WO2001026736A2 - Intraspinal compositions containing botulinum toxin for treating pain - Google Patents
Intraspinal compositions containing botulinum toxin for treating pain Download PDFInfo
- Publication number
- WO2001026736A2 WO2001026736A2 PCT/US2000/012597 US0012597W WO0126736A2 WO 2001026736 A2 WO2001026736 A2 WO 2001026736A2 US 0012597 W US0012597 W US 0012597W WO 0126736 A2 WO0126736 A2 WO 0126736A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- neurotoxin
- botulinum toxin
- pain
- administration
- nervous system
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002388681A CA2388681A1 (en) | 1999-10-12 | 2000-05-09 | Methods for treating pain |
DE60016794T DE60016794T2 (en) | 1999-10-12 | 2000-05-09 | INTRASPINAL BOTULINUS-TOXIN-CONTAINING COMPOUNDS FOR PAIN TREATMENT |
JP2001529797A JP4851039B2 (en) | 1999-10-12 | 2000-05-09 | Pain treatment method |
DK00932200T DK1237566T3 (en) | 2000-05-09 | 2000-05-09 | Intrinsic compositions containing botulinum toxin for the treatment of pain |
AT00932200T ATE284704T1 (en) | 1999-10-12 | 2000-05-09 | INTRASPINAL BOTULINUS TOXIN CONTAINING COMPOUNDS FOR PAIN TREATMENT |
BR0014710-9A BR0014710A (en) | 1999-10-12 | 2000-05-09 | Methods for treating pain |
EP00932200A EP1237566B1 (en) | 1999-10-12 | 2000-05-09 | Intraspinal compositions containing botulinum toxin for treating pain |
MXPA02003289A MXPA02003289A (en) | 1999-10-12 | 2000-05-09 | Intraspinal compositions containing botulinum toxin for treating pain. |
AU49954/00A AU771536B2 (en) | 1999-10-12 | 2000-05-09 | Methods for treating pain |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/417,195 | 1999-10-12 | ||
US09/417,195 US6113915A (en) | 1999-10-12 | 1999-10-12 | Methods for treating pain |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2001026736A2 true WO2001026736A2 (en) | 2001-04-19 |
WO2001026736A3 WO2001026736A3 (en) | 2002-03-21 |
Family
ID=23652970
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/012597 WO2001026736A2 (en) | 1999-10-12 | 2000-05-09 | Intraspinal compositions containing botulinum toxin for treating pain |
Country Status (15)
Country | Link |
---|---|
US (4) | US6113915A (en) |
EP (1) | EP1237566B1 (en) |
JP (1) | JP4851039B2 (en) |
KR (1) | KR100670479B1 (en) |
CN (2) | CN1321686C (en) |
AR (1) | AR021738A1 (en) |
AT (1) | ATE284704T1 (en) |
AU (1) | AU771536B2 (en) |
BR (1) | BR0014710A (en) |
CA (1) | CA2388681A1 (en) |
DE (1) | DE60016794T2 (en) |
ES (1) | ES2231203T3 (en) |
MX (1) | MXPA02003289A (en) |
TW (1) | TWI234462B (en) |
WO (1) | WO2001026736A2 (en) |
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WO2002094308A1 (en) * | 2001-05-22 | 2002-11-28 | Centre National De La Recherche Scientifique | Improved neuronal gene transfer |
US6818409B2 (en) | 2001-07-03 | 2004-11-16 | Eisai Company Ltd. | Isolation and purification of Clostridium botulinum toxins |
EP1586329A1 (en) * | 2000-02-08 | 2005-10-19 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions |
FR2907680A1 (en) * | 2006-10-27 | 2008-05-02 | Sod Conseils Rech Applic | Use of Botulinum neurotoxin to prepare medicament to treat/prevent post-chemotherapy pains, where the pains in patients with cancer e.g. in colon, rectum, breast, lung, pancreas, kidney, uterus skin, bones, testes, prostate, skin and ovary |
