WO2001091814A3 - Polyubiquitin based hydrogel and uses thereof - Google Patents

Polyubiquitin based hydrogel and uses thereof Download PDF

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Publication number
WO2001091814A3
WO2001091814A3 PCT/CA2001/000784 CA0100784W WO0191814A3 WO 2001091814 A3 WO2001091814 A3 WO 2001091814A3 CA 0100784 W CA0100784 W CA 0100784W WO 0191814 A3 WO0191814 A3 WO 0191814A3
Authority
WO
WIPO (PCT)
Prior art keywords
cross
novel
linking agent
polyubiquitin
dissolved
Prior art date
Application number
PCT/CA2001/000784
Other languages
French (fr)
Other versions
WO2001091814A2 (en
Inventor
Marc Bosse
Original Assignee
Viridis Biotech Inc
Marc Bosse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viridis Biotech Inc, Marc Bosse filed Critical Viridis Biotech Inc
Priority to EP01944783A priority Critical patent/EP1284992A2/en
Priority to AU2001267181A priority patent/AU2001267181A1/en
Priority to CA002409188A priority patent/CA2409188A1/en
Priority to US10/275,985 priority patent/US6881789B2/en
Priority to JP2001587826A priority patent/JP2003535165A/en
Publication of WO2001091814A2 publication Critical patent/WO2001091814A2/en
Publication of WO2001091814A3 publication Critical patent/WO2001091814A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin

Abstract

The present invention relates to a novel biopolymer consisting of a three-dimensional cross-linked mixture of (a) a cross-linking agent, activated with an activating agent, dissolved in a aqueous solution, and (b) a recombinant protein, namely polyubiquitin. The novel biopolymer is based on the cross-linking of ubiquitin (monomeric and/or polymeric) with a cross-linking agent, preferably bifunctionalized polyethylene oxides or a polyethylene glycol of various molecular masses (MW 2000 to 35 000 kDa), dissolved in aqueous solution in adequate proportions. The novel biopolymer offers a wide range of formulations since the number of ubiquitin units and cross-linking agent can vary both in length and ratio. The novel hydrogel is also biodegradable by a specific protease and is resistant to a wide range of other proteases.
PCT/CA2001/000784 2000-05-30 2001-05-29 Polyubiquitin based hydrogel and uses thereof WO2001091814A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01944783A EP1284992A2 (en) 2000-05-30 2001-05-29 Polyubiquitin based hydrogel and uses thereof
AU2001267181A AU2001267181A1 (en) 2000-05-30 2001-05-29 Polyubiquitin based hydrogel and uses thereof
CA002409188A CA2409188A1 (en) 2000-05-30 2001-05-29 Polyubiquitin based hydrogel and uses thereof
US10/275,985 US6881789B2 (en) 2000-05-30 2001-05-29 Polyubiquitin based hydrogel and uses thereof
JP2001587826A JP2003535165A (en) 2000-05-30 2001-05-29 Polyubiquitin-based hydrogel and its use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20732500P 2000-05-30 2000-05-30
US60/207,325 2000-05-30

Publications (2)

Publication Number Publication Date
WO2001091814A2 WO2001091814A2 (en) 2001-12-06
WO2001091814A3 true WO2001091814A3 (en) 2002-08-08

Family

ID=22770059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000784 WO2001091814A2 (en) 2000-05-30 2001-05-29 Polyubiquitin based hydrogel and uses thereof

Country Status (6)

Country Link
US (1) US6881789B2 (en)
EP (1) EP1284992A2 (en)
JP (1) JP2003535165A (en)
AU (1) AU2001267181A1 (en)
CA (1) CA2409188A1 (en)
WO (1) WO2001091814A2 (en)

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FR2842420B1 (en) * 2002-07-16 2006-07-14 Rocher Yves Biolog Vegetale COSMETIC COMPOSITION COMPRISING UBIQUITIN
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US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
JP5156890B2 (en) * 2002-09-11 2013-03-06 独立行政法人物質・材料研究機構 Crosslinked polymer and method for producing the same
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
AU2003267192A1 (en) * 2002-09-12 2004-04-30 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
JP4850709B2 (en) * 2003-05-14 2012-01-11 ダニスコ・ユーエス・インコーポレーテッド Controlled release of active agent using repetitive sequence protein polymer
EP1680148A1 (en) * 2003-10-21 2006-07-19 Bioartificial Gel Technologies Inc. Hydrogel-containing medical articles and methods of using and making the same
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
AU2005307746B2 (en) 2004-11-16 2011-05-12 Illumina, Inc. And methods and apparatus for reading coded microbeads
WO2006055735A2 (en) * 2004-11-16 2006-05-26 Illumina, Inc Scanner having spatial light modulator
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
CN100384923C (en) * 2006-04-28 2008-04-30 江南大学 Process for preparing hyaluronic acid-chitosan crosslinked biocompatible materials
US20090038066A1 (en) * 2007-04-04 2009-02-12 Global Sanitation Solutions, Inc. Systems and methods for providing a portable toilet system
US20100275362A1 (en) * 2007-04-04 2010-11-04 Stephen Biesinger Systems and methods for providing a portable toilet system
CA2747995A1 (en) 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
KR101811070B1 (en) 2009-12-16 2017-12-20 백스터 인터내셔널 인코포레이티드 Hemostatic sponge
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
CN105297440B (en) * 2015-11-11 2018-01-12 浙江理工大学 A kind of method to silk graft modification
TWI644676B (en) * 2017-08-28 2018-12-21 婁敬 Antibacterial hydrogel
IL293078A (en) * 2019-11-27 2022-07-01 Onegene Biotechnology Inc Multifunctional multispecific multimeric biomolecule polymer having prolonged in-vivo duration
CN111249532A (en) * 2020-01-16 2020-06-09 广东省人民医院(广东省医学科学院) Injectable hyaluronic acid hydrogel for cartilage repair and preparation method thereof

Citations (1)

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EP0400472A2 (en) * 1989-05-27 1990-12-05 Sumitomo Pharmaceuticals Company, Limited Process for preparing polyethylene glycol derivatives and modified protein.

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ATE151286T1 (en) * 1983-11-14 1997-04-15 Columbia Lab Inc BIOADHESIVE AGENTS
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Non-Patent Citations (2)

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Also Published As

Publication number Publication date
AU2001267181A1 (en) 2001-12-11
US6881789B2 (en) 2005-04-19
CA2409188A1 (en) 2001-12-06
WO2001091814A2 (en) 2001-12-06
EP1284992A2 (en) 2003-02-26
JP2003535165A (en) 2003-11-25
US20030114724A1 (en) 2003-06-19

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