WO2001087369A3 - Osteoimplant and method for making same - Google Patents

Osteoimplant and method for making same Download PDF

Info

Publication number
WO2001087369A3
WO2001087369A3 PCT/US2001/015599 US0115599W WO0187369A3 WO 2001087369 A3 WO2001087369 A3 WO 2001087369A3 US 0115599 W US0115599 W US 0115599W WO 0187369 A3 WO0187369 A3 WO 0187369A3
Authority
WO
WIPO (PCT)
Prior art keywords
osteoimplant
possessing
making same
cortical bone
monolithic section
Prior art date
Application number
PCT/US2001/015599
Other languages
French (fr)
Other versions
WO2001087369A2 (en
Inventor
Jean T Edwards
Lawrence A Shimp
Michele Diegmann
Todd M Boyce
Nelson L Scarborough
James L Russell
Original Assignee
Osteotech Inc
Jean T Edwards
Lawrence A Shimp
Michele Diegmann
Todd M Boyce
Nelson L Scarborough
James L Russell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osteotech Inc, Jean T Edwards, Lawrence A Shimp, Michele Diegmann, Todd M Boyce, Nelson L Scarborough, James L Russell filed Critical Osteotech Inc
Priority to CA002409479A priority Critical patent/CA2409479A1/en
Priority to DE60113095T priority patent/DE60113095T2/en
Priority to AU6158901A priority patent/AU6158901A/en
Priority to EP01935499A priority patent/EP1280564B1/en
Publication of WO2001087369A2 publication Critical patent/WO2001087369A2/en
Publication of WO2001087369A3 publication Critical patent/WO2001087369A3/en
Priority to US10/285,715 priority patent/US7179299B2/en
Priority to US11/676,429 priority patent/US7662184B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
PCT/US2001/015599 1999-06-08 2001-05-14 Osteoimplant and method for making same WO2001087369A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002409479A CA2409479A1 (en) 2000-05-12 2001-05-14 Osteoimplant and method for making same
DE60113095T DE60113095T2 (en) 2000-05-12 2001-05-14 SURFACES ENTMINERALIZED EASTERN OIL PLANTATE AND METHOD FOR THE PRODUCTION THEREOF
AU6158901A AU6158901A (en) 2000-05-12 2001-05-14 Osteoimplant and method for making same
EP01935499A EP1280564B1 (en) 2000-05-12 2001-05-14 Surface demineralized osteoimplant and method for making same
US10/285,715 US7179299B2 (en) 2000-05-12 2002-11-01 Osteoimplant and method for making same
US11/676,429 US7662184B2 (en) 1999-06-08 2007-02-19 Osteoimplant and method for making same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20406900P 2000-05-12 2000-05-12
US60/204,069 2000-05-12
US22105600P 2000-07-27 2000-07-27
US60/221,056 2000-07-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/328,242 Continuation-In-Part US6277149B1 (en) 1999-06-08 1999-06-08 Ramp-shaped intervertebral implant

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/285,715 Continuation US7179299B2 (en) 1999-06-08 2002-11-01 Osteoimplant and method for making same

Publications (2)

Publication Number Publication Date
WO2001087369A2 WO2001087369A2 (en) 2001-11-22
WO2001087369A3 true WO2001087369A3 (en) 2002-07-04

Family

ID=26899150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015599 WO2001087369A2 (en) 1999-06-08 2001-05-14 Osteoimplant and method for making same

Country Status (7)

