WO2000048644A9 - Systems and methods for shrinking collagen in the dermis - Google Patents
Systems and methods for shrinking collagen in the dermisInfo
- Publication number
- WO2000048644A9 WO2000048644A9 PCT/US2000/002778 US0002778W WO0048644A9 WO 2000048644 A9 WO2000048644 A9 WO 2000048644A9 US 0002778 W US0002778 W US 0002778W WO 0048644 A9 WO0048644 A9 WO 0048644A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electrodes
- electromagnetic energy
- carrier
- tissue
- epidermal
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/148—Probes or electrodes therefor having a short, rigid shaft for accessing the inner body transcutaneously, e.g. for neurosurgery or arthroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A61B2018/00023—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00059—Material properties
- A61B2018/00071—Electrical conductivity
- A61B2018/00083—Electrical conductivity low, i.e. electrically insulating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00702—Power or energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1425—Needle
- A61B2018/143—Needle multiple needles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1472—Probes or electrodes therefor for use with liquid electrolyte, e.g. virtual electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1497—Electrodes covering only part of the probe circumference
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1861—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter
Definitions
- the invention is directed to systems and methods for treating cosmetic conditions in the human body.
- the invention is directed to systems and methods for treating cosmetic conditions affecting the skin of the face and neck, as evidenced by the appearance of lines and wrinkles in the face, or neck, or both.
- the skin is the principal seat of the sense of touch.
- the skin also provides protection against the physical forces of the environment, such as heat, cold, sun rays, friction, pressure, and chemicals.
- Exposure of the skin to these environmental forces can, over time, cause the skin to sag or wrinkle.
- Hyperfunctional nervous disorders and normal contraction of facial and neck muscles e.g. by frowning or squinting, can also over time form furrows or bands in the face and neck region.
- the invention provides improved systems and methods of systems and methods of achieving the cosmetically beneficial effects of shrinking collagen tissue in the der is in an effective, non- invasive manner, which leaves the outer layer of skin intact and undamaged.
- One aspect of the invention provides systems and methods for applying electromagnetic energy to skin.
- the systems and methods include a carrier and an array of electrodes on the carrier, which are connectable to a source of electromagnetic energy to apply the electromagnetic energy.
- a microporou ⁇ pad on the carrier overlays the array of electrodes, forming an interior chamber to contain an electrically conductive material.
- the microporous pad is adapted, in use, to contact an epidermal skin region and ionically transport the applied electromagnetic energy to ohmically heat dermal tissue beneath the epidermal skin region.
- the shape of the carrier can differ to match different skin region topographies.
- Another aspect of the invention provides systems and methods for applying electromagnetic energy to skin, in which the array of electrodes on the carrier are sized so that, while the carrier contacts an epidermal skin region, the electrodes extend into tissue beneath the epidermal skin region to ohmically heat dermal tissue.
- the electrodes are sized to extend into dermal tissue. In another embodiment, the electrodes are sized to extend into subdermal tissue.
- the shape of the carrier can differ to match different skin region topographies.
- the systems and methods include a carrier and at least one electrode on the carrier connectable to a source of electromagnetic energy to apply the electromagnetic energy.
- the electrode is sized so that, while the carrier contacts a backside of the flap, the electrode ohmically heats the dermal tissue.
- the electrode in use, rests on a surface on the backside of the flap. in another embodiment, the electrode is sized to extend into dermal tissue within the flap.
- Another aspect of the invention provides a family of devices for applying electromagnetic energy to skin.
- Each device comprising a carrier having a shape and an array of electrodes on the carrier connectable to a source of electromagnetic energy to apply the electromagnetic energy.
- the shapes of the carriers differ to match different skin region topographies.
- the carrier is adapted, in use, to contact epidermal tissue.
- the electrodes are sized to extend into tissue beneath the epidermal tissue.
- the electrodes can be sized to extend into dermal tissue.
- the electrodes are sized to extend into subdermal tissue.
- Fig. 1 is a representative side section view of skin and underlying subcutaneous tissue
- Fig. 2 is a schematic view of a system that, in use, heats collagen tissue in the dermis for the purpose of treating cosmetic conditions affecting the skin;
- Fig. 3 is an exploded perspective view of one category of an energy applicator, usable in association with the system shown in Fig. 2, to transmit energy into the dermis externally through the epidermis;
- Fig. 4 is a side section view of the energy applicator shown in Fig. 3 in use to heat collagen tissue in the dermis
- Fig. 5 is a front view of the facial and neck region showing various energy applicator, like that shown in Fig. 3, specially shaped to match the topography of a skin region under the eye, below the ear, under the chin, around the lips, and on the forehead above the eyebrows;
- Fig. 6 is an exploded perspective view of another category of an energy applicator, usable in association with the system shown in Fig. 2, to transmit energy internally directly into the dermis;
- Fig. 7 is a side section view of the energy applicator shown in Fig. 6 in use to heat collagen tissue in the dermis;
- Fig. 8 is an exploded perspective view, with portions in section, of another category of an energy applicator, usable in association with the system shown in Fig. 2, to transmit energy into the dermis internally through subcutaneous tissue;
- Fig. 9 is a side section view of the energy applicator shown in Fig. 8 in use to heat collagen tissue in the dermis;
- Fig. 10 is an exploded, perspective view of another category of an energy applicator, usable in association with the system shown in Fig. 2, to transmit energy into the dermis from the backside of a surgically created facelift flap.
- Fig. 11 is a side section view of the energy applicator shown in Fig. 10 in use to heat collagen tissue in the dermis from the backside of a facelift flap;
- Fig. 12 is a perspective view of an energy applicator of the type shown in Fig. 3, with associated probes for sensing temperature in the dermis;
- Fig. 13 is a side section view of an energy applicator shown in Fig. 3, with the sensors deployed in the dermis to sense temperature conditions;
- Fig. 14 is a side section view of an energy applicator of the type shown in Fig. 6, with associated sensors located in the dermis to sense temperature conditions; and
- Fig. 15 is a side section view of a penetration tissue temperature sensing probe of the type shown in Figs. 12 to 14, with multiple sensors deployed in a stacked arrangement to sense a temperature gradient in the dermis.
- the invention provides systems and methods of treating cosmetic conditions affecting the skin.
- the system and methods are applicable for use throughout the body.
- the systems and methods are particularly well suited for treating cosmetic conditions in the facial or neck area of the body. For this reason, the systems and methods will be described in this context.
- the skin 10 overlies and protects subcutaneous tissue 12 and muscle tissue 14 of the body. In the face and neck areas, the skin 10 measures about 2mm in cross section.
- the skin 10 includes an external, non- vascular covering of epithelial cells, called the epidermis 16. In the face and neck regions, the epidermis measures about 100 ⁇ m in cross section.
- the skin 10 also includes a layer of vascular tissue, named the dermis 18.
- the dermis 18 measures about 1900 ⁇ m in cross section.
