WO2002050584A2 - Microneedle array systems - Google Patents
Microneedle array systems Download PDFInfo
- Publication number
- WO2002050584A2 WO2002050584A2 PCT/US2001/049797 US0149797W WO0250584A2 WO 2002050584 A2 WO2002050584 A2 WO 2002050584A2 US 0149797 W US0149797 W US 0149797W WO 0250584 A2 WO0250584 A2 WO 0250584A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- array
- needle
- fiber
- needles
- optical
- Prior art date
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Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/38—Mechanical coupling means having fibre to fibre mating means
- G02B6/3807—Dismountable connectors, i.e. comprising plugs
- G02B6/3833—Details of mounting fibres in ferrules; Assembly methods; Manufacture
- G02B6/3834—Means for centering or aligning the light guide within the ferrule
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/26—Optical coupling means
- G02B6/262—Optical details of coupling light into, or out of, or between fibre ends, e.g. special fibre end shapes or associated optical elements
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/42—Coupling light guides with opto-electronic elements
- G02B6/4201—Packages, e.g. shape, construction, internal or external details
- G02B6/4202—Packages, e.g. shape, construction, internal or external details for coupling an active element with fibres without intermediate optical elements, e.g. fibres with plane ends, fibres with shaped ends, bundles
- G02B6/4203—Optical features
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/42—Coupling light guides with opto-electronic elements
- G02B6/4201—Packages, e.g. shape, construction, internal or external details
- G02B6/4219—Mechanical fixtures for holding or positioning the elements relative to each other in the couplings; Alignment methods for the elements, e.g. measuring or observing methods especially used therefor
- G02B6/4228—Passive alignment, i.e. without a detection of the degree of coupling or the position of the elements
- G02B6/4232—Passive alignment, i.e. without a detection of the degree of coupling or the position of the elements using the surface tension of fluid solder to align the elements, e.g. solder bump techniques
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/42—Coupling light guides with opto-electronic elements
- G02B6/4201—Packages, e.g. shape, construction, internal or external details
- G02B6/4249—Packages, e.g. shape, construction, internal or external details comprising arrays of active devices and fibres
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/38—Mechanical coupling means having fibre to fibre mating means
- G02B6/3807—Dismountable connectors, i.e. comprising plugs
- G02B6/381—Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres
- G02B6/3818—Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres of a low-reflection-loss type
- G02B6/382—Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres of a low-reflection-loss type with index-matching medium between light guides
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/38—Mechanical coupling means having fibre to fibre mating means
- G02B6/3807—Dismountable connectors, i.e. comprising plugs
- G02B6/3833—Details of mounting fibres in ferrules; Assembly methods; Manufacture
- G02B6/3855—Details of mounting fibres in ferrules; Assembly methods; Manufacture characterised by the method of anchoring or fixing the fibre within the ferrule
- G02B6/3861—Adhesive bonding
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/38—Mechanical coupling means having fibre to fibre mating means
- G02B6/3807—Dismountable connectors, i.e. comprising plugs
- G02B6/3873—Connectors using guide surfaces for aligning ferrule ends, e.g. tubes, sleeves, V-grooves, rods, pins, balls
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/38—Mechanical coupling means having fibre to fibre mating means
- G02B6/3807—Dismountable connectors, i.e. comprising plugs
- G02B6/3873—Connectors using guide surfaces for aligning ferrule ends, e.g. tubes, sleeves, V-grooves, rods, pins, balls
- G02B6/3874—Connectors using guide surfaces for aligning ferrule ends, e.g. tubes, sleeves, V-grooves, rods, pins, balls using tubes, sleeves to align ferrules
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/38—Mechanical coupling means having fibre to fibre mating means
- G02B6/3807—Dismountable connectors, i.e. comprising plugs
- G02B6/3873—Connectors using guide surfaces for aligning ferrule ends, e.g. tubes, sleeves, V-grooves, rods, pins, balls
- G02B6/3885—Multicore or multichannel optical connectors, i.e. one single ferrule containing more than one fibre, e.g. ribbon type
Definitions
- NCSELs vertical cavity surface emitting lasers
- Optical components such as those using vertical cavity surface emitting lasers (VCSELs) have been the subject of increasing investigation over the past decade throughout the world. NCSEL manufacturing has been initiated at several companies and commercial products incorporating NCSELs are available. The high performance of NCSELs such as high output power, high speed modulation provide for many commercial applications of NCSELs such as data links, smart pixels, print heads, display, scanning, sensors, etc. NCSEL arrays are successfully being integrated with optics and microelectronics.
- Optical components need to be manufactured economically and combine active components, such as lasers with optical fibers. Further, the manufacturing of integrated optical sensors needs to be improved.
- the present invention includes systems of microneedle arrays to align multiple fibers to a laser or detector array.
