WO2002037938A3 - Method and device for selectively targeting cells within a three -dimensional specimen - Google Patents

Method and device for selectively targeting cells within a three -dimensional specimen Download PDF

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Publication number
WO2002037938A3
WO2002037938A3 PCT/US2001/050646 US0150646W WO0237938A3 WO 2002037938 A3 WO2002037938 A3 WO 2002037938A3 US 0150646 W US0150646 W US 0150646W WO 0237938 A3 WO0237938 A3 WO 0237938A3
Authority
WO
WIPO (PCT)
Prior art keywords
specimen
interest
particle
selectively targeting
targeting cells
Prior art date
Application number
PCT/US2001/050646
Other languages
French (fr)
Other versions
WO2002037938A2 (en
Inventor
Timothy M Eisfeld
Bernhard O Palsson
Manfred R Koller
Original Assignee
Oncosis Llc
Timothy M Eisfeld
Bernhard O Palsson
Manfred R Koller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncosis Llc, Timothy M Eisfeld, Bernhard O Palsson, Manfred R Koller filed Critical Oncosis Llc
Priority to EP01992423.2A priority Critical patent/EP1344181B1/en
Priority to JP2002540540A priority patent/JP2004512845A/en
Priority to CA002426871A priority patent/CA2426871A1/en
Priority to AU3289202A priority patent/AU3289202A/en
Priority to AU2002232892A priority patent/AU2002232892B2/en
Publication of WO2002037938A2 publication Critical patent/WO2002037938A2/en
Publication of WO2002037938A3 publication Critical patent/WO2002037938A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
    • A61N5/1069—Target adjustment, e.g. moving the patient support
    • G01N15/1433—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N15/149—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1404—Fluid conditioning in flow cytometers, e.g. flow cells; Supply; Control of flow
    • G01N2015/1415—Control of particle position
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/144—Imaging characterised by its optical setup
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/144—Imaging characterised by its optical setup
    • G01N2015/1443—Auxiliary imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/144—Imaging characterised by its optical setup
    • G01N2015/1445—Three-dimensional imaging, imaging in different image planes, e.g. under different angles or at different depths, e.g. by a relative motion of sample and detector, for instance by tomography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/1452—Adjustment of focus; Alignment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N2015/1472—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle with colour

Abstract

The invention provides an apparatus for electromagnetically affecting a particle of interest in a specimen (600). The apparatus includes a stage (500) capable of supporting the specimen, a detector including at least one camera (450A) , wherein the detector is capable of resolving a particle of interest within the specimen (600) means for locating the particle of interest in three dimension, a means for focusing electromagnetic radiation to a focal volume within the specimen; and a means for adjusting the relative positions of the stage and electromagnetic radiation focusing means, thereby positioning the particle of interest within the focal volume.
PCT/US2001/050646 2000-10-24 2001-10-24 Method and device for selectively targeting cells within a three -dimensional specimen WO2002037938A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01992423.2A EP1344181B1 (en) 2000-10-24 2001-10-24 Method and device for selectively targeting cells within a three -dimensional specimen
JP2002540540A JP2004512845A (en) 2000-10-24 2001-10-24 Methods and devices for selectively targeting cells in a three-dimensional specimen
CA002426871A CA2426871A1 (en) 2000-10-24 2001-10-24 Method and device for selectively targeting cells within a three -dimensional specimen
AU3289202A AU3289202A (en) 2000-10-24 2001-10-24 Method and device for selectively targeting cells within a three -dimensional specimen
AU2002232892A AU2002232892B2 (en) 2000-10-24 2001-10-24 Method and device for selectively targeting cells within a three -dimensional specimen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24301500P 2000-10-24 2000-10-24
US60/243,015 2000-10-24

Publications (2)

Publication Number Publication Date
WO2002037938A2 WO2002037938A2 (en) 2002-05-16
WO2002037938A3 true WO2002037938A3 (en) 2002-09-26

Family

ID=22917015

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/050646 WO2002037938A2 (en) 2000-10-24 2001-10-24 Method and device for selectively targeting cells within a three -dimensional specimen

Country Status (6)

Country Link
US (5) US6804385B2 (en)
EP (2) EP2363828A1 (en)
JP (4) JP2004512845A (en)
AU (2) AU3289202A (en)
CA (1) CA2426871A1 (en)
WO (1) WO2002037938A2 (en)

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