WO2000069560A1 - Systeme microfluidique a fonctionnement centripete destine a effectuer une hybridation in vitro et une amplification des acides nucleiques - Google Patents

Systeme microfluidique a fonctionnement centripete destine a effectuer une hybridation in vitro et une amplification des acides nucleiques Download PDF

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Publication number
WO2000069560A1
WO2000069560A1 PCT/US2000/013131 US0013131W WO0069560A1 WO 2000069560 A1 WO2000069560 A1 WO 2000069560A1 US 0013131 W US0013131 W US 0013131W WO 0069560 A1 WO0069560 A1 WO 0069560A1
Authority
WO
WIPO (PCT)
Prior art keywords
platform
microchannels
heating elements
microsystem
fluid
Prior art date
Application number
PCT/US2000/013131
Other languages
English (en)
Inventor
Gregory Kellogg
Bruce L. Carvalho
Norman F. Sheppard, Jr.
Kevin E. Noonan
Original Assignee
Gamera Bioscience Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gamera Bioscience Corporation filed Critical Gamera Bioscience Corporation
Priority to AU47134/00A priority Critical patent/AU4713400A/en
Publication of WO2000069560A1 publication Critical patent/WO2000069560A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G01N2035/00366—Several different temperatures used

Abstract

L'invention concerne des procédés et un appareil permettant de mener à bien des analyses et des procédés microsynthétiques et microanalytiques. L'invention concerne une plate-forme de microsystème et un dispositif de micromanipulation servant à manipuler la plate-forme exploitant la force centripète résultant de la rotation de la plate-forme, favorisant de ce fait le mouvement fluidique à travers les microcanaux. Les plates-formes de microsystème de l'invention présentent des réseaux de zones de commande thermique, dans lesquels le fluide acheminé vers la plate-forme peut être soumis à une température et maintenu à cette température pendant un laps de temps tributaire de la longueur du chemin du canal dans la zone, de la dimension transversale du canal et de la vitesse de rotation de la plate-forme. Des procédés spécifiques permettent de mettre en oeuvre un large éventail de procédés microanalytiques ou microsynthétiques.
PCT/US2000/013131 1999-05-14 2000-05-12 Systeme microfluidique a fonctionnement centripete destine a effectuer une hybridation in vitro et une amplification des acides nucleiques WO2000069560A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU47134/00A AU4713400A (en) 1999-05-14 2000-05-12 A centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13408699P 1999-05-14 1999-05-14
US60/134,086 1999-05-14

Publications (1)

Publication Number Publication Date
WO2000069560A1 true WO2000069560A1 (fr) 2000-11-23

Family

ID=22461715

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/013131 WO2000069560A1 (fr) 1999-05-14 2000-05-12 Systeme microfluidique a fonctionnement centripete destine a effectuer une hybridation in vitro et une amplification des acides nucleiques

Country Status (2)

Country Link
AU (1) AU4713400A (fr)
WO (1) WO2000069560A1 (fr)

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399361B2 (en) * 1997-05-23 2002-06-04 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
WO2003016558A1 (fr) * 2001-08-16 2003-02-27 Corbett Research Pty Ltd Dispositif thermique a ecoulement continu
WO2003018198A1 (fr) * 2001-08-28 2003-03-06 Gyros Ab Microcavite microfluidique de retention microfluidique et autres structures microfluidiques
WO2003052427A1 (fr) 2001-12-14 2003-06-26 Arkray, Inc. Dispositif de mesure d'echantillons
WO2003058253A1 (fr) 2001-12-28 2003-07-17 3M Innovative Properties Company Systemes modulaires et procedes d'utilisation de dispositifs de traitement d'echantillons
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
EP1379852A1 (fr) * 2001-04-18 2004-01-14 3M Innovative Properties Company Dispositifs, procede et systemes de traitement d'echantillons multi-format
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US7005265B1 (en) 2002-06-20 2006-02-28 Wenhong Fan Nonenzymatic catalytic signal amplification for nucleic acid hybridization assays
WO2006075966A1 (fr) 2005-01-17 2006-07-20 Gyros Patent Ab Parcours d'ecoulement polyvalent
WO2006110095A1 (fr) 2005-04-14 2006-10-19 Gyros Patent Ab Dispositif microfluidique comprenant des valves digitiformes
US7332129B2 (en) 2003-01-09 2008-02-19 3M Innovative Properties Company Sample processing device having process chambers with bypass slots
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
US7431889B2 (en) 2003-01-30 2008-10-07 Gyros Patent Ab Inner walls of microfluidic devices
EP2126119A1 (fr) * 2007-03-02 2009-12-02 Corbett Research Pty Ltd Appareil et procédé d'amplification d'acide nucléique
EP2158966A1 (fr) * 2008-08-26 2010-03-03 Roche Diagnostics GmbH Plaque multi-puits haute densité pour PCR
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7767937B2 (en) 2005-07-05 2010-08-03 3M Innovative Properties Company Modular sample processing kits and modules
EP2261663A2 (fr) 2003-03-23 2010-12-15 Gyros Patent Ab Procédé pour quantifier une pluralité de différents analytes
US8133438B2 (en) 2004-01-29 2012-03-13 Gyros Patent Ab Flow paths comprising one or two porous beds
US8592219B2 (en) 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
US8931331B2 (en) 2011-05-18 2015-01-13 3M Innovative Properties Company Systems and methods for volumetric metering on a sample processing device
US9067205B2 (en) 2011-05-18 2015-06-30 3M Innovative Properties Company Systems and methods for valving on a sample processing device
JP2015121493A (ja) * 2013-12-24 2015-07-02 凸版印刷株式会社 試料分析チップ
US9168523B2 (en) 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
US10052630B2 (en) 2003-03-23 2018-08-21 Gyros Patent Ab Preloaded microfluidic devices

