WO2001013958A3 - Drug conjugates and methods of designing the same - Google Patents

Drug conjugates and methods of designing the same Download PDF

Info

Publication number
WO2001013958A3
WO2001013958A3 PCT/US2000/023593 US0023593W WO0113958A3 WO 2001013958 A3 WO2001013958 A3 WO 2001013958A3 US 0023593 W US0023593 W US 0023593W WO 0113958 A3 WO0113958 A3 WO 0113958A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmacophore
methods
designing
drug conjugates
same
Prior art date
Application number
PCT/US2000/023593
Other languages
French (fr)
Other versions
WO2001013958A2 (en
Inventor
Sydney Brenner
Philip Goelet
Joseph Stackhouse
Steven W Millward
Original Assignee
Sydney Brenner
Philip Goelet
Joseph Stackhouse
Steven W Millward
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sydney Brenner, Philip Goelet, Joseph Stackhouse, Steven W Millward filed Critical Sydney Brenner
Priority to JP2001518093A priority Critical patent/JP2003507439A/en
Priority to AU70824/00A priority patent/AU7082400A/en
Priority to EP00959512A priority patent/EP1212096A2/en
Priority to CA002382202A priority patent/CA2382202A1/en
Publication of WO2001013958A2 publication Critical patent/WO2001013958A2/en
Publication of WO2001013958A3 publication Critical patent/WO2001013958A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound

Abstract

The invention relates to drug conjugates and methods of their design. One embodiment of the invention is directed to a method of designing vector-linker-pharmacophore ('VLP') conjugates that is generally applicable to a wide variety of vectors, linkers, and pharmacophores. The invention also encompasses a method of improving the delivery of a pharmacophore to a patient, as well as a method of improving the therapeutic efficacy of a pharmacophore and a method of decreasing the toxicity of a pharmacophore. A method of increasing the concentration of a pharmacophore in a cell is further encompassed by the invention.
PCT/US2000/023593 1999-08-26 2000-08-28 Drug conjugates and methods of designing the same WO2001013958A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2001518093A JP2003507439A (en) 1999-08-26 2000-08-28 Drug conjugate and method for designing the same
AU70824/00A AU7082400A (en) 1999-08-26 2000-08-28 Drug conjugates and methods of designing the same
EP00959512A EP1212096A2 (en) 1999-08-26 2000-08-28 Drug conjugates and methods of designing the same
CA002382202A CA2382202A1 (en) 1999-08-26 2000-08-28 Drug conjugates and methods of designing the same

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US15076599P 1999-08-26 1999-08-26
US15089499P 1999-08-26 1999-08-26
US60/150,765 1999-08-26
US60/150,894 1999-08-26
US18441100P 2000-02-23 2000-02-23
US18441200P 2000-02-23 2000-02-23
US60/184,412 2000-02-23
US60/184,411 2000-02-23

Publications (2)

Publication Number Publication Date
WO2001013958A2 WO2001013958A2 (en) 2001-03-01
WO2001013958A3 true WO2001013958A3 (en) 2002-01-31

Family

ID=27495944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/023593 WO2001013958A2 (en) 1999-08-26 2000-08-28 Drug conjugates and methods of designing the same

Country Status (5)

Country Link
EP (1) EP1212096A2 (en)
JP (1) JP2003507439A (en)
AU (1) AU7082400A (en)
CA (1) CA2382202A1 (en)
WO (1) WO2001013958A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL163931A0 (en) * 2002-03-08 2005-12-18 Paratek Pharm Innc Amino-methyl substituted tetracyline compounds
US8110559B2 (en) 2006-09-15 2012-02-07 Enzon Pharmaceuticals, Inc. Hindered ester-based biodegradable linkers for oligonucleotide delivery
CN101534861B (en) 2006-09-15 2013-10-02 安佐制药股份有限公司 Polyalkylene oxides having hindered ester-based biodegradable linkers
CA2662978A1 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Hindered ester-based biodegradable linkers for oligonucleotide delivery
CN102993116A (en) * 2012-12-04 2013-03-27 常州大学 Preparation method of benzoxazine excitant
CN110963946B (en) * 2019-12-12 2022-03-11 万华化学集团股份有限公司 Preparation method of sodium methyl taurate
CN111549071A (en) * 2020-05-15 2020-08-18 乾元康安(苏州)生物科技有限公司 Construction method and application of drug toxicity tolerance production cell strain for producing protein drug conjugate
KR102604462B1 (en) * 2021-03-08 2023-11-22 비엔제이바이오파마 주식회사 Method for drug design and device using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416016A (en) * 1989-04-03 1995-05-16 Purdue Research Foundation Method for enhancing transmembrane transport of exogenous molecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416016A (en) * 1989-04-03 1995-05-16 Purdue Research Foundation Method for enhancing transmembrane transport of exogenous molecules
US5635382A (en) * 1989-04-03 1997-06-03 Purdue Research Foundation Method for enhancing transmembrane transport of exogenous molecules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARCHAND-BRYNAERT J ET AL: "Design and Synthesis of a Bifunctional Label for Selection of beta-Lactamase displayed on Filamentous Bacteriophage by Catalytic Activity", TETRAHEDRON,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 52, no. 15, 8 April 1996 (1996-04-08), pages 5591 - 5606, XP004104212, ISSN: 0040-4020 *

Also Published As

Publication number Publication date
EP1212096A2 (en) 2002-06-12
AU7082400A (en) 2001-03-19
WO2001013958A2 (en) 2001-03-01
JP2003507439A (en) 2003-02-25
CA2382202A1 (en) 2001-03-01

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