of a patient's neck adjoining one of carotid arteries so that when applied said hollow pads contact the areas exclusively adjacent to the carotid arteries and are spaced from one another; and supplying by liquid circulating means a cooling liquid from a liquid source to a respective one of said pads and withdrawing the liquid from the same pad, whereby the cooling liquid can circulate either through one of said pads independently from the other of said pads, or the cooling liquid can circulate through the other of said pads independently from one of said pads, or both said pads, to cool either one half of the brain, or another half of the brain, or both halves thereof.
- the apparatus When the apparatus is designed and a method is performed in accordance with the present invention, it becomes possible for the first time to selectively cool either a left part of the brain or a right part of the brain, or both parts of the brain simultaneously. This is important because in some instances it is necessary to cool only one half of the brain when this half of the brain is damaged. Also, the remaining part of the neck between the areas of carotid arteries are not cooled, since cooling of this remaining part is undesirable especially in view of increased sensitivity of the back of the neck. When it is exactly determined which part of the brain is damaged by a stroke, then a corresponding one of the pads which is applied on the area of the carotid artery leading to the damaged part of the brain is cooled, and cooled blood flows to the damaged part of the brain.
- Figure 1 is a view schematically showing an apparatus for cooling the brain, which performs the inventive method
- Figure 2 is a view schematically showing one of the cooling pads of the inventive apparatus.
- Figure 3 is a view showing a further embodiment of the present invention.
- An apparatus in accordance with the present invention includes two hollow pads which are identified with reference numerals 1 and 2.
- the dimensions of the hollow pads 1 or 2 are selected so that each of the hollow pads can be applied exclusively on an area of a corresponding carotid artery leading to a brain.
- each pad covers the immediate narrowing strip on the neck which extends along the carotid artery and small areas around this narrow strip.
- the pads 1 and 2 have inlets 3 and 4 for supplying a cooling liquid into the pads and outlet 5 and 6 for withdrawing the liquid from the pads.
- the preferable liquid for cooling the brain is water, since it does not cause frost bite.
- the apparatus further has a source of cooling liquids which is identified with reference numeral 7.
- the cooling liquid source 7 can be formed as a liquid reservoir provided with corresponding inlets, outlets, faucets, etc., which are not shown in the drawings in detail for the sake of clarity.
- Means for cooling the cooling liquid reservoir 7 are further provided. They can include a compressor 8 which supplies a refrigerant into a cooling coil 9 which surrounds the reservoir 7.
- Cooling liquid circulating means are further provided for circulating the cooling liquid through each of the pads 1 and 2, independently from one another.
- the first cooling circulating means include a supply line 10 which leads from the cooling liquid reservoir 7 to the inlet 4 of the pad 2 so as to supply the cooling liquid into the pad 2, and a return conduit 11 which connects the outlet 5 to the pad 2 with the cooling reservoir 7 to withdraw the liquid from the pad 2 back into the cooling liquid reservoir 7.
- the second circulating means include a supply conduit 12 which connects the cooling liquid reservoir 7 with the inlet 3 of the pad 1 for supplying the cooling liquid into the pad 1, ⁇ and a return conduit 13 which connects the outlet 6 of the pad 1 with the cooling liquid reservoir 7 to withdraw the liquid from the pad 1 back into the reservoir.
- Pumps 14 and 15 are provided for pumping the cooling liquid from the reservoir 7 into the supply line 10 and into the supply line 12 and then withdrawing the liquid through the return lines 11 and 13 back to the reservoir 7.
- the pumps 14 and 15 can be arranged outside or inside the liquid reservoir 7.
- the pumps are formed as adjustable pumps. They can adjust a speed of liquid supply, a flow rate of the liquid supply, etc.
- the inventive apparatus further has means for monitoring cooling process of the patient's brain.
- the monitoring means includes sensors for monitoring a temperature of each half of the brain.
- the sensors are identified with reference numerals 16 and 17. They are attachable to a corresponding part of a patient's head and connected to a monitoring and control unit 18.
- the monitoring and control unit 18 is connected with a device which adjusts the temperature of the cooling liquid, for example a thermostat 19.
- the thermostat 19 is connected with the compressor 8 and can control the supply of the refrigerant so as to adjust the cooling temperature of the liquid in the reservoir 7, depending on the temperature of a corresponding half of the brain sensed by the sensors 16, 17.
- the monitoring means further includes liquid temperature sensors 20 and 21 arranged in the supply lines 10 and 12 which supply the liquid from the reservoir 7 to the pads 1 and 2. Also, additional sensors 22, 23 can be provided on the return lines 11 and 13.
- the sensors 20-23 sense the temperature of the liquid in two separate liquid circulating means and supply corresponding signals to the monitoring and control unit 18, in which signals these temperatures are processed and used for controlling for example of the thermostat 19 for correspondingly cooling the liquid supply from the cooling reservoir 7.