US7579010B2 (en) | 2000-02-08 | 2009-08-25 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions with a recombinant human serum albumin |
WO2009130600A2 (en) * | 2008-04-25 | 2009-10-29 | Ipsen Pharma S.A.S. | Therapeutic use of at least one botulinum neurotoxin in the treatment of pain associated with diabetic neuropathy |
US7758873B2 (en) | 2000-02-08 | 2010-07-20 | Allergan, Inc. | Polysaccharide containing botulinum toxin pharmaceutical compositions and uses thereof |
JP2010222367A (en) * | 2002-06-26 | 2010-10-07 | Allergan Inc | Botulinum toxins for treating priapism |
US8557255B2 (en) | 2006-06-29 | 2013-10-15 | Merz Pharma Gmbh & Co. Kgaa | High frequency application of botulinum toxin therapy |
US8632785B2 (en) | 2000-02-08 | 2014-01-21 | Allergan, Inc. | Clostridial toxin pharmaceutical composition containing a gelatin fragment |
US8921322B2 (en) | 2006-12-22 | 2014-12-30 | Ipsen Pharma S.A.S. | Use of at least one botulinum neurotoxin for treating the pain induced by therapeutic treatments for the AIDS virus |
US9080220B2 (en) | 2006-06-16 | 2015-07-14 | Ipsen Pharma S.A.S. | Simultaneous, separate or sequential therapeutic use of at least one botulinum neurotoxin and of at least one opiate derivative |
US9176119B2 (en) | 2005-09-01 | 2015-11-03 | Ipsen Pharma S.A.S. | Method for quantifying a cholinergic neurotoxin in a sample |
US9238061B2 (en) | 2003-10-29 | 2016-01-19 | Allergan, Inc. | Botulinum toxin treatment of anxiety and bipolar disorders |
US10792344B2 (en) | 2006-06-29 | 2020-10-06 | Merz Pharma Gmbh & Co. Kgaa | High frequency application of botulinum toxin therapy |
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---|---|---|---|---|
GB9120306D0 (en) * | 1991-09-24 | 1991-11-06 | Graham Herbert K | Method and compositions for the treatment of cerebral palsy |
US6974578B1 (en) * | 1993-12-28 | 2005-12-13 | Allergan, Inc. | Method for treating secretions and glands using botulinum toxin |
US8187612B2 (en) * | 1993-12-28 | 2012-05-29 | Allergan, Inc. | Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle |
US8557256B2 (en) * | 1993-12-28 | 2013-10-15 | Allergan, Inc. | Treatment for cervical dystonia with the neurotoxic component of a botulinum toxin |
US20040126396A1 (en) * | 1993-12-28 | 2004-07-01 | Allergan, Inc. | Botulinum toxin treatment for strabismus |
US7537773B1 (en) | 1998-08-25 | 2009-05-26 | Botulinum Toxin Research Associates, Inc. | Chemodenervating pharmaceutical as anti-inflammatory agent |
TW574036B (en) | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
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US7838008B2 (en) * | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating diverse cancers |
US7838007B2 (en) | 1999-12-07 | 2010-11-23 | Allergan, Inc. | Methods for treating mammary gland disorders |
US6429189B1 (en) | 1999-12-10 | 2002-08-06 | Botulinum Toxin Research Associates, Inc. | Cytotoxin (non-neurotoxin) for the treatment of human headache disorders and inflammatory diseases |
US20060269575A1 (en) * | 2000-02-08 | 2006-11-30 | Allergan, Inc. | Botulinum toxin pharmaceutical compositions formulated with recombinant albumin |
US20030138460A1 (en) * | 2000-02-08 | 2003-07-24 | Allergan, Inc | Methods of treating animals with botulinum toxin pharmaceutical compositions |
