WO2002030298A1 - Minimally invasive annuloplasty procedure and apparatus - Google Patents
Minimally invasive annuloplasty procedure and apparatus Download PDFInfo
- Publication number
- WO2002030298A1 WO2002030298A1 PCT/US2001/042653 US0142653W WO0230298A1 WO 2002030298 A1 WO2002030298 A1 WO 2002030298A1 US 0142653 W US0142653 W US 0142653W WO 0230298 A1 WO0230298 A1 WO 0230298A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- clips
- tissue
- clip
- end points
- open configuration
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/064—Surgical staples, i.e. penetrating the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0469—Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
- A61B2017/0472—Multiple-needled, e.g. double-needled, instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06004—Means for attaching suture to needle
- A61B2017/06009—Means for attaching suture to needle having additional means for releasably clamping the suture to the needle, e.g. actuating rod slideable within the needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B2017/06057—Double-armed sutures, i.e. sutures having a needle attached to each end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/08—Wound clamps or clips, i.e. not or only partly penetrating the tissue ; Devices for bringing together the edges of a wound
- A61B2017/081—Tissue approximator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2445—Annuloplasty rings in direct contact with the valve annulus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2442—Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve
- A61F2/2466—Delivery devices therefor
Definitions
- This invention relates to methods and apparatus for annuloplasty repair and replacement.
- Valve repair and valve replacement are currently done in surgical procedures as described, for example, in "Mitral Valve Repair: Ischemic” by W. Randolph Chitwood, Jr. (Mastery of Cardiothorcic Surgery, Lippincott-Raven Publishers (1998) 309-321) and “Mitral Valve Replacement” by Kwok L. Yun and D. Craig Miller (ibid. (1998) 329-341 ). Cumbersome suture management, knot tying, pain and long recovery time are inherent to such surgical procedures. It now goes without saying that quickly operable methods and apparatus are desirable for allowing surgeons to perform procedures with less pain and disability than known surgical procedures. Tissue-connector apparatus and methods easily usable in such surgical procedures have recently been disclosed in U.S. patent applications Serial Nos.
- Such clips may be deployed each in the form of a clip assembly, having one of its end points connected to a tissue-piecing needle through a flexible member such as a suture and a release mechanism by which the clip can be easily released. The clip is then caused to penetrate the tissue at two circumferentially separated positions one after the other.
- a clip delivery device may be used with a plurality of clips loaded to a clip-holder serving to keep these clips in their open configurations.
- a pusher is provided for pushing a specified number of such clips out of the device at a time.
- Clip assemblies of this invention can be effectively used in ring annuloplasty and valve replacement procedures by placing clips circumferentially around a ring or a mitral prosthesis sewing cuff. Cumbersome problems associated with suture management and suture knotting can be thereby obviated.
- Fig. 1 is an external view of a single-arm clip assembly which may be used in an annuloplasty method embodying this invention
- Figs. 1A and 1B show a release mechanism for the clip of Fig. 1;
- Fig. 1C shows a similar release mechanism arranged for the other end of a double arm clip such as shown in Fig. 9;
- Fig. 2 is a schematic view of the clip assembly of Fig. 1 being used in an annuloplasty procedure
- Fig. 3 is a sectional front view of a clip delivery device embodying this invention.
- Fig. 4 is a sectional side view of the clip delivery device of Fig. 3;
- Fig. 5 is a side view of the cartridges shown in Figs. 3 and 4;
- Fig. 6 is an axial view of the cartridge shown in Figs. 3, 4 and 5;
- Fig. 7A is a sketch of the clip assembly of Fig. 1 being used in a ring annuloplasty procedure and Fig. 7B is a sketch of the ring which has been attached to an annulus by a procedure embodying this invention;
- Fig. 8A is a sketch of the clip assembly of Fig. 1 being used in a valve replacement procedure
- Fig. 8B is a sketch of the mitral prosthesis sewing cuff which has been inserted in a procedure embodying this invention.
- Fig. 9 is an external view of a double-arm clip assembly which may be used in an annuloplasty method embodying this invention.
- Fig. 10 is a sketch of the clip assembly of Fig. 9 being used in a ring annuloplasty procedure. Throughout herein, like components are indicated by the same numerals even where they are components of different assemblies and may not be repetitiously described for explanation.