- the present invention fabricates microneedles using techniques that include, for example, but not limited to, laser drilled Kapton or epoxy molding, and combines them with optical fibers, bump bonding, and UN curing adjhesives, to manufacture a variety of optical modules useful for communications and sensing.
- the present invention provides economical optical components with precise optical alignment and high coupling efficiency.
- the components are scalable to a large number of lasers and/or detectors.
- the microneedle array is tapered.
- the present invention includes the use of Vertical Cavity Surface Emitting
- the taper of the hollow needles allows fibers to be conveniently inserted into the wider end and then guided by the taper to a very precise position determined by the needle bore and the precision of the needle placement. Since the needles are fabricated using photolithography and or laser drilling, both of which can achieve very accurate placement of the needles, alignment to tolerances of approximately a micron can be achieved.
- the fibers are fixed in place using epoxy that is thermally or UV cured (or done in combination). The z-orientation is determined by fixturing the needles so that the fibers, when inserted, come in contact with a stop. Typical needle dimensions are about 125 ⁇ m exit hole, 125 ⁇ m length,
- the present invention can be utilized in applications such as, but not limited to, the gigabit ethemet, and other high speed optical interconnects requiring low-cost packaging, servers, optical bacl ⁇ lanes, and intranets. Further, the present invention has applications in sensing systems.
- Figures 1A and IB are schematic views of flip chip components.
- Figure 2A is a top view of an assembly in accordance with the present invention.
- Figure 2B is a detailed view of the flip chip assembly in accordance with the present invention.
- FIGS 3 A and 3B are flow charts of the microneedle fabrication process and fiber/VCSEL assembly process in accordance with the present invention.
- Figures 4A-4C are cross-sectional views of fiber assemblies in accordance with the present invention.
- Figure 5 is a cross-sectional view of fibers with graded epoxy lens in accordance with the present invention.
- Figure 6 is a cross-sectional view of an extruded optical waveguide in accordance with the present invention.
- Figures 7 A and 7B are views illustrating the coupling of the fiber connector to the laser array, before and after the coupling respectively, in accordance with the present invention.
- Figure 8 is a cross-sectional view illustrating a lensed fiber connector in accordance with the present invention.
- Figure 9 is a cross-sectional view illustrating an un-lensed fiber connector in accordance with the present invention.
- Figure 10 is a cross-sectional view of a lensed fiber connector with an alignment spacer in accordance with the present invention.
- Figure 11 is a cross-sectional view of an un-lensed fiber connector with an alignment spacer in accordance with the present invention.
- Figures 12A-12C are cross-sectional views of microneedle/fiber arrays with sensing elements in accordance with the present invention. DETAILED DESCRIPTION OF THE INVENTION
- the present invention relates to using microneedles, in particular, tapered microneedles, to align and form optical components.
- Active components such as lasers, can be combined with optical fibers, either singly or in arrays with a large number of fibers.
- Microneedle devices and manufacturing methods for the microneedles are described in the following patent applications, U.S. Serial No. 09/095,221 filed on June 10, 1998, U.S. Serial No. 09/448,107 filed on November 23, 1999, U.S. Serial No. 09/452,979 filed on December 2, 1999 and U.S. Serial No. 09/453,109 filed on December 2, 1999, all of which are herein incorporated by reference in their entirety.
- bump bonding using solder bumps 14 is used. This technique utilizes the surface tension of molten solder to align the two substrates. It has been shown that large misalignments (depending on the bump size, a few mils of lateral misalignment) may be taken up upon melting of the solder. The bump height, and hence the distance from the fibers to the laser array , may also be accurately controlled by controlling the pad 16 size on the needle array and the size of the solder ball on its mating piece.
- microneedle devices include a substrate to which the base of the microneedle(s) is secured or integrated.
- the substrate can be formed from a variety of materials including, but not limited to, metals, ceramics, semiconductors, organics, polymers and composites.
- the substrate is coated with a photolithographically patterned epoxy molded per step 32 and seed metal is then deposited thereon per step 34.
- the needles are then plated per step 36, such as, for example, by electroplating.
- the substrate is then removed per step 38, leaving the microneedle array.
- the needles are separated per step 40 and then mounted per step 42.
- the assembly process for the fiber and VCSEL arrays includes the step of taking the microneedle array with alignment pads per step 50 and inserting fibers into the microneedle array per step 52.
- epoxy is dispensed and cured to form the fiber assembly of step 58.
- solder balls are first placed, or plated, onto the diode laser wafer in such a manner that each VCSEL array on the wafer has associated with it a number of solder bumps arranged in a symmetric geometry. These solder bumps are reflowed to form a hemispherical shape. The wafer is then diced into individual laser array chips.
