WO2001076743A3 - Fluid analyte detection based on flow rate or viscosity measurement - Google Patents

Fluid analyte detection based on flow rate or viscosity measurement Download PDF

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Publication number
WO2001076743A3
WO2001076743A3 PCT/GB2001/001650 GB0101650W WO0176743A3 WO 2001076743 A3 WO2001076743 A3 WO 2001076743A3 GB 0101650 W GB0101650 W GB 0101650W WO 0176743 A3 WO0176743 A3 WO 0176743A3
Authority
WO
WIPO (PCT)
Prior art keywords
flow rate
chamber
fluid sample
detection based
analyte detection
Prior art date
Application number
PCT/GB2001/001650
Other languages
French (fr)
Other versions
WO2001076743A2 (en
Inventor
Elizabeth Anne Howlett Hall
Ian Stuart Harding
Original Assignee
Univ Cambridge Tech
Elizabeth Anne Howlett Hall
Ian Stuart Harding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cambridge Tech, Elizabeth Anne Howlett Hall, Ian Stuart Harding filed Critical Univ Cambridge Tech
Priority to AU2001248542A priority Critical patent/AU2001248542A1/en
Publication of WO2001076743A2 publication Critical patent/WO2001076743A2/en
Publication of WO2001076743A3 publication Critical patent/WO2001076743A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/704—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow using marked regions or existing inhomogeneities within the fluid stream, e.g. statistically occurring variations in a fluid parameter
    • G01F1/708—Measuring the time taken to traverse a fixed distance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085—Flow Injection Analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties

Abstract

A sensor for quantifying the flow rate or viscosity of a fluid sample, or the concentration of an analyte within that fluid sample. The sensor comprises a chamber for holding a fluid sample and guiding it through a channel containing a detection means. The chamber has at least one and preferably two changes in a diameter and the flow of the sample from the chamber thereby causes detectable changes in the readings of the detection means. Given the known chamber dimensions, this enables flow rate and viscosity of a fluid sample to be calculated. This can then be used to calculate the concentration of an analyte, directly or indirectly, despite any flow rate dependency of the detection means.
PCT/GB2001/001650 2000-04-12 2001-04-12 Fluid analyte detection based on flow rate or viscosity measurement WO2001076743A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001248542A AU2001248542A1 (en) 2000-04-12 2001-04-12 Fluid analyte detection based on flow rate or viscosity measurement

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0008950.8 2000-04-12
GB0008950A GB0008950D0 (en) 2000-04-12 2000-04-12 Apparatus and method for assay of a fluid analyte

Publications (2)

Publication Number Publication Date
WO2001076743A2 WO2001076743A2 (en) 2001-10-18
WO2001076743A3 true WO2001076743A3 (en) 2004-02-26

Family

ID=9889722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001650 WO2001076743A2 (en) 2000-04-12 2001-04-12 Fluid analyte detection based on flow rate or viscosity measurement

Country Status (3)

Country Link
AU (1) AU2001248542A1 (en)
GB (1) GB0008950D0 (en)
WO (1) WO2001076743A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5311801B2 (en) * 2007-11-09 2013-10-09 キヤノン株式会社 Liquid feed drive mechanism using osmotic pressure pump and microchip having the liquid feed drive mechanism
CN103439260B (en) * 2013-09-17 2015-07-29 国核电站运行服务技术有限公司 Solid sample bracket of spectrophotometer
CN107389911A (en) * 2017-07-12 2017-11-24 柳州康云互联科技有限公司 Quick separating detection sensor for mobile terminal

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3138514A1 (en) * 1981-09-28 1983-04-14 Klaus Dipl.-Ing. 5100 Aachen Mussler Method and device for determining the flow behaviour of biological liquids
US4793174A (en) * 1987-10-05 1988-12-27 E. I. Du Pont De Nemours And Company Differential pressure capillary viscometer
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
WO1999009388A2 (en) * 1997-08-18 1999-02-25 Metasensors, Inc. Method and apparatus for real time gas analysis and medical fluids monitoring
WO2001024297A1 (en) * 1999-09-24 2001-04-05 Siemens Aktiengesellschaft Determination of alcohol concentration in an electrolyte of fuel cells

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3138514A1 (en) * 1981-09-28 1983-04-14 Klaus Dipl.-Ing. 5100 Aachen Mussler Method and device for determining the flow behaviour of biological liquids
US4793174A (en) * 1987-10-05 1988-12-27 E. I. Du Pont De Nemours And Company Differential pressure capillary viscometer
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
WO1999009388A2 (en) * 1997-08-18 1999-02-25 Metasensors, Inc. Method and apparatus for real time gas analysis and medical fluids monitoring
WO2001024297A1 (en) * 1999-09-24 2001-04-05 Siemens Aktiengesellschaft Determination of alcohol concentration in an electrolyte of fuel cells
DE19945931A1 (en) * 1999-09-24 2001-05-03 Siemens Ag Determination of the alcohol concentration in the electrolyte of fuel cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GOODING J J ET AL: "A FILL-AND-FLOW BIOSENSOR", ANALYTICAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. COLUMBUS, vol. 70, no. 15, 1 August 1998 (1998-08-01), pages 3131 - 3136, XP000776674, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
AU2001248542A1 (en) 2001-10-23
GB0008950D0 (en) 2000-05-31
WO2001076743A2 (en) 2001-10-18

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