WO2002012888A3 - Capsules encapsulating solid particles of signal-generating organic substances - Google Patents

Capsules encapsulating solid particles of signal-generating organic substances Download PDF

Info

Publication number
WO2002012888A3
WO2002012888A3 PCT/EP2001/009114 EP0109114W WO0212888A3 WO 2002012888 A3 WO2002012888 A3 WO 2002012888A3 EP 0109114 W EP0109114 W EP 0109114W WO 0212888 A3 WO0212888 A3 WO 0212888A3
Authority
WO
WIPO (PCT)
Prior art keywords
signal
organic substances
solid particles
generating organic
encapsulating solid
Prior art date
Application number
PCT/EP2001/009114
Other languages
French (fr)
Other versions
WO2002012888A2 (en
Inventor
Dieter Trau
Reinhard Renneberg
Frank Caruso
Matthias Lehmann
Original Assignee
8Sens Biognostic Ag
Dieter Trau
Reinhard Renneberg
Frank Caruso
Matthias Lehmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 8Sens Biognostic Ag, Dieter Trau, Reinhard Renneberg, Frank Caruso, Matthias Lehmann filed Critical 8Sens Biognostic Ag
Priority to AU2001291746A priority Critical patent/AU2001291746A1/en
Priority to US10/344,016 priority patent/US20040014073A1/en
Priority to EP01971884A priority patent/EP1309867B1/en
Priority to CA002417714A priority patent/CA2417714A1/en
Priority to DE60123806T priority patent/DE60123806D1/en
Publication of WO2002012888A2 publication Critical patent/WO2002012888A2/en
Publication of WO2002012888A3 publication Critical patent/WO2002012888A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles

Abstract

The present invention refers to capsules encapsulating solid particles of signal-generating organic substances and carrying on the outer surface affinity molecules for secific recognition of and binding to target molecules in a sample. The invention is directed to teh use of these capsules for signal production in the optical, electrochemical or chemical detection of target molecules. To obtain a signal the signal-generating organic substances are released and dissolved. A detection method and a kit are provided.
PCT/EP2001/009114 2000-08-08 2001-08-07 Capsules encapsulating solid particles of signal-generating organic substances WO2002012888A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001291746A AU2001291746A1 (en) 2000-08-08 2001-08-07 Capsules encapsulating solid particles of signal-generating organic substances and their use in in vitro bioassays for detection of target molecules in a sample
US10/344,016 US20040014073A1 (en) 2000-08-08 2001-08-07 Capsules encapsulating solid particles of signal-generating organic substances and their use in vitro bioassays for detection of target molecules in a sample
EP01971884A EP1309867B1 (en) 2000-08-08 2001-08-07 Capsules encapsulating solid particles of signal-generating organic substances
CA002417714A CA2417714A1 (en) 2000-08-08 2001-08-07 Capsules encapsulating solid particles of signal-generating organic substances
DE60123806T DE60123806D1 (en) 2000-08-08 2001-08-07 Capsules Containing Solid Particles of Signaling Organics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10042023A DE10042023C2 (en) 2000-08-08 2000-08-08 Capsules that encapsulate solid particles of signal-generating substances and their use in bioassays for the detection of target molecules in a sample
DE10042023.0 2000-08-08

Publications (2)

Publication Number Publication Date
WO2002012888A2 WO2002012888A2 (en) 2002-02-14
WO2002012888A3 true WO2002012888A3 (en) 2002-05-16

Family

ID=7653916

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/009114 WO2002012888A2 (en) 2000-08-08 2001-08-07 Capsules encapsulating solid particles of signal-generating organic substances

Country Status (7)

Country Link
US (1) US20040014073A1 (en)
EP (1) EP1309867B1 (en)
AT (1) ATE342508T1 (en)
AU (1) AU2001291746A1 (en)
CA (1) CA2417714A1 (en)
DE (2) DE10042023C2 (en)
WO (1) WO2002012888A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383337B2 (en) 2008-07-18 2013-02-26 General Electric Company Methods using metal oxide particles for analyte detection
US8691754B2 (en) 2003-09-22 2014-04-08 Bioarray Solutions, Ltd. Microparticles with enhanced covalent binding capacity and their uses
US8691594B2 (en) 1996-04-25 2014-04-08 Bioarray Solutions, Ltd. Method of making a microbead array with attached biomolecules
US9147037B2 (en) 2004-08-02 2015-09-29 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US9251583B2 (en) 2002-11-15 2016-02-02 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US9436088B2 (en) 2001-06-21 2016-09-06 Bioarray Solutions, Ltd. Un-supported polymeric film with embedded microbeads

