WO2002009671A3 - Microemulsion and micelle systems for solubilizing drugs - Google Patents

Microemulsion and micelle systems for solubilizing drugs Download PDF

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Publication number
WO2002009671A3
WO2002009671A3 PCT/US2001/024167 US0124167W WO0209671A3 WO 2002009671 A3 WO2002009671 A3 WO 2002009671A3 US 0124167 W US0124167 W US 0124167W WO 0209671 A3 WO0209671 A3 WO 0209671A3
Authority
WO
WIPO (PCT)
Prior art keywords
microemulsion
micelle systems
solubilizing drugs
drugs
component
Prior art date
Application number
PCT/US2001/024167
Other languages
French (fr)
Other versions
WO2002009671A2 (en
Inventor
Donn M Dennis
Nikolaus Gravenstein
Jerome H Modell
Timothy E Morey
Dinesh Shah
Original Assignee
Univ Florida
Donn M Dennis
Nikolaus Gravenstein
Jerome H Modell
Timothy E Morey
Dinesh Shah
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida, Donn M Dennis, Nikolaus Gravenstein, Jerome H Modell, Timothy E Morey, Dinesh Shah filed Critical Univ Florida
Priority to EP01956089A priority Critical patent/EP1305005A2/en
Priority to AU2001278124A priority patent/AU2001278124A1/en
Priority to CA002417800A priority patent/CA2417800C/en
Priority to JP2002515224A priority patent/JP4932123B2/en
Publication of WO2002009671A2 publication Critical patent/WO2002009671A2/en
Publication of WO2002009671A3 publication Critical patent/WO2002009671A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Abstract

A microemulsion delivery system for water insoluble or sparingly water soluble drugs that comprise a long polymer chain surfactant component and a short fatty acid sufractant component, with the amount of each being selected to provide stable microemulsion or micellar systems.
PCT/US2001/024167 2000-08-01 2001-07-31 Microemulsion and micelle systems for solubilizing drugs WO2002009671A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01956089A EP1305005A2 (en) 2000-08-01 2001-07-31 Microemulsion and micelle systems for solubilizing drugs
AU2001278124A AU2001278124A1 (en) 2000-08-01 2001-07-31 Novel microemulsion and micelle systems for solubilizing drugs
CA002417800A CA2417800C (en) 2000-08-01 2001-07-31 Novel microemulsion and micelle systems for solubilizing drugs
JP2002515224A JP4932123B2 (en) 2000-08-01 2001-07-31 A novel microemulsion and micellar system for solubilizing drugs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/630,237 2000-08-01
US09/630,237 US6623765B1 (en) 2000-08-01 2000-08-01 Microemulsion and micelle systems for solubilizing drugs

Publications (2)

Publication Number Publication Date
WO2002009671A2 WO2002009671A2 (en) 2002-02-07
WO2002009671A3 true WO2002009671A3 (en) 2002-05-16

Family

ID=24526357

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/024167 WO2002009671A2 (en) 2000-08-01 2001-07-31 Microemulsion and micelle systems for solubilizing drugs
PCT/US2002/024745 WO2003015823A1 (en) 2000-08-01 2002-08-05 Novel microemulsion and micelle systems for solubilizing drugs

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024745 WO2003015823A1 (en) 2000-08-01 2002-08-05 Novel microemulsion and micelle systems for solubilizing drugs

Country Status (6)