- the bumps are coined as necessary to flatten them out.
- the fiber/needle assembly put together as described above, is fixtured and held in place.
- a laser chip is then picked up using a manual tool or a pick and place machine, flipped over, the bumps coated with flux by a dipping process per step 62, and placed and coarsely aligned onto the fiber assembly.
- the VCSEL array and fiber assembly are then joined per step 64. This procedure is optimally performed using a flip-chip bonder.
- the fiber assembly is then heated to reflow the solder per step 66.
- the laser chip moves to align over the bumps and the assembly is cooled to harden the solder.
- Transparent underfill is then applied between the laser chip and the fiber/needle array per step 68, providing both mechanical strength as well as increasing the coupling efficiency.
- the assembly is then tested per step 70.
- the method of the present invention results in several improvements.
- the needles offer improvement over simple holes because they protrude from the substrate and allow the solder bumps to be of the appropriate height. Since the needles may be economically fabricated with precise dimensions from, for example, metal, using circuit board techniques, they are inherently cheaper than silicon MEMS structures.
- UV-curing epoxy is first injected into the needles 80, 86 to form a tapered waveguide.
- the needle array is fixtured into place in proximity to a UV light source with the narrow exit hole facing the source.
- a controlled amount of UV curing epoxy 84, 90 (Norland) is injected into a chamber above the needles and down the needle bores.
- the UV light source is switched on and the epoxy cures at the exit hole.
- the epoxy cures j-urther up the tube, but this is a slow process.
- the epoxy forms a plug or stop at the end of the tapered needle.
- the optical fibers 82, 88 are then inserted into the uncured epoxy in the tapers, and fixed into place using a second UN light source behind the needle array.
- the epoxy is then totally cured using further UN exposure or a thermal curing process.
- the cured epoxy plug at the end of the needle forms an intermediate waveguide to couple the light from the laser into the fiber. Since the laser dimensions are much smaller than the needle dimension (approximately 10 ⁇ m vs. 100 ⁇ m for the needle) the beam divergence is small and there is little chance for scattering into higher order optical modes in the epoxy plug, and the coupling even into single mode fiber is efficient.
- the epoxy 96 is injected through the needle 92 and allowed to form a spherical drop at the end of the needle before the UN light source is turned on.
- the UV light source can then be turned on the cure the epoxy into a lens shape.
- the radius of the lens is determined by the viscosity of the epoxy, the flow rate, surface tension, and the amount of time the UN light source is delayed before it is turned on to expose the epoxy.
- the fibers 94 are then inserted and attached as described above.
- the lens on the end of the needles serves to increase the coupling efficiency and alignment tolerances.
- the lensed fiber array may then be aligned to the detector or laser array as described above.
- the lenses are formed on a first needle array with minimal UN exposure.
- a fiber assembly is built up separately using a second needle array as described previously. This fiber assembly is then inserted into the first lensed needle array and the epoxy cured to form a coupled lensed fiber array.
- the two tapers serve to provide the mechanical alignment while the lens increases the optical alignment tolerances and the coupling efficiency.
- the taper of the fibered needles may be chosen to have a larger angle than the lensed needle array.
- the fibered needle array encounters a mechanical stop upon insertion which provides both lateral and longitudinal alignment and stability.
- the tapers may be filled with an epoxy plug with a step or graded refractive index profile.
- This profile has the advantage of minimizing scattering into higher order modes in the expanding taper, or minimizing losses in the contracting taper because the interaction with the metal taper walls is less.
- a first needle array 124 is formed with either a lens or a plug at the end by the UN curing process described above. The excess epoxy is removed from the back of the array. A soft elastomer such as PDMS may be dispensed into the holes as necessary. Pins through holes in the needles arrays are then used for coarse alignment. Fine alignment is provided by the tapered shapes of the needles themselves. A second fibered needle array 122 may then be repeatably inserted or removed to couple the fiber array 120 to the light sources.
- two fiber/needle arrays 138, 140, 148, 150 maybe combined to form a connector by facing the two needle arrays towards each other to couple light from one to the other.
- the fiber arrays 138, 140, 148, 150 may have either fibers only, the UN cured epoxy plug 154, or the UN-shaped lens arrays 146 for improved coupling. Alignment may be provided by precision pins through the two fiber arrays as is commonly done today in fiber-optic ribbon connectors.
- a compliant, transparent spacer sheet 158 maybe used between the needle arrays to provide improved optical coupling by reducing beam divergence, hi that case, the needles 164, 174 form indentations in the compliant sheet and provide good coupling.
- a spacer sheet 180 is provided with laser drilled or lithographically patterned holes having a double taper of dimensions comparable to the needle dimensions. The sheet may be bonded onto one end of the fiber connecter with the tapers over the needle array. When the second fiber/needle assembly is inserted, fine alignment is achieved by the second taper in the spacer sheet.
