WO2001001106A1 - Pneumatic control of formation and transport of small volume liquid samples - Google Patents
Pneumatic control of formation and transport of small volume liquid samples Download PDFInfo
- Publication number
- WO2001001106A1 WO2001001106A1 PCT/US2000/017735 US0017735W WO0101106A1 WO 2001001106 A1 WO2001001106 A1 WO 2001001106A1 US 0017735 W US0017735 W US 0017735W WO 0101106 A1 WO0101106 A1 WO 0101106A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- capillary
- storage volume
- liquid
- conduit
- fluid communication
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/143—Quality control, feedback systems
- B01L2200/146—Employing pressure sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00943231A EP1192437B1 (en) | 1999-06-30 | 2000-06-26 | Pneumatic control of formation and transport of small volume liquid samples |
DE60033394T DE60033394T2 (en) | 1999-06-30 | 2000-06-26 | PNEUMATIC CONTROL OF THE FORMATION AND TRANSPORT OF LIQUID SAMPLES |
JP2001506473A JP2003503184A (en) | 1999-06-30 | 2000-06-26 | Pneumatic control of the formation and transport of small liquid samples |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/345,072 | 1999-06-30 | ||
US09/345,072 US6193471B1 (en) | 1999-06-30 | 1999-06-30 | Pneumatic control of formation and transport of small volume liquid samples |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2001001106A1 true WO2001001106A1 (en) | 2001-01-04 |
Family
ID=23353376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/017735 WO2001001106A1 (en) | 1999-06-30 | 2000-06-26 | Pneumatic control of formation and transport of small volume liquid samples |
Country Status (5)
Country | Link |
---|---|
US (1) | US6193471B1 (en) |
EP (1) | EP1192437B1 (en) |
JP (1) | JP2003503184A (en) |
DE (1) | DE60033394T2 (en) |
WO (1) | WO2001001106A1 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005530608A (en) * | 2002-06-24 | 2005-10-13 | ビヨメリユー | Hydraulic device for thermopneumatic isolation and optional agitation of the contents of the working cavity |
WO2007091229A1 (en) * | 2006-02-07 | 2007-08-16 | Stokes Bio Limited | A microfluidic droplet queuing network |
WO2007091228A1 (en) * | 2006-02-07 | 2007-08-16 | Stokes Bio Limited | A liquid bridge and system |
WO2010086328A1 (en) * | 2009-01-30 | 2010-08-05 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Microfluidic chip comprising a pressure measuring device |
US20100297685A1 (en) * | 2003-09-05 | 2010-11-25 | Stokes Bio Limited | Methods for culturing and analyzing cells |
EP2426497A1 (en) * | 2010-09-02 | 2012-03-07 | Ludwig-Maximilians-Universität München | Generation and use of liquid stacks in microchannels or capillaries |
US8501497B2 (en) | 2006-02-07 | 2013-08-06 | Stokes Bio Limited | Forming sample combinations using liquid bridge systems |
US8735169B2 (en) | 2006-02-07 | 2014-05-27 | Stokes Bio Limited | Methods for analyzing agricultural and environmental samples |
US10676786B2 (en) | 2003-09-05 | 2020-06-09 | Stokes Bio Ltd. | Microfluidic analysis system |
US11306351B2 (en) | 2005-12-21 | 2022-04-19 | Affymetrix, Inc. | Methods for genotyping |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6591852B1 (en) | 1998-10-13 | 2003-07-15 | Biomicro Systems, Inc. | Fluid circuit components based upon passive fluid dynamics |
US6601613B2 (en) | 1998-10-13 | 2003-08-05 | Biomicro Systems, Inc. | Fluid circuit components based upon passive fluid dynamics |
US6637463B1 (en) | 1998-10-13 | 2003-10-28 | Biomicro Systems, Inc. | Multi-channel microfluidic system design with balanced fluid flow distribution |