US6821520B2 (en) * | 2000-02-15 | 2004-11-23 | Allergan, Inc. | Clostridial toxin therapy for Hashimoto's thyroiditis |
US6464986B1 (en) * | 2000-04-14 | 2002-10-15 | Allegan Sales, Inc. | Method for treating pain by peripheral administration of a neurotoxin |
US6565870B1 (en) * | 2000-04-28 | 2003-05-20 | Allergan, Inc. | Methods for treating bone tumors |
US20040170665A1 (en) * | 2000-06-02 | 2004-09-02 | Allergan, Inc. | Intravitreal botulinum toxin implant |
US20040033241A1 (en) * | 2000-06-02 | 2004-02-19 | Allergan, Inc. | Controlled release botulinum toxin system |
US6306403B1 (en) | 2000-06-14 | 2001-10-23 | Allergan Sales, Inc. | Method for treating parkinson's disease with a botulinum toxin |
US6903187B1 (en) * | 2000-07-21 | 2005-06-07 | Allergan, Inc. | Leucine-based motif and clostridial neurotoxins |
US20040219619A1 (en) * | 2000-07-21 | 2004-11-04 | Ester Fernandez-Salas | Methods of identifying compounds that alter toxin persistence and/or protease activity |
US7491799B2 (en) * | 2000-07-21 | 2009-02-17 | Allergan, Inc. | Modified botulinum neurotoxins |
US7691983B2 (en) | 2000-07-21 | 2010-04-06 | Allergan, Inc. | Chimera botulinum toxin type E |
US6827931B1 (en) | 2000-10-20 | 2004-12-07 | Allergan, Inc. | Method for treating endocrine disorders |
US7223577B2 (en) | 2000-11-17 | 2007-05-29 | Allergan, Inc. | Post-translational modifications and Clostridial neurotoxins |
US20040146590A1 (en) * | 2001-03-22 | 2004-07-29 | Iadarola Michael J | Molecular neurochirurgie for pain control administering locally capsaicin or resinferatoxin |
JP4707254B2 (en) * | 2001-04-24 | 2011-06-22 | クミアイ化学工業株式会社 | Granular composition and method for producing the same |
US7438701B2 (en) * | 2001-07-26 | 2008-10-21 | Durect Corporation | Local concentration management system |
US6984375B2 (en) * | 2001-08-03 | 2006-01-10 | Allergan, Inc. | Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles |
KR20030018827A (en) * | 2001-08-31 | 2003-03-06 | 서구일 | Sympathetic nerve bl0cking agent comprising botulinum toxin type a, and composition for treatment of the sympathetic nerve related diseases |
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US7255866B2 (en) | 2001-09-17 | 2007-08-14 | Allergan, Inc. | Botulinum toxin therapy for fibromyalgia |
US6623742B2 (en) | 2001-09-17 | 2003-09-23 | Allergan, Inc. | Methods for treating fibromyalgia |
US20030113349A1 (en) * | 2001-12-18 | 2003-06-19 | Coleman William P. | Topically applied clostridium botulinum toxin compositions and treatment methods |
CA2369810C (en) | 2002-01-30 | 2007-08-07 | 1474791 Ontario Limited | Method of treating pain |
US20050106183A1 (en) * | 2002-01-31 | 2005-05-19 | Lamb Gregory B. | Method of treating pain |
WO2003068159A2 (en) * | 2002-02-11 | 2003-08-21 | Wake Forest University | Compositions and methods for treating pain using cyclooxygenase-1 inhibitors |
US7022329B2 (en) * | 2002-02-25 | 2006-04-04 | Allergan, Inc. | Method for treating neurogenic inflammation pain with botulinum toxin and substance P components |
US20030224019A1 (en) * | 2002-03-01 | 2003-12-04 | O'brien Christopher | Methods of treating nerve entrapment syndromes |
