WO2002043759A3 - Method and composition for modulating bone growth - Google Patents

Method and composition for modulating bone growth Download PDF

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Publication number
WO2002043759A3
WO2002043759A3 PCT/US2001/046291 US0146291W WO0243759A3 WO 2002043759 A3 WO2002043759 A3 WO 2002043759A3 US 0146291 W US0146291 W US 0146291W WO 0243759 A3 WO0243759 A3 WO 0243759A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
compositions
bone growth
modulating bone
methods
Prior art date
Application number
PCT/US2001/046291
Other languages
French (fr)
Other versions
WO2002043759A2 (en
Inventor
Karen M Lyons
Vicki Rosen
Aaron Daluiski
Thomas Engstrand
Mathew F Bahamonde
Laura W Gamer
Eric Agius
Karen Cox
Original Assignee
Wyeth Corp
Univ California
Karen M Lyons
Vicki Rosen
Aaron Daluiski
Thomas Engstrand
Mathew F Bahamonde
Laura W Gamer
Eric Agius
Karen Cox
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Univ California, Karen M Lyons, Vicki Rosen, Aaron Daluiski, Thomas Engstrand, Mathew F Bahamonde, Laura W Gamer, Eric Agius, Karen Cox filed Critical Wyeth Corp
Priority to AU2002236558A priority Critical patent/AU2002236558A1/en
Priority to EP01986092A priority patent/EP1370287A2/en
Publication of WO2002043759A2 publication Critical patent/WO2002043759A2/en
Publication of WO2002043759A3 publication Critical patent/WO2002043759A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Abstract

Methods and compositions are provided for the treatment of defects and disease involving osteoporosis, or osteopenic conditions. The methods comprises applying to the site of osteoporotic or osteopenic conditions a composition comprising a BMP-3 inhibitor or antagonist. The invention further provides methods and compositions for modulating or regulating the formation of bone utilizing BMP-3 compositions.
PCT/US2001/046291 2000-12-01 2001-12-03 Method and composition for modulating bone growth WO2002043759A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002236558A AU2002236558A1 (en) 2000-12-01 2001-12-03 Method and composition for modulating bone growth
EP01986092A EP1370287A2 (en) 2000-12-01 2001-12-03 Method and composition for modulating bone growth

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25053500P 2000-12-01 2000-12-01
US60/250,535 2000-12-01

Publications (2)

Publication Number Publication Date
WO2002043759A2 WO2002043759A2 (en) 2002-06-06
WO2002043759A3 true WO2002043759A3 (en) 2003-10-09

Family

ID=22948150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046291 WO2002043759A2 (en) 2000-12-01 2001-12-03 Method and composition for modulating bone growth

Country Status (3)

Country Link
EP (1) EP1370287A2 (en)
AU (1) AU2002236558A1 (en)
WO (1) WO2002043759A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
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US9572865B2 (en) 2005-11-23 2017-02-21 Acceleron Pharma Inc. Activin-actriia antagonists and uses for treating multiple myeloma