US6495104B1 (en) * | 1999-08-19 | 2002-12-17 | Caliper Technologies Corp. | Indicator components for microfluidic systems |
US6481453B1 (en) | 2000-04-14 | 2002-11-19 | Nanostream, Inc. | Microfluidic branch metering systems and methods |
US6296452B1 (en) * | 2000-04-28 | 2001-10-02 | Agilent Technologies, Inc. | Microfluidic pumping |
US20020003001A1 (en) | 2000-05-24 | 2002-01-10 | Weigl Bernhard H. | Surface tension valves for microfluidic applications |
US6632400B1 (en) * | 2000-06-22 | 2003-10-14 | Agilent Technologies, Inc. | Integrated microfluidic and electronic components |
AU2001281076A1 (en) * | 2000-08-07 | 2002-02-18 | Nanostream, Inc. | Fluidic mixer in microfluidic system |
US6890093B2 (en) | 2000-08-07 | 2005-05-10 | Nanostream, Inc. | Multi-stream microfludic mixers |
US6418968B1 (en) | 2001-04-20 | 2002-07-16 | Nanostream, Inc. | Porous microfluidic valves |
US7318912B2 (en) * | 2001-06-07 | 2008-01-15 | Nanostream, Inc. | Microfluidic systems and methods for combining discrete fluid volumes |
US20020186263A1 (en) * | 2001-06-07 | 2002-12-12 | Nanostream, Inc. | Microfluidic fraction collectors |
US20020197733A1 (en) * | 2001-06-20 | 2002-12-26 | Coventor, Inc. | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
US7211442B2 (en) * | 2001-06-20 | 2007-05-01 | Cytonome, Inc. | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
US20030015425A1 (en) * | 2001-06-20 | 2003-01-23 | Coventor Inc. | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
US7179423B2 (en) | 2001-06-20 | 2007-02-20 | Cytonome, Inc. | Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system |
US20020195343A1 (en) * | 2001-06-20 | 2002-12-26 | Coventor, Inc. | Microfabricated separation device employing a virtual wall for interfacing fluids |
US7077152B2 (en) * | 2001-07-07 | 2006-07-18 | Nanostream, Inc. | Microfluidic metering systems and methods |
US6877892B2 (en) * | 2002-01-11 | 2005-04-12 | Nanostream, Inc. | Multi-stream microfluidic aperture mixers |
US6662818B2 (en) * | 2002-02-01 | 2003-12-16 | Perseptive Biosystems, Inc. | Programmable tracking pressure regulator for control of higher pressures in microfluidic circuits |
US6845787B2 (en) * | 2002-02-23 | 2005-01-25 | Nanostream, Inc. | Microfluidic multi-splitter |
US9943847B2 (en) | 2002-04-17 | 2018-04-17 | Cytonome/St, Llc | Microfluidic system including a bubble valve for regulating fluid flow through a microchannel |
TW590982B (en) * | 2002-09-27 | 2004-06-11 | Agnitio Science & Technology I | Micro-fluid driving device |
US8968659B2 (en) * | 2003-09-05 | 2015-03-03 | Stokes Bio Limited | Sample dispensing |
DE10360220A1 (en) * | 2003-12-20 | 2005-07-21 | Steag Microparts Gmbh | Fine structure arrangement in fluid ejection system, has predetermined region in transitional zone between inlet and discharge ports, at which capillary force is maximum |
KR100540143B1 (en) | 2003-12-22 | 2006-01-10 | 한국전자통신연구원 | Microfluidic control device and method for controlling microfluidic |
US7758814B2 (en) * | 2004-06-05 | 2010-07-20 | Freeslate, Inc. | Microfluidic fluid distribution manifold for use with multi-channel reactor systems |
US9260693B2 (en) | 2004-12-03 | 2016-02-16 | Cytonome/St, Llc | Actuation of parallel microfluidic arrays |
US8695355B2 (en) | 2004-12-08 | 2014-04-15 | California Institute Of Technology | Thermal management techniques, apparatus and methods for use in microfluidic devices |
US20060204699A1 (en) * | 2004-12-08 | 2006-09-14 | George Maltezos | Parylene coated microfluidic components and methods for fabrication thereof |