- the spacer sheet may be fabricated in Kapton like the needle molds.
- Kapton layers separated by a metal layer are used.
- Standard, aligned tapers are formed on both sides of the proper dimensions, and then the metal layer drilled or etched through to couple the two holes.
- the spacer sheet is fabricated to accommodate one or two of the microlenses formed on the end of the needles.
- the lenses fit coaxially down the apertures in the spacer layer to provide high coupling efficiency. This embodiment has the advantage of controlling rotational variations quite effectively.
- the lens parameters are chosen to emit a nearly collimated beam for good optical tolerances. Larger lenses may be formed for better lateral tolerances.
- an emitter for example, a laser or LED
- a detector array are coupled to needles filled with epoxy, each having a flat back surface.
- the emitter/needle assembly is then placed back to back with the detector/needle array and cemented together to form a multichannel opto-isolator.
- Voltage isolation is determined by the dielectric strength of the epoxy.
- plastic fiber is of interest for low cost visible optical waveguides.
- plastic optical waveguide may be extruded in dimensions of the range 20-200 ⁇ m. hi order to form a core/cladding structure coaxial needles as described above may be utilized.
- a standard waveguide refractive index profile may be extruded under appropriate conditions of temperature and pressure.
- Fiber arrays can be readily extruded by using a one-dimension or 2-dimension needle array.
- a graded index profile is also achieved, primarily by compressing the outer plastic into the inner core as it passes through the needle.
- the present invention has application in sensing systems.
- Optical sensors are commonly formed by doping host matrices with colorimetric or fluorescent materials that are sensitive to environmental conditions. Common applications are blood gas sensing, biological oxygen demand, food safety, etc. By combining such indicators with microneedles, several advantages are attained. Small sensors can be formed within the needles by injecting the appropriately doped matrix materials 204, 210, 218, into the needles 202, 208. Small sensor elements result in fast response times.
- sensing elements are readily combined with excitation and detection devices using the coupling geometries described herein above.
- the sensors can be remotely excited and/or detected using optical fibers coupled as described herein.
- sensor arrays are readily fabricated.
- multiple sensing materials can be incorporated into one position.
- excitation can be focussed or reflected by the lens section for greater sensitivity.
- the exposed spherical region has greater surface area for faster and larger response to, for example, an analyte.
- a detachable or disposable sensing element that is readily connected and disconnected is achieved.
- the detachable sensor array fits on the end of a multiple fiber excitation device that is coupled through a second needle array with a wider angle than the sensor needles, h addition, the sensor elements themselves are low cost and therefore economical.
- the needles provide an excellent means to bring the sensing elements contained within into contact with the environment to be sensed.
- the sensing elements comprise a supporting matrix doped with various environmentally sensitive dyes.
- Matrix elements include, for example, sol gels, hydro gels, and other polymers with a high gas or liquid permeability. By using a hydrophobic matrix, efficient gas-liquid separation is achieved.
- dyes which can be incorporated, including, but not limited to, rhodamines, various bodipy dyes, ruthenium-based and other rare earth dyes, and metal intercalating dyes.
- the sensor elements are fabricated by dispensing the polymers under pressure into a needle array in much the same way the epoxies are dispensed as described herein.
- the matrices either set up or are cured using thermal or photochemical processes.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002231207A AU2002231207A1 (en) | 2000-12-21 | 2001-12-20 | Microneedle array systems |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US25775700P | 2000-12-21 | 2000-12-21 | |
US60/257,757 | 2000-12-21 |
Publications (2)
Publication Number | Publication Date |
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WO2002050584A2 true WO2002050584A2 (en) | 2002-06-27 |