- the dermis 18 is tough, flexible, and highly elastic. It is divided into a papillary (upper) layer 20 and a reticular (lower) layer 22.
- the most numerous fibers in the papillary and reticular layers 20 and 22 are collagen fibers, which in large part account for the strength and physical properties of the dermis 18. Hair bulbs, sweat ducts, and other glands also occupy the reticular layer 22.
- the fibrous structure of collagen tissue is observed to dissociate and contract along its length when heated to a defined temperature condition, i.e., about 65 sc.
- the contraction of collagen tissue causes the dermis 18 to reduce in size, which has an observable tightening effect.
- collagen contacts wrinkles and sag lines in the skin are ameliorated.
- the outward cosmetic appearance of the skin 10 improves.
- the temperature conditions conducive to the beneficial results of collagen shrinkage lay well above the temperature conditions at which irreversible thermal damage to epithelial cells begins to occur, i.e., above about 47° C.
- Fig. 2 shows a system 24 for renovating and reconstituting the dermis.
- the system 24 applies energy to the dermis to elevate and maintain its temperature at a predetermined temperature condition, at or about 65s C, without increasing the temperature of the epidermis beyond 472 c. In this way, the system applies energy to the dermis in a targeted, selective fashion, to dissociate and contract collagen tissue, while preserving and protecting epithelial cells against thermal damage.
- the system 24 includes a treatment device 26.
- the device 26 includes a handle 28 made, e.g., from molded plastic.
- the handle 28 carries at its distal end a treatment energy applicator 30, which, in use, contacts the epidermis.
- the handle 28 is sized to be conveniently grasped like a pencil or paint brush by a physician, to thereby manipulate the applicator 30 on the epidermis 16.
- the system 24 further includes a device 32 to generate treatment energy.
- the generator 32 generates radio frequency energy, e.g. , having a frequency in the range of about 400 kHz to about 10 mHz.
- a cable 34 extending from the proximal end of the handle 28 terminates with an electrical connector 36.
- the cable 34 is electrically coupled to the applicator 30, e.g., by wires that extend through the interior of the handle 28.
- connector 36 plugs into the generator 32, to convey the generated energy to the applicator 30 for transmission to the skin.
- the system 24 also includes certain auxiliary processing equipment 38 and 40.
- the processing equipment 38 comprises an external fluid delivery apparatus
- the processing equipment 40 comprises an external aspirating apparatus.
- the handle 28 of the treatment device 26 includes one or more interior lumens 42. The lumens terminate in fittings 44 and 46, located at the proximal end of the handle 28.
- One fitting 44 connects to the fluid delivery apparatus 38, to convey processing fluid to the distal end of the handle 28 for discharge.
- the other fitting 46 connects to the aspirating apparatus 40, to convey aspirated material from the distal end of the handle 28 for discharge.
- the system 24 also includes a controller
- the controller 48 which preferably includes a central processing unit (CPU) , is linked to the generator 32, the fluid delivery apparatus 38, and the aspirating apparatus 40.
- the controller 48 governs the power levels, cycles, and duration that the radio frequency energy is distributed to the applicator 30, to achieve and maintain power levels appropriate to achieve the desired treatment objectives.
- the controller 48 also governs the delivery of processing fluid to the applicator 30 and the removal of aspirated material from the applicator 30.
- the controller 48 includes an input/output (I/O) device 50.
- the I/O device 50 allows the physician to input control and processing variables, to enable the controller 48 to generate appropriate command signals.
- the I/O device 50 also receives real time processing feedback information from one or more sensors 52 associated with the applicator, for processing by the controller 48, e.g., to govern the application of energy and the delivery of processing fluid.
- the I/O device 50 also includes a display 54 , to graphically present processing information to the physician for viewing or analysis.
- the structure of the treatment device 26 and associated electrical energy applicator 30 can vary.
- the illustrated embodiments describe and show four representative categories of energy applicators 30, as follows:
- a first category applicator 30(1) (shown in Figs. 3 and 4) transmits energy into the dermis externally through the epidermis.
- a second category applicator 30(2) (shown in Figs. 6 and 7) transmits energy internally directly into the dermis.
- a third category applicator 30(3) (shown in Figs. 8 and 9) transmits energy into the dermis internally through subcutaneous tissue.
- a fourth category applicator 30(4) (shown in Figs. 10 and 11) transmits energy into the dermis from the backside of a surgically created facelift flap.
- the energy applicator 30(1) includes a carrier grid 56, which is mounted on the distal end of the handle 28.
- the carrier grid 56 is made from an electrically non-conducting material, e.g., plastic or ceramic.
- the carrier grid 56 carries a pattern of multiple, spaced apart electrodes 58. Each electrode
- the electrodes 58 comprises a discrete transmission source of radio frequency energy.
- the electrodes 58 can be made, e.g., from stainless steel, platinum, and other noble metals, or combinations thereof.
- the electrodes 58 may be fastened to the grid by various means, e.g., by adhesives, by painting, or by other coating or deposition techniques.
- the carrier grid 56 is formed by an outside frame 60 with crossing interior spacers 62. Together, the frame 60 and spacers 62 define an open lattice of cells 64. In the illustrated embodiment, the grid 56 defines sixteen cells 64. It should be appreciated that the cells 64 could number more or less than sixteen.
- the electrodes 58 are located on the grid 56 at the four corners of each cell 64. This arrangement provides a symmetric pattern of twenty-five electrodes 58 on the grid 56. Still, it should be appreciated that the electrodes 58 could be arranged in other symmetric or non-symmetric patterns in the grid.
- the energy applicator 30(1) includes an external pad 66, which is attached peripherally about the carrier grid 56.
- the pad 66 is made from a resilient microporous membrane.
- the pad 66 in use, makes surface contact with the epidermis 16.
- the resilience of the pad 66 makes it well suited to conform to a variable surface topography of the epidermis 16.
- the applicator 30(1) further includes a fluid manifold 70 inside the chamber 68.
- the fluid manifold 70 communicates with the fluid delivery apparatus 38, via the handle lumens 42.
- the manifold 70 uniformly introduces processing fluid through the grid 56 and into the interior chamber 68.
- the processing fluid comprises an electrically conductive liquid, such as saline (about 0.9% to 3.0%).
- the apparatus 38 includes a pump 72 to convey the electrically conductive liquid through the manifold 70 at a prescribed rate.
- the microporous membrane of the pad 66 has pores 74 sized to permit passage of the electrically conductive fluid in the chamber 68 through the membrane and into contact with the epidermis 16 the membrane contacts.
- the diffusion of electrically conductive liquid through the membrane pores 74 serves two purposes. First, it creates conductive cooling at the interface between the membrane pad 66 and the epidermis 16. Second, it serves to ionically transport radio frequency energy transmitted by the grid electrodes 58 through the membrane pores 74, for return (in a unipolar arrangement) through exterior patch electrode 76 coupled to patient ground.