Country Link
US (3) US6623765B1 (en)
EP (1) EP1305005A2 (en)
JP (1) JP4932123B2 (en)
AU (1) AU2001278124A1 (en)
CA (1) CA2417800C (en)
WO (2) WO2002009671A2 (en)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003502363A (en) * 1999-06-21 2003-01-21 コンイル ファーマシューティカル カンパニー、リミテッド Anesthetic composition for intravenous injection containing propofol
EP1401399A2 (en) * 2001-06-22 2004-03-31 Pfizer Products Inc. Pharmaceutical compositions containing polymer and drug assemblies
EP1414497A4 (en) * 2001-08-08 2007-11-21 Univ Florida Novel microemulsion and micelle systems for solubilizing drugs
GB0120701D0 (en) * 2001-08-24 2001-10-17 Maelor Pharmaceuticals Ltd Pharmaceutical formulations
GB0124071D0 (en) * 2001-10-08 2001-11-28 Kbig Ltd Improvement in the administration of high boiling point aneasthetics
EP1539122B1 (en) * 2002-07-29 2014-01-29 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
US7550155B2 (en) * 2002-07-29 2009-06-23 Transform Pharmaceuticals Inc. Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses
US20040220283A1 (en) * 2002-07-29 2004-11-04 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
KR100482269B1 (en) * 2002-10-08 2005-04-14 센츄론(주) Injectable Anaesthetic Agent Comprising 2,6-Diisopropylphenol as an Active Ingredient and Preparation Method thereof
AU2003275360A1 (en) * 2002-10-29 2004-05-25 Transform Pharmaceuticals, Inc. Aqueous 2,6-diisopropylphenol pharmaceutical compositions
AU2003900887A0 (en) * 2003-02-27 2003-03-13 Novasel Australia Pty Ltd Poloxamer emulsion preparations
US8802116B2 (en) 2003-02-27 2014-08-12 Novasel Australia Pty. Ltd. Poloxamer emulsion preparations
US8211448B2 (en) * 2003-07-07 2012-07-03 Nares Ab Microemulsions and its use for preventing airway diseases
EP1648948B1 (en) * 2003-07-18 2012-02-08 Agency for Science, Technology and Research Thermosensitive polymers for therapeutic use and methods of preparation
DE10334897A1 (en) * 2003-07-29 2005-03-10 Univ Koeln Microemulsions and their use as fuel
US7713440B2 (en) 2003-10-08 2010-05-11 Lyotropic Therapeutics, Inc. Stabilized uncoated particles of reversed liquid crystalline phase materials
PE20050596A1 (en) * 2003-12-19 2005-10-18 Novartis Ag MICROEMULSION INCLUDING A RENIN INHIBITOR
US20050152968A1 (en) * 2004-01-09 2005-07-14 Brophy Kristine M. Microemulsions for pharmaceutical compositions
CN100479812C (en) * 2004-02-13 2009-04-22 生物药效率有限公司 A microemulsion preparation of high concentration propofol for anesthetic uses
US20050232974A1 (en) * 2004-04-19 2005-10-20 Gore Makarand P System and a method for pharmaceutical dosage preparation using jettable microemulsions
US7659310B2 (en) * 2004-04-27 2010-02-09 Formatech, Inc. Methods of enhancing solubility of agents
EP1748759B1 (en) * 2004-04-27 2013-03-27 Javeri, Indu Methods of enhancing solubility in water of hydrophobic compounds by micellar dispersions
EP1652512A1 (en) * 2004-11-02 2006-05-03 Medesis Pharma Reverse micelle composition for delivery of metal cations comprising a diglyceride and a phytosterol and method of preparation
US20060198891A1 (en) 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
KR20070118069A (en) * 2004-12-09 2007-12-13 인시스 테라퓨틱스, 인코포레이티드 Room-temperature stable dronabinol formulations
GB0504950D0 (en) * 2005-03-10 2005-04-20 Novartis Ag Organic compositions
WO2006113505A2 (en) 2005-04-15 2006-10-26 Clarus Therapeutics, Inc. Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
US8492369B2 (en) 2010-04-12 2013-07-23 Clarus Therapeutics Inc Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
EP1906921B1 (en) * 2005-07-08 2008-12-03 Physica Pharma Clear pharmaceutical aqueous microemulsion comprising propofol and process for preparation
WO2007014445A1 (en) * 2005-08-02 2007-02-08 Miv Therapeutics Inc. Microdevices comprising nanocapsules for controlled delivery of drugs and method of manufacturing same
US8034765B2 (en) 2005-08-31 2011-10-11 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
KR101420445B1 (en) 2005-08-31 2014-07-16 아브락시스 바이오사이언스, 엘엘씨 Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
WO2007064845A1 (en) * 2005-11-29 2007-06-07 Pr Pharmaceuticals, Inc. Sustained release butorphanol drug delivery compositions for analgesia