JP4637610B2 (en) * | 2005-03-02 | 2011-02-23 | ローム株式会社 | Microchannel and microchip |
WO2006092959A1 (en) * | 2005-03-01 | 2006-09-08 | Rohm Co., Ltd | Microchannel and microfluid chip |
US8137626B2 (en) * | 2006-05-19 | 2012-03-20 | California Institute Of Technology | Fluorescence detector, filter device and related methods |
WO2008036614A1 (en) * | 2006-09-18 | 2008-03-27 | California Institute Of Technology | Apparatus for detecting target molecules and related methods |
US7814928B2 (en) * | 2006-10-10 | 2010-10-19 | California Institute Of Technology | Microfluidic devices and related methods and systems |
SG175199A1 (en) * | 2009-04-27 | 2011-11-28 | Agency Science Tech & Res | Apparatus and method for dispensing a liquid |
JP5997251B2 (en) * | 2011-04-02 | 2016-09-28 | バイオサーフィット、 ソシエダッド アノニマ | Analytical device liquid reagent storage and operation |
CN105828944B (en) | 2013-11-22 | 2018-02-02 | 瑞尼克斯有限公司 | Without channel pump and its method and application |
US9399216B2 (en) * | 2013-12-30 | 2016-07-26 | General Electric Company | Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure |
WO2020131070A1 (en) * | 2018-12-20 | 2020-06-25 | Tecan Trading Ag | Method of treating a sample |
CN116782997A (en) | 2020-06-12 | 2023-09-19 | 生物流体有限公司 | Dual depth thermoplastic microfluidic devices and related systems and methods |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1402283A (en) * | 1971-10-14 | 1975-08-06 | Coulter Electronics | Automatic chemical analysis apparatus |
US4405344A (en) * | 1980-09-30 | 1983-09-20 | Carlo Erba Strumentazione S.P.A. | Method and equipment for volumetrically controlled and reproducible introduction of small amounts of liquid samples into chromatographic analysis systems |
US4426451A (en) * | 1981-01-28 | 1984-01-17 | Eastman Kodak Company | Multi-zoned reaction vessel having pressure-actuatable control means between zones |
US4868129A (en) * | 1987-08-27 | 1989-09-19 | Biotrack Inc. | Apparatus and method for dilution and mixing of liquid samples |
US4936465A (en) * | 1987-12-07 | 1990-06-26 | Zoeld Tibor | Method and apparatus for fast, reliable, and environmentally safe dispensing of fluids, gases and individual particles of a suspension through pressure control at well defined parts of a closed flow-through system |
EP0392851A2 (en) * | 1989-04-13 | 1990-10-17 | Boehringer Mannheim Corporation | Dilution and mixing cartridge |
EP0501796A2 (en) * | 1991-03-01 | 1992-09-02 | Biotrack, Inc. | Capillary stop-flow junction having improved stability against accidental fluid flow |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5311238B2 (en) * | 1972-09-14 | 1978-04-20 | ||
US4367043A (en) * | 1980-05-05 | 1983-01-04 | Leland Stanford Junior University | Method and means for delivering liquid samples to a sample scanning device |
US4399362A (en) * | 1981-02-27 | 1983-08-16 | Instrumentation Laboratory Inc. | Liquid handling apparatus |
US4415011A (en) * | 1981-11-02 | 1983-11-15 | Isco, Inc. | Sample collector |
ES2049254T3 (en) * | 1987-08-27 | 1994-04-16 | Biotrack Inc | APPARATUS AND PROCEDURE FOR THE DILUTION AND MIXING OF LIQUID SAMPLES. |
CH673894A5 (en) * | 1987-10-15 | 1990-04-12 | Nivarox Sa | |
EP0595290B1 (en) * | 1992-10-27 | 1997-07-30 | Canon Kabushiki Kaisha | Method for driving liquid |
US20010055812A1 (en) * | 1995-12-05 | 2001-12-27 | Alec Mian | Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics |
-
1999
- 1999-06-30 US US09/345,072 patent/US6193471B1/en not_active Expired - Lifetime