- the basic units of the apparatus in particular the cooling liquid reservoir 7, the compressor 8, the monitoring and control unit 18, the pumps 14, 15, the sensors 20-23 are mounted on a support 24 which can be placed on wheels 25. Therefore, a patient can obtain the treatment, in particular cooling of the brain, and at the same time can be mobile and not bedridden. The patient can walk over corresponding distances with the apparatus moving beside said patient on the wheels.
- the lines 10, 11, 12, 13 can be formed as transparent hoses. They can be connected to the inlets and outlets 3-6 by releasable connections, for example in the form of plug-in elements so that they can be easily connected to and disconnected from the pads.
- each pad 1, 2 can be provided with an adhesive structure, for example an adhesive layer operating on chemical principle, a mechanical principle, etc.
- an adhesive structure for example an adhesive layer operating on chemical principle, a mechanical principle, etc.
- a ZOLL type structure can be utilized.
- FIG. 2 shows a further feature of the present invention.
- an auxiliary pad 27 is provided which is applicable on a chest area of the patient immediately adjacent to the patient's neck.
- Portion of the lines 10, 11, 12, 13 are attached to the outer surface of the auxiliary pad 27, for example with the use of a ZOLL BRAND type pad with NELCRO BRAND attachments, or other means.
- the end of the hoses which are connected to the pads 1 and 2 carry quick connectors which can be formed for example as plugs. Therefore, when necessary, the remaining portions of the apparatus can be disconnected from the pad by releasing the connections of the hoses to the pads and removing the auxiliary pad 27 which carries the end part of the hoses.
- the apparatus can have 2 separate control elements, such as buttons 28, 29. By actuating one of the buttons or both buttons, one of the pumps 14, 15 or both pumps can be turned on for circulating the cooling liquid through a corresponding one of the pads, or both pads. Of course, a multi-position switch can be also used for these purposes. Finally, the apparatus has an on/off switch 30.
- the apparatus operates and the method is performed in the following manner.
- the pads 1, 2 are applied to the patient's neck in the areas pad of the carotid arteries. Cooling water is circulated through a corresponding one or both pads to cool blood in the carotid arteries and thereby to cool the brain. The temperature of the liquid is initially adjusted 1-2 °C until the monitoring indicates that the brain temperature has dropped to 34-35°C. The water temperature is then gradually elevated to maintain the brain temperature at 34-35°C, with the above described monitoring system.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/793,553 US6511502B2 (en) | 2001-02-27 | 2001-02-27 | Apparatus for and method of cooling a brain |
US09/793,553 | 2001-02-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002067827A1 true WO2002067827A1 (en) | 2002-09-06 |
Family
ID=25160173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2002/000223 WO2002067827A1 (en) | 2001-02-27 | 2002-02-25 | Apparatus for and method of cooling a brain |
Country Status (2)
Country | Link |
---|---|
US (1) | US6511502B2 (en) |
WO (1) | WO2002067827A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005050970A1 (en) * | 2005-10-25 | 2007-04-26 | Universitätsklinikum Hamburg-Eppendorf Körperschaft des Öffentlichen Rechts | Device for cooling body part of patient in case of emergency, comprises specific shape for being closely attached to body and provided with coolant ducts |
Families Citing this family (33)
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US6682552B2 (en) * | 2001-09-17 | 2004-01-27 | Vivian R. Ramsden | Brain cooling device and monitoring system |
US7179279B2 (en) * | 2002-09-30 | 2007-02-20 | Medtronic Physio Control Corp. | Rapid induction of mild hypothermia |
AU2003277349A1 (en) * | 2002-10-11 | 2004-05-04 | Flint Hills Scientific, L.L.C. | Multi-modal system for detection and control of changes in brain state |
US6942686B1 (en) * | 2002-11-01 | 2005-09-13 | Coaxia, Inc. | Regulation of cerebral blood flow by temperature change-induced vasodilatation |
US7004961B2 (en) | 2003-01-09 | 2006-02-28 | Edward Wong | Medical device and method for temperature control and treatment of the brain and spinal cord |
US7077858B2 (en) | 2003-09-22 | 2006-07-18 | Coolhead Technologies, Inc. | Flexible heat exchangers for medical cooling and warming applications |
US20060191675A1 (en) * | 2003-09-22 | 2006-08-31 | Coolhead Technologies, Inc. | Apparatus and methods for warming and cooling bodies |
US20050131501A1 (en) * | 2003-12-15 | 2005-06-16 | Rowland Robert A.Iii | Apparatus and method for prevention and treatment of infection |