US7140371B2 (en) * | 2002-03-14 | 2006-11-28 | Allergan, Inc. | Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins |
US6688311B2 (en) * | 2002-03-14 | 2004-02-10 | Allergan, Inc. | Method for determining effect of a clostridial toxin upon a muscle |
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WO2004016167A1 (en) * | 2002-08-16 | 2004-02-26 | The General Hospital Corporation | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
US7238357B2 (en) * | 2002-11-05 | 2007-07-03 | Allergan, Inc. | Methods for treating ulcers and gastroesophageal reflux disease |
US20040086532A1 (en) * | 2002-11-05 | 2004-05-06 | Allergan, Inc., | Botulinum toxin formulations for oral administration |
US7844338B2 (en) | 2003-02-03 | 2010-11-30 | Enteromedics Inc. | High frequency obesity treatment |
US7613515B2 (en) * | 2003-02-03 | 2009-11-03 | Enteromedics Inc. | High frequency vagal blockage therapy |
US7167750B2 (en) * | 2003-02-03 | 2007-01-23 | Enteromedics, Inc. | Obesity treatment with electrically induced vagal down regulation |
US20040172084A1 (en) | 2003-02-03 | 2004-09-02 | Knudson Mark B. | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
US8071550B2 (en) * | 2003-03-03 | 2011-12-06 | Allergan, Inc. | Methods for treating uterine disorders |
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US20040247623A1 (en) * | 2003-03-24 | 2004-12-09 | Roger Cady | Method and article for treatment of sensory neuron related disorders through transdermal application of botulinum toxin |
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US7393538B2 (en) * | 2003-04-25 | 2008-07-01 | Ackerman Alan H | Clostridial toxin treatment for dermatillomania |
US7390496B2 (en) * | 2003-04-25 | 2008-06-24 | Allergan, Inc. | Therapeutic treatments for repetitive hand washing |
US7396535B2 (en) * | 2003-04-25 | 2008-07-08 | Ackerman Alan H | Therapy for obsessive compulsive head banging |
US7422753B2 (en) * | 2003-04-25 | 2008-09-09 | Allergan, Inc. | Methods for treating trichotillomania |
US6838434B2 (en) | 2003-05-02 | 2005-01-04 | Allergan, Inc. | Methods for treating sinus headache |
US7220422B2 (en) * | 2003-05-20 | 2007-05-22 | Allergan, Inc. | Methods and compositions for treating eye disorders |
US20040253274A1 (en) * | 2003-06-11 | 2004-12-16 | Allergan, Inc. | Use of a clostridial toxin to reduce appetite |
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US8609112B2 (en) | 2003-10-29 | 2013-12-17 | Allergan, Inc. | Botulinum toxin treatments of depression |
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US7172764B2 (en) * | 2003-11-17 | 2007-02-06 | Allergan, Inc. | Rescue agents for treating botulinum toxin intoxications |
US20050129677A1 (en) * | 2003-12-10 | 2005-06-16 | Shengwen Li | Lipid rafts and clostridial toxins |
US20050148935A1 (en) * | 2003-12-29 | 2005-07-07 | Rozalina Dimitrova | Botulinum toxin injection guide |
US7276244B2 (en) * | 2004-02-12 | 2007-10-02 | Philip Radovic | Methods of treating abnormalities of the first metatarsophalangeal joint of the foot |
US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
US7514088B2 (en) * | 2005-03-15 | 2009-04-07 | Allergan, Inc. | Multivalent Clostridial toxin derivatives and methods of their use |
US7811584B2 (en) * | 2004-06-30 | 2010-10-12 | Allergan, Inc. | Multivalent clostridial toxins |
