WO2002007585A3 - Tissue interrogation spectroscopy - Google Patents

Tissue interrogation spectroscopy Download PDF

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Publication number
WO2002007585A3
WO2002007585A3 PCT/US2001/022187 US0122187W WO0207585A3 WO 2002007585 A3 WO2002007585 A3 WO 2002007585A3 US 0122187 W US0122187 W US 0122187W WO 0207585 A3 WO0207585 A3 WO 0207585A3
Authority
WO
WIPO (PCT)
Prior art keywords
spectroscopy
interrogation
tissue
shock
measurement
Prior art date
Application number
PCT/US2001/022187
Other languages
French (fr)
Other versions
WO2002007585A2 (en
Inventor
Kevin R Ward
R Wayne Barbee
James Terner
Rao R Ivatury
Fred Hawkridge
Original Assignee
Univ Virginia Commonwealth
Kevin R Ward
R Wayne Barbee
James Terner
Rao R Ivatury
Fred Hawkridge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia Commonwealth, Kevin R Ward, R Wayne Barbee, James Terner, Rao R Ivatury, Fred Hawkridge filed Critical Univ Virginia Commonwealth
Priority to DE60137046T priority Critical patent/DE60137046D1/en
Priority to US10/332,613 priority patent/US7113814B2/en
Priority to EP01951068A priority patent/EP1304955B1/en
Priority to AU2001272003A priority patent/AU2001272003A1/en
Publication of WO2002007585A2 publication Critical patent/WO2002007585A2/en
Publication of WO2002007585A3 publication Critical patent/WO2002007585A3/en
Priority to US11/234,866 priority patent/US20060074282A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14539—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters

Abstract

In an emergency medicine patient, accurate measurement of change or lack thereof from non-shock, non-ischemic, non-inflammation, non-tissue injury, non-immune dysfunction conditions is important and is provided, as practical, real-time approaches for accurately characterizing a patient's condition, using Raman (3) and/or fluorescence (30) spectroscopy with a high degree of accuracy. Measurement times are on the order of seconds. High-accuracy measurement is achieved with Raman spectroscopy interrogation of tissue. Simultaneous interrogation by NADH fluorescence spectroscopy may be used. Measurements may be non-invasive to minimally invasive. Preclinical (ultra-early) states of shock can be detected (5), severity can be determined, and the effectiveness of various treatments can be determined.
PCT/US2001/022187 2000-07-13 2001-07-13 Tissue interrogation spectroscopy WO2002007585A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE60137046T DE60137046D1 (en) 2000-07-13 2001-07-13 USE OF ULTRAVIOLET, NAHULTRAVIOLET, AND NEAR-FRAROT RESONANT RMS SPECTROSCOPY AND FLUORESIS SPECTROSCOPY FOR TISSUE STUDY OF SHOCK, CRITICAL DISEASES OR OTHER ILLNESS STATES
US10/332,613 US7113814B2 (en) 2000-07-13 2001-07-13 Tissue interrogation spectroscopy
EP01951068A EP1304955B1 (en) 2000-07-13 2001-07-13 Use of ultraviolet, near-ultraviolet and near infrared resonance raman spectroscopy and fluorescence spectroscopy for tissue interrogation of shock states, critical illnesses, and other disease states
AU2001272003A AU2001272003A1 (en) 2000-07-13 2001-07-13 Use of ultraviolet, near-ultraviolet and near infrared resonance raman spectroscopy and fluorescence spectroscopy for tissue interrogation of shock states, critical illnesses, and other disease states
US11/234,866 US20060074282A1 (en) 2000-07-13 2005-09-26 Nitric-oxide detection using Raman spectroscopy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21805500P 2000-07-13 2000-07-13
US60/218,055 2000-07-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/234,866 Continuation-In-Part US20060074282A1 (en) 2000-07-13 2005-09-26 Nitric-oxide detection using Raman spectroscopy

Publications (2)

Publication Number Publication Date
WO2002007585A2 WO2002007585A2 (en) 2002-01-31
WO2002007585A3 true WO2002007585A3 (en) 2002-05-16

Family

ID=22813555

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022187 WO2002007585A2 (en) 2000-07-13 2001-07-13 Tissue interrogation spectroscopy

Country Status (6)

Country Link
US (1) US7113814B2 (en)
EP (1) EP1304955B1 (en)
AT (1) ATE417543T1 (en)
AU (1) AU2001272003A1 (en)
DE (1) DE60137046D1 (en)
WO (1) WO2002007585A2 (en)

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Also Published As

Publication number Publication date
DE60137046D1 (en) 2009-01-29
EP1304955B1 (en) 2008-12-17
US7113814B2 (en) 2006-09-26
AU2001272003A1 (en) 2002-02-05
ATE417543T1 (en) 2009-01-15
EP1304955A4 (en) 2005-09-28
US20040039269A1 (en) 2004-02-26
WO2002007585A2 (en) 2002-01-31
EP1304955A2 (en) 2003-05-02

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