US20070253909A1 (en) * 2006-05-01 2007-11-01 Medi-Flex, Inc. Aqueous Antiseptic Solution and Compatible Cationic Dye for Staining Skin
AU2007281918A1 (en) * 2006-08-04 2008-02-14 Insys Therapeutics Inc. Aqueous dronabinol formulations
US9918934B2 (en) * 2006-12-12 2018-03-20 Edgar Joel Acosta-Zara Linker-based lecithin microemulsion delivery vehicles
WO2008135855A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer
WO2008135828A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2009020666A1 (en) * 2007-08-06 2009-02-12 Insys Therapeutics Inc. Oral cannabinoid liquid formulations and methods of treatment
GB2451811A (en) 2007-08-09 2009-02-18 Ems Sa Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
WO2009073215A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
JP5518302B2 (en) * 2008-05-16 2014-06-11 一丸ファルコス株式会社 Method for sustained release of hydrophobic substances from polymer micelles
US8541360B2 (en) * 2008-11-19 2013-09-24 Ben Venue Laboratories, Inc. Parenteral formulations comprising sugar-based esters and ethers
CA2763458A1 (en) 2009-06-05 2010-12-09 Sunev Pharma Solution Limited Topical micro-emulsions for the treatment of rheumatic disorders
US8591942B2 (en) * 2009-09-23 2013-11-26 Indu JAVERI Methods for the preparation of liposomes comprising docetaxel
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
EP2335686A1 (en) * 2009-12-21 2011-06-22 LEK Pharmaceuticals d.d. An aqueous intravenous nanosuspension with reduced adverse effects
US20130039864A1 (en) * 2010-04-23 2013-02-14 Francois Ravenelle Non-Intravenous Dosage Form Comprising Solid Formulation of Liquid Biologically Active Agent and Uses Thereof
AU2011340797B2 (en) 2010-12-10 2017-08-10 Ns Technologies Pty Ltd Methods for forming miniemulsions and use thereof for delivering bioactive agents
US8808734B2 (en) * 2011-07-11 2014-08-19 Full Spectrum Laboratories Limited Cannabinoid formulations
US9308269B2 (en) 2011-07-27 2016-04-12 University Of Miami Stable liquid formulations of volatile gas anesthetics
US20140302113A1 (en) * 2011-09-30 2014-10-09 Sparkmed Research, Llc Systems, devices, and methods for embedding drug molecules into medical catheters or tubes
AU2014212275B2 (en) 2013-02-01 2018-09-06 Ocuphire Pharma, Inc. Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance
CA2899339C (en) 2013-02-01 2021-07-06 Ocularis Pharma, Llc Aqueous ophthalmic solutions of phentolamine and medical uses thereof
WO2014167554A2 (en) * 2013-04-12 2014-10-16 Vyome Biosciences Pvt. Ltd. Composition and formulation of antimicrobial agents, processes thereof and methods for treating microbial infections
WO2015100406A1 (en) 2013-12-26 2015-07-02 Clarus Therapeutics, Inc. Use of oral pharmaceutical products combining testosterone esters with hypolipidemic agents
CN104352433A (en) * 2014-10-21 2015-02-18 河南牧翔动物药业有限公司 Oil-in-water compound antimicrobial cefazolin nanoemulsion medicine
CN104523592B (en) * 2015-01-26 2017-03-15 湖北工业大学 Methylprednisolone acetate injection self-micro emulsion formulation and preparation method thereof
FR3041883B1 (en) * 2015-10-02 2019-03-15 Chu Clermont-Ferrand PROCESS FOR PREPARING A CICLOSPORIN A COLLYRE
JP6875685B2 (en) * 2015-10-08 2021-05-26 日油株式会社 O / W type emulsion
EP3523393A4 (en) * 2016-10-06 2020-05-20 The Administrators of The Tulane Educational Fund Water-soluble micelles for delivery of oil-soluble materials
WO2020087021A1 (en) 2018-10-26 2020-04-30 Ocuphire Pharma, Inc. Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders
BR102020001836A2 (en) * 2020-01-28 2021-08-03 Katia Solange Cardoso Rodrigues Dos Santos Geraldi WATER-BASED PROPYLENEGLYCOL-FREE MICROEMULSION FOR CARRYING MINOXIDIL IN THE TREATMENT OF HAIR LOSS AND PROCESSING METHOD
CN115368310A (en) 2021-05-18 2022-11-22 奥库菲尔医药公司 Method for synthesizing phentolamine mesylate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008610A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Corporation Pharmaceutical emulsion compositions
WO1997010814A1 (en) * 1995-09-18 1997-03-27 Vesifact Ag Propofol nanodispersions
US5925684A (en) * 1996-03-11 1999-07-20 Basf Aktiengesellschaft Stable carotenoid emulsions suitable for parenteral administration