US20060024794A1 (en) * | 2004-07-30 | 2006-02-02 | Shengwen Li | Novel methods for production of di-chain botulinum toxin |
JP5089388B2 (en) | 2004-09-01 | 2012-12-05 | アラーガン、インコーポレイテッド | Degradable clostridial toxin |
US20060046961A1 (en) * | 2004-09-02 | 2006-03-02 | Mckay William F | Controlled and directed local delivery of anti-inflammatory compositions |
US7429386B2 (en) | 2004-09-03 | 2008-09-30 | Allergan, Inc. | Stretch mark treatment |
US7179474B2 (en) * | 2004-09-03 | 2007-02-20 | Allergan, Inc. | Methods for treating a buttock deformity |
ES2347581T3 (en) * | 2004-09-10 | 2010-11-02 | Newron Pharmaceuticals S.P.A. | USE OF (R) - (HALOBENCILOXI) BENCILAMINE-PROPANAMIDS AS SELECTIVE MODULATORS OF THE SODIUM AND / OR CALCIUM CHANNEL. |
WO2006101809A1 (en) | 2005-03-15 | 2006-09-28 | Allergan, Inc. | Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems |
US7731411B2 (en) * | 2005-04-04 | 2010-06-08 | Schlumberger Technology Corporation | Circulating fluid system for powder fluidization and method of performing same |
US7419675B2 (en) * | 2005-05-26 | 2008-09-02 | Allergan, Inc. | Method for treating peritoneal adhesions |
US20060269574A1 (en) * | 2005-05-31 | 2006-11-30 | De Beer Johann F | Method of repairing tendons by surgery |
US7672727B2 (en) | 2005-08-17 | 2010-03-02 | Enteromedics Inc. | Neural electrode treatment |
US7822486B2 (en) * | 2005-08-17 | 2010-10-26 | Enteromedics Inc. | Custom sized neural electrodes |
US7910116B2 (en) * | 2005-08-24 | 2011-03-22 | Allergan, Inc. | Use of a botulinum toxin to improve gastric emptying and/or to treat GERD |
US20070128226A1 (en) * | 2005-12-01 | 2007-06-07 | Philip Radovic | Methods of treating pain associated with abnormalities of the first metatarsophalangeal joint of the foot |
US7794386B2 (en) | 2006-03-15 | 2010-09-14 | Allergan, Inc. | Methods for facilitating weight loss |
US9789161B2 (en) * | 2006-04-28 | 2017-10-17 | Warsaw Orthopedic, Inc. | Methods for treating back or neck pain caused by NGF using a therapeutic agent consisting of ReN-1820, ALE-0540 and capsaicin |
US8916611B2 (en) * | 2006-04-28 | 2014-12-23 | Warsaw Orthopedic, Inc. | Pharmaceutical removal of neuronal extensions from a degenerating disc |
US7811586B2 (en) * | 2006-05-02 | 2010-10-12 | Allergan, Inc. | Methods for alleviating testicular pain |
TW200817015A (en) * | 2006-10-06 | 2008-04-16 | Hen-Rich Cheng | A method for promoting axonal re-growth and behavior recovery in spinal cord injury |
US20080092910A1 (en) * | 2006-10-18 | 2008-04-24 | Allergan, Inc. | Apparatus and method for treating obesity using neurotoxins in conjunction with bariatric procedures |
US20080113051A1 (en) * | 2006-11-13 | 2008-05-15 | Allergan, Inc. | Methods for alleviating tattoo pain |
US8470337B2 (en) * | 2008-03-13 | 2013-06-25 | Allergan, Inc. | Therapeutic treatments using botulinum neurotoxin |
FR2934267B1 (en) * | 2008-07-23 | 2010-08-13 | Pharmaleads | AMINOPHOSPHINIC DERIVATIVES USEFUL IN THE TREATMENT OF PAIN |
ES2356883B1 (en) * | 2008-07-24 | 2012-02-22 | Bcn Peptides, S.A. | COMPOSITION FOR THE TREATMENT OF PAIN AND / OR INFLAMMATION. |
US20100022574A1 (en) * | 2008-07-28 | 2010-01-28 | EndogenX, Inc. | Methods to Treat Pain Using an Alpha-2 Adrenergic Agonist and an Endothelin Antagonist |