AT414094B (en) * | 2004-10-01 | 2006-09-15 | Emcools Emergency Medical Cool | EDITION FOR COOLING PATIENTS AND COOLING DEVICE WITH SUCH A EDITION |
WO2007074350A1 (en) * | 2005-12-28 | 2007-07-05 | Andrea Marinello | Device for the treatment of carotid artery diseases |
US11684510B2 (en) | 2006-04-20 | 2023-06-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Noninvasive, regional brain thermal stimuli for the treatment of neurological disorders |
US9211212B2 (en) | 2006-04-20 | 2015-12-15 | Cerêve, Inc. | Apparatus and method for modulating sleep |
US9492313B2 (en) | 2006-04-20 | 2016-11-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders |
WO2007124012A1 (en) | 2006-04-20 | 2007-11-01 | University Of Pittsburgh | Method and apparatus of noninvasive, regional brain thermal stimuli for the treatment of neurological disorders |
US8425583B2 (en) | 2006-04-20 | 2013-04-23 | University of Pittsburgh—of the Commonwealth System of Higher Education | Methods, devices and systems for treating insomnia by inducing frontal cerebral hypothermia |
WO2009004635A2 (en) * | 2007-07-04 | 2009-01-08 | Eliahu Arad | System and method for manipulating a temperature of a patient |
EP2240104A4 (en) * | 2008-01-25 | 2013-05-01 | Neurosave Inc | Rapid cooling of body and/or brain by irrigating aerodigestive tract with cooling liquid |
US20100032132A1 (en) * | 2008-08-05 | 2010-02-11 | Paul Brannon Collins | Personal cooling systems and related methods |
US9622907B2 (en) | 2010-09-10 | 2017-04-18 | Medivance Incorporated | Cooling medical pad |
US9687386B2 (en) | 2010-09-10 | 2017-06-27 | Medivance Incorporated | Cooling medical pad |
JP2014529315A (en) | 2011-07-25 | 2014-11-06 | ニューロセーブ インコーポレイテッド | Non-invasive systems, devices, and methods for selective brain cooling |
ITMO20120246A1 (en) * | 2012-10-10 | 2014-04-11 | Enrico Giuliani | THERAPEUTIC COLLAR |
USD685916S1 (en) | 2012-11-26 | 2013-07-09 | Medivance Incorporated | Medical cooling pad |
CA2896950C (en) | 2013-01-02 | 2021-10-19 | Cereve, Inc. | Systems for enhancing sleep |
WO2015048170A1 (en) * | 2013-09-30 | 2015-04-02 | The Regents Of The University Of California | Portable thermoelectric cooling device for therapeutic craniocervical hypothermia |
EP3250163B1 (en) | 2015-01-27 | 2023-07-12 | Medivance Incorporated | Medical pad for thermotherapy |
CA2980764C (en) | 2015-03-28 | 2023-07-11 | The Regents Of The University Of California | Thermoelectric temperature controlled cooler for biomedical applications |
AU2016401161A1 (en) | 2016-03-28 | 2018-10-18 | The Regents Of The University Of California | Heat exchange module and system for medical applications |
WO2017172836A1 (en) | 2016-03-28 | 2017-10-05 | Hypothermia Devices, Inc. | Heat exchange module, system and method |
AU2017335975B2 (en) | 2016-09-28 | 2022-12-01 | Hypothermia Devices, Inc. | Heat exchange module, system and method |
JP7304289B2 (en) | 2017-03-10 | 2023-07-06 | テクトラウム、インコーポレイティド | Systems and methods for treating brain injuries |
US11229547B2 (en) | 2018-03-23 | 2022-01-25 | Tectraum, Inc. | System and method for cooling or heating a human body part |
CN112587296B (en) * | 2020-12-15 | 2022-10-14 | 哈尔滨工业大学 | Medical ice cap of flexible |
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US6197045B1 (en) * | 1999-01-04 | 2001-03-06 | Medivance Incorporated | Cooling/heating pad and system |
US6416532B1 (en) * | 1999-09-24 | 2002-07-09 | Joel Fallik | Brain cooling apparatus and method |
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- 2001-02-27 US US09/793,553 patent/US6511502B2/en not_active Expired - Fee Related
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2002
- 2002-02-25 WO PCT/CA2002/000223 patent/WO2002067827A1/en not_active Application Discontinuation
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US4745922A (en) * | 1986-07-11 | 1988-05-24 | Taylor Kenneth G | Cervical heat transfer and immobilization device |
US4763866A (en) | 1988-02-19 | 1988-08-16 | Keystone Metal Products Company | Free standing base |
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US5643336A (en) | 1995-01-09 | 1997-07-01 | Lopez-Claros; Marcelo Enrique | Heating and cooling pad |
US5916242A (en) | 1996-11-04 | 1999-06-29 | Schwartz; George R. | Apparatus for rapid cooling of the brain and method of performing same |
US6183501B1 (en) * | 1998-12-18 | 2001-02-06 | Jeffrey W. Latham | Head and spine cooling device |
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---|---|---|---|---|
DE102005050970A1 (en) * | 2005-10-25 | 2007-04-26 | Universitätsklinikum Hamburg-Eppendorf Körperschaft des Öffentlichen Rechts | Device for cooling body part of patient in case of emergency, comprises specific shape for being closely attached to body and provided with coolant ducts |
Also Published As
Publication number | Publication date |
---|---|
US6511502B2 (en) | 2003-01-28 |
US20020120317A1 (en) | 2002-08-29 |
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