-
2000
- 2000-06-26 DE DE60033394T patent/DE60033394T2/en not_active Expired - Lifetime
- 2000-06-26 WO PCT/US2000/017735 patent/WO2001001106A1/en active IP Right Grant
- 2000-06-26 EP EP00943231A patent/EP1192437B1/en not_active Expired - Lifetime
- 2000-06-26 JP JP2001506473A patent/JP2003503184A/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1402283A (en) * | 1971-10-14 | 1975-08-06 | Coulter Electronics | Automatic chemical analysis apparatus |
US4405344A (en) * | 1980-09-30 | 1983-09-20 | Carlo Erba Strumentazione S.P.A. | Method and equipment for volumetrically controlled and reproducible introduction of small amounts of liquid samples into chromatographic analysis systems |
US4426451A (en) * | 1981-01-28 | 1984-01-17 | Eastman Kodak Company | Multi-zoned reaction vessel having pressure-actuatable control means between zones |
US4868129A (en) * | 1987-08-27 | 1989-09-19 | Biotrack Inc. | Apparatus and method for dilution and mixing of liquid samples |
US4936465A (en) * | 1987-12-07 | 1990-06-26 | Zoeld Tibor | Method and apparatus for fast, reliable, and environmentally safe dispensing of fluids, gases and individual particles of a suspension through pressure control at well defined parts of a closed flow-through system |
EP0392851A2 (en) * | 1989-04-13 | 1990-10-17 | Boehringer Mannheim Corporation | Dilution and mixing cartridge |
EP0501796A2 (en) * | 1991-03-01 | 1992-09-02 | Biotrack, Inc. | Capillary stop-flow junction having improved stability against accidental fluid flow |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005530608A (en) * | 2002-06-24 | 2005-10-13 | ビヨメリユー | Hydraulic device for thermopneumatic isolation and optional agitation of the contents of the working cavity |
US9597644B2 (en) * | 2003-09-05 | 2017-03-21 | Stokes Bio Limited | Methods for culturing and analyzing cells |
US11807902B2 (en) | 2003-09-05 | 2023-11-07 | Stokes Bio Ltd. | Microfluidic analysis system |
US10967338B2 (en) | 2003-09-05 | 2021-04-06 | Stokes Bio Ltd. | Methods of releasing and analyzing cellular components |
US20100297685A1 (en) * | 2003-09-05 | 2010-11-25 | Stokes Bio Limited | Methods for culturing and analyzing cells |
US10676786B2 (en) | 2003-09-05 | 2020-06-09 | Stokes Bio Ltd. | Microfluidic analysis system |
US11306351B2 (en) | 2005-12-21 | 2022-04-19 | Affymetrix, Inc. | Methods for genotyping |
EP2298438A1 (en) * | 2006-02-07 | 2011-03-23 | Stokes Bio Limited | A microfluidic droplet queuing network |
US8298833B2 (en) | 2006-02-07 | 2012-10-30 | Stokes Bio Limited | Liquid bridge and system |
US8563244B2 (en) | 2006-02-07 | 2013-10-22 | Stokes Bio Limited | Microfluidic droplet queuing network |
US8735169B2 (en) | 2006-02-07 | 2014-05-27 | Stokes Bio Limited | Methods for analyzing agricultural and environmental samples |
US9108177B2 (en) | 2006-02-07 | 2015-08-18 | Stokes Bio Limited | Microfluidic droplet queuing network |
US9322511B2 (en) | 2006-02-07 | 2016-04-26 | Stokes Bio Limited | Liquid bridge and system |
US9533304B2 (en) | 2006-02-07 | 2017-01-03 | Stokes Bio Limited | Forming sample combinations using liquid bridge systems |
US8501497B2 (en) | 2006-02-07 | 2013-08-06 | Stokes Bio Limited | Forming sample combinations using liquid bridge systems |
WO2007091229A1 (en) * | 2006-02-07 | 2007-08-16 | Stokes Bio Limited | A microfluidic droplet queuing network |
US10730051B2 (en) | 2006-02-07 | 2020-08-04 | Stokes Bio Ltd. | Liquid bridge and system |
US11772096B2 (en) | 2006-02-07 | 2023-10-03 | Stokes Bio Ltd. | System for processing biological sample |
