WO2002055136A3 - Intrasvascular drug delivery device and use therefor - Google Patents

Intrasvascular drug delivery device and use therefor Download PDF

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Publication number
WO2002055136A3
WO2002055136A3 PCT/US2001/044900 US0144900W WO02055136A3 WO 2002055136 A3 WO2002055136 A3 WO 2002055136A3 US 0144900 W US0144900 W US 0144900W WO 02055136 A3 WO02055136 A3 WO 02055136A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug
blood vessel
drug delivery
reservoir
delivery device
Prior art date
Application number
PCT/US2001/044900
Other languages
French (fr)
Other versions
WO2002055136A2 (en
Inventor
H. David Humes
Evangelos Tziampazis
Original Assignee
Nephros Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nephros Therapeutics, Inc. filed Critical Nephros Therapeutics, Inc.
Priority to CA002436814A priority Critical patent/CA2436814A1/en
Priority to EP01988209A priority patent/EP1341476A2/en
Priority to JP2002555867A priority patent/JP2005501573A/en
Priority to AU2002241538A priority patent/AU2002241538A1/en
Publication of WO2002055136A2 publication Critical patent/WO2002055136A2/en
Publication of WO2002055136A3 publication Critical patent/WO2002055136A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is an implantable drug delivery for delivering a pre-selected drug directly into the systemic circulation of an animal. The device comprises an anchor (10) immobilizable to an inner wall of an intact blood vessel. The device also comprises a drug containing reservoir that is retained in place within the blood vessel by the immobilized anchor. The reservoir (20) may include, for example, a drug containing osmotic pump or a drug permeable capsule having disposed therein drug containing particles, which release the drug directly into blood passing the reservoir. The invention also provides minimally invasive method for introducing into a blood vessel and, optionally, removing from the blood vessel the drug delivery device of the invention.
PCT/US2001/044900 2000-12-01 2001-11-30 Intrasvascular drug delivery device and use therefor WO2002055136A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002436814A CA2436814A1 (en) 2000-12-01 2001-11-30 Intravascular drug delivery device and use therefor
EP01988209A EP1341476A2 (en) 2000-12-01 2001-11-30 Intrasvascular drug delivery device and use therefor
JP2002555867A JP2005501573A (en) 2000-12-01 2001-11-30 Intravascular drug delivery device and use thereof
AU2002241538A AU2002241538A1 (en) 2000-12-01 2001-11-30 Intrasvascular drug delivery device and use therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25074600P 2000-12-01 2000-12-01
US60/250,746 2000-12-01

Publications (2)

Publication Number Publication Date
WO2002055136A2 WO2002055136A2 (en) 2002-07-18
WO2002055136A3 true WO2002055136A3 (en) 2003-01-30

Family

ID=22948967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044900 WO2002055136A2 (en) 2000-12-01 2001-11-30 Intrasvascular drug delivery device and use therefor

Country Status (6)

Country Link
US (1) US20020090388A1 (en)
EP (1) EP1341476A2 (en)
JP (1) JP2005501573A (en)
AU (1) AU2002241538A1 (en)
CA (1) CA2436814A1 (en)
WO (1) WO2002055136A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7899554B2 (en) 2003-06-04 2011-03-01 Synecor Llc Intravascular System and Method
US9029144B2 (en) 2008-06-18 2015-05-12 Innovative Bio Therapies, Inc. Methods for enhanced propagation of cells

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7780628B1 (en) * 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
US7651696B2 (en) * 2000-08-25 2010-01-26 Nexeon Medical Systems, Inc. Implantable device for treating disease states and methods of using same
US6740331B1 (en) * 2000-08-25 2004-05-25 Global Gene Therapies, Inc. Apparatus for the delivery of drugs or gene therapy into a patient's vasculature and methods of use
US9089450B2 (en) 2000-11-14 2015-07-28 Cochlear Limited Implantatable component having an accessible lumen and a drug release capsule for introduction into same
AUPR148400A0 (en) 2000-11-14 2000-12-07 Cochlear Limited Apparatus for delivery of pharmaceuticals to the cochlea