Country Link
US (2) US7179299B2 (en)
EP (1) EP1280564B1 (en)
AU (1) AU6158901A (en)
CA (1) CA2409479A1 (en)
DE (1) DE60113095T2 (en)
ES (1) ES2247113T3 (en)
WO (1) WO2001087369A2 (en)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7931692B2 (en) * 2001-02-14 2011-04-26 Osteotech, Inc. Implant derived from bone
US20050015147A1 (en) * 2001-12-18 2005-01-20 Jeffrey Schwardt Spinal implants
MXPA04005940A (en) * 2002-01-22 2004-09-13 Pfizer 3-(imidazolyl)-2-aminopropanoic acids for use as tafi-a inhibitors for the treatment of thrombotic diseases.
US7744597B2 (en) 2002-06-26 2010-06-29 Lifenet Health Device and process for producing fiber products and fiber products produced thereby
NZ538196A (en) * 2002-08-12 2007-05-31 Osteotech Inc Synthesis of a bone-polymer composite material for forming osteoimplants
US9107751B2 (en) * 2002-12-12 2015-08-18 Warsaw Orthopedic, Inc. Injectable and moldable bone substitute materials
US20050251267A1 (en) * 2004-05-04 2005-11-10 John Winterbottom Cell permeable structural implant
CA2514336C (en) 2003-02-04 2013-05-14 Osteotech, Inc. Polyurethanes for osteoimplants
US7985414B2 (en) * 2003-02-04 2011-07-26 Warsaw Orthopedic, Inc. Polyurethanes for osteoimplants
WO2004084742A1 (en) * 2003-03-24 2004-10-07 Theken Surgical Llc Spinal implant adjustment device
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US20050222687A1 (en) * 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US20050064042A1 (en) * 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US7494811B2 (en) 2003-05-01 2009-02-24 Lifenet Health In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20090291112A1 (en) * 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US7488348B2 (en) * 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
CA2550431A1 (en) * 2003-12-19 2005-07-14 Osteotech, Inc. Tissue-derived mesh for orthopedic regeneration
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
US8328876B2 (en) * 2003-12-31 2012-12-11 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US8012210B2 (en) * 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
AU2005210630A1 (en) * 2004-01-30 2005-08-18 Warsaw Orthopedic, Inc. Stacking implants for spinal fusion
CN101027015B (en) * 2004-03-26 2010-12-22 新特斯有限责任公司 Allograft implant
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20080220044A1 (en) * 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US20070038303A1 (en) * 2006-08-15 2007-02-15 Ebi, L.P. Foot/ankle implant and associated method
US7879109B2 (en) * 2004-12-08 2011-02-01 Biomet Manufacturing Corp. Continuous phase composite for musculoskeletal repair
US8535357B2 (en) * 2004-12-09 2013-09-17 Biomet Sports Medicine, Llc Continuous phase compositions for ACL repair
WO2006113586A2 (en) 2005-04-15 2006-10-26 Musculoskeletal Transplant Foundation Vertebral disc repair
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
WO2007053850A2 (en) 2005-11-01 2007-05-10 Osteotech, Inc. Bone matrix compositions and methods
US20070162132A1 (en) 2005-12-23 2007-07-12 Dominique Messerli Flexible elongated chain implant and method of supporting body tissue with same
EP1976459A4 (en) 2006-01-19 2012-06-20 Warsaw Orthopedic Inc Porous osteoimplant
EP2076220A2 (en) 2006-07-25 2009-07-08 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US20080294270A1 (en) * 2007-05-24 2008-11-27 Zimmer Orthobiologics, Inc. Differentially processed tissue and processing methods thereof
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
CA2945295C (en) 2007-06-15 2020-01-14 Warsaw Orthopedic, Inc. Method of treating tissue
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
US9492278B2 (en) * 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
US9138509B2 (en) * 2007-09-14 2015-09-22 Musculoskeletal Transplant Foundation Composition for filling bone defects
US8202539B2 (en) * 2007-10-19 2012-06-19 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
EP2224884A2 (en) * 2007-12-05 2010-09-08 Musculoskeletal Transplant Foundation Cancellous bone implant for cartilage repair
EP2265220A1 (en) * 2008-03-05 2010-12-29 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US8313528B1 (en) 2008-03-27 2012-11-20 Spinelogik, Inc. Intervertebral fusion device and method of use
US8333804B1 (en) 2008-03-27 2012-12-18 Spinelogik, Inc. Intervertebral fusion device and method of use
CA2719798A1 (en) * 2008-03-28 2009-10-01 Osteotech, Inc. Bone anchors for orthopedic applications
US9333276B2 (en) * 2008-10-30 2016-05-10 Vanderbilt University Bone/polyurethane composites and methods thereof
WO2012134540A2 (en) 2010-10-22 2012-10-04 Vanderbilt University Injectable synthetic pur composite
US20100274355A1 (en) * 2009-01-21 2010-10-28 Mcguire David A Bone-tendon-bone assembly with cancellous allograft bone block having cortical end portion
US9011537B2 (en) * 2009-02-12 2015-04-21 Warsaw Orthopedic, Inc. Delivery system cartridge
US9427324B1 (en) * 2010-02-22 2016-08-30 Spinelogik, Inc. Intervertebral fusion device and method of use
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8343229B2 (en) 2010-07-16 2013-01-01 Ebi, Llc Textured bone block implants
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US9358122B2 (en) 2011-01-07 2016-06-07 K2M, Inc. Interbody spacer
US9149365B2 (en) 2013-03-05 2015-10-06 Globus Medical, Inc. Low profile plate
US10881526B2 (en) 2011-09-16 2021-01-05 Globus Medical, Inc. Low profile plate
US9848994B2 (en) 2011-09-16 2017-12-26 Globus Medical, Inc. Low profile plate
US9398960B2 (en) 2011-09-16 2016-07-26 Globus Medical, Inc. Multi-piece intervertebral implants
US8961606B2 (en) 2011-09-16 2015-02-24 Globus Medical, Inc. Multi-piece intervertebral implants
US9237957B2 (en) 2011-09-16 2016-01-19 Globus Medical, Inc. Low profile plate
US9204975B2 (en) 2011-09-16 2015-12-08 Globus Medical, Inc. Multi-piece intervertebral implants
US9681959B2 (en) 2011-09-16 2017-06-20 Globus Medical, Inc. Low profile plate
US9770340B2 (en) 2011-09-16 2017-09-26 Globus Medical, Inc. Multi-piece intervertebral implants
US9539109B2 (en) 2011-09-16 2017-01-10 Globus Medical, Inc. Low profile plate
US10245155B2 (en) 2011-09-16 2019-04-02 Globus Medical, Inc. Low profile plate
US9554914B2 (en) * 2011-12-12 2017-01-31 Wright Medical Technology, Inc. Fusion implant
US9968455B2 (en) 2012-04-27 2018-05-15 Howmedica Osteonics Corp. Multiple component bone void filling implant
US9585764B2 (en) * 2012-07-26 2017-03-07 Warsaw Orthopedic, Inc. Bone implant device
US9345589B2 (en) * 2013-12-19 2016-05-24 Ilion Medical, Inc. Bone implants for orthopedic procedures and corresponding methods
US20150366668A1 (en) * 2014-06-23 2015-12-24 Community Blood Center Cellular-scale surface modification for increased osteogenic protein expression
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
US20170312079A1 (en) * 2016-04-28 2017-11-02 Warsaw Orthopedic, Inc. Mechanically entangled demineralized bone fibers
CN109923947B (en) * 2016-11-09 2022-04-05 昭和电工材料株式会社 Printed wiring board and semiconductor package
US10376385B2 (en) 2017-04-05 2019-08-13 Globus Medical, Inc. Decoupled spacer and plate and method of installing the same
US11452608B2 (en) 2017-04-05 2022-09-27 Globus Medical, Inc. Decoupled spacer and plate and method of installing the same
US10966816B1 (en) 2019-10-18 2021-04-06 Sparta Biopharma LLC Connective tissue to bone interface scaffolds
WO2022046701A1 (en) 2020-08-24 2022-03-03 Sparta Biopharma LLC Methods of forming bone interface scaffolds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
WO1999021515A1 (en) * 1997-10-27 1999-05-06 University Of Florida Tissue Bank, Inc. Segmentally demineralized bone implant
WO1999039757A1 (en) * 1998-02-06 1999-08-12 Osteotech, Inc. Osteoimplant and method for its manufacture