- the ionically conducted radio frequency energy transported through the membrane pore 74 will, in turn, cause localized ohmic heating of skin tissue.
- the applicator 30(1) thereby makes possible selective heating of the interior dermis 18 to a maximum tissue temperature TMAX of about 65SC, while maintaining the temperature of the epidermis 16 at or about 20sc to 30SC, thereby avoiding thermal damage to the epidermis 16.
- an electrically conductive jelly can occupy the interior chamber 68.
- the jelly causes ionic transport of radio frequency energy through the membrane pores 74.
- a manifold 78 distributes fluid about the periphery of the pad 66, but not into the chamber 68 itself, to nevertheless cause convective surface cooling effects.
- the fluid distributed by the manifold 78 need not be electrically conductive, but it can be to provide uniform distribution of the radio frequency energy at the pad 66.
- the physician places the pad 66 upon a targeted region of tissue.
- the controller 48 governs the application of radio frequency energy to the electrodes 58 in concert with the delivery of fluid to the manifold 70 (or 78) , to control the desired epidermal and dermal tissue temperature conditions.
- the controller 48 can also govern the withdrawal of fluid from the vicinity of the pad 66 through the aspirating apparatus 40 for this purpose.
- the controller 48 can alter the distribution of the radio frequency energy among selected sets or subsets of one or more grid electrodes 58. In this way, the controller 48 can focus the application of radio frequency in selected patterns.
- the controller 48 can depend upon empirically determined or modeled relationships among selected processing variables, including, e.g., tissue temperature, time, power, and fluid delivery rate, without actual temperature sensing. Preferably, however, localized tissue temperature conditions are sensed to provide direct feedback control, as will be described in greater detail later.
- selected processing variables including, e.g., tissue temperature, time, power, and fluid delivery rate, without actual temperature sensing.
- tissue temperature, time, power, and fluid delivery rate e.g., tissue temperature, time, power, and fluid delivery rate
- the energy applicator pad 66 can comprise a single use component that is temporarily fastened to the handle 28 at time of use, e.g., by a conventional snap-fit, and then removed after use for disposal.
- the pad 66 need not be sized to cover a targeted facial or neck region in its entirety. Instead, the physician can locate the pad 66 in contact with a localized area of epidermal tissue within a targeted region. After applying the desired amount of radio frequency energy, the physician can relocate the pad 66 to an adjacent tissue area in the targeted region and again apply radio frequency energy. The physician can repeat this successive process, until the entire targeted region has been subject to treatment by exposure to radio frequency energy.
- the energy applicator pads 66 can be specially shaped and contoured to provide different geometries, selected to match the topography of the targeted facial or neck region, e.g., under the eye (as pad 66(1) in Fig. 5 shows); or below the ear (as pad 66(2) in Fig. 5 shows); or under the chin (as pad 66(3) in Fig. 5 shows); or around the lips (as pad 66(4) in Fig. 5 shows); or on the forehead above the eyebrows (as pad 66(5) in Fig. 5 shows).
- the second category of energy applicator 30(2) includes a carrier 80 on the distal end of the handle 28.
- the carrier 80 supports an array of spaced-apart needle electrodes 82.
- the electrodes 82 are metallic, being made, e.g., from stainless steel, platinum, other noble metals, or combinations thereof.
- Each electrode 82 comprises a discrete transmission source of radio frequency energy, which the controller 48 governs.
- the carrier 80 can provide physical connections between control wires and each electrode 82, e.g., by solder or adhesive.
- the carrier 80 can have painted, coated, or otherwise deposited solid state circuitry to provide the electrical paths.
- the solid state circuitry can include a fuse element that interrupts electrical contact after a specified period of use, to thereby discourage reuse of the carrier 80.
- the electrodes 82 are intended to be inserted as a unit on the carrier 80 through the epidermis 16 and into the dermis 18.
- the controller 48 conditions the electrodes 82 for operation in a unipolar mode. In this mode, energy transmitted by one or more of the electrodes 82 is returned by an indifferent patch electrode 84, which is coupled to patient ground.
- the controller 48 can condition pairs of electrodes 82 to operate in a bipolar mode, with one electrode serving to transmit radio frequency energy, and the other electrode serving as the return path.
- the size and spacing of the electrodes 82 shown in Figs. 10 and 11 are purposely set to penetrate the skin to a depth sufficient to pass entirely through the epidermis 16 and penetrate the papillary and, preferable, extend into the reticular dermis (e.g., about 200 ⁇ m to 300 ⁇ m) .
- the electrodes 82 each possesses a total length of about 0.5 to about 3.0 mm.
- the electrodes are mutually spaced apart by about 0.5 mm to 10.0 mm.
- An electrical insulating material 86 surrounds the proximal end of each electrode 82 by at least 0.5 mm. This leaves an exposed, non- insulated length at the distal end of about 0.5 mm to 2.5 mm.
- the insulating material 82 insulates the epidermis 16 and a portion of the dermis 18 from direct exposure to radio frequency energy transmitted by the exposed distal end.
- the ratio between exposed and insulated regions on the electrodes 82 affects the impedance of the electrodes 82 during use. Generally speaking, the larger the exposed region is compared to the insulated region, a larger impedance value can be expected.
- the physician places the carrier 80 upon a desired region of tissue. The physician applies light pressure on the handle 28 to insert the needle electrodes 82 through the epidermis 16 and into the dermis 18.
- the controller 48 governs the application of radio frequency energy to the electrodes 82 to ohmically heat adjacent dermal tissue.
- the electrodes 82 can be operated individually or in groups to form defined energy application patterns. As before described, the controller 48 can depend upon the empirically determined or modeled relationships among processing variables to affect process control, with or without actual temperature sensing.
- the handle 28 can comprise a reusable component
- the carrier 80 with electrodes 82 can comprise a single use component, which is temporarily fastened to the distal end of the handle 28 for use and then removed after use for disposal.
- the carrier 80 need not be sized to cover a targeted facial or neck region in its entirety. Instead, the physician can successive locate the carrier 80 in a localized areas within a targeted region, and apply radio frequency energy to each localized area.
- the carrier 80 can also be specially shaped and contoured to provide different geometries, selected to match the topography of the targeted facial or neck region, as shown in Fig. 5.
- the third category of energy applicator 30(3) includes a carrier 88 mounted on the distal end of the handle 28.
- the carrier 88 shown in Fig. 8 holds an array of spaced-apart, metallic needle electrodes 90.
- Each electrode 90 comprises a discrete transmission source of radio frequency energy, which the controller 48 governs.
- the carrier 88 can provide physical connections between control wires and each electrode 90, or carry painted, coated, or otherwise deposited solid state circuitry to provide the electrical paths.
- the needle electrodes 90 shown in Fig. 8 differ from the electrode 82 in Fig. 6 in that they are longer than the needle electrodes 82.