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7892854B2 (en) * 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
CN100494395C (en) 2001-10-15 2009-06-03 生物芯片技术有限公司 polymorphic locus multiplexed analysis by concurrent probing and enzyme-mediated detection
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7312040B2 (en) * 2002-09-20 2007-12-25 Agilent Technologies, Inc. Microcapsule biosensors and methods of using the same
US7781172B2 (en) 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7927796B2 (en) * 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
JP2007518065A (en) * 2003-10-28 2007-07-05 バイオアレイ ソリューションズ リミテッド Gel-shell beads with adsorbed or bound biomolecules
EP1692298A4 (en) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimization of gene expression analysis using immobilized capture probes
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
PT1694859E (en) 2003-10-29 2015-04-13 Bioarray Solutions Ltd Multiplexed nucleic acid analysis by fragmentation of double-stranded dna
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) * 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US20050112703A1 (en) * 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US7094528B2 (en) * 2004-06-30 2006-08-22 Kimberly-Clark Worldwide, Inc. Magnetic enzyme detection techniques
US7906276B2 (en) 2004-06-30 2011-03-15 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
JP5189493B2 (en) * 2005-11-14 2013-04-24 ルイジアナ テク ユニバーシティ リサーチ ファウンデーション Polypeptide membrane and method
US8183184B2 (en) * 2006-09-05 2012-05-22 University Of Kansas Polyelectrolyte complexes for oil and gas applications
WO2008157372A2 (en) 2007-06-14 2008-12-24 Massachusetts Institute Of Technology Self assembled films for protein and drug delivery applications
US8530244B2 (en) * 2007-10-02 2013-09-10 Terapia Celular, L'N, Inc. Methods and materials for amplification of a signal in an immunoassay
WO2009083975A2 (en) * 2007-12-27 2009-07-09 Infigo Diagnostics Ltd. Small molecules and protein analysis devices based on molecular imprinted polymers
DE102008019928A1 (en) * 2008-04-21 2009-12-31 Siemens Healthcare Diagnostics Gmbh Procedures for applying spots with capture molecules on substrate surface for chip, particularly optical sensor, involve washing substrate surface of chip by dipping in aqueous solution of cationic polyelectrolyte
GB2470939A (en) 2009-06-10 2010-12-15 Dna Supernova Ltd Signal amplification microspheres
GB2470962A (en) 2009-06-12 2010-12-15 Dna Supernova Ltd Amplification medium for use with a solid-phase substrate
FR2965273B1 (en) * 2010-09-29 2015-07-17 Centre Nat Rech Scient PROCESS FOR PREPARING A CHEMICAL STRUCTURE HAVING A PHASE PARTITION, CAPABLE OF GENERATING A SPECIFIC FLUORESCENCE SPECTRUM AND ITS APPLICATIONS
US20130052748A1 (en) 2011-08-30 2013-02-28 Supernova Diagnostics, Inc. Assay device and method of assaying
US8586387B2 (en) 2011-08-30 2013-11-19 Supernova Diagnostics, Inc. Methods of triggering activation of encapsulated signal-generating substances and apparatus utilising activated signal-generating substances
EP2617759B1 (en) * 2012-01-19 2014-12-03 Acreo Swedish ICT AB Method of modifying the properties of a surface
JP5996234B2 (en) * 2012-03-30 2016-09-21 デンカ生研株式会社 Immunoassay method and reagent
US10278927B2 (en) 2012-04-23 2019-05-07 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
CN102706929B (en) * 2012-05-10 2017-09-01 江南大学 A kind of preparation of Photocrosslinkable modified hyaluronic acid molecular engram sensor
DE102013002575A1 (en) * 2013-02-11 2014-08-14 Max Renneberg Method for the visualized exclusion of acute diseases by means of color-marked proteins
CN104049079B (en) * 2013-03-14 2016-05-18 苏州德沃生物技术有限公司 A kind of orientation is from preparation method and the application thereof of labelled immune Nano microsphere
US9463244B2 (en) 2013-03-15 2016-10-11 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
US20150125879A1 (en) * 2013-09-25 2015-05-07 Massachusetts Institute Of Technology Biodegradable Layer-by-Layer (LbL) Films for Cell Capture and Release
MA40390A (en) * 2014-07-25 2017-05-31 Selux Diagnostics Inc Assay methods involving dissociable nanoparticles