WO2002050584A3 WO2002050584A3 (en) | 2003-05-30 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/US2001/049797 WO2002050584A2 (en) | 2000-12-21 | 2001-12-20 | Microneedle array systems |
Country Status (3)
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US (1) | US7027478B2 (en) |
AU (1) | AU2002231207A1 (en) |
WO (1) | WO2002050584A2 (en) |
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US8192787B2 (en) | 2004-08-16 | 2012-06-05 | Innoture Limited | Method of producing a microneedle or microimplant |
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US8798722B2 (en) | 2009-02-27 | 2014-08-05 | Virginia Tech Intellectual Properties, Inc. | Fiber array for optical imaging and therapeutics |
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US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
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US7963954B2 (en) | 2007-04-30 | 2011-06-21 | Medtronic Minimed, Inc. | Automated filling systems and methods |
US7959715B2 (en) | 2007-04-30 | 2011-06-14 | Medtronic Minimed, Inc. | Systems and methods allowing for reservoir air bubble management |
US8323250B2 (en) * | 2007-04-30 | 2012-12-04 | Medtronic Minimed, Inc. | Adhesive patch systems and methods |
CA2685474C (en) | 2007-04-30 | 2014-07-08 | Medtronic Minimed, Inc. | Reservoir filling, bubble management, and infusion medium delivery systems and methods with same |
US8434528B2 (en) * | 2007-04-30 | 2013-05-07 | Medtronic Minimed, Inc. | Systems and methods for reservoir filling |
US8597243B2 (en) | 2007-04-30 | 2013-12-03 | Medtronic Minimed, Inc. | Systems and methods allowing for reservoir air bubble management |
JP5183111B2 (en) * | 2007-07-05 | 2013-04-17 | キヤノン株式会社 | Vertical cavity surface emitting laser array and image forming apparatus using vertical cavity surface emitting laser array |
US8399410B2 (en) | 2007-08-06 | 2013-03-19 | Allergan, Inc. | Methods and devices for desmopressin drug delivery |
US20100121307A1 (en) * | 2007-08-24 | 2010-05-13 | Microfabrica Inc. | Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications |
WO2009029572A1 (en) * | 2007-08-24 | 2009-03-05 | Deka Products Limited Partnership | Microneedle systems and apparatus |
EP2205169B1 (en) * | 2007-09-28 | 2016-11-16 | The Queen's University of Belfast | Delivery device and method |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
ES2677548T3 (en) * | 2008-05-21 | 2018-08-03 | Ferring B.V. | Orodispersible desmopressin to increase the initial period of uninterrupted sleep due to nocturia |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
US8650937B2 (en) | 2008-09-19 | 2014-02-18 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
EP3284494A1 (en) | 2009-07-30 | 2018-02-21 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
AU2010313487A1 (en) | 2009-10-26 | 2012-05-24 | Emkinetics, Inc. | Method and apparatus for electromagnetic stimulation of nerve, muscle, and body tissues |
CA2781677C (en) * | 2009-12-10 | 2017-07-11 | Alcon Research Ltd. | Multi-spot laser surgical probe using faceted optical elements |
US8588884B2 (en) | 2010-05-28 | 2013-11-19 | Emkinetics, Inc. | Microneedle electrode |
JP5632966B2 (en) * | 2011-05-24 | 2014-11-26 | パナソニック株式会社 | Light emitting element manufacturing method and light emitting element manufacturing apparatus |
JP2013092758A (en) * | 2011-10-04 | 2013-05-16 | Citizen Holdings Co Ltd | Optical device and method for manufacturing optical device |
CN102336387B (en) * | 2011-10-10 | 2015-04-08 | 无锡英普林纳米科技有限公司 | Quartz micro-needle array tip spherical shell microstructure and preparation method thereof |
US8571364B2 (en) | 2011-11-09 | 2013-10-29 | Alcon Research, Ltd. | Multi-spot laser probe with faceted optical element |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US10194840B2 (en) | 2012-12-06 | 2019-02-05 | Medtronic Minimed, Inc. | Microarray electrodes useful with analyte sensors and methods for making and using them |
US9308128B2 (en) | 2013-01-08 | 2016-04-12 | Novartis Ag | Multi-spot laser probe with micro-structured faceted proximal surface |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
US10698165B2 (en) * | 2013-03-15 | 2020-06-30 | Te Connectivity Corporation | Multi-fiber ferrule connector |
US20150122647A1 (en) | 2013-11-07 | 2015-05-07 | Medtronic Minimed, Inc. | Enzyme matrices for use with ethylene oxide sterilization |
JP6906885B2 (en) | 2014-11-14 | 2021-07-21 | ロレアル | Microneedle sheet to reduce wrinkles |
US10126504B2 (en) * | 2015-05-27 | 2018-11-13 | The United States Of America, As Represented By The Secretary Of The Navy | Antireflective surface structures for active and passive optical fiber |
