WO2002059589A3 - Multi-channel bio-separation cartridge - Google Patents

Multi-channel bio-separation cartridge Download PDF

Info

Publication number
WO2002059589A3
WO2002059589A3 PCT/US2002/002515 US0202515W WO02059589A3 WO 2002059589 A3 WO2002059589 A3 WO 2002059589A3 US 0202515 W US0202515 W US 0202515W WO 02059589 A3 WO02059589 A3 WO 02059589A3
Authority
WO
WIPO (PCT)
Prior art keywords
separation
cartridge
capillaries
integrated
reservoir
Prior art date
Application number
PCT/US2002/002515
Other languages
French (fr)
Other versions
WO2002059589A2 (en
Inventor
Varouj Amirkhanian
Ming-Sun Liu
Paul Mooney
Original Assignee
Biocal Technology Inc
Varouj Amirkhanian
Ming-Sun Liu
Paul Mooney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocal Technology Inc, Varouj Amirkhanian, Ming-Sun Liu, Paul Mooney filed Critical Biocal Technology Inc
Priority to CA2436136A priority Critical patent/CA2436136C/en
Priority to AU2002247040A priority patent/AU2002247040A1/en
Priority to AT02714795T priority patent/ATE522802T1/en
Priority to DK02714795.8T priority patent/DK1354192T3/en
Priority to JP2002559655A priority patent/JP2004532384A/en
Priority to EP02714795A priority patent/EP1354192B1/en
Publication of WO2002059589A2 publication Critical patent/WO2002059589A2/en
Publication of WO2002059589A3 publication Critical patent/WO2002059589A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Peptides Or Proteins (AREA)
  • Electrostatic Separation (AREA)
  • External Artificial Organs (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

A bio-separation system using an efficient, compact, portable, interchangeable, reusable, recyclable, multi-channel cartridge, has integrated pre-aligned optics and an integrated reagent reservoir. The cartridge supports, for example, multiple capillaries for CE separation. An integrated reservoir containing a separation support medium (e.g., a gel buffer) is common to all capillaries. The chemistry of the medium and the characteristics of the capillaries (e.g., capillary size, coating and length) are defined for each cartridge. Different cartridges can be easily interchanged in the bio-separation system to suit the particular sample based separation. The reservoir is coupled to an air pressure pump that pressurizes the gel reservoir to purge and fill the capillaries with buffer as the separation support medium. In another aspect of the present invention, optics requiring fine alignment with respect to the detection zones (such as fiber optics for directing incident radiation and/or radiation emissions) are integrated into the cartridge.
PCT/US2002/002515 2001-01-26 2002-01-28 Multi-channel bio-separation cartridge WO2002059589A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2436136A CA2436136C (en) 2001-01-26 2002-01-28 Multi-channel bio-separation cartridge
AU2002247040A AU2002247040A1 (en) 2001-01-26 2002-01-28 Multi-channel bio-separation cartridge
AT02714795T ATE522802T1 (en) 2001-01-26 2002-01-28 MULTI-CHANNEL CASSETTE FOR BIOSEPARATION
DK02714795.8T DK1354192T3 (en) 2001-01-26 2002-01-28 Multichannel cassette for bioseparation
JP2002559655A JP2004532384A (en) 2001-01-26 2002-01-28 Multi-channel biological separation cartridge
EP02714795A EP1354192B1 (en) 2001-01-26 2002-01-28 Multi-channel bio-separation cartridge

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26460501P 2001-01-26 2001-01-26
US60/264,605 2001-01-26

Publications (2)

Publication Number Publication Date
WO2002059589A2 WO2002059589A2 (en) 2002-08-01
WO2002059589A3 true WO2002059589A3 (en) 2003-04-10

Family

ID=23006811

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/002515 WO2002059589A2 (en) 2001-01-26 2002-01-28 Multi-channel bio-separation cartridge

Country Status (13)

Country Link
US (1) US7309409B2 (en)
EP (1) EP1354192B1 (en)
JP (1) JP2004532384A (en)
CN (1) CN100533138C (en)
AT (1) ATE522802T1 (en)
AU (1) AU2002247040A1 (en)
CA (1) CA2436136C (en)
CY (1) CY1112666T1 (en)
DK (1) DK1354192T3 (en)
ES (1) ES2370633T3 (en)
PT (1) PT1354192E (en)
TW (1) TWI273238B (en)
WO (1) WO2002059589A2 (en)

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Also Published As

Publication number Publication date
US7309409B2 (en) 2007-12-18
EP1354192A2 (en) 2003-10-22
WO2002059589A2 (en) 2002-08-01
CN100533138C (en) 2009-08-26
TWI273238B (en) 2007-02-11
CN1494654A (en) 2004-05-05
CA2436136C (en) 2010-04-20
ES2370633T3 (en) 2011-12-21
US20020123073A1 (en) 2002-09-05
CY1112666T1 (en) 2016-02-10
CA2436136A1 (en) 2002-08-01
EP1354192B1 (en) 2011-08-31
PT1354192E (en) 2011-12-21
AU2002247040A1 (en) 2002-08-06
DK1354192T3 (en) 2011-12-12
JP2004532384A (en) 2004-10-21
ATE522802T1 (en) 2011-09-15

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