WO2002041844A3 - Chemotherapeutic composition using nanocrystalline calcium phosphate paste - Google Patents

Chemotherapeutic composition using nanocrystalline calcium phosphate paste Download PDF

Info

Publication number
WO2002041844A3
WO2002041844A3 PCT/US2001/051419 US0151419W WO0241844A3 WO 2002041844 A3 WO2002041844 A3 WO 2002041844A3 US 0151419 W US0151419 W US 0151419W WO 0241844 A3 WO0241844 A3 WO 0241844A3
Authority
WO
WIPO (PCT)
Prior art keywords
calcium phosphate
paste
composition
phosphate paste
chemotherapeutic composition
Prior art date
Application number
PCT/US2001/051419
Other languages
French (fr)
Other versions
WO2002041844A2 (en
WO2002041844A9 (en
Inventor
Dosuk D Lee
Maria Aiolova
Original Assignee
Etex Corp
Dosuk D Lee
Maria Aiolova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Etex Corp, Dosuk D Lee, Maria Aiolova filed Critical Etex Corp
Priority to AU2002241805A priority Critical patent/AU2002241805A1/en
Publication of WO2002041844A2 publication Critical patent/WO2002041844A2/en
Publication of WO2002041844A3 publication Critical patent/WO2002041844A3/en
Publication of WO2002041844A9 publication Critical patent/WO2002041844A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Abstract

A method and composition are provided for treating cancer in a mammal. The method includes administering to a tumor site of the mammal an anticancer composition comprising a mixture of an anticancer agent and a nanocrystalline or poorly crystalline calcium phosphate paste, said paste comprised of one or more calcium phosphates and a physiologically acceptable fluid, the paste having an injectable or formable consistency at the time of administration and hardenable at the tumor.
PCT/US2001/051419 2000-10-20 2001-10-19 Chemotherapeutic composition using nanocrystalline calcium phosphate paste WO2002041844A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002241805A AU2002241805A1 (en) 2000-10-20 2001-10-19 Chemotherapeutic composition using nanocrystalline calcium phosphate paste

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69312000A 2000-10-20 2000-10-20
US09/693,120 2000-10-20

Publications (3)

Publication Number Publication Date
WO2002041844A2 WO2002041844A2 (en) 2002-05-30
WO2002041844A3 true WO2002041844A3 (en) 2003-02-27
WO2002041844A9 WO2002041844A9 (en) 2003-05-22

Family

ID=24783390

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/051419 WO2002041844A2 (en) 2000-10-20 2001-10-19 Chemotherapeutic composition using nanocrystalline calcium phosphate paste

Country Status (2)

Country Link
AU (1) AU2002241805A1 (en)
WO (1) WO2002041844A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004057959A2 (en) 2002-12-20 2004-07-15 Generipharm, Inc. Intracutaneous injection
AU2014200476C1 (en) * 2002-12-20 2015-12-03 Xeris Pharmaceuticals, Inc. Intracutaneous injection
EP1680089B1 (en) * 2003-10-22 2013-09-11 Lidds AB Composition comprising biodegradable hydrating ceramics for controlled drug delivery
WO2005074991A1 (en) * 2004-02-09 2005-08-18 Kabushiki Kaisha Sangi Antitumor agent
EP1872798B1 (en) 2005-04-06 2013-06-05 Kabushiki Kaisha Sangi Intestinal absorptive anti-tumor agent
EP2076241B1 (en) * 2006-07-12 2014-04-16 Nanunanu Ltd. Fibrous calcium pyrophosphate particles and methods of making and using same
CN109432493B (en) * 2018-09-26 2021-04-06 四川大学 Nano-hydroxyapatite coating porous titanium scaffold and preparation method and application thereof
SE545583C2 (en) * 2021-08-08 2023-10-31 Aduro Mat Ab Controlled drug release material

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016252A (en) * 1972-04-06 1977-04-05 Institut Pasteur Calcium phosphate gel for adsorbing vaccines
US5085861A (en) * 1987-03-12 1992-02-04 The Beth Israel Hospital Association Bioerodable implant composition comprising crosslinked biodegradable polyesters
US5462751A (en) * 1990-06-22 1995-10-31 The Regeants Of The University Of California Biological and pharmaceutical agents having a nanomeric biodegradable core
US5782971A (en) * 1991-06-28 1998-07-21 Norian Corporation Calcium phosphate cements comprising amorophous calcium phosphate

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016252A (en) * 1972-04-06 1977-04-05 Institut Pasteur Calcium phosphate gel for adsorbing vaccines
US5085861A (en) * 1987-03-12 1992-02-04 The Beth Israel Hospital Association Bioerodable implant composition comprising crosslinked biodegradable polyesters
US5462751A (en) * 1990-06-22 1995-10-31 The Regeants Of The University Of California Biological and pharmaceutical agents having a nanomeric biodegradable core
US5782971A (en) * 1991-06-28 1998-07-21 Norian Corporation Calcium phosphate cements comprising amorophous calcium phosphate
US5782971B1 (en) * 1991-06-28 1999-09-21 Norian Corp Calcium phosphate cements comprising amorophous calcium phosphate

Also Published As

Publication number Publication date
AU2002241805A1 (en) 2002-06-03
WO2002041844A2 (en) 2002-05-30
WO2002041844A9 (en) 2003-05-22

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