WO2001054764A3 - Bioabsorbable brachytherapy device - Google Patents

Bioabsorbable brachytherapy device Download PDF

Info

Publication number
WO2001054764A3
WO2001054764A3 PCT/US2001/002545 US0102545W WO0154764A3 WO 2001054764 A3 WO2001054764 A3 WO 2001054764A3 US 0102545 W US0102545 W US 0102545W WO 0154764 A3 WO0154764 A3 WO 0154764A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioabsorbable
brachytherapy device
tubular housing
radioactive material
sealed
Prior art date
Application number
PCT/US2001/002545
Other languages
French (fr)
Other versions
WO2001054764A2 (en
Inventor
Paul O Zamora
Robert A Stern
Original Assignee
Biosurface Eng Tech Inc
Paul O Zamora
Robert A Stern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosurface Eng Tech Inc, Paul O Zamora, Robert A Stern filed Critical Biosurface Eng Tech Inc
Priority to AU2001237969A priority Critical patent/AU2001237969A1/en
Publication of WO2001054764A2 publication Critical patent/WO2001054764A2/en
Publication of WO2001054764A3 publication Critical patent/WO2001054764A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1027—Interstitial radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1024—Seeds

Abstract

A bioabsorbable brachytherapy device (110) includes a tubular housing (112) with sealed ends (122, 124) enclosed radioactive material (126). The radioactive material includes a radioisotope, such as palladium-103 or iodine-125. The tubular housing is made from a biocompatible and bioabsorbable polymeric material, and is sealed by means such as heat welding or solvent fixing. The device may further include a radiopaque medium and one or more therapeutic drugs.
PCT/US2001/002545 2000-01-25 2001-01-25 Bioabsorbable brachytherapy device WO2001054764A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001237969A AU2001237969A1 (en) 2000-01-25 2001-01-25 Bioabsorbable brachytherapy device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17808300P 2000-01-25 2000-01-25
US60/178,083 2000-01-25
US09/769,194 US6575888B2 (en) 2000-01-25 2001-01-24 Bioabsorbable brachytherapy device
US09/769,194 2001-01-24

Publications (2)

Publication Number Publication Date
WO2001054764A2 WO2001054764A2 (en) 2001-08-02
WO2001054764A3 true WO2001054764A3 (en) 2002-05-02

Family

ID=26873947

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/002545 WO2001054764A2 (en) 2000-01-25 2001-01-25 Bioabsorbable brachytherapy device

Country Status (3)

