WO2001046465A3 - Microfluid analysis device - Google Patents

Microfluid analysis device Download PDF

Info

Publication number
WO2001046465A3
WO2001046465A3 PCT/EP2000/013145 EP0013145W WO0146465A3 WO 2001046465 A3 WO2001046465 A3 WO 2001046465A3 EP 0013145 W EP0013145 W EP 0013145W WO 0146465 A3 WO0146465 A3 WO 0146465A3
Authority
WO
WIPO (PCT)
Prior art keywords
analysis device
microfluid analysis
microfluid
shaped
microstructure
Prior art date
Application number
PCT/EP2000/013145
Other languages
French (fr)
Other versions
WO2001046465A2 (en
Inventor
Per Andersson
Arvi Aksberg
Gunnar Ekstrand
Original Assignee
Gyros Ab
Per Andersson
Arvi Aksberg
Gunnar Ekstrand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP1999/010347 external-priority patent/WO2000040750A1/en
Application filed by Gyros Ab, Per Andersson, Arvi Aksberg, Gunnar Ekstrand filed Critical Gyros Ab
Priority to CA002395159A priority Critical patent/CA2395159A1/en
Priority to EP00992452A priority patent/EP1239962B1/en
Priority to DE60035611T priority patent/DE60035611T2/en
Priority to US10/169,056 priority patent/US7261859B2/en
Priority to AU44105/01A priority patent/AU4410501A/en
Priority to JP2001546961A priority patent/JP4612262B2/en
Publication of WO2001046465A2 publication Critical patent/WO2001046465A2/en
Publication of WO2001046465A3 publication Critical patent/WO2001046465A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Fluid Mechanics (AREA)
  • Physics & Mathematics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Centrifugal Separators (AREA)

Abstract

Microstructure for fluids provided in a rotatable disc (D) having a U-shaped volume-defining structure (7) connected at its base to an inlet arm of a U-shaped chamber (10).
PCT/EP2000/013145 1998-12-30 2000-12-22 Microfluid analysis device WO2001046465A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002395159A CA2395159A1 (en) 1999-12-23 2000-12-22 Microfluid analysis device
EP00992452A EP1239962B1 (en) 1999-12-23 2000-12-22 Microfluidic analysis device
DE60035611T DE60035611T2 (en) 1999-12-23 2000-12-22 MICRO FLUID ANALYSIS DEVICE
US10/169,056 US7261859B2 (en) 1998-12-30 2000-12-22 Microanalysis device
AU44105/01A AU4410501A (en) 1999-12-23 2000-12-22 Microanalysis device
JP2001546961A JP4612262B2 (en) 1999-12-23 2000-12-22 Micro analyzer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/EP1999/010347 WO2000040750A1 (en) 1998-12-30 1999-12-23 Method for sequencing dna using a microfluidic device
EPPCT/EP99/10347 1999-12-23
SE0001779-8 2000-05-12
SE0001779A SE0001779D0 (en) 2000-05-12 2000-05-12 Microanalysis device

Publications (2)

Publication Number Publication Date
WO2001046465A2 WO2001046465A2 (en) 2001-06-28
WO2001046465A3 true WO2001046465A3 (en) 2001-12-27

Family

ID=20279665

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/013145 WO2001046465A2 (en) 1998-12-30 2000-12-22 Microfluid analysis device

Country Status (7)