WO2007091228A1 (en) * | 2006-02-07 | 2007-08-16 | Stokes Bio Limited | A liquid bridge and system |
WO2010086328A1 (en) * | 2009-01-30 | 2010-08-05 | INSTITUT FüR MIKROTECHNIK MAINZ GMBH | Microfluidic chip comprising a pressure measuring device |
US11964244B2 (en) | 2009-11-12 | 2024-04-23 | Stokes Bio Limited | Methods of releasing and analyzing cellular components |
EP2426497A1 (en) * | 2010-09-02 | 2012-03-07 | Ludwig-Maximilians-Universität München | Generation and use of liquid stacks in microchannels or capillaries |
Also Published As
Publication number | Publication date |
---|---|
EP1192437B1 (en) | 2007-02-14 |
EP1192437A1 (en) | 2002-04-03 |
US6193471B1 (en) | 2001-02-27 |
JP2003503184A (en) | 2003-01-28 |
DE60033394T2 (en) | 2007-10-31 |
DE60033394D1 (en) | 2007-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6193471B1 (en) | Pneumatic control of formation and transport of small volume liquid samples | |
Sammarco et al. | Thermocapillary pumping of discrete drops in microfabricated analysis devices | |
Madou et al. | Design and fabrication of CD-like microfluidic platforms for diagnostics: microfluidic functions | |
US8652852B2 (en) | Method of pumping fluid through a microfluidic device | |
Sharp et al. | Liquid flows in microchannels | |
AU2003204633B2 (en) | Device for displacement of small liquid volumes along a micro-catenary line by electrostatic forces | |
JP3732159B2 (en) | Method and apparatus for processing fluid in substrate | |
EP1386079B1 (en) | A liquid pumping system | |
US20090282978A1 (en) | Microfluidic Separators for Multiphase Fluid-Flow Based On Membranes | |
US8075778B2 (en) | Fluid separation | |
Greenwood et al. | Sample manipulation in micro total analytical systems | |
US20090268548A1 (en) | Microfluidic systems, devices and methods for reducing diffusion and compliance effects at a fluid mixing region | |
CA2406718A1 (en) | Microfluidic devices and methods to regulate hydrodynamic and electrical resistance utilizing bulk viscosity enhancers | |
KR970705020A (en) | Apparatus and method for performing precise flow control for chemical analysis and synthesis | |
JP2020109413A (en) | Capillary barriers for staged loading of microfluidic devices | |
US8394645B2 (en) | Method for performing a high throughput assay | |
US20070295372A1 (en) | Device for passive microfluidic washing using capillary force | |
Reichert et al. | Predicting droplet velocity in a Hele-Shaw cell | |
Besselink et al. | Electroosmotic guiding of sample flows in a laminar flow chamber | |
Radhakrishnan et al. | Hydrodynamic characterization of phase separation in devices with microfabricated capillaries | |
JP2003200041A (en) | Device for injecting various reactants successively and synchronously in parallel | |
Puntambekar et al. | A new fixed-volume metering microdispenser module based on sPROMs technology | |
Yager | Transverse diffusion in microfluidic systems | |
WO2001085342A1 (en) | Metering dispenser with capillary stop | |
Lettieri | A novel microfluidic concept for bioanalysis using controlled recirculating flows. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): JP |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
ENP | Entry into the national phase |
Ref country code: JP Ref document number: 2001 506473 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2000943231 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 2000943231 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 2000943231 Country of ref document: EP |