Country Link
US (1) US6575888B2 (en)
AU (1) AU2001237969A1 (en)
WO (1) WO2001054764A2 (en)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6589502B1 (en) * 1995-11-27 2003-07-08 International Brachytherapy S.A. Radioisotope dispersed in a matrix for brachytherapy
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US7637948B2 (en) 1997-10-10 2009-12-29 Senorx, Inc. Tissue marking implant
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
US20090030309A1 (en) * 2007-07-26 2009-01-29 Senorx, Inc. Deployment of polysaccharide markers
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US6725083B1 (en) * 1999-02-02 2004-04-20 Senorx, Inc. Tissue site markers for in VIVO imaging
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US7651505B2 (en) 2002-06-17 2010-01-26 Senorx, Inc. Plugged tip delivery for marker placement
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US7983734B2 (en) 2003-05-23 2011-07-19 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US6575991B1 (en) 1999-06-17 2003-06-10 Inrad, Inc. Apparatus for the percutaneous marking of a lesion
SE0000363L (en) * 2000-02-04 2001-08-05 Zoucas Kirurgkonsult Ab Coated medical device
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US6471671B1 (en) 2000-08-23 2002-10-29 Scimed Life Systems, Inc. Preloaded gas inflation device for balloon catheter
US7803149B2 (en) * 2002-07-12 2010-09-28 Cook Incorporated Coated medical device
US6746661B2 (en) 2000-11-16 2004-06-08 Microspherix Llc Brachytherapy seed
EP1545705A4 (en) * 2000-11-16 2010-04-28 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
CA2659518A1 (en) 2000-11-20 2002-05-30 Senorx, Inc. Tissue site markers for in vivo imaging
US7266687B2 (en) * 2001-02-16 2007-09-04 Motorola, Inc. Method and apparatus for storing and distributing encryption keys
US6875165B2 (en) 2001-02-22 2005-04-05 Retinalabs, Inc. Method of radiation delivery to the eye
GB0104383D0 (en) * 2001-02-22 2001-04-11 Psimedica Ltd Cancer Treatment
DE10115740A1 (en) 2001-03-26 2002-10-02 Ulrich Speck Preparation for restenosis prophylaxis
US20030120355A1 (en) * 2001-06-08 2003-06-26 Urs Hafeli Biocompatible and biodegradable polymers for diagnostic and therapeutic radioisotope delivery
SE523216C2 (en) * 2001-07-27 2004-04-06 Zoucas Kirurgkonsult Ab heparin stent
US6761680B2 (en) 2001-11-02 2004-07-13 Richard A. Terwilliger Delivery system and method for interstitial radiation therapy using seed strands constructed with preformed strand housing
US7074291B2 (en) * 2001-11-02 2006-07-11 Worldwide Medical Technologies, L.L.C. Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings
US6786858B2 (en) * 2001-11-02 2004-09-07 Ideamatrix, Inc. Delivery system and method for interstitial radiotherapy using hollow seeds
US7060020B2 (en) * 2001-11-02 2006-06-13 Ideamatrix, Inc. Delivery system and method for interstitial radiation therapy
US7094198B2 (en) * 2001-11-02 2006-08-22 Worldwide Medical Technologies, Llc Delivery system and method for interstitial radiation therapy using seed elements with ends having one of projections and indentations
WO2003045274A2 (en) * 2001-11-21 2003-06-05 Nuvasive, Inc. Thermopolymer composition and related methods
US20030191355A1 (en) * 2002-04-04 2003-10-09 Ferguson Patrick J. Hollow bioabsorbable elements for positioning material in living tissue
DE10244847A1 (en) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medical device for drug delivery
US20060036158A1 (en) 2003-11-17 2006-02-16 Inrad, Inc. Self-contained, self-piercing, side-expelling marking apparatus
KR101130187B1 (en) 2003-04-30 2012-03-29 라모트 앳 텔-아비브 유니버시티 리미티드 Method and device for radiotherapy
US7037252B2 (en) * 2003-05-05 2006-05-02 Draxis Specialty Pharmaceuticals, Inc. Brachytherapy seed transport devices and methods for using same
US6997862B2 (en) * 2003-05-13 2006-02-14 Ideamatrix, Inc. Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing
US7877133B2 (en) 2003-05-23 2011-01-25 Senorx, Inc. Marker or filler forming fluid
US20050080314A1 (en) * 2003-10-09 2005-04-14 Terwilliger Richard A. Shielded transport for multiple brachytheapy implants with integrated measuring and cutting board
US20050273002A1 (en) 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
AU2005214040B2 (en) 2004-02-12 2011-03-31 Neo Vista, Inc. Methods and apparatus for intraocular brachytherapy
EP1616597B1 (en) * 2004-07-15 2010-10-27 Nucletron B.V. Device for radiation treatment of proliferative tissue surrounding a cavity in an animal body
US20060034878A1 (en) * 2004-08-16 2006-02-16 Satterfield Artus L Iodized oil
US7350479B2 (en) * 2004-09-10 2008-04-01 United States Of America As Represented By The Secretary Of The Army System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp
US8702580B2 (en) * 2004-10-06 2014-04-22 Brainlab Ag Method and device for assisting in a tissue treatment
US10357328B2 (en) 2005-04-20 2019-07-23 Bard Peripheral Vascular, Inc. and Bard Shannon Limited Marking device with retractable cannula
US20090081122A1 (en) * 2005-05-23 2009-03-26 Universite De Geneve Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
US7736293B2 (en) * 2005-07-22 2010-06-15 Biocompatibles Uk Limited Implants for use in brachytherapy and other radiation therapy that resist migration and rotation
US8187159B2 (en) 2005-07-22 2012-05-29 Biocompatibles, UK Therapeutic member including a rail used in brachytherapy and other radiation therapy
PT2510952T (en) * 2005-07-26 2018-12-18 Alpha Tau Medical Ltd A radioactive surface source and a method for producing the same
US20070036842A1 (en) * 2005-08-15 2007-02-15 Concordia Manufacturing Llc Non-woven scaffold for tissue engineering
US8052658B2 (en) 2005-10-07 2011-11-08 Bard Peripheral Vascular, Inc. Drug-eluting tissue marker