US20190223771A1 (en) | 2018-01-23 | 2019-07-25 | Medtronic Minimed, Inc. | Implantable polymer surfaces exhibiting reduced in vivo inflammatory responses |
US11186859B2 (en) | 2018-02-07 | 2021-11-30 | Medtronic Minimed, Inc. | Multilayer electrochemical analyte sensors and methods for making and using them |
EP4004809A4 (en) | 2019-07-25 | 2023-09-06 | Blackdot, Inc. | Robotic tattooing systems and related technologies |
US11718865B2 (en) | 2019-07-26 | 2023-08-08 | Medtronic Minimed, Inc. | Methods to improve oxygen delivery to implantable sensors |
US11523757B2 (en) | 2019-08-01 | 2022-12-13 | Medtronic Minimed, Inc. | Micro-pillar working electrodes design to reduce backflow of hydrogen peroxide in glucose sensor |
EP4048152B1 (en) | 2020-07-29 | 2023-12-20 | Biolinq Incorporated | Continuous analyte monitoring system with microneedle array |
US20220133190A1 (en) | 2020-10-29 | 2022-05-05 | Medtronic Minimed, Inc. | Glucose biosensors comprising direct electron transfer enzymes and methods of making and using them |
CN116113454A (en) | 2021-05-08 | 2023-05-12 | 比奥林股份有限公司 | Continuous analyte monitoring device fault detection based on microneedle arrays |
US20230123613A1 (en) | 2021-10-14 | 2023-04-20 | Medtronic Minimed, Inc. | Sensors for 3-hydroxybutyrate detection |
US20230172497A1 (en) | 2021-12-02 | 2023-06-08 | Medtronic Minimed, Inc. | Ketone limiting membrane and dual layer membrane approach for ketone sensing |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0560627A2 (en) * | 1992-03-12 | 1993-09-15 | De Beers Industrial Diamond Division (Proprietary) Limited | Radiation probe |
DE29911250U1 (en) * | 1999-06-24 | 1999-10-21 | Radchenko Sergey | Physiotherapy mat |
Family Cites Families (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3123212A (en) | 1964-03-03 | Multiple disposable intracutaneous injector package | ||
USRE25637E (en) | 1964-09-08 | Means for vaccinating | ||
US25637A (en) * | 1859-10-04 | Cooking-stove | ||
US2893392A (en) | 1958-01-08 | 1959-07-07 | American Cyanamid Co | Article of manufacture for intracutaneous injections |
GB885036A (en) | 1958-12-10 | 1961-12-20 | Allen & Hanburys Ltd | Improvements relating to surgical multiple puncture devices |
US3034507A (en) | 1960-05-10 | 1962-05-15 | American Cyanamid Co | Intracutaneous injection device |
US3136314A (en) | 1960-08-01 | 1964-06-09 | Kravitz Harvey | Vaccinating devices |
US3221739A (en) | 1962-03-26 | 1965-12-07 | Rosenthal Sol Roy | Injection device |
US3221740A (en) | 1962-08-31 | 1965-12-07 | Rosenthal Sol Roy | Injection device |
US3556080A (en) | 1968-04-08 | 1971-01-19 | Lincoln Lab Inc | Skin allergy testing device |
US3596660A (en) | 1969-05-12 | 1971-08-03 | Illinois Tool Works | Injection device |
US3675766A (en) | 1970-02-04 | 1972-07-11 | Sol Roy Rosenthal | Multiple puncture injector device |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
FR2232331B1 (en) | 1973-06-06 | 1978-03-24 | Guerin A Ets | |
US4047935A (en) | 1974-12-11 | 1977-09-13 | United States Steel Corporation | Process for direct-reduction of iron-ore employing nuclear reactor-powdered catalytic reformer |
OA05448A (en) | 1975-10-16 | 1981-03-31 | Manufrance Manufacture Francai | Multi-penetrating vaccine device. |
US4222392A (en) | 1979-05-23 | 1980-09-16 | Alier-Screen, Inc. | Allergy testing device with vented base |
US4320758A (en) | 1979-05-07 | 1982-03-23 | Alza Corporation | Osmotically driven fluid dispenser |
CA1247960A (en) | 1983-03-24 | 1989-01-03 | Hideki Aoki | Transcutaneously implantable element |
US4921475A (en) | 1983-08-18 | 1990-05-01 | Drug Delivery Systems Inc. | Transdermal drug patch with microtubes |
US5865786A (en) | 1983-08-18 | 1999-02-02 | Drug Delivery Systems, Inc. | Programmable control and mounting system for transdermal drug applicator |
US4664651A (en) | 1985-03-01 | 1987-05-12 | The Procter & Gamble Company | Subatmospheric method and apparatus for expanding blood vessels to facilitate puncture with a cannula |
US4671288A (en) | 1985-06-13 | 1987-06-09 | The Regents Of The University Of California | Electrochemical cell sensor for continuous short-term use in tissues and blood |
US5335670A (en) | 1986-04-18 | 1994-08-09 | Henry Fishman | Allergy testing method and apparatus |
US4969468A (en) | 1986-06-17 | 1990-11-13 | Alfred E. Mann Foundation For Scientific Research | Electrode array for use in connection with a living body and method of manufacture |