- This invention relates to methods and apparatus for annuloplasty repair and replacement, characterized as using staples, or surgical clips (hereinafter referred to as "clips") of the so-called self-closing kind.
- a clip of a self-closing type may be broadly characterized as having two l o end points which tend to come closer together either by elasticity or so- called pseudoelasticity.
- Such a clip may be made by heat-treating a NiTi wire to a certain temperature and time to have a desired undeformed shape. Examples of such clips, including methods of making them as well as materials which may be used, were disclosed in aforementioned
- the minimum conditions such clips should satisfy include that they each have two end points, have a naturally closed configuration, can be forced to assume an open configuration but will tend to return to the naturally closed configuration by reducing the separation between these two end points if forced to assume the open 5 configuration.
- Such a clip may be deployed, for example, in the form of a single- arm clip assembly as generally shown in Fig. 1 at 1 (as well as in aforementioned U.S. patent applications Serial Nos. 09/089,884 and 09/090,305, and the section of International Application No. PCT/US99/12566 from page 10, line 10 through page 11 , line 21 , which section and accompanying Fig. 1 is hereby specifically incorporated by reference herein) with a tissue-piercing needle 3 connected through a flexible member 4 such as a suture to one of the end points of such a clip
- a release mechanism 7 such as disclosed in aforementioned U.S. patent application Serial No. 09/260,623, (or International Application No. PCT/US99/12566, which published on December 9, 1999 under international Publication Nos. WO 99/62406) is provided such that the clip 5 can be easily released, say, by pressing thereon by a surgical instrument.
- the release mechanism description in International Application No. PCT/US99/12566 from page 25, Iine12 through page 27, line 30 ending with the text "mechanism 23c" (but without the text "such as needle 17 as shown in Fig. 1" on line 27 of page 27) and the referenced figures are hereby incorporated by reference herein.
- a summary of such a release mechanism is provided below with reference to Figs. 1 A-C.
- a release mechanism 7' generally comprises a plurality of substantially rigid strands, cables or wires 106, which may be metallic, and which are arranged substantially parallel to one another and circularly about a longitudinal axis.
- the hidden end portions of the strands are coupled to tapered section "T", which is coupled to a piercing member or needle through a flexible member 4.
- the strands may be coupled to rod 162, which is fixed to the tapered element.
- End portions of the strands include notches, which form a chamber 108 for releasably receiving enlarged portion "E" of the clip (or fastener wire "W.”
- the notches preferably are placed about 0.015 from the free ends of the strands, but this distance can be varied depending upon the desired compression on the fastener or clip spring.
- a shrink wrap layer, preferably a shrink tubing 110 as set forth in the cited PCT application is provided around at least the free end portions of the strands and the shrink wrap or tubing heated to compress against the strands and hold them in place against the enlarged wire portion to effectively hold the enlarged portion captive until the shrink wrap is squeezed, the strands displaced and the enlarged portion released. Referring to Fig.
- the release mechanism may also be used to releaseably couple the other end of the fastener to another flexible member and needle as shown in Fig. 9.
- an annular member or stopper 115 is secured to the other end of the fastener or wire to prevent the enlarged portion of the wire at this end from passing through the compression spring upon release of from the release mechanism.
- Fig. 2 illustrates a method of annuloplasty embodying this invention by using the single-arm clip assembly 1 of Fig. 1.
- the surgeon will guide the needle 3 to the surgical site, cause it to penetrate and pass through the tissue of the annulus sequentially at two positions one after the other which are circumferentially separated with respect to the annulus, and pull the flexible member 4 such that the clip 5 will have its two end points penetrate the tissue at these two positions.
- the stopper 6 serves to secure the clip 5 at this position.
- the release mechanism 7 is pressed and the needle 3 is released from the clip 5
- the clip 5 tends to return to its naturally closed configuration, tending to bring the two end points closer towards each other, thereby pinching the portion of the tissue therebetween.
- Figs. 3 and 4 show a clip delivery device 10 embodying this invention for carrying out an annuloplasty procedure in an alternative way.
- the device 10 is comprised of an outer tube 20 with a hollow cylindrical interior and an elongated slit 25 at the bottom, affixed to a cap 22, a pusher 30 provided with a knob 32 and adapted to be pushed longitudinally inside the outer tube 20 for pushing one clip at a time, and a pair of cartridges 40 for mounting clips 50 thereon.