CA2629648A1 (en) 2005-11-15 2007-05-24 Neovista Inc. Methods and apparatus for intraocular brachytherapy
ES2554527T3 (en) * 2006-01-24 2015-12-21 Biocompatibles Uk Limited Process to fill polymer particles with a drug
US20080230001A1 (en) * 2006-02-23 2008-09-25 Meadwestvaco Corporation Method for treating a substrate
US20070233073A1 (en) * 2006-03-02 2007-10-04 Sdgi Holdings, Inc. Spinal rod characterized by a time-varying stiffness
US7988611B2 (en) 2006-05-09 2011-08-02 Biocompatibles Uk Limited After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy
US20070265487A1 (en) * 2006-05-09 2007-11-15 Worldwide Medical Technologies Llc Applicators for use in positioning implants for use in brachytherapy and other radiation therapy
EP3009477B1 (en) 2006-07-20 2024-01-24 Orbusneich Medical Pte. Ltd Bioabsorbable polymeric composition for a medical device
US8460364B2 (en) * 2006-07-20 2013-06-11 Orbusneich Medical, Inc. Bioabsorbable polymeric medical device
US20090216063A1 (en) * 2008-01-29 2009-08-27 Biocompatibles Uk Limited Bio-absorbable brachytherapy strands
WO2008011612A2 (en) * 2006-07-20 2008-01-24 Orbusneich Medical, Inc. Bioabsorbable polymeric medical device
US20100228074A1 (en) * 2006-08-25 2010-09-09 C.R. Bard, Inc. Therapeutic and Directionally Dosed Implants
US7686756B2 (en) * 2006-08-29 2010-03-30 Ciratech Oncology Brachytherapy devices and related methods and computer program products
US7874976B1 (en) 2006-09-07 2011-01-25 Biocompatibles Uk Limited Echogenic strands and spacers therein
US7878964B1 (en) 2006-09-07 2011-02-01 Biocompatibles Uk Limited Echogenic spacers and strands
EP2073754A4 (en) * 2006-10-20 2012-09-26 Orbusneich Medical Inc Bioabsorbable polymeric composition and medical device background
US7959942B2 (en) * 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US8064987B2 (en) 2006-10-23 2011-11-22 C. R. Bard, Inc. Breast marker
EP3542748B1 (en) 2006-12-12 2023-08-16 C. R. Bard, Inc. Multiple imaging mode tissue marker
ES2432572T3 (en) 2006-12-18 2013-12-04 C.R. Bard, Inc. Biopsy marker with imaging properties generated in situ
US20080269540A1 (en) * 2007-04-27 2008-10-30 Worldwide Medical Technologies Llc Seed cartridge adaptor and methods for use therewith
JP5577245B2 (en) * 2007-07-11 2014-08-20 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Seeds and markers for use in imaging
US20110130822A1 (en) * 2007-07-20 2011-06-02 Orbusneich Medical, Inc. Bioabsorbable Polymeric Compositions and Medical Devices
US8311610B2 (en) 2008-01-31 2012-11-13 C. R. Bard, Inc. Biopsy tissue marker
EP2293842B1 (en) * 2008-05-02 2020-08-12 Civatech Oncology Brachytherapy devices and related methods
EP2296756A1 (en) 2008-06-04 2011-03-23 Neovista, Inc. Handheld radiation delivery system for advancing a radiation source wire
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
WO2010042854A1 (en) * 2008-10-10 2010-04-15 Orbusneich Medical, Inc. Bioabsorbable polymeric medical device
WO2010042952A1 (en) * 2008-10-11 2010-04-15 Orbusneich Medical, Inc. Bioabsorbable polymeric compositions and medical devices
US8670818B2 (en) 2008-12-30 2014-03-11 C. R. Bard, Inc. Marker delivery device for tissue marker placement
US8663210B2 (en) 2009-05-13 2014-03-04 Novian Health, Inc. Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
WO2011015958A2 (en) * 2009-08-06 2011-02-10 Koninklijke Philips Electronics N.V. Oncology therapies employing radioactive seeds
US20150231409A1 (en) 2009-10-15 2015-08-20 Covidien Lp Buttress brachytherapy and integrated staple line markers for margin identification
US10293553B2 (en) 2009-10-15 2019-05-21 Covidien Lp Buttress brachytherapy and integrated staple line markers for margin identification
US8550649B2 (en) * 2010-02-15 2013-10-08 Webb T. Nelson Stereoscopic illumination system for retroreflective materials
MX356514B (en) 2011-01-20 2018-05-30 Univ Texas Mri markers, delivery and extraction systems, and methods of manufacture and use thereof.
JP6365983B2 (en) * 2011-04-28 2018-08-01 ジーティー メディカル テクノロジーズ、インコーポレイテッド Radionuclide carrier system
US10350431B2 (en) 2011-04-28 2019-07-16 Gt Medical Technologies, Inc. Customizable radioactive carriers and loading system
EP2968884B1 (en) 2013-03-15 2018-10-03 Boston Scientific Corporation Device for delivering medicaments
US9492683B2 (en) 2013-03-15 2016-11-15 Gammatile Llc Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
US9821174B1 (en) 2015-02-06 2017-11-21 Gammatile Llc Radioactive implant planning system and placement guide system
US9403033B1 (en) 2015-04-24 2016-08-02 Gammatile Llc Apparatus and method for loading radioactive seeds into carriers
WO2016179420A1 (en) 2015-05-06 2016-11-10 Gammatile Llc Radiation shielding
US10159850B2 (en) 2016-01-06 2018-12-25 Covidien Lp Brachytherapy clip and applicator
US10888710B1 (en) 2016-11-29 2021-01-12 Gt Medical Technologies, Inc. Transparent loading apparatus
CN106823120B (en) * 2017-01-24 2024-01-16 原子高科股份有限公司 Preparation method of degradable radioactive particle chain with shape memory function
CN106823121B (en) * 2017-01-24 2021-02-23 原子高科股份有限公司 Degradable radioactive particle chain with shape memory function
RU2763750C2 (en) 2017-05-11 2022-01-10 Альфа Тау Медикал Лтд. Polymer coatings for brachytherapy devices
WO2019099813A1 (en) * 2017-11-17 2019-05-23 Musara Mubayiwa Cornelious Multilayered biologic mesh and methods of use thereof
US10981018B2 (en) 2019-02-14 2021-04-20 Gt Medical Technologies, Inc. Radioactive seed loading apparatus
US11224761B1 (en) 2019-11-19 2022-01-18 Pointsource Technologies, Llc Radioactive therapeutic device
AU2021400142A1 (en) 2020-12-16 2023-06-22 Alpha Tau Medical Ltd. Diffusing alpha-emitters radiation therapy with enhanced beta treatment