- the longer electrodes 90 are intended to be inserted as a unit through both the epidermis 16 and the dermis 18, and extend into the subcutaneous tissue region 12 a short distance beyond the reticular dermis 22.
- the electrodes 90 each possesses a total length of about 3.0 mm to 10.0 mm.
- the electrodes 90 are mutually spaced apart by about 0.5 mm to 3.0 mm.
- An electrical insulating material 92 surrounds the proximal end of each electrode 90 by at least 2.0 mm. This leaves an exposed, non- insulated length at the distal end of each electrode 90 of about 3.0 mm to 4.0 mm.
- the insulating material 92 insulates the epidermis 16 and dermis 18 from direct exposure to radio frequency energy transmitted by the exposed distal ends of the electrodes 90.
- the needle electrodes 90 include interior fluid passages 94 (see Fig. 8) .
- a manifold 96 couples a select number of the passages 94 in communication with the fluid delivery apparatus 38. This way, processing fluid can be introduced through the electrodes 90 and into the subcutaneous tissue surrounding the distal ends of the electrodes 90.
- the manifold 96 couples other passages 94 in communication with the aspirating device 40, to evacuate material through the distal ends of the electrodes 90.
- the processing fluid comprises an electrically conductive liquid, such as saline.
- the apparatus 38 includes a pump 72 (see Fig. 1) to convey the electrically conductive liquid to the manifold 96 at a prescribed rate.
- the manifold 96 disperses the electrically conductive liquid through the selected passages 94.
- the controller conditions the electrodes 90 to operate in a unipolar mode. Energy transmitted by one or more of the electrodes 90 is returned by an indifferent patch electrode 100, which is coupled to patient ground (see Fig. 9) . At the same time, electrically conductive liquid flows through the selected passages 94 into the surrounding subcutaneous tissue region 12 (shown by arrows 122 in Fig. 9) , while liquid and other material is evacuated through the other passages 94 by the aspirating device 40 (as shown by arrows 124 in Fig.
- the radio frequency energy transmitted by the exposed, distal ends of the electrodes 90 will cause localized ohmic heating of subcutaneous tissue.
- the conduction of the electrically conductive fluid ionically distributes the radio frequency energy in a uniform manner, while also providing a localized cooling effect.
- the cooling effect places the tissue region where maximum temperature conditions exist at a location (designated TMAX in Fig. 9) spaced from the distal ends of the electrodes 90, which includes the reticular dermis 22.
- the localized heating effects will all cause fat tissue 102 in the subcutaneous tissue 12 to flow (see Fig. 9) .
- Suction applied by the aspirating device 40 through the passages 94 can be used to evacuate flowing fat tissue from subcutaneous tissue 12 (as arrows 124 in Fig. 9 show) .
- This provides localized liposuction effects in the subcutaneous region 12 , in tandem with collagen heating effects in the dermis 18.
- the physician places the carrier 88 upon a desired region of tissue.
- the physician applies light pressure on the handle 18 to insert the needle electrodes 90 through the epidermis 16 and dermis 18 and into a subcutaneous tissue region 12.
- the controller 48 governs the application of radio frequency energy to the electrodes 90, which can be operated individually or in defined patterns.
- the carrier 88 need not be sized to cover an entire targeted region.
- the physician can locate the carrier 88 in successive local areas within a targeted region, and apply radio frequency energy to each localized area.
- the carrier 88 can also be specially shaped and contoured to provide different geometries, selected to match the topography of the targeted facial or neck region, as shown in Fig. 5.
- controller 48 can depend upon the empirically determined or modeled relationships among processing variables to affect process control, with or without actual temperature sensing.
- the handle 28 can comprise a reusable component
- the carrier 88 and needle electrodes 90 can comprise a single use component that is temporarily fastened to the handle 28 for use and then removed after use for disposal.
- the fourth category of energy applicator 30(4) likewise includes a carrier 104 on the distal end of the handle 28.
- the carrier 104 holds a pair of bipolar metallic electrodes 106.
- energy transmitted by one of the electrodes 106 is returned by the other electrode 106 to patient ground.
- the carrier 104 can hold an array of several needle electrodes, which are operated in either a bipolar or unipolar mode.
- the physician surgically creates a facelift flap 108 in the targeted tissue region.
- the flap 108 extends well into the dermis 18 (e.g., 200 ⁇ m to 300 ⁇ m) .
- the physician inserts the needle electrodes 106 into the backside of the flap 108 and applies radio frequency energy.
- the size and spacing of the electrodes 106 are purposely set to penetrate into the backside of the skin flap 108 to a depth sufficient to locate the distal ends of the electrodes 106 in dermal tissue.
- the electrodes 106 each possesses a total length of about 3.0 mm to 8.0 mm.
- the electrodes 106 are mutually spaced apart by about 0.5 mm to 10.0 mm.
- the applicator 30(4) can comprise an array of surface electrodes 106 that do not penetrate the skin flap 108, but which rest on the surface of the backside of the skin flap.
- the controller 48 governs application of radio frequency energy to achieve the desired tissue effects.
- the handle 28 can comprise a reusable component, and the carrier 104 and electrodes 106 can comprise a single use component that is temporarily fastened to the handle for use and then removed after use for disposal.
- the controller 48 preferable relies upon sensing tissue temperature conditions as a form of active process feedback control.
- the energy applicator carries at least one sensor 112 (see Fig. 12) , which senses tissue temperature conditions.
- the at least one sensor 112 is located beneath the epidermis 16 and into the dermis 18 (see Fig. 13) , to sense actual tissue temperature conditions in the dermis 18.
- an array of probes 114 is arranged in a spaced-apart relationship along the periphery of the pad 66.
- Each probe 114 carries at least one temperature sensor 112.
- the probes 114 extend through the epidermis 16 and into the dermis 18, as Fig. 13 shows.
- each needle electrode 82, 90, or 106 can carry at least one temperature sensor 112.
- probes could be used to carry the sensors 112, in the manner shown in Figs. 12 and 13.
- the sensors 112 are located so that, in use, they are positioned in the region of the dermis 118 where radio frequency heating is targeted, as Fig. 14 shows.
- a tissue penetrating probe 116 (or needle electrode, as the case may be) may support a vertically stacked array 118 of temperature sensors 120.
- the temperature sensors 120 are arranged at known, fixed intervals along the probe 116.
- the stacked sensors 120 sense a dermal tissue temperature gradient along the length of the probe 116.
- the sensing of a temperature gradient within dermal tissue targeted for radio frequency heating permits the controller 48 to identify along the gradient the location of the maximum tissue temperature region TMAX.
- the controller 48 can include an algorithm that selects the maximum tissue temperature TMAX and also identifies the depth D(TMAX) at which the maximum tissue temperature occurs.
- the controller 48 can adjust the maximum tissue temperature TMAX to achieve the desired control point temperature, which for collagen shrinkage is 652 c.
