WO2002008744A3 - Method and devices for capillary electrophoresis with a norbornene based surface coating - Google Patents

Method and devices for capillary electrophoresis with a norbornene based surface coating Download PDF

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Publication number
WO2002008744A3
WO2002008744A3 PCT/US2001/023048 US0123048W WO0208744A3 WO 2002008744 A3 WO2002008744 A3 WO 2002008744A3 US 0123048 W US0123048 W US 0123048W WO 0208744 A3 WO0208744 A3 WO 0208744A3
Authority
WO
WIPO (PCT)
Prior art keywords
norbornene based
capillary electrophoresis
devices
surface coating
based surface
Prior art date
Application number
PCT/US2001/023048
Other languages
French (fr)
Other versions
WO2002008744A2 (en
Inventor
Hilary S Lackritz
Ingrid Cruzado
Hongdong R Tan
Original Assignee
Aclara Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclara Biosciences Inc filed Critical Aclara Biosciences Inc
Priority to JP2002514387A priority Critical patent/JP4896349B2/en
Priority to AU2001277075A priority patent/AU2001277075A1/en
Priority to DE60106053T priority patent/DE60106053T2/en
Priority to EP01954855A priority patent/EP1305615B1/en
Publication of WO2002008744A2 publication Critical patent/WO2002008744A2/en
Publication of WO2002008744A3 publication Critical patent/WO2002008744A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Capillary electrophoresis is performed under conventional conditions in microchannels having a norbornene based polymer surface. The norbornene based polymers can be used as a solid substrate for forming the necessary features for a microfluidic device, where the entire may be made of norbornene based polymer. Conveniently, a norbornene based polymer layer having a lower glass transition temperature may be used to adhere a cover or enclosing layer to the substrate to enclose the microchannels and provide a bottom for the reservoirs.
PCT/US2001/023048 2000-07-21 2001-07-20 Method and devices for capillary electrophoresis with a norbornene based surface coating WO2002008744A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002514387A JP4896349B2 (en) 2000-07-21 2001-07-20 Methods and devices for capillary electrophoresis using a norbornene-based surface coating.
AU2001277075A AU2001277075A1 (en) 2000-07-21 2001-07-20 Method and devices for capillary electrophoresis with a norbornene based surface coating
DE60106053T DE60106053T2 (en) 2000-07-21 2001-07-20 METHOD AND DEVICES FOR CAPILLARY ELECTROPHORESIS USING A NORBORN-SUSTAINED SURFACE COATING
EP01954855A EP1305615B1 (en) 2000-07-21 2001-07-20 Method and devices for capillary electrophoresis with a norbornene based surface coating

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22005900P 2000-07-21 2000-07-21
US60/220,059 2000-07-21

Publications (2)

Publication Number Publication Date
WO2002008744A2 WO2002008744A2 (en) 2002-01-31
WO2002008744A3 true WO2002008744A3 (en) 2002-10-24

Family

ID=22821876

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/023048 WO2002008744A2 (en) 2000-07-21 2001-07-20 Method and devices for capillary electrophoresis with a norbornene based surface coating

Country Status (6)

Country Link
US (1) US6787015B2 (en)
EP (1) EP1305615B1 (en)
JP (1) JP4896349B2 (en)
AU (1) AU2001277075A1 (en)
DE (1) DE60106053T2 (en)
WO (1) WO2002008744A2 (en)

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US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
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Also Published As

Publication number Publication date
DE60106053T2 (en) 2005-11-17
WO2002008744A2 (en) 2002-01-31
AU2001277075A1 (en) 2002-02-05
JP4896349B2 (en) 2012-03-14
JP2004523728A (en) 2004-08-05
US6787015B2 (en) 2004-09-07
EP1305615A2 (en) 2003-05-02
DE60106053D1 (en) 2004-11-04
EP1305615B1 (en) 2004-09-29
US20020056639A1 (en) 2002-05-16

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