- Each cartridge 40 is generally of a cylindrical shape attached to a fixture 41, as shown in Figs. 5 and 6, with a quasi-circular cross-sectional shape and serves to have a plurality of clips 50 mounted thereon one next to another in a generally U-shaped open configuration with their end points pointing uniformly downward.
- the two cartridges 40 are positioned coaxially in a face-to-face relationship, extending perpendicularly to the slit 25 at the bottom of the outer tube 20, leaving therebetween a narrow gap 45 barely wide enough for one of the clips 50 to pass through vertically.
- Each carriage 40 is provided with a spring 42 such that the clips 50 mounted thereon are biased towards the gap 45.
- Each cartridge 40 has chamfered edge portion 47 adjacent the gap 45.
- the cartridges 40 fully loaded with the clips 50, are positioned inside the outer tube 20, as shown in Figs. 3 and 4.
- the pusher 30 is inserted thereafter into the outer tube 20, and a spring 35 and the cap 22 are assembled onto the outer tube 20.
- the knob 32 is screwed into the pusher 30 to complete the clip delivery device 10.
- the device 10 fully loaded with clips
- the pusher 30 moves down and pushes one of the clips 50 which may originally have been on either of the cartridges 40 but has been pushed by the springs 42 to the position of the gap 45. Since the gap 45 is exactly above the slit 25 at the bottom of the outer tube 20, the clip 50 at the gap 45 is pushed out through the slit 25 to be inserted into the patient's tissue, both end points penetrating the tissue simultaneously at two positions that are separated circumferentially with respect to the annulus, as shown in Fig. 2, in the same way in which a staple is pushed out of a stapler of an ordinary kind.
- the clip 50 tends to return to its naturally closed configuration, by reducing the distance between its two end points. Since the tissue is less firm than the cartridges 40, the portion of the tissue between the two end points of the clip 50 plicates to a certain extent, allowing the two end points of the clip 50 to come somewhat closer than when the clip 50 was kept on the cartridge 40. After a plurality of such clips 50 are thus implanted circumferentially as shown in Fig. 2, the net effect is to reduce the circumference of the annulus.
- the gap 45 was described as being barely wide enough to one of the clips 50 to be pushed down at a time, but this is not intended to limit the scope of the invention.
- Clip assemblies as shown at 1 in Fig. 1 may be used in a ring annuloplasty as shown, for example, in Figs. 7A and 7B by using an annuloplasty ring 60 of a known kind. Although an open ring 60 is shown for illustration, a ring of a closed shape may be used. Fig.
- FIG. 7A shows the clip assembly 1 being used, with the needle 3 operated to penetrate the ring 60 at one position 60a, then into the tissue at one position 90a and out therefrom at another position 90b of the annulus and then again through the ring 60 at another position 60b.
- These positions 60a, 90a, 90b and 60b are selected such that the distance between the two positions 60a and 60b of penetration through the ring 60 is smaller than the distance between the position 90a of entry into the tissue by the needle 3 and the position 90b at which the needle 3 is pulled out of the tissue.
- the flexible member 4 is pulled until the clip 5 passes partially through the ring 60, its end point connected to the flexible member 4 having completely passed through the ring 60 twice and the other end point being stopped by the stopper 6 before penetrating the ring 60.
- This has the effect of contracting the portion of the tissue between the two positions 90a and 90b to the smaller distance between the two points of penetration 60a and 60b through the ring 60 by the needle 3 than the original separation of these two positions 90a and 90b of the tissue before the stitching is carried out.
- the flexible member 4 is thereafter released from the clip 5 by pressing the release mechanism 7, as described above.
- the clip 5, deployed while it was in an open configuration, has now only the ring 60 and the portion of the tissue between its two end points to prevent it from completely returning to its naturally closed configuration but still tends to reduce the distance separating the two end points.
- This internal force of the clip 5 tends to keep the ring 60 firmly attached to the tissue, thereby allowing the ring 60 to perform its intended function of keeping the annulus in its intended size.
- Fig. 7B shows the ring 60 fastened around the annulus after a plurality of clips 5 have thus been deployed to keep the ring 60 at the surgical site.
- the clips 5 may be positioned to be circumferentially overlapping or separated. The two modes of arrangement may also be mixed.