- the controller 48 can also establish and maintain a control depth (D(TMAX) at which the desired control point temperature occurs, e.g., at a skin depth of 200 ⁇ m to 300 ⁇ m (pre-set or set by the physician) , to achieve optimal collagen shrinkage.
- D(TMAX) a control depth at which the desired control point temperature occurs, e.g., at a skin depth of 200 ⁇ m to 300 ⁇ m (pre-set or set by the physician) , to achieve optimal collagen shrinkage.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
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AU36964/00A AU757624B2 (en) | 1999-02-17 | 2000-02-02 | Systems and methods for shrinking collagen in the dermis |
EP00915739A EP1152701A2 (en) | 1999-02-17 | 2000-02-02 | Systems and methods for shrinking collagen in the dermis |
CA002362276A CA2362276A1 (en) | 1999-02-17 | 2000-02-02 | Systems and methods for shrinking collagen in the dermis |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US09/251,554 US6277116B1 (en) | 1994-05-06 | 1999-02-17 | Systems and methods for shrinking collagen in the dermis |
US09/251,554 | 1999-02-17 |
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WO2000048644A2 WO2000048644A2 (en) | 2000-08-24 |
WO2000048644A3 WO2000048644A3 (en) | 2000-12-14 |
WO2000048644A9 true WO2000048644A9 (en) | 2002-03-28 |
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PCT/US2000/002778 WO2000048644A2 (en) | 1999-02-17 | 2000-02-02 | Systems and methods for shrinking collagen in the dermis |
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US (1) | US6277116B1 (en) |
EP (1) | EP1152701A2 (en) |
AU (1) | AU757624B2 (en) |
CA (1) | CA2362276A1 (en) |
WO (1) | WO2000048644A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9095357B2 (en) | 2004-04-01 | 2015-08-04 | The General Hospital Corporation | Method and apparatus for dermatological treatment and tissue reshaping |
Families Citing this family (207)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6024733A (en) * | 1995-06-07 | 2000-02-15 | Arthrocare Corporation | System and method for epidermal tissue ablation |
US6425912B1 (en) * | 1995-05-05 | 2002-07-30 | Thermage, Inc. | Method and apparatus for modifying skin surface and soft tissue structure |
US7758537B1 (en) | 1995-11-22 | 2010-07-20 | Arthrocare Corporation | Systems and methods for electrosurgical removal of the stratum corneum |
US20030212393A1 (en) * | 1996-01-05 | 2003-11-13 | Knowlton Edward W. | Handpiece with RF electrode and non-volatile memory |
US7229436B2 (en) | 1996-01-05 | 2007-06-12 | Thermage, Inc. | Method and kit for treatment of tissue |
US6091995A (en) * | 1996-11-08 | 2000-07-18 | Surx, Inc. | Devices, methods, and systems for shrinking tissues |
US6104959A (en) | 1997-07-31 | 2000-08-15 | Microwave Medical Corp. | Method and apparatus for treating subcutaneous histological features |
US6391023B1 (en) | 1998-05-28 | 2002-05-21 | Pearl Technology Holdings, Llc | Thermal radiation facelift device |
US7494488B2 (en) * | 1998-05-28 | 2009-02-24 | Pearl Technology Holdings, Llc | Facial tissue strengthening and tightening device and methods |
EP2428249B1 (en) * | 1998-07-13 | 2015-10-07 | Inovio Pharmaceuticals, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
US6678556B1 (en) * | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
US7922709B2 (en) | 1998-07-13 | 2011-04-12 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
EP1158919B1 (en) * | 1999-03-09 | 2005-06-29 | Thermage, Inc. | Apparatus for treatment of tissue |
US6587730B2 (en) * | 1999-07-27 | 2003-07-01 | Mattioli Engineering Ltd. | Method and apparatus for skin brown spot removal and collagen formation |
US20020087155A1 (en) * | 1999-08-30 | 2002-07-04 | Underwood Ronald A. | Systems and methods for intradermal collagen stimulation |
CN1420748A (en) * | 1999-12-30 | 2003-05-28 | 珍品技术控股有限公司 | Face-lifting device |
US20080033492A1 (en) * | 2000-01-07 | 2008-02-07 | Biowave Corporation | Electro-therapy method |
US20070016268A1 (en) * | 2000-01-07 | 2007-01-18 | John Carter | Percutaneous electrode array |
US20040092860A1 (en) * | 2000-07-26 | 2004-05-13 | Dev Nagendu B. | Skin and muscle-targeted gene therapy by pulsed electrical field |
US6673063B2 (en) * | 2000-10-06 | 2004-01-06 | Expanding Concepts, Llc. | Epidural thermal posterior annuloplasty |
US6740085B2 (en) * | 2000-11-16 | 2004-05-25 | Olympus Corporation | Heating treatment system |
US20040162551A1 (en) * | 2000-12-15 | 2004-08-19 | Brown Tony R. | Method and device for creating transmural lesions |
US7422586B2 (en) * | 2001-02-28 | 2008-09-09 | Angiodynamics, Inc. | Tissue surface treatment apparatus and method |
ATE387374T1 (en) * | 2002-02-22 | 2008-03-15 | Bombardier Recreational Prod | THREE-WHEEL VEHICLE WITH TWO-PART RADIATOR AND INNER STORAGE COMPARTMENT |
US6662054B2 (en) * | 2002-03-26 | 2003-12-09 | Syneron Medical Ltd. | Method and system for treating skin |
WO2004004545A2 (en) * | 2002-07-03 | 2004-01-15 | Expanding Concepts, L.L.C. | Ribbon epidural thermal posterior annuloplasty |
US8986297B2 (en) * | 2002-08-21 | 2015-03-24 | Resect Medical, Inc. | Thermal hemostasis and/or coagulation of tissue |
US7341586B2 (en) * | 2002-08-21 | 2008-03-11 | Resect Medical, Inc. | Thermal coagulation of tissue during tissue resection |
AU2004226378A1 (en) * | 2003-03-27 | 2004-10-14 | The General Hospital Corporation | Method and apparatus for dermatological treatment and fractional skin resurfacing |
GB0322766D0 (en) * | 2003-09-29 | 2003-10-29 | Emcision Ltd | Surgical resection device |
US7613523B2 (en) * | 2003-12-11 | 2009-11-03 | Apsara Medical Corporation | Aesthetic thermal sculpting of skin |
GB0402569D0 (en) * | 2004-02-05 | 2004-03-10 | Neurodan As | Nerve and/or muscle stimulation electrodes |
CA2579146C (en) * | 2004-04-01 | 2016-06-21 | The General Hospital Corporation | Method and apparatus for dermatological treatment |