DE102014113688A1 (en) 2014-09-22 2016-03-24 Jacobs University Bremen Ggmbh ANTIGEN-SPECIFIC IMMUNE COLORING OF T CELLS
WO2017015145A2 (en) * 2015-07-17 2017-01-26 SeLux Diagnostics, Inc. Dissociable transition-metal nanoparticles
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
CN113267529B (en) * 2021-05-12 2022-10-25 江西师范大学 Temperature type biosensor and method for detecting target aptamer by using temperature type biosensor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0577092A2 (en) * 1992-07-02 1994-01-05 Becton, Dickinson and Company Immunoassays using microparticles containing different detectable substances
US5593843A (en) * 1993-01-04 1997-01-14 Becton, Dickinson And Company Stabilized microspheres and methods of preparation
WO1999047252A2 (en) * 1998-03-19 1999-09-23 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4528177A (en) * 1982-10-18 1985-07-09 Eli Lilly And Company Imaging agents and method
US4703017C1 (en) * 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
JPS61277062A (en) * 1985-05-31 1986-12-08 Hitachi Ltd Immunological assay and reagent used therein
CA1291031C (en) * 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4874710A (en) * 1986-02-20 1989-10-17 Becton Dickinson And Company Assay and product in which binder and liposomes are supported on a solid support
US6013531A (en) * 1987-10-26 2000-01-11 Dade International Inc. Method to use fluorescent magnetic polymer particles as markers in an immunoassay
AU641936B2 (en) * 1989-08-18 1993-10-07 Monsanto Company Ferritin analogs
JP2979414B2 (en) * 1989-09-29 1999-11-15 富士レビオ株式会社 Magnetic particles and immunoassay using the same
US5460830A (en) * 1990-06-22 1995-10-24 The Regents Of The University Of California Biochemically active agents for chemical catalysis and cell receptor activation
DE4117782C2 (en) * 1991-05-28 1997-07-17 Diagnostikforschung Inst Nanocrystalline magnetic iron oxide particles, processes for their production and diagnostic and / or therapeutic agents
US5248590A (en) * 1991-07-22 1993-09-28 Becton, Dickinson And Company Surface modified liposomes
US5756362A (en) * 1993-10-12 1998-05-26 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
US6129828A (en) * 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US5786219A (en) * 1996-10-28 1998-07-28 Molecular Probes, Inc. Microspheres with fluorescent spherical zones
EP1231905B1 (en) * 1999-11-15 2009-04-08 BioCure, Inc. Responsive polymeric hollow particles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0577092A2 (en) * 1992-07-02 1994-01-05 Becton, Dickinson and Company Immunoassays using microparticles containing different detectable substances
US5593843A (en) * 1993-01-04 1997-01-14 Becton, Dickinson And Company Stabilized microspheres and methods of preparation
WO1999047252A2 (en) * 1998-03-19 1999-09-23 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691594B2 (en) 1996-04-25 2014-04-08 Bioarray Solutions, Ltd. Method of making a microbead array with attached biomolecules
US9400259B2 (en) 1996-04-25 2016-07-26 Bioarray Solutions, Ltd. Method of making a microbead array with attached biomolecules
US9436088B2 (en) 2001-06-21 2016-09-06 Bioarray Solutions, Ltd. Un-supported polymeric film with embedded microbeads
US9251583B2 (en) 2002-11-15 2016-02-02 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US8691754B2 (en) 2003-09-22 2014-04-08 Bioarray Solutions, Ltd. Microparticles with enhanced covalent binding capacity and their uses
US9147037B2 (en) 2004-08-02 2015-09-29 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US8383337B2 (en) 2008-07-18 2013-02-26 General Electric Company Methods using metal oxide particles for analyte detection

Also Published As

Publication number Publication date
ATE342508T1 (en) 2006-11-15
US20040014073A1 (en) 2004-01-22
WO2002012888A2 (en) 2002-02-14
DE60123806D1 (en) 2006-11-23
DE10042023A1 (en) 2002-02-28
DE10042023C2 (en) 2003-04-10
EP1309867B1 (en) 2006-10-11
AU2001291746A1 (en) 2002-02-18
EP1309867A2 (en) 2003-05-14
CA2417714A1 (en) 2002-02-14

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