- the clip assembly 1 shown in Fig. 1 may be used also in a valve replacement procedure wherein mitral valve portions are removed and a mitral prosthesis sewing cuff is inserted.
- Fig. 8A shows the clip assembly 1 being used, with the needle 3 operated to penetrate a mitral prosthesis sewing cuff 70 at one position, then into the tissue at one position where the prosthesis sewing cuff 70 is to be placed and out therefrom at another position of the tissue and then again through the prosthesis sewing cuff 70.
- the flexible member 4 is pulled until the clip 5 passes partially through the prosthesis sewing cuff 70, its end point connected to the flexible member 4 completely passing through the prosthesis sewing cuff 70 twice and the other end point being stopped before penetrating the prosthesis sewing cuff 70 by the stopper 6.
- the flexible member 4 is thereafter released from the clip 5 by pressing the release mechanism 7, as described above.
- the clip 5, deployed while it was in an open configuration, has now only the prosthesis sewing cuff 70 and the portion of the tissue between its two end points to prevent it from returning to its naturally closed configuration but still tends to reduce the distance separating the two end points. This force of the clip 5 tends to keep the prosthesis sewing cuff 70 attached to the tissue.
- a clip of the kind described above may be deployed in the form of a double-arm clip assembly as generally shown in Fig. 9 at 101 , as well as in aforementioned U.S. patent applications Serial Nos. 09/259,705 and 09/260,623, having a tissue-piercing needle 3 connected through a flexible member 4 such as a suture to each of the end points of a clip 5, maintained in its generally U-shaped open configuration.
- a release mechanism 7 is provided at each end point of the clip 5 such that the clip 5 can be easily released from the flexible member 4.
- a further description of a suitable double-arm clip assembly is provided in International Application No. PCT/US99/12566, the section and figure described from page 24, line 8 through line 14 and ending with the term "configuration" being specifically incorporated by reference herein.
- Fig. 10 shows the double-arm clip assembly 101 being used in a ring annuloplasty process.
- the pair of needles 3 are each caused to penetrate the tissue and be pulled out and then penetrate through a ring 60 such that the distance between the two positions at which the needles 3 are caused to penetrate and come out of the tissue is greater than the distance between the two positions on the ring 60 where the needles 3 pass through the ring 60, as explained above with reference to Fig. 7A.
- the flexible member 4 is pulled until the both end points of the clip 5 in its open configuration pass through the tissue and the ring 60.
- the flexible members 4 are then released from the clip 5 by pressing the release mechanisms 7, and the tendency of the clip 5 to coil up and return to its closed configuration serves to keep the ring 60 firmly attached to the tissue, as explained above with reference to the single-arm clip assembly 1.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002211907A AU2002211907A1 (en) | 2000-10-10 | 2001-10-10 | Minimally invasive annuloplasty procedure and apparatus |
US10/120,579 US6921407B2 (en) | 2000-10-10 | 2002-04-10 | Minimally invasive annuloplasty procedure and apparatus |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/686,729 | 2000-10-10 | ||
US09/686,729 US6918917B1 (en) | 2000-10-10 | 2000-10-10 | Minimally invasive annuloplasty procedure and apparatus |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/686,729 Continuation-In-Part US6918917B1 (en) | 2000-10-10 | 2000-10-10 | Minimally invasive annuloplasty procedure and apparatus |
US10/120,579 Continuation-In-Part US6921407B2 (en) | 2000-10-10 | 2002-04-10 | Minimally invasive annuloplasty procedure and apparatus |
Publications (1)
Publication Number | Publication Date |
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WO2002030298A1 true WO2002030298A1 (en) | 2002-04-18 |
Family
ID=24757491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/042653 WO2002030298A1 (en) | 2000-10-10 | 2001-10-10 | Minimally invasive annuloplasty procedure and apparatus |
Country Status (3)
Country | Link |
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US (2) | US6918917B1 (en) |
AU (1) | AU2002211907A1 (en) |
WO (1) | WO2002030298A1 (en) |
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Also Published As
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US6918917B1 (en) | 2005-07-19 |
AU2002211907A1 (en) | 2002-04-22 |
US20030074012A1 (en) | 2003-04-17 |
US6921407B2 (en) | 2005-07-26 |
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