WO2001024871A3 - Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue - Google Patents

Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue Download PDF

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Publication number
WO2001024871A3
WO2001024871A3 PCT/IB2000/001523 IB0001523W WO0124871A3 WO 2001024871 A3 WO2001024871 A3 WO 2001024871A3 IB 0001523 W IB0001523 W IB 0001523W WO 0124871 A3 WO0124871 A3 WO 0124871A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
intracellular calcium
calcium concentration
modulation
electrical signals
Prior art date
Application number
PCT/IB2000/001523
Other languages
French (fr)
Other versions
WO2001024871A2 (en
Inventor
Itzik Shemer
Bella Felzen
Nissim Darvish
Yuval Mika
Walid Haddad
Ricardo Aviv
Yaakov Haham
Original Assignee
Impulse Dynamics Nv
Itzik Shemer
Bella Felzen
Nissim Darvish
Yuval Mika
Walid Haddad
Ricardo Aviv
Yaakov Haham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Impulse Dynamics Nv, Itzik Shemer, Bella Felzen, Nissim Darvish, Yuval Mika, Walid Haddad, Ricardo Aviv, Yaakov Haham filed Critical Impulse Dynamics Nv
Priority to AU78117/00A priority Critical patent/AU7811700A/en
Publication of WO2001024871A2 publication Critical patent/WO2001024871A2/en
Publication of WO2001024871A3 publication Critical patent/WO2001024871A3/en
Priority to US10/116,201 priority patent/US8825152B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

Abstract

According to a method and device for modulating intracellular calcium concentration in biological tissue, a stimulation probe is applied to the tissue, a non-excitatory stimulation pulse is generated, and the pulse is conveyed to the stimulation probe. In one embodiment concerning cardiac tissue, a stimulation probe is applied to a patient"s heart, a signal is received from at least one sensor responsive to the patient"s cardiac muscle activity, a non-excitatory stimulation pulse responsive to the signal is generated, and the pulse is conveyed to the stimulation probe.
PCT/IB2000/001523 1996-01-08 2000-10-04 Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue WO2001024871A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU78117/00A AU7811700A (en) 1999-10-04 2000-10-04 Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue
US10/116,201 US8825152B2 (en) 1996-01-08 2002-04-03 Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15751199P 1999-10-04 1999-10-04
US60/157,511 1999-10-04

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/039,845 Continuation-In-Part US9289618B1 (en) 1996-01-08 2001-10-23 Electrical muscle controller

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/116,201 Continuation US8825152B2 (en) 1996-01-08 2002-04-03 Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue

Publications (2)

Publication Number Publication Date
WO2001024871A2 WO2001024871A2 (en) 2001-04-12
WO2001024871A3 true WO2001024871A3 (en) 2002-01-10

Family

ID=22564055

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2000/001523 WO2001024871A2 (en) 1996-01-08 2000-10-04 Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue

Country Status (2)

Country Link
AU (1) AU7811700A (en)
WO (1) WO2001024871A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8934975B2 (en) 2010-02-01 2015-01-13 Metacure Limited Gastrointestinal electrical therapy
US9101765B2 (en) 1999-03-05 2015-08-11 Metacure Limited Non-immediate effects of therapy
US9186514B2 (en) 1996-01-08 2015-11-17 Impulse Dynamics Nv Electrical muscle controller
US9289618B1 (en) 1996-01-08 2016-03-22 Impulse Dynamics Nv Electrical muscle controller
US9440080B2 (en) 2004-03-10 2016-09-13 Impulse Dynamics Nv Protein activity modification

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9713723B2 (en) 1996-01-11 2017-07-25 Impulse Dynamics Nv Signal delivery through the right ventricular septum
US11439815B2 (en) 2003-03-10 2022-09-13 Impulse Dynamics Nv Protein activity modification
US11779768B2 (en) 2004-03-10 2023-10-10 Impulse Dynamics Nv Protein activity modification
EP1827571B1 (en) 2004-12-09 2016-09-07 Impulse Dynamics NV Protein activity modification
US8406864B2 (en) 2006-02-07 2013-03-26 Impulse Dynamics Nv Assessing cardiac activity

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320643A (en) * 1992-10-06 1994-06-14 Medtronic, Inc. Automatic cardiac capture restoration and threshold-seeking method and apparatus
US5320642A (en) * 1990-06-01 1994-06-14 Board Of Regents For The University Of Ok Method for alleviating and diagnosing symptoms of heart block
US5871506A (en) * 1996-08-19 1999-02-16 Mower; Morton M. Augmentation of electrical conduction and contractility by biphasic cardiac pacing
US6136019A (en) * 1996-08-19 2000-10-24 Mower Family Chf Treatment Irrevocable Trust Augmentation of electrical conduction and contractility by biphasic cardiac pacing administered via the cardiac blood pool
US6141587A (en) * 1996-08-19 2000-10-31 Mower Family Chf Treatment Irrevocable Trust Augmentation of muscle contractility by biphasic stimulation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5320642A (en) * 1990-06-01 1994-06-14 Board Of Regents For The University Of Ok Method for alleviating and diagnosing symptoms of heart block
US5320643A (en) * 1992-10-06 1994-06-14 Medtronic, Inc. Automatic cardiac capture restoration and threshold-seeking method and apparatus
US5871506A (en) * 1996-08-19 1999-02-16 Mower; Morton M. Augmentation of electrical conduction and contractility by biphasic cardiac pacing
US6136019A (en) * 1996-08-19 2000-10-24 Mower Family Chf Treatment Irrevocable Trust Augmentation of electrical conduction and contractility by biphasic cardiac pacing administered via the cardiac blood pool
US6141587A (en) * 1996-08-19 2000-10-31 Mower Family Chf Treatment Irrevocable Trust Augmentation of muscle contractility by biphasic stimulation

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9186514B2 (en) 1996-01-08 2015-11-17 Impulse Dynamics Nv Electrical muscle controller
US9289618B1 (en) 1996-01-08 2016-03-22 Impulse Dynamics Nv Electrical muscle controller
US9101765B2 (en) 1999-03-05 2015-08-11 Metacure Limited Non-immediate effects of therapy
US9440080B2 (en) 2004-03-10 2016-09-13 Impulse Dynamics Nv Protein activity modification
US8934975B2 (en) 2010-02-01 2015-01-13 Metacure Limited Gastrointestinal electrical therapy

Also Published As

Publication number Publication date
WO2001024871A2 (en) 2001-04-12
AU7811700A (en) 2001-05-10

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