US20100124559A1 (en) * | 2008-11-20 | 2010-05-20 | Allergan, Inc. | Early Treatment and Prevention of Increased Muscle Tonicity |
US20100184685A1 (en) * | 2009-01-19 | 2010-07-22 | Zavala Jr Gerardo | Systems and methods for treating post- operative, acute, and chronic pain using an intra-muscular catheter administrated combination of a local anesthetic and a neurotoxin protein |
BRPI1013903B1 (en) | 2009-04-30 | 2020-03-03 | Midwestern University | Use of an adrenergic agent and an endothelin-A antagonist, composition and use of centaquin |
US8825164B2 (en) | 2010-06-11 | 2014-09-02 | Enteromedics Inc. | Neural modulation devices and methods |
WO2013009625A1 (en) | 2011-07-08 | 2013-01-17 | Allergan, Inc. | Method for treatment of autonomic nervous system disorders |
US8992941B2 (en) | 2011-07-08 | 2015-03-31 | Allergan, Inc. | Method for treatment of esophageal spasm |
CN103813802A (en) | 2011-07-14 | 2014-05-21 | 阿勒根公司 | Methods for treatment of incontinence associated with sexual activity |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4719231A (en) * | 1984-05-25 | 1988-01-12 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | 3-[N-(mercaptoacyl)]amino-4-arylbutanoic acid derivatives and an analgesic agent comprising the same |
WO1998001754A1 (en) * | 1996-07-08 | 1998-01-15 | University Of Massachusetts Dartmouth | Novel proteins within the type e botulinum neurotoxin complex |
US5714468A (en) * | 1994-05-09 | 1998-02-03 | Binder; William J. | Method for reduction of migraine headache pain |
US5846216A (en) * | 1995-04-06 | 1998-12-08 | G & P Technologies, Inc. | Mucous membrane infusor and method of use for dispensing medications |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5919665A (en) | 1989-10-31 | 1999-07-06 | Ophidian Pharmaceuticals, Inc. | Vaccine for clostridium botulinum neurotoxin |
JP4381477B2 (en) * | 1993-01-15 | 2009-12-09 | ボツリヌム トキシン リサーチ アソシエイト インコーポレイテッド | Method for treating fascial pain syndrome |
US5766605A (en) * | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
GB9508204D0 (en) * | 1995-04-21 | 1995-06-07 | Speywood Lab Ltd | A novel agent able to modify peripheral afferent function |
US5721215A (en) * | 1996-03-20 | 1998-02-24 | Allergan | Injectable therapy for control of muscle spasms and pain related to muscle spasms |
GB9617671D0 (en) * | 1996-08-23 | 1996-10-02 | Microbiological Res Authority | Recombinant toxin fragments |
DE19637082A1 (en) | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Rapidly disintegrating pellets |
GB9721189D0 (en) * | 1997-10-08 | 1997-12-03 | Speywood Lab The Limited | Analgesic conjugates |
-
1999
- 1999-10-12 US US09/417,195 patent/US6113915A/en not_active Expired - Lifetime
-
2000
- 2000-05-09 EP EP00932200A patent/EP1237566B1/en not_active Expired - Lifetime
- 2000-05-09 CN CNB2005100547029A patent/CN1321686C/en not_active Expired - Fee Related
- 2000-05-09 KR KR1020027004558A patent/KR100670479B1/en not_active IP Right Cessation
- 2000-05-09 WO PCT/US2000/012597 patent/WO2001026736A2/en active IP Right Grant
- 2000-05-09 CN CN008142572A patent/CN1216639C/en not_active Expired - Fee Related
- 2000-05-09 DE DE60016794T patent/DE60016794T2/en not_active Expired - Lifetime
- 2000-05-09 MX MXPA02003289A patent/MXPA02003289A/en active IP Right Grant