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US5906827A (en) † 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
AU6267798A (en) † 1997-02-07 1998-08-26 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
DK1223990T3 (en) 1999-10-15 2004-11-29 Inst Genetics Llc Formulations of hyaluronic acid for delivery of osteogenic proteins
US7625867B2 (en) * 2004-03-26 2009-12-01 Acceleron Pharma Inc. BMP-3 propeptides and related methods
US7741284B2 (en) 2004-05-12 2010-06-22 Acceleron Pharma Inc. BMP10 propeptides and related methods
CA2572330A1 (en) 2004-06-24 2006-01-05 Acceleron Pharma Inc. Gdf3 propeptides and related methods
US7709605B2 (en) 2004-07-23 2010-05-04 Acceleron Pharma Inc. ActRII receptor polypeptides, methods and compositions
US20060115462A1 (en) * 2004-12-01 2006-06-01 Vladimir Subbotin Direct DNA delivery to bone cells
EP1885749B1 (en) 2005-05-27 2017-08-23 BBS-Bioactive Bone Substitutes Oy Bone morphogenetic protein 3 and osteogenic devices and pharmaceutical products containing thereof
CN105001320A (en) 2005-11-23 2015-10-28 阿塞勒隆制药公司 Activin-ActRIIa antagonists and uses for promoting bone growth
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
WO2007123896A2 (en) 2006-04-18 2007-11-01 The Trustees Of The University Of Pennsylvania Mutated acvr1 for diagnosis and treatment of fibrodyplasia ossificans progressiva (fop)
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
KR101831534B1 (en) 2006-12-18 2018-02-22 악셀레론 파마 인코포레이티드 Activin-actrii antagonists and uses for increasing red blood cell levels
ES2415666T3 (en) 2007-02-01 2013-07-26 Acceleron Pharma, Inc. Pharmaceutical compositions comprising Activin-ActRIIa antagonists for use in the prevention or treatment of breast cancer metastases or bone loss related to breast cancer
TW201940502A (en) 2007-02-02 2019-10-16 美商艾瑟勒朗法瑪公司 Variants derived from ActRIIB and uses therefor
EP3243524A1 (en) 2007-09-18 2017-11-15 Acceleron Pharma Inc. Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
PT3750552T (en) 2008-08-14 2023-06-28 Acceleron Pharma Inc Gdf traps
WO2010083034A1 (en) 2009-01-13 2010-07-22 Acceleron Pharma Inc. Methods for increasing adiponectin
AU2010258931B2 (en) 2009-06-08 2015-04-23 Acceleron Pharma Inc. Methods for increasing thermogenic adipocytes
MX2011013364A (en) 2009-06-12 2012-03-16 Acceleron Pharma Inc Truncated actriib-fc fusion proteins.
JP6267425B2 (en) 2009-11-17 2018-01-24 アクセルロン ファーマ， インコーポレイテッド ACTRIIB protein and its variants and uses thereof for utrophin induction for the treatment of muscular dystrophy
EP2638065A4 (en) 2010-11-08 2014-04-09 Acceleron Pharma Inc Actriia binding agents and uses thereof
KR102279522B1 (en) 2012-11-02 2021-07-19 셀진 코포레이션 Activin-actrii antagonists and uses for treating bone and other disorders
TN2016000553A1 (en) 2014-06-13 2018-04-04 Acceleron Pharma Inc Methods and compositions for treating ulcers
MA41052A (en) 2014-10-09 2017-08-15 Celgene Corp TREATMENT OF CARDIOVASCULAR DISEASE USING ACTRII LIGAND TRAPS
WO2016090077A1 (en) 2014-12-03 2016-06-09 Celgene Corporation Activin-actrii antagonists and uses for treating anemia
JP2020502218A (en) 2016-12-21 2020-01-23 メレオ バイオファーマ ３ リミテッド Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta

Citations (2)

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US5116738A (en) * 1986-07-01 1992-05-26 Genetics Institute, Inc. DNA sequences encoding
US5393739A (en) * 1990-11-30 1995-02-28 Celtrix Pharmaceuticals, Inc. Use of bone morphogenetic protein in synergistic combination with TGF-β for bone repair

Patent Citations (2)

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US5116738A (en) * 1986-07-01 1992-05-26 Genetics Institute, Inc. DNA sequences encoding
US5393739A (en) * 1990-11-30 1995-02-28 Celtrix Pharmaceuticals, Inc. Use of bone morphogenetic protein in synergistic combination with TGF-β for bone repair

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FAUCHEUX C ET AL: "Effect of 1,25(OH)2D3 on bone morphogenetic protein-3 mRNA expression.", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 73, no. 1, 1 April 1999 (1999-04-01), pages 11 - 19, XP002224340, ISSN: 0730-2312 *
FAUCHEUX C ET AL: "Opposing actions of BMP3 and TGFbeta1 in human bone marrow stromal cell growth and differentiation.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 241, no. 3, 29 December 1997 (1997-12-29), pages 787 - 793, XP002224339, ISSN: 0006-291X *
See also references of EP1370287A2 *
THOMADAKIS GEORGIOS ET AL: "Immunolocalization of Bone Morphogenetic Protein-2 and -3 and Osteogenic Protein-1 during murine tooth root morphogenesis and in other craniofacial structures.", EUROPEAN JOURNAL OF ORAL SCIENCES, vol. 107, no. 5, October 1999 (1999-10-01), pages 368 - 377, XP001127481, ISSN: 0909-8836 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9572865B2 (en) 2005-11-23 2017-02-21 Acceleron Pharma Inc. Activin-actriia antagonists and uses for treating multiple myeloma

Also Published As

Publication number Publication date
EP1370287A2 (en) 2003-12-17
WO2002043759A2 (en) 2002-06-06
AU2002236558A1 (en) 2002-06-11

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