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4697575A (en) * 1984-11-21 1987-10-06 Henry Ford Hospital Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member
US5391547A (en) * 1990-06-15 1995-02-21 University Of California Office Of Technology Transfer Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5736152A (en) * 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6080099A (en) * 1998-08-12 2000-06-27 Syntheon, Llc Radioactive therapeutic seeds

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3976071A (en) 1974-01-07 1976-08-24 Dynatech Corporation Methods of improving control of release rates and products useful in same
US4832686A (en) 1986-06-24 1989-05-23 Anderson Mark E Method for administering interleukin-2
US4883666A (en) 1987-04-29 1989-11-28 Massachusetts Institute Of Technology Controlled drug delivery system for treatment of neural disorders
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
US5338770A (en) 1988-06-08 1994-08-16 Cardiopulmonics, Inc. Gas permeable thrombo-resistant coatings and methods of manufacture
US5268178A (en) * 1989-09-25 1993-12-07 The Board Of Regents, The University Of Texas System Biodegradable antibiotic implants and methods of their use in treating and preventing infections
US5484584A (en) 1990-10-02 1996-01-16 Board Of Regents, The University Of Texas System Therapeutic and diagnostic use of modified polymeric microcapsules
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US5656297A (en) 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
US5531715A (en) 1993-05-12 1996-07-02 Target Therapeutics, Inc. Lubricious catheters
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US5463010A (en) 1993-11-12 1995-10-31 Surface Engineering Technologies, Division Of Innerdyne, Inc. Hydrocyclosiloxane membrane prepared by plasma polymerization process
US5662960A (en) 1995-02-01 1997-09-02 Schneider (Usa) Inc. Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with a poly (n-vinylpyrrolidone) polymer hydrogel
US5713828A (en) 1995-11-27 1998-02-03 International Brachytherapy S.A Hollow-tube brachytherapy device
US5993374A (en) * 1997-06-17 1999-11-30 Radiance Medical Systems, Inc. Microcapsules for site-specific delivery
US6174330B1 (en) 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6015541A (en) 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
EP1054707B1 (en) 1998-02-12 2005-04-27 Robert Robertson Encapsulated low-energy brachytherapy sources
US5997463A (en) 1998-03-26 1999-12-07 North American Scientific Laser welded brachytherapy source and method of making the same
US6159143A (en) 1998-06-17 2000-12-12 Scimed Life Systems, Inc. Method and device for delivery of therapeutic agents in conjunction with isotope seed placement
JP2002524108A (en) * 1998-07-28 2002-08-06 インナーダイン， インコーポレイテッド Absorbable brachytherapy and chemotherapy delivery devices and methods
US6007475A (en) 1998-08-12 1999-12-28 Cns Technology, Inc. Radioactive therapeutic seeds
US6132359A (en) 1999-01-07 2000-10-17 Nycomed Amersham Plc Brachytherapy seeds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4697575A (en) * 1984-11-21 1987-10-06 Henry Ford Hospital Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member
US5391547A (en) * 1990-06-15 1995-02-21 University Of California Office Of Technology Transfer Method using 5,10,15,20-tetrakis(4-carboxyphenyl)porphine for treating cancers of the lung
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5736152A (en) * 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US6080099A (en) * 1998-08-12 2000-06-27 Syntheon, Llc Radioactive therapeutic seeds

