WO2002067182A3 - Characterizing biological stimuli by response curves - Google Patents

Characterizing biological stimuli by response curves Download PDF

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Publication number
WO2002067182A3
WO2002067182A3 PCT/US2002/005553 US0205553W WO02067182A3 WO 2002067182 A3 WO2002067182 A3 WO 2002067182A3 US 0205553 W US0205553 W US 0205553W WO 02067182 A3 WO02067182 A3 WO 02067182A3
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WO
WIPO (PCT)
Prior art keywords
response curves
cell
stimulus
stimuli
phenotype
Prior art date
Application number
PCT/US2002/005553
Other languages
French (fr)
Other versions
WO2002067182A2 (en
Inventor
Cynthia L Adams
Donald R Oestreicher
Eugeni A Vaisberg
Original Assignee
Cytokinetics Inc
Cynthia L Adams
Donald R Oestreicher
Eugeni A Vaisberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc, Cynthia L Adams, Donald R Oestreicher, Eugeni A Vaisberg filed Critical Cytokinetics Inc
Priority to AU2002306581A priority Critical patent/AU2002306581A1/en
Priority to EP02742492A priority patent/EP1362239A2/en
Priority to GB0318962A priority patent/GB2389120B/en
Publication of WO2002067182A2 publication Critical patent/WO2002067182A2/en
Publication of WO2002067182A3 publication Critical patent/WO2002067182A3/en

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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/40—Software arrangements specially adapted for pattern recognition, e.g. user interfaces or toolboxes therefor
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/94—Hardware or software architectures specially adapted for image or video understanding
    • G06V10/945—User interactive design; Environments; Toolboxes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/80—Data visualisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C99/00—Subject matter not provided for in other groups of this subclass

Abstract

A method for generating stimulus response curves (e.g., dose response curves) shows how the phenotype of one or more cells change in response to varying levels of the stimulus. Each 'point' on the curve represents quantitative phenotype for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The quantitative phenotypes are multivariate phenotypic representations of the cell(s). They include various features of the cell(s) obtained by image analysis. Such features often include basic parameters obtained from images (e.g., cell shape, nucleus area, Golgi texture) and/or biological characterizations derived from the basic parameters (e.g., cell cycle state, mitotic index, etc.). The stimulus response curves may be compared to allow classification of stimuli and identify subtle differences in related stimuli. To facilitate the comparison, it may be desirable to present the response curves in a principal component space.
PCT/US2002/005553 2001-02-20 2002-02-20 Characterizing biological stimuli by response curves WO2002067182A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002306581A AU2002306581A1 (en) 2001-02-20 2002-02-20 Characterizing biological stimuli by response curves
EP02742492A EP1362239A2 (en) 2001-02-20 2002-02-20 Characterizing biological stimuli by response curves
GB0318962A GB2389120B (en) 2001-02-20 2002-02-20 Characterizing biological stimuli by response curves

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/789,595 US7016787B2 (en) 2001-02-20 2001-02-20 Characterizing biological stimuli by response curves
US09/789,595 2001-02-20

Publications (2)

Publication Number Publication Date
WO2002067182A2 WO2002067182A2 (en) 2002-08-29
WO2002067182A3 true WO2002067182A3 (en) 2003-07-03

Family

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Family Applications (1)

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PCT/US2002/005553 WO2002067182A2 (en) 2001-02-20 2002-02-20 Characterizing biological stimuli by response curves

Country Status (5)

Country Link
US (2) US7016787B2 (en)
EP (1) EP1362239A2 (en)
AU (1) AU2002306581A1 (en)
GB (1) GB2389120B (en)
WO (1) WO2002067182A2 (en)

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Also Published As

Publication number Publication date
GB0318962D0 (en) 2003-09-17
WO2002067182A2 (en) 2002-08-29
US7016787B2 (en) 2006-03-21
GB2389120A (en) 2003-12-03
US7657076B2 (en) 2010-02-02
EP1362239A2 (en) 2003-11-19
GB2389120B (en) 2005-01-05
US20020155420A1 (en) 2002-10-24
AU2002306581A1 (en) 2002-09-04
US20050283317A1 (en) 2005-12-22

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