US4703761A (en) | 1986-08-04 | 1987-11-03 | Rathbone R Rodion | Blood sampling device for obtaining small quantity of venous blood |
US4812002A (en) * | 1986-10-24 | 1989-03-14 | Hitachi, Ltd. | Optical coupling device and method of making the same |
US4771660A (en) | 1987-08-24 | 1988-09-20 | Harold Yacowitz | Needle holder |
US4798582A (en) | 1987-10-27 | 1989-01-17 | Permark Corp. C/O Sci/Med Advances Corp. | Needle cartridge |
EP0429842B1 (en) | 1989-10-27 | 1996-08-28 | Korea Research Institute Of Chemical Technology | Device for the transdermal administration of protein or peptide drug |
US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
US5054339A (en) | 1990-02-20 | 1991-10-08 | Harold Yacowitz | Tattooing assembly |
US5858188A (en) | 1990-02-28 | 1999-01-12 | Aclara Biosciences, Inc. | Acrylic microchannels and their use in electrophoretic applications |
US5093879A (en) * | 1990-06-22 | 1992-03-03 | International Business Machines Corporation | Electro-optical connectors |
US5138220A (en) | 1990-12-05 | 1992-08-11 | Science Applications International Corporation | Field emission cathode of bio-molecular or semiconductor-metal eutectic composite microstructures |
US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
TW279133B (en) | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
US5279544A (en) | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
US5312456A (en) | 1991-01-31 | 1994-05-17 | Carnegie Mellon University | Micromechanical barb and method for making the same |
JP2692461B2 (en) * | 1991-10-26 | 1997-12-17 | 日本電気株式会社 | Semiconductor device |
US5170455A (en) * | 1991-10-30 | 1992-12-08 | At&T Bell Laboratories | Optical connective device |
US5605662A (en) | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
AU4282793A (en) | 1992-04-10 | 1993-11-18 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | A microneedle for injection of ocular blood vessels |
US5371822A (en) * | 1992-06-09 | 1994-12-06 | Digital Equipment Corporation | Method of packaging and assembling opto-electronic integrated circuits |
US5279552A (en) | 1993-01-11 | 1994-01-18 | Anton Magnet | Intradermal injection device |
US5383512A (en) | 1993-01-27 | 1995-01-24 | Midwest Research Institute | Method for fabricating a substrate having spaced apart microcapillaries thereon |
US5401242A (en) | 1993-02-25 | 1995-03-28 | Yacowitz; Harold | Apparatus for injecting a substance into the skin |
US5420954A (en) * | 1993-05-24 | 1995-05-30 | Photonics Research Incorporated | Parallel optical interconnect |
US5582184A (en) | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
US5618295A (en) | 1993-10-16 | 1997-04-08 | Samsung Electro-Mechanics Co., Ltd. | Apparatus for preparing skin in advance |
EP0892445B1 (en) | 1993-11-02 | 2004-04-07 | Matsushita Electric Industrial Co., Ltd. | Semiconductor device comprising an aggregate of semiconductor micro-needles |
JP3590805B2 (en) | 1993-11-10 | 2004-11-17 | 株式会社ニコン | Blood collection device |
JPH07196314A (en) | 1993-12-28 | 1995-08-01 | Maruo Calcium Co Ltd | Tubular synthetic inorganic fine particle |
US5475215A (en) * | 1994-01-03 | 1995-12-12 | Hsu; Winston | Optical communicating apparatus for communcating optical signals between electronic circuts |
US5457041A (en) | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
JP2551742B2 (en) | 1994-05-23 | 1996-11-06 | 三星電機株式会社 | Skin wound forming device for drug administration |
KR0134152B1 (en) | 1994-05-23 | 1998-04-14 | 이형도 | Skin treatment device for medication |
US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
US5473716A (en) * | 1994-08-29 | 1995-12-05 | Motorola, Inc. | Fiber bundle interconnect and method of making same |
IE72524B1 (en) | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
US5611942A (en) | 1995-03-02 | 1997-03-18 | Kabushiki Kaisha Toshiba | Method for producing tips for atomic force microscopes |
WO1996037256A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical patch for enhancing the delivery of compounds through the skin |
AU5740496A (en) | 1995-05-22 | 1996-12-11 | General Hospital Corporation, The | Micromechanical device and method for enhancing delivery of compounds through the skin |
US5983130A (en) | 1995-06-07 | 1999-11-09 | Alza Corporation | Electrotransport agent delivery method and apparatus |
AU6104896A (en) | 1995-06-07 | 1996-12-30 | Regents Of The University Of California, The | Therapeutic microdevices and methods of making and using sam e |