US20080082090A1 (en) * | 2004-04-01 | 2008-04-03 | The General Hospital Corporation | Method and apparatus for dermatological treatment and tissue reshaping |
EP3695799A1 (en) * | 2004-04-05 | 2020-08-19 | The General Hospital Corporation | Device and method for treating tissue |
US8571648B2 (en) * | 2004-05-07 | 2013-10-29 | Aesthera | Apparatus and method to apply substances to tissue |
US7842029B2 (en) * | 2004-05-07 | 2010-11-30 | Aesthera | Apparatus and method having a cooling material and reduced pressure to treat biological external tissue |
US20060047281A1 (en) * | 2004-09-01 | 2006-03-02 | Syneron Medical Ltd. | Method and system for invasive skin treatment |
ES2645676T3 (en) * | 2004-10-19 | 2017-12-07 | Meagan Medical, Inc. | Means for electrical stimulation of sensitive skin receptors |
US8417352B2 (en) * | 2004-10-19 | 2013-04-09 | Meagan Medical, Inc. | System and method for stimulating sensory nerves |
US20120226271A1 (en) * | 2005-03-25 | 2012-09-06 | Peter Callas | Vacuum Ablation Apparatus and Method |
US7850683B2 (en) | 2005-05-20 | 2010-12-14 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
US7713266B2 (en) * | 2005-05-20 | 2010-05-11 | Myoscience, Inc. | Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat) |
US8024022B2 (en) * | 2005-05-25 | 2011-09-20 | Alfred E. Mann Foundation For Scientific Research | Hermetically sealed three-dimensional electrode array |
US20060287615A1 (en) * | 2005-06-15 | 2006-12-21 | Tsung-I Yu | Massaging mask |
WO2007019365A2 (en) * | 2005-08-03 | 2007-02-15 | Massachusetts Eye & Ear Infirmary | Targeted muscle ablation for reducing signs of aging |
US8518069B2 (en) | 2005-09-07 | 2013-08-27 | Cabochon Aesthetics, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US10548659B2 (en) | 2006-01-17 | 2020-02-04 | Ulthera, Inc. | High pressure pre-burst for improved fluid delivery |
US9486274B2 (en) | 2005-09-07 | 2016-11-08 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
CA2621535A1 (en) * | 2005-09-07 | 2007-03-15 | The Foundry, Inc. | Apparatus and method for disrupting subcutaneous structures |
US9011473B2 (en) | 2005-09-07 | 2015-04-21 | Ulthera, Inc. | Dissection handpiece and method for reducing the appearance of cellulite |
US9358033B2 (en) * | 2005-09-07 | 2016-06-07 | Ulthera, Inc. | Fluid-jet dissection system and method for reducing the appearance of cellulite |
US7967763B2 (en) * | 2005-09-07 | 2011-06-28 | Cabochon Aesthetics, Inc. | Method for treating subcutaneous tissues |
US7957815B2 (en) | 2005-10-11 | 2011-06-07 | Thermage, Inc. | Electrode assembly and handpiece with adjustable system impedance, and methods of operating an energy-based medical system to treat tissue |
US8702691B2 (en) | 2005-10-19 | 2014-04-22 | Thermage, Inc. | Treatment apparatus and methods for delivering energy at multiple selectable depths in tissue |
US20070142885A1 (en) * | 2005-11-29 | 2007-06-21 | Reliant Technologies, Inc. | Method and Apparatus for Micro-Needle Array Electrode Treatment of Tissue |
US9248317B2 (en) | 2005-12-02 | 2016-02-02 | Ulthera, Inc. | Devices and methods for selectively lysing cells |
US7885793B2 (en) | 2007-05-22 | 2011-02-08 | International Business Machines Corporation | Method and system for developing a conceptual model to facilitate generating a business-aligned information technology solution |
US20080195036A1 (en) * | 2005-12-02 | 2008-08-14 | Cabochon Aesthetics, Inc. | Devices and methods for selectively lysing cells |
US7920926B2 (en) * | 2005-12-09 | 2011-04-05 | Apsara Medical Corporation | Method and apparatus for carrying out the controlled heating of tissue in the region of dermis |
US8048089B2 (en) | 2005-12-30 | 2011-11-01 | Edge Systems Corporation | Apparatus and methods for treating the skin |
WO2007092610A2 (en) | 2006-02-07 | 2007-08-16 | Tivamed, Inc. | Vaginal remodeling device and methods |
US20070213705A1 (en) * | 2006-03-08 | 2007-09-13 | Schmid Peter M | Insulated needle and system |
ITRM20060166A1 (en) * | 2006-03-24 | 2007-09-25 | Promoitalia Internat Srl | SUBDERMAL PROBE FOR AESTHETIC RADIOFREQUENCY TREATMENTS |
US9566088B2 (en) | 2006-03-29 | 2017-02-14 | Edge Systems Llc | Devices, systems and methods for treating the skin |
US20070244529A1 (en) * | 2006-04-18 | 2007-10-18 | Zoom Therapeutics, Inc. | Apparatus and methods for treatment of nasal tissue |
CA2905086C (en) | 2006-05-12 | 2021-03-30 | Hira V. Thapliyal | Device for ablating body tissue |
EP2034917A2 (en) * | 2006-07-05 | 2009-03-18 | Bovie Medical | Apparatus and method for skin tightening and corrective forming |
US20080027520A1 (en) * | 2006-07-25 | 2008-01-31 | Zoom Therapeutics, Inc. | Laser treatment of tissue |
US20080027423A1 (en) * | 2006-07-25 | 2008-01-31 | Zoom Therapeutics, Inc. | Systems for treatment of nasal tissue |
US8273080B2 (en) | 2006-10-16 | 2012-09-25 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US8133216B2 (en) | 2006-10-16 | 2012-03-13 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US8007493B2 (en) | 2006-10-16 | 2011-08-30 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US8142426B2 (en) * | 2006-10-16 | 2012-03-27 | Syneron Medical Ltd. | Methods and devices for treating tissue |
US20080097557A1 (en) * | 2006-10-19 | 2008-04-24 | Apsara Medical Corporation | Method and apparatus for carrying out the controlled heating of tissue in the region of dermis |
US9254162B2 (en) | 2006-12-21 | 2016-02-09 | Myoscience, Inc. | Dermal and transdermal cryogenic microprobe systems |
WO2008091983A2 (en) * | 2007-01-25 | 2008-07-31 | Thermage, Inc. | Treatment apparatus and methods for inducing microburn patterns in tissue |
US8211099B2 (en) * | 2007-01-31 | 2012-07-03 | Tyco Healthcare Group Lp | Thermal feedback systems and methods of using the same |
US8409185B2 (en) | 2007-02-16 | 2013-04-02 | Myoscience, Inc. | Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling |
JP2010524589A (en) | 2007-04-19 | 2010-07-22 | ザ ファウンドリー, インコーポレイテッド | Method, apparatus and system for non-invasive delivery of microwave therapy |
EP2532320A3 (en) | 2007-04-19 | 2013-04-03 | Miramar Labs, Inc. | Apparatus for reducing sweat production |
EP2837351B1 (en) | 2007-04-19 | 2018-05-30 | Miramar Labs, Inc. | Systems for creating an effect using microwave energy to specified tissue |
US20100211059A1 (en) | 2007-04-19 | 2010-08-19 | Deem Mark E | Systems and methods for creating an effect using microwave energy to specified tissue |
US20080269735A1 (en) * | 2007-04-26 | 2008-10-30 | Agustina Vila Echague | Optical array for treating biological tissue |
US9364287B2 (en) * | 2007-06-05 | 2016-06-14 | Reliant Technologies, Inc. | Method for reducing pain of dermatological treatments |
US20080312648A1 (en) * | 2007-06-12 | 2008-12-18 | Darion Peterson | Fat removal and sculpting device |
US20120143178A9 (en) * | 2007-06-15 | 2012-06-07 | Primaeva Medical, Inc. | Devices and methods for percutaneous energy delivery |
US8845630B2 (en) | 2007-06-15 | 2014-09-30 | Syneron Medical Ltd | Devices and methods for percutaneous energy delivery |
US20090012434A1 (en) * | 2007-07-03 | 2009-01-08 | Anderson Robert S | Apparatus, method, and system to treat a volume of skin |
WO2009009661A1 (en) | 2007-07-10 | 2009-01-15 | Thermage, Inc. | Treatment apparatus and methods for delivering high frequency energy across large tissue areas |
US8103355B2 (en) * | 2007-07-16 | 2012-01-24 | Invasix Ltd | Method and device for minimally invasive skin and fat treatment |
US20090069795A1 (en) * | 2007-09-10 | 2009-03-12 | Anderson Robert S | Apparatus and method for selective treatment of tissue |
WO2009042268A1 (en) * | 2007-09-28 | 2009-04-02 | Choi George Y | Device and methods for treatment of tissue |
US20090093723A1 (en) * | 2007-10-05 | 2009-04-09 | Cabochon Aesthetics, Inc. | Ultrasound device including dispenser |
US20090093864A1 (en) * | 2007-10-08 | 2009-04-09 | Anderson Robert S | Methods and devices for applying energy to tissue |
EP2209424A1 (en) * | 2007-10-09 | 2010-07-28 | Cabochon Aesthetics, Inc. | Ultrasound apparatus with treatment lens |
US8439940B2 (en) | 2010-12-22 | 2013-05-14 | Cabochon Aesthetics, Inc. | Dissection handpiece with aspiration means for reducing the appearance of cellulite |
US20090093738A1 (en) * | 2007-10-09 | 2009-04-09 | Cabochon Aesthetics, Inc. | Device and method for monitoring a treatment area |
US20090157152A1 (en) * | 2007-10-19 | 2009-06-18 | Shiseido Company, Ltd. | Cosmetic method for improving skin condition of face and neck, and apparatus thereof |
EP2209432B1 (en) | 2007-10-31 | 2013-12-25 | Syneron Medical Ltd. | Energy delivery device comprising an electrode cartridge |
US20090112205A1 (en) * | 2007-10-31 | 2009-04-30 | Primaeva Medical, Inc. | Cartridge electrode device |
WO2009065061A1 (en) | 2007-11-14 | 2009-05-22 | Myoscience, Inc. | Pain management using cryogenic remodeling |
KR101287351B1 (en) * | 2007-12-05 | 2013-07-23 | 시네론 메디컬 리미티드 | A carrier for use in a skin treatment apparatus |
US20090156958A1 (en) | 2007-12-12 | 2009-06-18 | Mehta Bankim H | Devices and methods for percutaneous energy delivery |
KR102052152B1 (en) | 2007-12-12 | 2020-01-08 | 미라마 랩스 인코포레이티드 | A disposable medical apparatus for use with an applicator which radiates microwave energy |
EP2231274B1 (en) | 2007-12-12 | 2014-03-12 | Miramar Labs, Inc. | System and apparatus for the noninvasive treatment of tissue using microwave energy |
KR101836310B1 (en) | 2008-01-04 | 2018-03-08 | 엣지 시스템즈 엘엘씨 | Appratus and method for treating the skin |
DE202009017814U1 (en) | 2008-01-17 | 2010-07-01 | Syneron Medical Ltd. | Hair removal device for personal use |
JP2011509791A (en) | 2008-01-24 | 2011-03-31 | シネロン メディカル リミテッド | Apparatus, device and method for adipose tissue treatment |
WO2009099988A2 (en) * | 2008-02-01 | 2009-08-13 | The General Hospital Corporation | Method and apparatus for fat removal |
KR100852500B1 (en) * | 2008-03-31 | 2008-08-18 | (주)엠큐어 | Gun type multi injection microneedle theraphy system |
JP5181791B2 (en) * | 2008-04-03 | 2013-04-10 | ソニー株式会社 | Voltage controlled variable frequency oscillation circuit and signal processing circuit |
US8682426B2 (en) * | 2008-04-07 | 2014-03-25 | Old Dominion Research Foundation | Delivery device, system, and method for delivering nanosecond pulsed electric fields |
EP2907465A1 (en) | 2008-04-17 | 2015-08-19 | Miramar Labs, Inc. | Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy |
US9155588B2 (en) | 2008-06-13 | 2015-10-13 | Vytronus, Inc. | System and method for positioning an elongate member with respect to an anatomical structure |
US20090312693A1 (en) * | 2008-06-13 | 2009-12-17 | Vytronus, Inc. | System and method for delivering energy to tissue |
US20090312673A1 (en) * | 2008-06-14 | 2009-12-17 | Vytronus, Inc. | System and method for delivering energy to tissue |
US8882753B2 (en) * | 2008-07-14 | 2014-11-11 | Syneron Medical Ltd | Devices and methods for percutaneous energy delivery |
WO2010009150A1 (en) | 2008-07-14 | 2010-01-21 | Primaeva Medical, Inc. | Devices and methods for percutaneous energy delivery |
US9314293B2 (en) | 2008-07-16 | 2016-04-19 | Syneron Medical Ltd | RF electrode for aesthetic and body shaping devices and method of using same |
US20100017750A1 (en) | 2008-07-16 | 2010-01-21 | Avner Rosenberg | User interface |
US10363057B2 (en) | 2008-07-18 | 2019-07-30 | Vytronus, Inc. | System and method for delivering energy to tissue |
US20100049099A1 (en) * | 2008-07-18 | 2010-02-25 | Vytronus, Inc. | Method and system for positioning an energy source |
KR101013581B1 (en) * | 2008-08-06 | 2011-02-14 | 라종주 | Electric Skin Treatment Device |
CN102143724B (en) * | 2008-08-07 | 2015-02-25 | 通用医疗公司 | Method and apparatus for dermatological hypopigmentation |
