WO2001039764A3 - Methods for treating conditions and illnesses associated with abnormal vasculature - Google Patents

Methods for treating conditions and illnesses associated with abnormal vasculature Download PDF

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Publication number
WO2001039764A3
WO2001039764A3 PCT/US2000/041110 US0041110W WO0139764A3 WO 2001039764 A3 WO2001039764 A3 WO 2001039764A3 US 0041110 W US0041110 W US 0041110W WO 0139764 A3 WO0139764 A3 WO 0139764A3
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WO
WIPO (PCT)
Prior art keywords
dyes
methods
abnormal vasculature
treating conditions
illnesses associated
Prior art date
Application number
PCT/US2000/041110
Other languages
French (fr)
Other versions
WO2001039764A2 (en
Inventor
Robert W Flower
Abu Alam
Original Assignee
Akorn Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akorn Inc filed Critical Akorn Inc
Priority to AU41340/01A priority Critical patent/AU4134001A/en
Publication of WO2001039764A2 publication Critical patent/WO2001039764A2/en
Publication of WO2001039764A3 publication Critical patent/WO2001039764A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Use of radiation-absorbing dyes (e.g., indocyanine green (ICG), fluorescein, rose bengal) and photodynamic dyes (e.g., hematoporphyrins, aminolevulinic acids, porphyrins, merocyanines, porphycenes, porfimer sodium, verteporfin, Photofrin II, PH-10, chlorins, zinc phthalocyanine, purpurins, pheophorbides, monoclonal antibody-dye conjugates of any of the foregoing dyes) for the treatment of conditions associated with abnormal vasculature, including, generally, lesions, and, more specifically, tumors (cancerous and benign) and choroidal neovascularization (CNV) associated with age-related macular degeneration (ARMD).
PCT/US2000/041110 1999-11-30 2000-10-10 Methods for treating conditions and illnesses associated with abnormal vasculature WO2001039764A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU41340/01A AU4134001A (en) 1999-11-30 2000-10-10 Methods for treating conditions and illnesses associated with abnormal vasculature

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/452,117 1999-11-30
US09/452,117 US6443976B1 (en) 1999-11-30 1999-11-30 Methods for treating conditions and illnesses associated with abnormal vasculature

Publications (2)

Publication Number Publication Date
WO2001039764A2 WO2001039764A2 (en) 2001-06-07
WO2001039764A3 true WO2001039764A3 (en) 2002-01-10

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Family Applications (1)

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PCT/US2000/041110 WO2001039764A2 (en) 1999-11-30 2000-10-10 Methods for treating conditions and illnesses associated with abnormal vasculature

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US (1) US6443976B1 (en)
AU (1) AU4134001A (en)
WO (1) WO2001039764A2 (en)

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AU4134001A (en) 2001-06-12
WO2001039764A2 (en) 2001-06-07

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