Also Published As

Publication number Publication date
AU2001237969A1 (en) 2001-08-07
US6575888B2 (en) 2003-06-10
WO2001054764A2 (en) 2001-08-02
US20010044567A1 (en) 2001-11-22

Similar Documents

Publication Publication Date Title
WO2001054764A3 (en) Bioabsorbable brachytherapy device
GB9023293D0 (en) Sensing radiation,e.g.x-rays
HU9302576D0 (en) Chemical and heat resisting, mettable by tungsten, boro-silicate
WO2003039655A3 (en) Delivery system and method for interstitial radiation therapy
EP0591143A4 (en) Medical device valving mechanism.
EP1183070A4 (en) Coiled brachytherapy device
EP0635801A3 (en) External storage device.
EP1043383A4 (en) Phosphors, and radiation detectors and x-ray ct unit made by using the same
AU5558499A (en) Radioactive therapeutic seeds
DE69204628D1 (en) PIGMENTED BLUE-EMITTING FLUORESCENT AND COLOR-CATHODE RADIATION TUBE.
TR199600421A2 (en) Florphenyl substituted alkenyl carbon acid-guanidide, the method for their manufacture, their use as a drug or diagnostic agent, and medicaments containing them.
EP0660996A3 (en) Seedling planting apparatus having an operation platform.
EP0656532A3 (en) Heat source detector.
GB2339379B (en) Radiation therapy device
DE69433505D1 (en) PORTABLE MEDICAL PANORAMIC X-RAY UNIT
EP0604931A3 (en) Medical laser apparatus and diagnosing/curing apparatus using the medical laser apparatus.
EP0627238A3 (en) Pace generating device.
DE69205767T2 (en) Radiation curable resin composition.
WO2002041762A3 (en) Automated implantation system for radioisotope seeds
WO2002007784A3 (en) CARRIER-FREE 103Pd BRACHYTHERAPY SEEDS
EP0637021A3 (en) Cassette loading device.
ZA962461B (en) Low dose ridogrel formulations.
IT9048081A0 (en) PROCEDURE AND SYSTEM FOR DROWNING IN RESIN THE INTERIOR OF AN ELECTRICAL APPARATUS SUCH AS A PROXIMITY DETECTOR, ELECTRICAL APPARATUS SO OBTAINED AND ITS CONTAINER.
ITRM930007A0 (en) DEVICE COMPLEX FOR FILLING ANESTHETIC VAPORIZERS.
EP0638825A3 (en) Detecting ionising radiation.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP