WO2000079268A3 - Method and apparatus for assaying a drug candidate to estimate a pharmacokinetic parameter associated therewith - Google Patents

Method and apparatus for assaying a drug candidate to estimate a pharmacokinetic parameter associated therewith Download PDF

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Publication number
WO2000079268A3
WO2000079268A3 PCT/SE2000/001297 SE0001297W WO0079268A3 WO 2000079268 A3 WO2000079268 A3 WO 2000079268A3 SE 0001297 W SE0001297 W SE 0001297W WO 0079268 A3 WO0079268 A3 WO 0079268A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug candidate
estimate
binding interaction
drug
adme
Prior art date
Application number
PCT/SE2000/001297
Other languages
French (fr)
Other versions
WO2000079268A2 (en
Inventor
Maikku Haemaelaeinen
Robert Karlsson
Stefan Loefaas
Original Assignee
Biacore Ab
Maikku Haemaelaeinen
Robert Karlsson
Stefan Loefaas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biacore Ab, Maikku Haemaelaeinen, Robert Karlsson, Stefan Loefaas filed Critical Biacore Ab
Priority to DE60020119T priority Critical patent/DE60020119T2/en
Priority to AU60340/00A priority patent/AU775060B2/en
Priority to EP00946608A priority patent/EP1188058B1/en
Priority to JP2001505186A priority patent/JP4543187B2/en
Priority to AT00946608T priority patent/ATE295541T1/en
Publication of WO2000079268A2 publication Critical patent/WO2000079268A2/en
Publication of WO2000079268A3 publication Critical patent/WO2000079268A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Abstract

A method and apparatus for assaying a drug candidate with a biosensor having one or more sensing surface-bound biomolecules associated therewith are disclosed. The method comprises the steps of measuring the binding interaction between the drug candidate and the one or more sensing surface-bound biomolecules of the bisensor to obtain an estimate of at least one binding interaction parameter of the drug candidate, and then comparing the estimated binding interaction parameter against a mathematical expression correlated from binding interaction data associated with known drug compounds to determine an estimate of at least pharmacokinetic parameter of absorption, distribution, metabolism, or excretion (ADME) that is related to the drug candidate. The present invention allows for the simultaneous measurement of different pharmacokinetic parameters of the drug candidate, as well as an indication of the drug candidate's solubility, by use of a single analytical instrument. The pharmacokinetic data may be represented as a ADME characterization profile; such ADME profiles are of great utility for purposes of drug screening and lead optimization.
PCT/SE2000/001297 1999-06-18 2000-06-19 Method and apparatus for assaying a drug candidate to estimate a pharmacokinetic parameter associated therewith WO2000079268A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE60020119T DE60020119T2 (en) 1999-06-18 2000-06-19 Method and device for investigating drug candidates and for determining their pharmacokinetic parameters
AU60340/00A AU775060B2 (en) 1999-06-18 2000-06-19 Method and apparatus for assaying a drug candidate to estimate a pharmacokineticparameter associated therewith
EP00946608A EP1188058B1 (en) 1999-06-18 2000-06-19 Method and apparatus for assaying a drug candidate to estimate a pharmacokinetic parameter associated therewith
JP2001505186A JP4543187B2 (en) 1999-06-18 2000-06-19 Method and apparatus for assaying drug candidates for estimating pharmacokinetic parameters associated with the drug candidate
AT00946608T ATE295541T1 (en) 1999-06-18 2000-06-19 METHOD AND DEVICE FOR EXAMINING ACTIVE INGREDIENTS CANDIDATES AND FOR DETERMINING THEIR PHARMACOKINETIC PARAMETERS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33686599A 1999-06-18 1999-06-18
US09/336,865 1999-06-18

Publications (2)

Publication Number Publication Date
WO2000079268A2 WO2000079268A2 (en) 2000-12-28
WO2000079268A3 true WO2000079268A3 (en) 2001-07-19

Family

ID=23318018

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2000/001297 WO2000079268A2 (en) 1999-06-18 2000-06-19 Method and apparatus for assaying a drug candidate to estimate a pharmacokinetic parameter associated therewith

Country Status (7)

Country Link
US (2) US6808938B2 (en)
EP (1) EP1188058B1 (en)
JP (1) JP4543187B2 (en)
AT (1) ATE295541T1 (en)
AU (1) AU775060B2 (en)
DE (1) DE60020119T2 (en)
WO (1) WO2000079268A2 (en)

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Also Published As

Publication number Publication date
JP2003502668A (en) 2003-01-21
AU6034000A (en) 2001-01-09
AU775060B2 (en) 2004-07-15
DE60020119T2 (en) 2005-10-06
ATE295541T1 (en) 2005-05-15
EP1188058B1 (en) 2005-05-11
JP4543187B2 (en) 2010-09-15
DE60020119D1 (en) 2005-06-16
US20020019019A1 (en) 2002-02-14
WO2000079268A2 (en) 2000-12-28
US20050037418A1 (en) 2005-02-17
EP1188058A2 (en) 2002-03-20
US6808938B2 (en) 2004-10-26

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