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061286A (en) * 1989-08-18 1991-10-29 Osteotech, Inc. Osteoprosthetic implant
US5290558A (en) * 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US6652592B1 (en) * 1997-10-27 2003-11-25 Regeneration Technologies, Inc. Segmentally demineralized bone implant
US6458375B1 (en) * 1998-02-27 2002-10-01 Musculoskeletal Transplant Foundation Malleable paste with allograft bone reinforcement for filling bone defects
US6200347B1 (en) * 1999-01-05 2001-03-13 Lifenet Composite bone graft, method of making and using same
US6206923B1 (en) * 1999-01-08 2001-03-27 Sdgi Holdings, Inc. Flexible implant using partially demineralized bone
US6277149B1 (en) * 1999-06-08 2001-08-21 Osteotech, Inc. Ramp-shaped intervertebral implant
US6436101B1 (en) * 1999-10-13 2002-08-20 James S. Hamada Rasp for use in spine surgery
US6340477B1 (en) * 2000-04-27 2002-01-22 Lifenet Bone matrix composition and methods for making and using same
US6638310B2 (en) * 2000-07-26 2003-10-28 Osteotech, Inc. Intervertebral spacer and implant insertion instrumentation
US6776800B2 (en) * 2001-02-28 2004-08-17 Synthes (U.S.A.) Implants formed with demineralized bone
EP1439802A2 (en) * 2001-10-30 2004-07-28 Osteotech, Inc. Bone implant and insertion tools

