WO2002048684A3 - System for normalizing spectra - Google Patents

System for normalizing spectra Download PDF

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Publication number
WO2002048684A3
WO2002048684A3 PCT/US2001/047631 US0147631W WO0248684A3 WO 2002048684 A3 WO2002048684 A3 WO 2002048684A3 US 0147631 W US0147631 W US 0147631W WO 0248684 A3 WO0248684 A3 WO 0248684A3
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WO
WIPO (PCT)
Prior art keywords
spectrum
segments
wavelength
segment
spectra
Prior art date
Application number
PCT/US2001/047631
Other languages
French (fr)
Other versions
WO2002048684A2 (en
Inventor
Peter J Costa
Kwong Hui
Robert J Nordstrom
Original Assignee
Medispectra Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medispectra Inc filed Critical Medispectra Inc
Priority to AU2002227343A priority Critical patent/AU2002227343B2/en
Priority to EP01996202A priority patent/EP1342068A2/en
Priority to JP2002549942A priority patent/JP2004521324A/en
Priority to CA002431163A priority patent/CA2431163A1/en
Priority to AU2734302A priority patent/AU2734302A/en
Publication of WO2002048684A2 publication Critical patent/WO2002048684A2/en
Publication of WO2002048684A3 publication Critical patent/WO2002048684A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction

Abstract

A method and system for normalizing optical spectra using a non-uniform segment normalization. A spectrum is obtained and is represented as a function of wavelength as an amplitude at each of a plurality of wavelengths. At least one segment of the spectrum is selected, each selected segment being bounded by an upper wavelength and a lower wavelength. A normalization factor is computed as the sum of the areas for each of the selected segments. The spectrum is normalized by dividing at least one amplitude of the spectrum by the normalization factor. Segments can be selected with different wavelength ranges, that is, segments can be non-uniform. Test specimens can be categorized based on an analysis of normalized spectra. In particular, the specimen to be tested can be human cervical tissue, and the state of health of the tissue can be determined.
PCT/US2001/047631 2000-12-15 2001-12-11 System for normalizing spectra WO2002048684A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2002227343A AU2002227343B2 (en) 2000-12-15 2001-12-11 System for normalizing spectra
EP01996202A EP1342068A2 (en) 2000-12-15 2001-12-11 System for normalizing spectra
JP2002549942A JP2004521324A (en) 2000-12-15 2001-12-11 System for spectrum normalization
CA002431163A CA2431163A1 (en) 2000-12-15 2001-12-11 System for normalizing spectra
AU2734302A AU2734302A (en) 2000-12-15 2001-12-11 System for normalizing spectra

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/738,612 US6839661B2 (en) 2000-12-15 2000-12-15 System for normalizing spectra
US09/738,612 2000-12-15

Publications (2)

Publication Number Publication Date
WO2002048684A2 WO2002048684A2 (en) 2002-06-20
WO2002048684A3 true WO2002048684A3 (en) 2003-03-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047631 WO2002048684A2 (en) 2000-12-15 2001-12-11 System for normalizing spectra

Country Status (6)

Country Link
US (2) US6839661B2 (en)
EP (1) EP1342068A2 (en)
JP (1) JP2004521324A (en)
AU (2) AU2734302A (en)
CA (1) CA2431163A1 (en)
WO (1) WO2002048684A2 (en)

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