WO2001062289A3 - Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant - Google Patents

Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant Download PDF

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Publication number
WO2001062289A3
WO2001062289A3 PCT/US2001/005718 US0105718W WO0162289A3 WO 2001062289 A3 WO2001062289 A3 WO 2001062289A3 US 0105718 W US0105718 W US 0105718W WO 0162289 A3 WO0162289 A3 WO 0162289A3
Authority
WO
WIPO (PCT)
Prior art keywords
cellular
eradication
organism
acellular
association
Prior art date
Application number
PCT/US2001/005718
Other languages
French (fr)
Other versions
WO2001062289A2 (en
WO2001062289B1 (en
Inventor
Merrill A Biel
Original Assignee
Advanced Photodynamic Technolo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/514,070 external-priority patent/US7229447B1/en
Application filed by Advanced Photodynamic Technolo filed Critical Advanced Photodynamic Technolo
Priority to EP01914446A priority Critical patent/EP1263465B9/en
Priority to CA2401624A priority patent/CA2401624C/en
Priority to JP2001561353A priority patent/JP2003531828A/en
Priority to AU2001239835A priority patent/AU2001239835A1/en
Publication of WO2001062289A2 publication Critical patent/WO2001062289A2/en
Publication of WO2001062289A3 publication Critical patent/WO2001062289A3/en
Publication of WO2001062289B1 publication Critical patent/WO2001062289B1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention relates to a method of photoeradication of cellular and acellular organisms including the steps of providing a surface acting agent in association with a cellular or acellular organism, the surface acting agent disorienting a membrane structure so that said membrane no longer functions as an effective osmotic barrier; providing a photosensitive material in association with the cellular or acellular organism; and applying light in association with the cellular or acellular organism to cause a disruption of the organism. The method according to the present invention may be utilized in invitro and invivo treatment protocols for infections, sterilization procedures, cancer cell eradication, virus and fungus eradication, spore eradication, and biofilm organism eradication. Additional aspects of the invention include particular combinations of photosensitive materials and surfactants for use in photodynamic therapies.
PCT/US2001/005718 2000-02-26 2001-02-23 Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant WO2001062289A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01914446A EP1263465B9 (en) 2000-02-26 2001-02-23 Photodynamic cellular organism eradication using a photosensitive material and surfactant
CA2401624A CA2401624C (en) 2000-02-26 2001-02-23 Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant
JP2001561353A JP2003531828A (en) 2000-02-26 2001-02-23 Eradicate photodynamic cells and acellular organisms using photosensitizers and surfactants
AU2001239835A AU2001239835A1 (en) 2000-02-26 2001-02-23 Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/514,070 2000-02-26
US09/514,070 US7229447B1 (en) 1998-08-25 2000-02-26 Photodynamic therapy utilizing a solution of photosensitizing compound and surfactant
US09/792,578 2001-02-23
US09/792,578 US8267982B2 (en) 1998-08-25 2001-02-23 Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant

Publications (3)

Publication Number Publication Date
WO2001062289A2 WO2001062289A2 (en) 2001-08-30
WO2001062289A3 true WO2001062289A3 (en) 2002-05-02
WO2001062289B1 WO2001062289B1 (en) 2002-07-25

Family

ID=27058084

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/005718 WO2001062289A2 (en) 2000-02-26 2001-02-23 Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant

Country Status (6)

Country Link
US (1) US8267982B2 (en)
EP (1) EP1263465B9 (en)
JP (1) JP2003531828A (en)
AU (1) AU2001239835A1 (en)
CA (1) CA2401624C (en)
WO (1) WO2001062289A2 (en)

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Also Published As

Publication number Publication date
JP2003531828A (en) 2003-10-28
WO2001062289A2 (en) 2001-08-30
CA2401624C (en) 2011-08-16
US20020183808A1 (en) 2002-12-05
AU2001239835A1 (en) 2001-09-03
EP1263465A2 (en) 2002-12-11
EP1263465B1 (en) 2012-05-30
EP1263465B9 (en) 2012-12-05
US8267982B2 (en) 2012-09-18
WO2001062289B1 (en) 2002-07-25
CA2401624A1 (en) 2001-08-30

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