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798846A (en) * 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions
US5342625A (en) * 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 A multiphase cyclosporin composition
US5274093A (en) * 1989-08-03 1993-12-28 Huels Aktiengesellschaft Process for the preparation of sodium thiobarbiturate
IL101007A (en) * 1992-02-18 1997-08-14 Pharmos Ltd Dry stable compositions prepared by lyophilization
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
CH686761A5 (en) * 1993-05-27 1996-06-28 Sandoz Ag Pharmaceutical formulations.
US5478860A (en) 1993-06-04 1995-12-26 Inex Pharmaceuticals Corp. Stable microemulsions for hydrophobic compound delivery
US5952004A (en) * 1994-03-18 1999-09-14 Shire Laboratories Inc. Emulsified drug delivery systems
US5731355A (en) 1994-03-22 1998-03-24 Zeneca Limited Pharmaceutical compositions of propofol and edetate
DE4440337A1 (en) 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmaceutical nanosuspensions for drug application as systems with increased saturation solubility and dissolution rate
US5560931A (en) 1995-02-14 1996-10-01 Nawosystems L.L.C. Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
EP0733372A3 (en) 1995-03-21 1998-05-20 Ciba-Geigy Ag Pharmaceutical base for the formulation of nanosuspensions
US5637625A (en) 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations
US5993858A (en) * 1996-06-14 1999-11-30 Port Systems L.L.C. Method and formulation for increasing the bioavailability of poorly water-soluble drugs
US5908619A (en) 1997-01-09 1999-06-01 Minnesota Mining And Manufacturing Company Hydroalcoholic compositions thickened using surfactant/polymer complexes
US5908825A (en) 1997-01-09 1999-06-01 University Of Maryland At Baltimore Dosage composition for nasal delivery and method of use of the same
DE19709704C2 (en) * 1997-03-10 1999-11-04 Michael Georgieff Use of a liquid preparation of xenon for intravenous administration when inducing and / or maintaining anesthesia
DE69804624T2 (en) * 1997-07-29 2002-09-19 Upjohn Co SELF-TEMPERATURE FORMULATION CONTAINING LIPOPHILE COMPOUNDS
US6063762A (en) * 1997-12-05 2000-05-16 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition
KR100587551B1 (en) * 1997-12-10 2006-06-08 싸이클로스포린 테라퓨틱스 리미티드 Pharmaceutical compositions containing an omega-3 fatty acid oil
US6241969B1 (en) * 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6383471B1 (en) * 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
JP2003502363A (en) * 1999-06-21 2003-01-21 コンイル ファーマシューティカル カンパニー、リミテッド Anesthetic composition for intravenous injection containing propofol
KR100482269B1 (en) * 2002-10-08 2005-04-14 센츄론(주) Injectable Anaesthetic Agent Comprising 2,6-Diisopropylphenol as an Active Ingredient and Preparation Method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008610A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Corporation Pharmaceutical emulsion compositions
WO1997010814A1 (en) * 1995-09-18 1997-03-27 Vesifact Ag Propofol nanodispersions
US5925684A (en) * 1996-03-11 1999-07-20 Basf Aktiengesellschaft Stable carotenoid emulsions suitable for parenteral administration

Also Published As

Publication number Publication date
JP2004505033A (en) 2004-02-19
CA2417800C (en) 2007-01-02
US6638537B2 (en) 2003-10-28
AU2001278124A1 (en) 2002-02-13
WO2003015823B1 (en) 2003-04-10
WO2003015823A1 (en) 2003-02-27
CA2417800A1 (en) 2002-02-07
US20040198813A1 (en) 2004-10-07
WO2002009671A2 (en) 2002-02-07
EP1305005A2 (en) 2003-05-02
US6623765B1 (en) 2003-09-23
JP4932123B2 (en) 2012-05-16
US20020120015A1 (en) 2002-08-29

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