WO2001007889A3 - Miniaturized cell array methods and apparatus for cell-based screening - Google Patents

Miniaturized cell array methods and apparatus for cell-based screening Download PDF

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Publication number
WO2001007889A3
WO2001007889A3 PCT/US2000/020003 US0020003W WO0107889A3 WO 2001007889 A3 WO2001007889 A3 WO 2001007889A3 US 0020003 W US0020003 W US 0020003W WO 0107889 A3 WO0107889 A3 WO 0107889A3
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WO
WIPO (PCT)
Prior art keywords
cell
based screening
miniaturized
array methods
cell array
Prior art date
Application number
PCT/US2000/020003
Other languages
French (fr)
Other versions
WO2001007889A2 (en
Inventor
Ravi Kapur
Kenneth Giuliano
Original Assignee
Cellomics Inc
Ravi Kapur
Kenneth Giuliano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/513,783 external-priority patent/US6416959B1/en
Priority claimed from US09/540,862 external-priority patent/US6548263B1/en
Application filed by Cellomics Inc, Ravi Kapur, Kenneth Giuliano filed Critical Cellomics Inc
Priority to AU63662/00A priority Critical patent/AU6366200A/en
Publication of WO2001007889A2 publication Critical patent/WO2001007889A2/en
Publication of WO2001007889A3 publication Critical patent/WO2001007889A3/en

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    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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Abstract

The present invention describes methods and cassettes for cell-based toxin detection and organ localization. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a domain individually addressable by microfluidic channels in the device.
PCT/US2000/020003 1999-07-27 2000-07-21 Miniaturized cell array methods and apparatus for cell-based screening WO2001007889A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU63662/00A AU6366200A (en) 1999-07-27 2000-07-21 Miniaturized cell array methods and apparatus for cell-based screening

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US14575799P 1999-07-27 1999-07-27
US60/145,757 1999-07-27
US40121299A 1999-09-22 1999-09-22
US09/401,212 1999-09-22
US09/513,783 2000-02-25
US09/513,783 US6416959B1 (en) 1997-02-27 2000-02-25 System for cell-based screening
US09/540,862 2000-03-31
US09/540,862 US6548263B1 (en) 1997-05-29 2000-03-31 Miniaturized cell array methods and apparatus for cell-based screening

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Publication Number Publication Date
WO2001007889A2 WO2001007889A2 (en) 2001-02-01
WO2001007889A3 true WO2001007889A3 (en) 2001-05-31

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WO (1) WO2001007889A2 (en)

Cited By (4)

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US9216412B2 (en) 2009-11-23 2015-12-22 Cyvek, Inc. Microfluidic devices and methods of manufacture and use
US9229001B2 (en) 2009-11-23 2016-01-05 Cyvek, Inc. Method and apparatus for performing assays
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9546932B2 (en) 2009-11-23 2017-01-17 Cyvek, Inc. Microfluidic assay operating system and methods of use

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US20020106715A1 (en) * 2001-02-02 2002-08-08 Medisel Ltd System and method for collecting data from individual cells
US20040002064A1 (en) * 2002-06-27 2004-01-01 Ye Fang Toxin detection and compound screening using biological membrane microarrays
US20040197836A1 (en) * 2003-04-04 2004-10-07 Hashemi Brian B. Measurement of F-actin in whole blood cellular subsets
EP1938101A2 (en) 2005-09-13 2008-07-02 Fluidigm Corporation Microfluidic assay devices and methods
BRPI0619273A2 (en) * 2005-10-26 2011-09-20 Gen Electric METHODS AND SYSTEMS FOR THE PROVISION OF FLUID SAMPLES FOR SENSORS GROUPS
US8133741B2 (en) 2005-10-26 2012-03-13 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
US7723120B2 (en) 2005-10-26 2010-05-25 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
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