DE19525607A1 (en) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneal drug delivery system |
TR199800347T1 (en) | 1995-08-29 | 1998-05-21 | Spectrx, Inc. | Micro-poring of human skin for drug application and monitoring applications. |
US5658515A (en) | 1995-09-25 | 1997-08-19 | Lee; Abraham P. | Polymer micromold and fabrication process |
US5883211A (en) | 1996-01-19 | 1999-03-16 | Aclara Biosciences, Inc. | Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis |
US5801057A (en) | 1996-03-22 | 1998-09-01 | Smart; Wilson H. | Microsampling device and method of construction |
US6234990B1 (en) | 1996-06-28 | 2001-05-22 | Sontra Medical, Inc. | Ultrasound enhancement of transdermal transport |
DK0921840T3 (en) | 1996-07-03 | 2003-09-22 | Altea Therapeutics Corp | Multiple mechanical microperforation of skin or mucosa |
US5699157A (en) | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
WO1998028037A1 (en) | 1996-12-20 | 1998-07-02 | Alza Corporation | Device and method for enhancing transdermal agent flux |
US5876675A (en) | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
AU739616B2 (en) | 1997-12-11 | 2001-10-18 | Alza Corporation | Device for enhancing transdermal agent flux |
JPH11305082A (en) * | 1998-02-23 | 1999-11-05 | Oki Electric Ind Co Ltd | Optical coupling module |
WO1999064580A1 (en) | 1998-06-10 | 1999-12-16 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
US6611707B1 (en) * | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
AU2119301A (en) * | 1999-10-22 | 2001-05-08 | Teraconnect, Inc. | Wafer scale integration and remoted subsystems using opto-electronic transceivers |
AU4708201A (en) * | 1999-11-15 | 2001-06-25 | Teraconnect, Inc. | Active optical interconnect |
US6527457B2 (en) * | 2001-02-01 | 2003-03-04 | International Business Machines Corporation | Optical fiber guide module and a method for making the same |
US6553174B2 (en) * | 2001-04-27 | 2003-04-22 | Corning Incorporated | Optical fiber array assembly with preform for supporting fibers |
-
2001
- 2001-12-20 US US10/027,115 patent/US7027478B2/en not_active Expired - Fee Related
- 2001-12-20 WO PCT/US2001/049797 patent/WO2002050584A2/en not_active Application Discontinuation
- 2001-12-20 AU AU2002231207A patent/AU2002231207A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0560627A2 (en) * | 1992-03-12 | 1993-09-15 | De Beers Industrial Diamond Division (Proprietary) Limited | Radiation probe |
DE29911250U1 (en) * | 1999-06-24 | 1999-10-21 | Radchenko Sergey | Physiotherapy mat |
Non-Patent Citations (2)
Title |
---|
DUTHIE P J ET AL: "PASSIVELY ALIGNED FOUR-CHANNEL REFLECTIVE INP MQW MODULATOR TRANSMITTER" ELECTRONICS LETTERS, IEE STEVENAGE, GB, vol. 31, no. 14, 6 July 1995 (1995-07-06), pages 1177-1179, XP000525334 ISSN: 0013-5194 * |
WIPIEJEWSKI T ET AL: "EFFICIENT ALIGNMENT TOLERANT COUPLING OF VERTICAL-CAVITY LASERS TO SINGLE-MODE FIBERS" PROCEEDINGS OF THE EUROPEAN CONFERENCE ON OPTICAL COMMUNICATION (ECOC) MONTREUX, SEPT. 12 - 16, 1993. REGULAR PAPERS, ZURICH, SEV, CH, vol. 2 CONF. 19, 12 September 1993 (1993-09-12), pages 333-336, XP000492234 * |
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Publication number | Priority date | Publication date | Assignee | Title |
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US8192787B2 (en) | 2004-08-16 | 2012-06-05 | Innoture Limited | Method of producing a microneedle or microimplant |
KR100701344B1 (en) | 2004-09-03 | 2007-03-29 | 한국과학기술원 | Micro-needle array kit and manufacture method of micro-needle array kit using ultraviolet exposure |
US7805080B2 (en) | 2007-06-22 | 2010-09-28 | Hewlett-Packard Development Company, L.P. | Optical interconnect |
US8798722B2 (en) | 2009-02-27 | 2014-08-05 | Virginia Tech Intellectual Properties, Inc. | Fiber array for optical imaging and therapeutics |
US10220124B2 (en) | 2009-02-27 | 2019-03-05 | Virginia Tech Intellectual Properties, Inc. | Fiber array for optical imaging and therapeutics |
EP2575964A2 (en) * | 2010-05-28 | 2013-04-10 | Lockheed Martin Corporation | Implantable infrared nerve stimulation devices for peripheral and cranial nerve interfaces |
EP2575964A4 (en) * | 2010-05-28 | 2013-12-04 | Lockheed Corp | Implantable infrared nerve stimulation devices for peripheral and cranial nerve interfaces |
Also Published As
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US7027478B2 (en) | 2006-04-11 |
WO2002050584A3 (en) | 2003-05-30 |
US20030095582A1 (en) | 2003-05-22 |
AU2002231207A1 (en) | 2002-07-01 |
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