- 2000-05-09 AU AU49954/00A patent/AU771536B2/en not_active Ceased
- 2000-05-09 AT AT00932200T patent/ATE284704T1/en active
- 2000-05-09 CA CA002388681A patent/CA2388681A1/en not_active Abandoned
- 2000-05-09 JP JP2001529797A patent/JP4851039B2/en not_active Expired - Fee Related
- 2000-05-09 ES ES00932200T patent/ES2231203T3/en not_active Expired - Lifetime
- 2000-05-09 BR BR0014710-9A patent/BR0014710A/en not_active Application Discontinuation
- 2000-05-25 US US09/578,181 patent/US6333037B1/en not_active Expired - Fee Related
- 2000-05-25 US US09/578,097 patent/US6235289B1/en not_active Expired - Lifetime
- 2000-06-08 TW TW089111106A patent/TWI234462B/en not_active IP Right Cessation
- 2000-06-28 AR ARP000103262A patent/AR021738A1/en unknown
-
2001
- 2001-03-01 US US09/797,556 patent/US6372226B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4719231A (en) * | 1984-05-25 | 1988-01-12 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | 3-[N-(mercaptoacyl)]amino-4-arylbutanoic acid derivatives and an analgesic agent comprising the same |
US5714468A (en) * | 1994-05-09 | 1998-02-03 | Binder; William J. | Method for reduction of migraine headache pain |
US5846216A (en) * | 1995-04-06 | 1998-12-08 | G & P Technologies, Inc. | Mucous membrane infusor and method of use for dispensing medications |
WO1998001754A1 (en) * | 1996-07-08 | 1998-01-15 | University Of Massachusetts Dartmouth | Novel proteins within the type e botulinum neurotoxin complex |
Non-Patent Citations (3)
Title |
---|
BENOLIEL RAFAEL ET AL: "Actions of intrathecal diphtheria toxin-substance P fusion protein on models of persistent pain." PAIN, vol. 79, no. 2-3, February 1999 (1999-02), pages 243-253, XP001012206 ISSN: 0304-3959 * |
BERGE O-G ET AL: "SELECTIVE NEUROTOXIC LESIONS OF DESCENDING SEROTONERGIC AND NORADRENERGIC PATHWAYS IN THE RAT" JOURNAL OF NEUROCHEMISTRY, vol. 44, no. 4, 1985, pages 1156-1161, XP001011356 ISSN: 0022-3042 * |
GARZON J ET AL: "EFFECT OF INTRATHECAL INJECTION OF PERTUSSIS TOXIN ON SUBSTANCE P NOREPINEPHRINE AND SEROTONIN CONTENTS IN VARIOUS NEURAL STRUCTURES OF ARTHRITIC RATS" LIFE SCIENCES, vol. 47, no. 21, 1990, pages 1915-1924, XP001011386 ISSN: 0024-3205 * |
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Also Published As
Publication number | Publication date |
---|---|
CN1321686C (en) | 2007-06-20 |
US6333037B1 (en) | 2001-12-25 |
AR021738A1 (en) | 2002-08-07 |
EP1237566A2 (en) | 2002-09-11 |
US6372226B2 (en) | 2002-04-16 |
CN1216639C (en) | 2005-08-31 |
ES2231203T3 (en) | 2005-05-16 |
JP2003514594A (en) | 2003-04-22 |
US6113915A (en) | 2000-09-05 |
US6235289B1 (en) | 2001-05-22 |
AU4995400A (en) | 2001-04-23 |
MXPA02003289A (en) | 2002-09-02 |
TWI234462B (en) | 2005-06-21 |
DE60016794D1 (en) | 2005-01-20 |
KR100670479B1 (en) | 2007-01-18 |
JP4851039B2 (en) | 2012-01-11 |
BR0014710A (en) | 2002-06-18 |
CN1379679A (en) | 2002-11-13 |
CA2388681A1 (en) | 2001-04-19 |
DE60016794T2 (en) | 2005-11-24 |
EP1237566B1 (en) | 2004-12-15 |
WO2001026736A3 (en) | 2002-03-21 |
US20010012828A1 (en) | 2001-08-09 |
CN1683004A (en) | 2005-10-19 |
KR20020048956A (en) | 2002-06-24 |
AU771536B2 (en) | 2004-03-25 |
ATE284704T1 (en) | 2005-01-15 |
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