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0693560A2 (fr) * 1994-07-19 1996-01-24 Becton, Dickinson and Company Procédé et appareil pour amplification automatique d'acides nucleiques essai sur acide nucleique et immunoessai
WO1997021090A1 (fr) * 1995-12-05 1997-06-12 Gamera Bioscience Dispositifs et procedes d'utilisation de l'acceleration centripete pour commander le deplacement de liquides dans le traitement de laboratoire automatise
WO1998053311A2 (fr) * 1997-05-23 1998-11-26 Gamera Bioscience Corporation Dispositifs et procedes permettant d'utiliser l'acceleration centripete pour commander le deplacement de fluides sur un systeme microfluidique
WO1998054580A1 (fr) * 1997-05-29 1998-12-03 Herst C V Taylor Dispositif permettant d'isoler un composant d'echantillon physiologique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0693560A2 (fr) * 1994-07-19 1996-01-24 Becton, Dickinson and Company Procédé et appareil pour amplification automatique d'acides nucleiques essai sur acide nucleique et immunoessai
WO1997021090A1 (fr) * 1995-12-05 1997-06-12 Gamera Bioscience Dispositifs et procedes d'utilisation de l'acceleration centripete pour commander le deplacement de liquides dans le traitement de laboratoire automatise
WO1998053311A2 (fr) * 1997-05-23 1998-11-26 Gamera Bioscience Corporation Dispositifs et procedes permettant d'utiliser l'acceleration centripete pour commander le deplacement de fluides sur un systeme microfluidique
WO1998054580A1 (fr) * 1997-05-29 1998-12-03 Herst C V Taylor Dispositif permettant d'isoler un composant d'echantillon physiologique