CA2430554A1 (en) * 2000-12-01 2002-07-25 Nephros Therapeutics, Inc. Intravascular blood conditioning device and use thereof
DE10105592A1 (en) 2001-02-06 2002-08-08 Achim Goepferich Placeholder for drug release in the frontal sinus
AUPR879201A0 (en) 2001-11-09 2001-12-06 Cochlear Limited Subthreshold stimulation of a cochlea
US7588564B2 (en) * 2002-07-03 2009-09-15 Pharmaco Kinesis Corporation Apparatus for piezoelectric layer-wise pump and valve for use in local administration of biological response modifiers and therapeutic agents
US8920826B2 (en) * 2002-07-31 2014-12-30 Boston Scientific Scimed, Inc. Medical imaging reference devices
US20050197624A1 (en) 2004-03-04 2005-09-08 Flowmedica, Inc. Sheath for use in peripheral interventions
WO2004032791A2 (en) 2002-09-20 2004-04-22 Flowmedica, Inc. Method and apparatus for selective material delivery via an intra-renal catheter
WO2004030718A2 (en) * 2002-09-20 2004-04-15 Flowmedica, Inc. Method and apparatus for intra aortic substance delivery to a branch vessel
JP2006513809A (en) * 2002-09-20 2006-04-27 フローメディカ，インコーポレイテッド Apparatus and method for inserting an intra-aortic catheter through a delivery sheath
US7063679B2 (en) * 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
US7993325B2 (en) 2002-09-20 2011-08-09 Angio Dynamics, Inc. Renal infusion systems and methods
US8317816B2 (en) 2002-09-30 2012-11-27 Acclarent, Inc. Balloon catheters and methods for treating paranasal sinuses
CA2513721C (en) * 2002-11-08 2013-04-16 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
US20070156197A1 (en) * 2005-12-15 2007-07-05 Cardiac Pacemakers, Inc. Method and apparatus for improved medical device profile
US7811606B2 (en) 2003-04-16 2010-10-12 Dey, L.P. Nasal pharmaceutical formulations and methods of using the same
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
US9808471B2 (en) 2003-04-16 2017-11-07 Mylan Specialty Lp Nasal pharmaceutical formulations and methods of using the same
US7288084B2 (en) * 2003-04-28 2007-10-30 Boston Scientific Scimed, Inc. Drug-loaded medical device
CA2526534C (en) 2003-05-22 2011-07-12 United Therapeutics Corporation Compounds and methods for delivery of prostacyclin analogs
US7082336B2 (en) 2003-06-04 2006-07-25 Synecor, Llc Implantable intravascular device for defibrillation and/or pacing
US8239045B2 (en) 2003-06-04 2012-08-07 Synecor Llc Device and method for retaining a medical device within a vessel
US7617007B2 (en) 2003-06-04 2009-11-10 Synecor Llc Method and apparatus for retaining medical implants within body vessels
JP2006526464A (en) 2003-06-05 2006-11-24 フローメディカ，インコーポレイテッド System and method for performing bilateral intervention or diagnosis in a branched body lumen
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
WO2005058415A2 (en) 2003-12-12 2005-06-30 Synecor, Llc Implantable medical device having pre-implant exoskeleton
ATE534426T1 (en) * 2004-02-10 2011-12-15 Synecor Llc INTRAVASCULAR DELIVERY SYSTEM FOR THERAPEUTIC AGENTS
US7998060B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US8092549B2 (en) 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US8024036B2 (en) 2007-03-19 2011-09-20 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US7850676B2 (en) 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US8000784B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling device
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US8337482B2 (en) 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US8361013B2 (en) 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US9801527B2 (en) 2004-04-19 2017-10-31 Gearbox, Llc Lumen-traveling biological interface device
US9399121B2 (en) 2004-04-21 2016-07-26 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US20060063973A1 (en) 2004-04-21 2006-03-23 Acclarent, Inc. Methods and apparatus for treating disorders of the ear, nose and throat
US20060004323A1 (en) 2004-04-21 2006-01-05 Exploramed Nc1, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US7419497B2 (en) 2004-04-21 2008-09-02 Acclarent, Inc. Methods for treating ethmoid disease
US9089258B2 (en) 2004-04-21 2015-07-28 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US8764729B2 (en) 2004-04-21 2014-07-01 Acclarent, Inc. Frontal sinus spacer