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999021515A1 (en) * 1997-10-27 1999-05-06 University Of Florida Tissue Bank, Inc. Segmentally demineralized bone implant
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
WO1999039757A1 (en) * 1998-02-06 1999-08-12 Osteotech, Inc. Osteoimplant and method for its manufacture

Also Published As

Publication number Publication date
US7179299B2 (en) 2007-02-20
WO2001087369A2 (en) 2001-11-22
US7662184B2 (en) 2010-02-16
EP1280564B1 (en) 2005-08-31
US20030144743A1 (en) 2003-07-31
ES2247113T3 (en) 2006-03-01
EP1280564A2 (en) 2003-02-05
US20070168030A1 (en) 2007-07-19
DE60113095D1 (en) 2005-10-06
DE60113095T2 (en) 2006-05-18
CA2409479A1 (en) 2001-11-22
AU6158901A (en) 2001-11-26

Similar Documents

Publication Publication Date Title
WO2001087369A3 (en) Osteoimplant and method for making same
WO2000042954A3 (en) Intervertebral implant
US5147402A (en) Implant for ingrowth of osseous tissue
EP0639356B1 (en) Process for shaping external anchoring surfaces for joint implants
CA2424261A1 (en) Method and apparatus for stabilizing adjacent bones
CA2191089A1 (en) Intervertebral fusion implant
CA2386396A1 (en) Implant of bone matter
CA2361620A1 (en) Bone-derived implant for load-supporting applications
WO2001082993A3 (en) Implants for orthopedic applications
WO2001068004A8 (en) Synthetic reinforced interbody fusion implants
EP0678285A3 (en) Orthopaedic implant and method of making same.
CA2219163A1 (en) Machining assembly and methods for preparing the medullary cavity of a femur in hip arthroplasty
EP0681845A3 (en) Polymer composite implant and method of making the same.
US6656226B2 (en) Plastic jacket for a cementless artificial joint stem and artificial joint having the jacket
AU4267589A (en) Prosthetic device and method of implantation
EP0649640A3 (en) Composite femoral implant having increased neck strength.
AU4294397A (en) Endoprosthesis
ATE149820T1 (en) BONE PROSTHESIS PART WITH FLUTED WEDGES
WO1985003426A1 (en) Apparatus for affixing a prosthesis to bone
FI971804A0 (en) Hip vase spacer assembly
CA2006595A1 (en) Method for producing a hollow shaft endoprosthesis
USD461248S1 (en) Assembled bone implants
EP1399098A1 (en) Hip endoprosthesis
WO2006125711A1 (en) Prosthetic component with recesses provided beneath the outer surface
AU2904999A (en) Self-forming partial breast prosthesis and a method of making the same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 10285715

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2409479

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001935499

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001935499

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWG Wipo information: grant in national office

Ref document number: 2001935499

Country of ref document: EP