Cited By (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399361B2 (en) * 1997-05-23 2002-06-04 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US6814935B2 (en) 2000-06-28 2004-11-09 3M Innovative Properties Company Sample processing devices and carriers
US7435933B2 (en) 2000-06-28 2008-10-14 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US7445752B2 (en) 2000-06-28 2008-11-04 3M Innovative Properties Company Sample processing devices and carriers
US7026168B2 (en) 2000-06-28 2006-04-11 3M Innovative Properties Company Sample processing devices
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US7939018B2 (en) 2000-06-28 2011-05-10 3M Innovative Properties Company Multi-format sample processing devices and systems
US6987253B2 (en) 2000-06-28 2006-01-17 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
EP1379852A1 (fr) * 2001-04-18 2004-01-14 3M Innovative Properties Company Dispositifs, procede et systemes de traitement d'echantillons multi-format
EP1379852A4 (fr) * 2001-04-18 2004-11-17 3M Innovative Properties Co Dispositifs, procede et systemes de traitement d'echantillons multi-format
EP1729105A1 (fr) * 2001-04-18 2006-12-06 3M Innovative Properties Company Dispositifs, procédés et systèmes de traitement d'échantillon multiformat
US7709250B2 (en) 2001-08-16 2010-05-04 Corbett Research Pty Ltd Continuous flow thermal device
WO2003016558A1 (fr) * 2001-08-16 2003-02-27 Corbett Research Pty Ltd Dispositif thermique a ecoulement continu
WO2003018198A1 (fr) * 2001-08-28 2003-03-06 Gyros Ab Microcavite microfluidique de retention microfluidique et autres structures microfluidiques
US7300199B2 (en) 2001-08-28 2007-11-27 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US7275858B2 (en) 2001-08-28 2007-10-02 Gyros Patent Ab Retaining microfluidic microcavity and other microfluidic structures
US7749442B2 (en) 2001-12-14 2010-07-06 Arkray, Inc. Sample measuring device
EP1462805A4 (fr) * 2001-12-14 2006-06-07 Arkray Inc Dispositif de mesure d'echantillons
WO2003052427A1 (fr) 2001-12-14 2003-06-26 Arkray, Inc. Dispositif de mesure d'echantillons
EP1462805A1 (fr) * 2001-12-14 2004-09-29 Arkray, Inc. Dispositif de mesure d'echantillons
JPWO2003052427A1 (ja) * 2001-12-14 2005-04-28 アークレイ株式会社 試料測定用ディバイス
US8003051B2 (en) 2001-12-28 2011-08-23 3M Innovative Properties Company Thermal structure for sample processing systems
EP1459076A4 (fr) * 2001-12-28 2005-12-14 3M Innovative Properties Co Systemes modulaires et procedes d'utilisation de dispositifs de traitement d'echantillons
WO2003058253A1 (fr) 2001-12-28 2003-07-17 3M Innovative Properties Company Systemes modulaires et procedes d'utilisation de dispositifs de traitement d'echantillons
EP1459076A1 (fr) * 2001-12-28 2004-09-22 3M Innovative Properties Company Systemes modulaires et procedes d'utilisation de dispositifs de traitement d'echantillons
US7005265B1 (en) 2002-06-20 2006-02-28 Wenhong Fan Nonenzymatic catalytic signal amplification for nucleic acid hybridization assays
US7332129B2 (en) 2003-01-09 2008-02-19 3M Innovative Properties Company Sample processing device having process chambers with bypass slots
US7431889B2 (en) 2003-01-30 2008-10-07 Gyros Patent Ab Inner walls of microfluidic devices
US10052630B2 (en) 2003-03-23 2018-08-21 Gyros Patent Ab Preloaded microfluidic devices
EP2261663A2 (fr) 2003-03-23 2010-12-15 Gyros Patent Ab Procédé pour quantifier une pluralité de différents analytes
US8133438B2 (en) 2004-01-29 2012-03-13 Gyros Patent Ab Flow paths comprising one or two porous beds
WO2006075966A1 (fr) 2005-01-17 2006-07-20 Gyros Patent Ab Parcours d'ecoulement polyvalent
US8592219B2 (en) 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent
WO2006110095A1 (fr) 2005-04-14 2006-10-19 Gyros Patent Ab Dispositif microfluidique comprenant des valves digitiformes
US8080409B2 (en) 2005-07-05 2011-12-20 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7767937B2 (en) 2005-07-05 2010-08-03 3M Innovative Properties Company Modular sample processing kits and modules
EP2126119A1 (fr) * 2007-03-02 2009-12-02 Corbett Research Pty Ltd Appareil et procédé d'amplification d'acide nucléique
EP2126119A4 (fr) * 2007-03-02 2014-07-16 Corbett Res Pty Ltd Appareil et procédé d'amplification d'acide nucléique
EP2158966A1 (fr) * 2008-08-26 2010-03-03 Roche Diagnostics GmbH Plaque multi-puits haute densité pour PCR
US8980621B2 (en) 2008-08-26 2015-03-17 Roche Molecular Systems, Inc. High-density multiwell-plate
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
US8931331B2 (en) 2011-05-18 2015-01-13 3M Innovative Properties Company Systems and methods for volumetric metering on a sample processing device
US9168523B2 (en) 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
US9725762B2 (en) 2011-05-18 2017-08-08 Diasorin S.P.A. Systems and methods for detecting the presence of a selected volume of material in a sample processing device
US9067205B2 (en) 2011-05-18 2015-06-30 3M Innovative Properties Company Systems and methods for valving on a sample processing device
JP2015121493A (ja) * 2013-12-24 2015-07-02 凸版印刷株式会社 試料分析チップ

Also Published As

Publication number Publication date
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