Country Link
JP (1) JP4612262B2 (en)
AT (1) ATE367204T1 (en)
AU (1) AU4410501A (en)
CA (1) CA2395159A1 (en)
DE (1) DE60035611T2 (en)
SE (1) SE0001779D0 (en)
WO (1) WO2001046465A2 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026131B2 (en) 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US7087203B2 (en) 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
SE0004297D0 (en) 2000-11-23 2000-11-23 Gyros Ab Device for thermal cycling
SE0004296D0 (en) 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
WO2002046721A2 (en) 2000-12-08 2002-06-13 Burstein Technologies, Inc. Optical discs for measuring analytes
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
US7091034B2 (en) 2000-12-15 2006-08-15 Burstein Technologies, Inc. Detection system for disk-based laboratory and improved optical bio-disc including same
WO2002075312A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
WO2003018198A1 (en) 2001-08-28 2003-03-06 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
JP4368681B2 (en) * 2001-09-17 2009-11-18 ユィロス・パテント・アクチボラグ Functional unit that enables control of flow in microfluidic devices
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
EP1459795A4 (en) * 2001-12-28 2011-07-06 Hitachi High Tech Corp Extractor, chemical analyzer, and chemical analyzing method
WO2003087779A1 (en) 2002-04-08 2003-10-23 Gyros Ab Homing process
AU2003235970A1 (en) * 2002-04-30 2003-11-17 Arkray, Inc. Analysis instrument, sample analysis method and analysis device using the instrument, and method of forming opening in the instrument
DE60328392D1 (en) * 2002-04-30 2009-08-27 Gyros Patent Ab BY MEANS OF AN INTEGRATED MICROFLUIDIC DEVICE
US7005265B1 (en) 2002-06-20 2006-02-28 Wenhong Fan Nonenzymatic catalytic signal amplification for nucleic acid hybridization assays
US20060096906A1 (en) 2002-10-13 2006-05-11 Adam Rubin Microfluid biomolecule separation system
SE0301945D0 (en) 2003-06-30 2003-06-30 Gyros Ab Confidence determination
US20060210426A1 (en) * 2003-08-05 2006-09-21 Taiyo Yuden Co., Ltd. Sample analyzer and disk-like sample analyzing medium
EP1703982A1 (en) * 2004-01-06 2006-09-27 Gyros Patent Ab Contact heating arrangement
EP1874469A4 (en) 2005-04-14 2014-02-26 Gyros Patent Ab A microfluidic device with finger valves
GB2464721C (en) 2008-10-23 2013-08-14 Biosurfit Sa Jet deflection device
GB2466644B (en) * 2008-12-30 2011-05-11 Biosurfit Sa Liquid handling
JP5521454B2 (en) * 2009-09-15 2014-06-11 凸版印刷株式会社 Sample analysis chip, sample analysis apparatus and sample analysis method using the same
GB2476474B (en) 2009-12-22 2012-03-28 Biosurfit Sa Surface plasmon resonance detection system
GB2479139A (en) 2010-03-29 2011-10-05 Biosurfit Sa A liquid distribution and metering device
EP2486978A1 (en) 2010-10-28 2012-08-15 Roche Diagnostics GmbH Microfluid test carrier for separating a fluid volume in partial volumes
EP2455162A1 (en) 2010-10-29 2012-05-23 Roche Diagnostics GmbH Microfluidic element for analysing a fluid sample
WO2013083822A1 (en) 2011-12-08 2013-06-13 Biosurfit S.A. Sequential aliqoting and determination of an indicator of sedimentation rate
JP5549719B2 (en) * 2012-09-20 2014-07-16 ブラザー工業株式会社 Inspection target
US9993819B2 (en) 2014-12-30 2018-06-12 Stmicroelectronics S.R.L. Apparatus for actuating and reading a centrifugal microfluidic disk for biological and biochemical analyses, and use of the apparatus
WO2017154750A1 (en) * 2016-03-11 2017-09-14 パナソニック株式会社 Disk for liquid sample inspection and filter cartridge used in same, disk body, measurement plate, sample detection plate, fluorescence detection system, and fluorescence detection method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3547547A (en) * 1969-03-13 1970-12-15 Atomic Energy Commission Analytical photometer with means for measuring,holding and transferring discrete liquid volumes and method of use thereof
US4284602A (en) * 1979-12-10 1981-08-18 Immutron, Inc. Integrated fluid manipulator
US5160702A (en) * 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
US5591643A (en) * 1993-09-01 1997-01-07 Abaxis, Inc. Simplified inlet channels
WO2000040750A1 (en) * 1998-12-30 2000-07-13 Gyros Ab Method for sequencing dna using a microfluidic device

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4632908A (en) * 1984-05-03 1986-12-30 Abbott Laboratories Heating system for rotating members
US5230866A (en) * 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
WO1993019827A1 (en) * 1992-04-02 1993-10-14 Abaxis, Inc. Analytical rotor with dye mixing chamber
US6299839B1 (en) * 1995-08-31 2001-10-09 First Medical, Inc. System and methods for performing rotor assays
JP2002503336A (en) * 1997-05-16 2002-01-29 アルバータ リサーチ カウンシル Micro-distribution system and method of using the same
AU7591998A (en) * 1997-05-23 1998-12-11 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US5919711A (en) * 1997-08-07 1999-07-06 Careside, Inc. Analytical cartridge
US5916522A (en) * 1997-08-07 1999-06-29 Careside, Inc. Electrochemical analytical cartridge

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3547547A (en) * 1969-03-13 1970-12-15 Atomic Energy Commission Analytical photometer with means for measuring,holding and transferring discrete liquid volumes and method of use thereof
US4284602A (en) * 1979-12-10 1981-08-18 Immutron, Inc. Integrated fluid manipulator
US5160702A (en) * 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
US5591643A (en) * 1993-09-01 1997-01-07 Abaxis, Inc. Simplified inlet channels
WO2000040750A1 (en) * 1998-12-30 2000-07-13 Gyros Ab Method for sequencing dna using a microfluidic device

Also Published As

Publication number Publication date
WO2001046465A2 (en) 2001-06-28
CA2395159A1 (en) 2001-06-28
DE60035611D1 (en) 2007-08-30
ATE367204T1 (en) 2007-08-15
SE0001779D0 (en) 2000-05-12
DE60035611T2 (en) 2008-05-21
JP2003518250A (en) 2003-06-03
AU4410501A (en) 2001-07-03
JP4612262B2 (en) 2011-01-12

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