US7654997B2 (en) 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat
US7559925B2 (en) 2006-09-15 2009-07-14 Acclarent Inc. Methods and devices for facilitating visualization in a surgical environment
US10188413B1 (en) 2004-04-21 2019-01-29 Acclarent, Inc. Deflectable guide catheters and related methods
US8747389B2 (en) 2004-04-21 2014-06-10 Acclarent, Inc. Systems for treating disorders of the ear, nose and throat
US20190314620A1 (en) 2004-04-21 2019-10-17 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US9101384B2 (en) 2004-04-21 2015-08-11 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat
US20070208252A1 (en) 2004-04-21 2007-09-06 Acclarent, Inc. Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses
US7803150B2 (en) 2004-04-21 2010-09-28 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US20070167682A1 (en) 2004-04-21 2007-07-19 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US8932276B1 (en) 2004-04-21 2015-01-13 Acclarent, Inc. Shapeable guide catheters and related methods
US8146400B2 (en) 2004-04-21 2012-04-03 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US7410480B2 (en) 2004-04-21 2008-08-12 Acclarent, Inc. Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders
US9351750B2 (en) 2004-04-21 2016-05-31 Acclarent, Inc. Devices and methods for treating maxillary sinus disease
US8894614B2 (en) 2004-04-21 2014-11-25 Acclarent, Inc. Devices, systems and methods useable for treating frontal sinusitis
US7462175B2 (en) 2004-04-21 2008-12-09 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US8702626B1 (en) 2004-04-21 2014-04-22 Acclarent, Inc. Guidewires for performing image guided procedures
US9554691B2 (en) 2004-04-21 2017-01-31 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US7361168B2 (en) * 2004-04-21 2008-04-22 Acclarent, Inc. Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders
US20060069323A1 (en) * 2004-09-24 2006-03-30 Flowmedica, Inc. Systems and methods for bi-lateral guidewire cannulation of branched body lumens
WO2006047198A2 (en) * 2004-10-26 2006-05-04 Caritas St. Elizabeth Medical Center Of Boston, Inc. Composition and method for using a cytokine to treat restenosis
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US8114113B2 (en) 2005-09-23 2012-02-14 Acclarent, Inc. Multi-conduit balloon catheter
US20070106277A1 (en) * 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Remote controller for substance delivery system
US8585684B2 (en) 2005-11-09 2013-11-19 The Invention Science Fund I, Llc Reaction device controlled by magnetic control signal
US20070106271A1 (en) 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Remote control of substance delivery system
US8273071B2 (en) 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US9028467B2 (en) 2005-11-09 2015-05-12 The Invention Science Fund I, Llc Osmotic pump with remotely controlled osmotic pressure generation
US9107733B2 (en) * 2006-01-13 2015-08-18 W. L. Gore & Associates, Inc. Removable blood conduit filter
US20090081296A1 (en) * 2006-02-02 2009-03-26 Humes H David Extracorporeal cell-based therapeutic device and delivery system
EP1989144A4 (en) 2006-02-02 2014-01-29 Innovative Bio Therapies An extracorporeal cell-based therapeutic device and delivery system
US20070191816A1 (en) * 2006-02-13 2007-08-16 Boston Scientific Scimed, Inc. Radio frequency induced drug elution
US20070231363A1 (en) * 2006-03-29 2007-10-04 Yung-Ming Chen Coatings formed from stimulus-sensitive material
US20080058785A1 (en) 2006-04-12 2008-03-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US20120035437A1 (en) 2006-04-12 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Navigation of a lumen traveling device toward a target
US8747897B2 (en) * 2006-04-27 2014-06-10 Supernus Pharmaceuticals, Inc. Osmotic drug delivery system
US8190389B2 (en) 2006-05-17 2012-05-29 Acclarent, Inc. Adapter for attaching electromagnetic image guidance components to a medical device
US7771401B2 (en) 2006-06-08 2010-08-10 Angiodynamics, Inc. Selective renal cannulation and infusion systems and methods
US8388573B1 (en) 2006-06-28 2013-03-05 Abbott Cardiovascular Systems Inc. Local delivery with a balloon covered by a cage
US7722665B2 (en) * 2006-07-07 2010-05-25 Graft Technologies, Inc. System and method for providing a graft in a vascular environment
US9820688B2 (en) 2006-09-15 2017-11-21 Acclarent, Inc. Sinus illumination lightwire device
US8025634B1 (en) * 2006-09-18 2011-09-27 Baxter International Inc. Method and system for controlled infusion of therapeutic substances
US8439687B1 (en) 2006-12-29 2013-05-14 Acclarent, Inc. Apparatus and method for simulated insertion and positioning of guidewares and other interventional devices
WO2008091570A2 (en) * 2007-01-23 2008-07-31 Dtherapeutics, Llc Devices, systems and methods for controlling local blood pressure
WO2008124787A2 (en) 2007-04-09 2008-10-16 Acclarent, Inc. Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis
US8118757B2 (en) 2007-04-30 2012-02-21 Acclarent, Inc. Methods and devices for ostium measurement
US8485199B2 (en) 2007-05-08 2013-07-16 Acclarent, Inc. Methods and devices for protecting nasal turbinate during surgery
US9149610B2 (en) * 2007-05-31 2015-10-06 Abbott Cardiovascular Systems Inc. Method and apparatus for improving delivery of an agent to a kidney
US8216209B2 (en) 2007-05-31 2012-07-10 Abbott Cardiovascular Systems Inc. Method and apparatus for delivering an agent to a kidney
US9144509B2 (en) 2007-05-31 2015-09-29 Abbott Cardiovascular Systems Inc. Method and apparatus for delivering an agent to a kidney
US9364586B2 (en) 2007-05-31 2016-06-14 Abbott Cardiovascular Systems Inc. Method and apparatus for improving delivery of an agent to a kidney
US8133215B2 (en) 2007-08-13 2012-03-13 Cochlear Limited Independently-manufactured drug delivery module and corresponding receptacle in an implantable medical device
US8366652B2 (en) 2007-08-17 2013-02-05 The Invention Science Fund I, Llc Systems, devices, and methods including infection-fighting and monitoring shunts
US8702640B2 (en) 2007-08-17 2014-04-22 The Invention Science Fund I, Llc System, devices, and methods including catheters configured to monitor and inhibit biofilm formation
US8706211B2 (en) 2007-08-17 2014-04-22 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having self-cleaning surfaces
US8165663B2 (en) * 2007-10-03 2012-04-24 The Invention Science Fund I, Llc Vasculature and lymphatic system imaging and ablation
US8734718B2 (en) 2007-08-17 2014-05-27 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component
US8647292B2 (en) 2007-08-17 2014-02-11 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having components that are actively controllable between two or more wettability states
US8753304B2 (en) 2007-08-17 2014-06-17 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having acoustically actuatable waveguide components for delivering a sterilizing stimulus to a region proximate a surface of the catheter
US8460229B2 (en) 2007-08-17 2013-06-11 The Invention Science Fund I, Llc Systems, devices, and methods including catheters having components that are actively controllable between transmissive and reflective states
US9005263B2 (en) 2007-08-17 2015-04-14 The Invention Science Fund I, Llc System, devices, and methods including actively-controllable sterilizing excitation delivery implants
US8100855B2 (en) 2007-09-17 2012-01-24 Abbott Cardiovascular Systems, Inc. Methods and devices for eluting agents to a vessel
US8285367B2 (en) * 2007-10-05 2012-10-09 The Invention Science Fund I, Llc Vasculature and lymphatic system imaging and ablation associated with a reservoir
US8285366B2 (en) 2007-10-04 2012-10-09 The Invention Science Fund I, Llc Vasculature and lymphatic system imaging and ablation associated with a local bypass
EP2047884B1 (en) * 2007-10-09 2018-04-04 Cochlear Limited Implantable component having an accessible lumen and a drug delivery capsule for introduction into same
US10206821B2 (en) 2007-12-20 2019-02-19 Acclarent, Inc. Eustachian tube dilation balloon with ventilation path
US8182432B2 (en) 2008-03-10 2012-05-22 Acclarent, Inc. Corewire design and construction for medical devices
MX2011001099A (en) 2008-07-30 2011-03-15 Acclarent Inc Paranasal ostium finder devices and methods.
JP5584687B2 (en) 2008-09-18 2014-09-03 アクラレント インコーポレイテッド Method and apparatus for treating ear, nose and throat disorders
US9623222B2 (en) * 2008-10-30 2017-04-18 Warsaw Orthopedic, Inc. Drug depot with anchor
EP2356227B1 (en) * 2008-11-14 2018-03-28 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
US8585627B2 (en) 2008-12-04 2013-11-19 The Invention Science Fund I, Llc Systems, devices, and methods including catheters configured to monitor biofilm formation having biofilm spectral information configured as a data structure
US20110295090A1 (en) 2008-12-04 2011-12-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems, devices, and methods including implantable devices with anti-microbial properties
US20100241155A1 (en) 2009-03-20 2010-09-23 Acclarent, Inc. Guide system with suction
US8435290B2 (en) 2009-03-31 2013-05-07 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US7978742B1 (en) 2010-03-24 2011-07-12 Corning Incorporated Methods for operating diode lasers
US20100268191A1 (en) * 2009-04-21 2010-10-21 Medtronic Vascular, Inc. Drug Delivery Catheter using Frangible Microcapsules and Delivery Method
WO2011079222A2 (en) 2009-12-23 2011-06-30 Boston Scientific Scimed, Inc. Less traumatic method of delivery of mesh-based devices into human body
US8617097B2 (en) 2010-05-24 2013-12-31 Cochlear Limited Drug-delivery accessory for an implantable medical device
US9155492B2 (en) 2010-09-24 2015-10-13 Acclarent, Inc. Sinus illumination lightwire device
EP2680917A1 (en) * 2011-03-04 2014-01-08 Johns Hopkins University Implantable pressure-actuated drug delivery systems and methods of manufacture and use
US9629684B2 (en) 2013-03-15 2017-04-25 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US9433437B2 (en) 2013-03-15 2016-09-06 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US20150273156A1 (en) * 2014-03-26 2015-10-01 Boston Scientific Scimed, Inc. Devices for systemic drug delivery and related methods of use
GB2529249B (en) 2014-08-15 2017-09-27 Cook Medical Technologies Llc Endoluminal drug delivery device
US10105469B2 (en) 2015-02-26 2018-10-23 Jacob Schneiderman Composition-of-matter and method for treating cardiovascular disorders
CA2977607A1 (en) * 2015-02-26 2016-09-01 Jacob Schneiderman Methods and compositions relating to leptin antagonists
US9867974B2 (en) * 2015-06-01 2018-01-16 Wisconsin Alumni Research Foundation Microfluidic device for multiplexed point source administration of compounds
US10967122B2 (en) 2015-08-07 2021-04-06 Massachusetts Institute Of Technology Subcutaneous drug delivery device with manual activation and deactivation of drug release
WO2017066355A1 (en) 2015-10-12 2017-04-20 Reflow Medical, Inc. Stents having protruding drug-delivery features and associated systems and methods
DE102018006061A1 (en) * 2018-08-01 2020-02-06 Universität Duisburg-Essen implant
CN115337462B (en) * 2022-09-07 2024-02-27 河南纳牛新材料科技有限公司 Electrostatic spinning polytetrafluoroethylene small-caliber artificial blood vessel and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479796A (en) * 1982-11-15 1984-10-30 Medtronic, Inc. Self-regenerating drug administration device
EP0341039A1 (en) * 1988-05-04 1989-11-08 Triangle Research And Development Corporation Transendoscopic implant capsule
WO1996039098A1 (en) * 1995-06-05 1996-12-12 Nephros Therapeutics, Inc. A device for delivering a preselected molecule into the system circulation
WO1999048545A1 (en) * 1998-03-25 1999-09-30 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
WO2002056796A1 (en) * 2000-12-01 2002-07-25 Nephros Therapeutics, Inc. Intravascular blood conditioning device and use thereof

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US964745A (en) * 1909-05-19 1910-07-19 Robert Blakoe Device for developing and strengthening the muscles of the body and arms.
US3943936A (en) * 1970-09-21 1976-03-16 Rasor Associates, Inc. Self powered pacers and stimulators
US3952747A (en) * 1974-03-28 1976-04-27 Kimmell Jr Garman O Filter and filter insertion instrument
US4309776A (en) * 1980-05-13 1982-01-12 Ramon Berguer Intravascular implantation device and method of using the same
US4332893A (en) * 1980-06-13 1982-06-01 Rosenberg Ralph A Process for the production of an insulin-producing cell line of pancreatic beta cells
US4865585A (en) * 1981-07-13 1989-09-12 Alza Corporation Method of administering drug by using cell comprising drug
US4511353A (en) * 1981-07-13 1985-04-16 Alza Corporation Intravenous system for delivering a beneficial agent
US4985017A (en) * 1981-07-13 1991-01-15 Alza Corporation Parenteral therapeutical system comprising drug cell
US4378016A (en) * 1981-07-15 1983-03-29 Biotek, Inc. Artificial endocrine gland containing hormone-producing cells
SE445884B (en) * 1982-04-30 1986-07-28 Medinvent Sa DEVICE FOR IMPLANTATION OF A RODFORM PROTECTION
US4494531A (en) * 1982-12-06 1985-01-22 Cook, Incorporated Expandable blood clot filter
US4503569A (en) * 1983-03-03 1985-03-12 Dotter Charles T Transluminally placed expandable graft prosthesis
US4673391A (en) * 1983-05-31 1987-06-16 Koichi Sakurai Non-contact controlled micropump
US4777049A (en) * 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
US4685918A (en) * 1985-02-01 1987-08-11 Merck & Co., Inc. Lipid osmotic pump
US4820626A (en) * 1985-06-06 1989-04-11 Thomas Jefferson University Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
FR2606641B1 (en) * 1986-11-17 1991-07-12 Promed FILTERING DEVICE FOR BLOOD CLOTS
US4817600A (en) * 1987-05-22 1989-04-04 Medi-Tech, Inc. Implantable filter
US5035891A (en) * 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
US5133732A (en) * 1987-10-19 1992-07-28 Medtronic, Inc. Intravascular stent
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US4871352A (en) * 1987-12-07 1989-10-03 Controlled Release Technologies, Inc. Self-regulated therapeutic agent delivery system and method
US4938742A (en) * 1988-02-04 1990-07-03 Smits Johannes G Piezoelectric micropump with microvalves
US4832055A (en) * 1988-07-08 1989-05-23 Palestrant Aubrey M Mechanically locking blood clot filter
US5152743A (en) * 1988-08-05 1992-10-06 Healthdyne, Inc. Apparatus and method for selective separation of blood cholesterol
US4969871A (en) * 1989-02-15 1990-11-13 Alza Corporation Intravenous system for delivering a beneficial agent
US5059205A (en) * 1989-09-07 1991-10-22 Boston Scientific Corporation Percutaneous anti-migration vena cava filter
US5391164A (en) * 1991-05-03 1995-02-21 Giampapa; Vincent C. Subcutaneous implantable multiple-agent delivery system
US5350398A (en) * 1991-05-13 1994-09-27 Dusan Pavcnik Self-expanding filter for percutaneous insertion
US5649906A (en) * 1991-07-17 1997-07-22 Gory; Pierre Method for implanting a removable medical apparatus in a human body
US5415630A (en) * 1991-07-17 1995-05-16 Gory; Pierre Method for removably implanting a blood filter in a vein of the human body
US5411550A (en) * 1991-09-16 1995-05-02 Atrium Medical Corporation Implantable prosthetic device for the delivery of a bioactive material
US5429938A (en) * 1992-03-02 1995-07-04 University Of Michigan Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules
US5549674A (en) * 1992-03-02 1996-08-27 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
US6060270A (en) * 1992-03-02 2000-05-09 The University Of Michigan Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules
US6059825A (en) * 1992-03-05 2000-05-09 Angiodynamics, Inc. Clot filter
US5282823A (en) * 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
US5260068A (en) * 1992-05-04 1993-11-09 Anda Sr Pharmaceuticals Inc. Multiparticulate pulsatile drug delivery system
US5383928A (en) * 1992-06-10 1995-01-24 Emory University Stent sheath for local drug delivery
US5428634A (en) * 1992-11-05 1995-06-27 The United States Of America As Represented By The United States Department Of Energy Visible light emitting vertical cavity surface emitting lasers
US5368555A (en) * 1992-12-29 1994-11-29 Hepatix, Inc. Organ support system
US5429634A (en) * 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
US5419760A (en) * 1993-01-08 1995-05-30 Pdt Systems, Inc. Medicament dispensing stent for prevention of restenosis of a blood vessel
US5368588A (en) * 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
GB9311784D0 (en) * 1993-06-08 1993-07-28 Univ Alberta Vascular bioartificial organ
EP0706353A1 (en) * 1993-07-02 1996-04-17 Materials Evolution and Development USA, Inc. Implantable system for cell growth control
CA2173118C (en) * 1993-10-01 2000-09-26 Hannah S. Kim Improved vena cava filter
WO1995010989A1 (en) * 1993-10-19 1995-04-27 Scimed Life Systems, Inc. Intravascular stent pump
JP2626528B2 (en) * 1993-11-22 1997-07-02 日本電気株式会社 Figure recognition device
US6001123A (en) * 1994-04-01 1999-12-14 Gore Enterprise Holdings Inc. Folding self-expandable intravascular stent-graft
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
US5810767A (en) * 1994-05-11 1998-09-22 Localmed, Inc. Method and apparatus for pressurized intraluminal drug delivery
DE9409484U1 (en) * 1994-06-11 1994-08-04 Naderlinger Eduard Vena cava thrombus filter
US5681278A (en) * 1994-06-23 1997-10-28 Cormedics Corp. Coronary vasculature treatment method
US5591230A (en) * 1994-09-07 1997-01-07 Global Therapeutics, Inc. Radially expandable stent
CA2179304C (en) * 1994-10-17 2008-02-05 Keiji Igaki Stent for liberating drug
US5788468A (en) * 1994-11-03 1998-08-04 Memstek Products, Llc Microfabricated fluidic devices
US6099864A (en) * 1994-12-02 2000-08-08 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration In situ activation of microcapsules
US6027516A (en) * 1995-05-04 2000-02-22 The United States Of America As Represented By The Department Of Health And Human Services Highly elastic, adjustable helical coil stent
US5788673A (en) * 1995-06-05 1998-08-04 Atrion Medical Products, Inc. Drug infusion system
AU716005B2 (en) * 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US5713853A (en) * 1995-06-07 1998-02-03 Interventional Innovations Corporation Methods for treating thrombosis
US5609629A (en) * 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
DE19521642C2 (en) * 1995-06-14 2000-11-09 Aesculap Ag & Co Kg Implant, its use in surgery and process for its manufacture
FR2744924B1 (en) * 1996-02-21 1998-04-24 Franchi Pierre PRESSURE GENERATOR / REGULATOR DEVICE FOR AN IMPLANTABLE HEART ASSISTANCE PUMP OF THE COUNTERPRESSURE BALLOON TYPE
US5713949A (en) * 1996-08-06 1998-02-03 Jayaraman; Swaminathan Microporous covered stents and method of coating
US5800421A (en) * 1996-06-12 1998-09-01 Lemelson; Jerome H. Medical devices using electrosensitive gels
US5834449A (en) * 1996-06-13 1998-11-10 The Research Foundation Of State University Of New York Treatment of aortic and vascular aneurysms with tetracycline compounds
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5797887A (en) * 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
US5902336A (en) * 1996-10-15 1999-05-11 Mirimedical, Inc. Implantable device and method for removing fluids from the blood of a patient method for implanting such a device and method for treating a patient experiencing renal failure
ZA9710342B (en) * 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US6056734A (en) * 1997-02-07 2000-05-02 Sarcos Lc Method for automatic dosing of drugs
US6022333A (en) * 1997-05-01 2000-02-08 S.L.I.M. Tech, Ltd. Method and system for removing materials from lymphatic and other fluids
US5891154A (en) * 1997-05-06 1999-04-06 Advanced Cardiovascular System, Inc. Passive perfusion stent delivery system
US5911734A (en) * 1997-05-08 1999-06-15 Embol-X, Inc. Percutaneous catheter and guidewire having filter and medical device deployment capabilities
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US5899935A (en) * 1997-08-04 1999-05-04 Schneider (Usa) Inc. Balloon expandable braided stent with restraint
US6030414A (en) * 1997-11-13 2000-02-29 Taheri; Syde A. Variable stent and method for treatment of arterial disease
US6099495A (en) * 1998-04-30 2000-08-08 Medtronic, Inc. Implantable electrical transducer powered from capacitive storage energy source
US6132458A (en) * 1998-05-15 2000-10-17 American Medical Systems, Inc. Method and device for loading a stent
US6129757A (en) * 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
US6036725A (en) * 1998-06-10 2000-03-14 General Science And Technology Expandable endovascular support device
US6136011A (en) * 1998-07-14 2000-10-24 Advanced Cardiovascular Systems, Inc. Stent delivery system and method of use
US6093199A (en) * 1998-08-05 2000-07-25 Endovascular Technologies, Inc. Intra-luminal device for treatment of body cavities and lumens and method of use
US6290728B1 (en) * 1998-09-10 2001-09-18 Percardia, Inc. Designs for left ventricular conduit
US6113608A (en) * 1998-11-20 2000-09-05 Scimed Life Systems, Inc. Stent delivery device
US6080178A (en) * 1999-04-20 2000-06-27 Meglin; Allen J. Vena cava filter
US6585756B1 (en) * 1999-05-14 2003-07-01 Ernst P. Strecker Implantable lumen prosthesis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479796A (en) * 1982-11-15 1984-10-30 Medtronic, Inc. Self-regenerating drug administration device
EP0341039A1 (en) * 1988-05-04 1989-11-08 Triangle Research And Development Corporation Transendoscopic implant capsule
WO1996039098A1 (en) * 1995-06-05 1996-12-12 Nephros Therapeutics, Inc. A device for delivering a preselected molecule into the system circulation
WO1999048545A1 (en) * 1998-03-25 1999-09-30 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
WO2002056796A1 (en) * 2000-12-01 2002-07-25 Nephros Therapeutics, Inc. Intravascular blood conditioning device and use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7899554B2 (en) 2003-06-04 2011-03-01 Synecor Llc Intravascular System and Method
US9029144B2 (en) 2008-06-18 2015-05-12 Innovative Bio Therapies, Inc. Methods for enhanced propagation of cells

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