EP2163218A1 (en) * | 2008-09-16 | 2010-03-17 | Osyris Medical | Device for treating part of a human or animal body comprising an instrument for dispensing and/or an instrument for locally sucking up treatment doses and means for controlling dosimetry |
EP2334249B1 (en) | 2008-09-21 | 2013-03-13 | Syneron Medical Ltd. | A method and apparatus for personal skin treatment |
US20100106063A1 (en) * | 2008-10-29 | 2010-04-29 | Cabochon Aesthetics, Inc. | Ultrasound Enhancing Target for Treating Subcutaneous Tissue |
US8414508B2 (en) | 2008-10-30 | 2013-04-09 | Vytronus, Inc. | System and method for delivery of energy to tissue while compensating for collateral tissue |
US9220924B2 (en) | 2008-10-30 | 2015-12-29 | Vytronus, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US9033885B2 (en) * | 2008-10-30 | 2015-05-19 | Vytronus, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US11298568B2 (en) | 2008-10-30 | 2022-04-12 | Auris Health, Inc. | System and method for energy delivery to tissue while monitoring position, lesion depth, and wall motion |
US9192789B2 (en) | 2008-10-30 | 2015-11-24 | Vytronus, Inc. | System and method for anatomical mapping of tissue and planning ablation paths therein |
US8475379B2 (en) * | 2008-11-17 | 2013-07-02 | Vytronus, Inc. | Systems and methods for ablating body tissue |
WO2010057211A1 (en) | 2008-11-17 | 2010-05-20 | Vytronus, Inc. | Systems and methods for ablating body tissue |
US8357150B2 (en) | 2009-07-20 | 2013-01-22 | Syneron Medical Ltd. | Method and apparatus for fractional skin treatment |
JP5642087B2 (en) | 2008-12-22 | 2014-12-17 | ミオサイエンス インコーポレーティッド | Integrated cryosurgery system with refrigerant and power supply |
US8882758B2 (en) * | 2009-01-09 | 2014-11-11 | Solta Medical, Inc. | Tissue treatment apparatus and systems with pain mitigation and methods for mitigating pain during tissue treatments |
US8506506B2 (en) | 2009-01-12 | 2013-08-13 | Solta Medical, Inc. | Tissue treatment apparatus with functional mechanical stimulation and methods for reducing pain during tissue treatments |
KR100943089B1 (en) * | 2009-01-23 | 2010-02-18 | 강동환 | Handpiece for treating skin |
US9254168B2 (en) * | 2009-02-02 | 2016-02-09 | Medtronic Advanced Energy Llc | Electro-thermotherapy of tissue using penetrating microelectrode array |
US20100211055A1 (en) * | 2009-02-18 | 2010-08-19 | Shimon Eckhouse | Method for body toning and an integrated data management system for the same |
KR20120090007A (en) | 2009-02-25 | 2012-08-16 | 프리마바 메디컬, 아이엔씨. | Devices and methods for percutaneous energy delivery |
EP2730313A1 (en) | 2009-02-25 | 2014-05-14 | Syneron Medical Ltd. | Electrical skin rejuvenation |
US8167280B2 (en) * | 2009-03-23 | 2012-05-01 | Cabochon Aesthetics, Inc. | Bubble generator having disposable bubble cartridges |
US20100249772A1 (en) * | 2009-03-26 | 2010-09-30 | Primaeva Medical, Inc. | Treatment of skin deformation |
US20100256596A1 (en) * | 2009-04-07 | 2010-10-07 | Cabochon Aesthetics, Inc. | Fiber growth promoting implants for reducing the appearance of cellulite |
WO2010144560A2 (en) * | 2009-06-09 | 2010-12-16 | The General Hospital Corporation | Method and apparatus for dermatological treatment and tissue reshaping |
US8788060B2 (en) * | 2009-07-16 | 2014-07-22 | Solta Medical, Inc. | Tissue treatment systems with high powered functional electrical stimulation and methods for reducing pain during tissue treatments |
WO2011016019A1 (en) * | 2009-08-04 | 2011-02-10 | Pollogen Ltd. | Cosmetic skin rejuvination |
US11096708B2 (en) | 2009-08-07 | 2021-08-24 | Ulthera, Inc. | Devices and methods for performing subcutaneous surgery |
US9358064B2 (en) | 2009-08-07 | 2016-06-07 | Ulthera, Inc. | Handpiece and methods for performing subcutaneous surgery |
EP2477695B1 (en) | 2009-09-18 | 2015-10-21 | Viveve Inc. | Vaginal remodeling device |
US8361069B2 (en) * | 2009-09-25 | 2013-01-29 | Covidien Lp | Energized needles for wound sealing |
AU2010317380B2 (en) | 2009-11-16 | 2016-02-11 | Pollogen Ltd. | Non-invasive fat removal |
US11590346B2 (en) | 2009-11-16 | 2023-02-28 | Pollogen Ltd. | Apparatus and method for cosmetic treatment of human mucosal tissue |
US20110202048A1 (en) * | 2010-02-12 | 2011-08-18 | Solta Medical, Inc. | Methods for pain reduction with functional thermal stimulation and tissue treatment systems |
PL2542300T3 (en) * | 2010-03-01 | 2017-06-30 | Inovio Pharmaceuticals, Inc. | A tolerable and minimally invasive skin electroporation device |
WO2011163264A2 (en) | 2010-06-21 | 2011-12-29 | Candela Corporation | Driving microneedle arrays into skin and delivering rf energy |
US8968289B2 (en) | 2010-10-22 | 2015-03-03 | Covidien Lp | Microwave spacers and methods of use |
US9433781B2 (en) * | 2010-12-03 | 2016-09-06 | Syneron Medical Ltd. | Method and apparatus for improving electrode-skin contact |
CA2820731A1 (en) | 2010-12-13 | 2012-06-21 | Myoscience, Inc. | Method for reducing hyperdynamic facial wrinkles |
CN102631243B (en) * | 2011-02-15 | 2014-09-17 | 成功大学 | Therapeutic device for electromagnetic thermotherapy |
US9409006B2 (en) * | 2011-04-10 | 2016-08-09 | David Hirshberg | Fat removal device and obesity treatment |
US20120271219A1 (en) * | 2011-04-19 | 2012-10-25 | David John Weisgerber | Combined Energy and Topical Composition Application For Regulating the Condition of Mammalian Skin |
US20120270743A1 (en) * | 2011-04-19 | 2012-10-25 | David John Weisgerber | Genetic Signatures and Gene Chips Associated With Administration of Electrically Conducted Radio Frequency Current to Skin and Methods and Treatments Relating Thereto |
KR101277450B1 (en) * | 2011-04-21 | 2013-06-27 | 주식회사 루트로닉 | A treatment apparutus using radio frequency energy |
WO2012173405A2 (en) * | 2011-06-14 | 2012-12-20 | Na Jong Ju | Apparatus and method for improving skin using a ra-effect or ra plus-effect |
WO2013066427A1 (en) * | 2011-06-28 | 2013-05-10 | Inovio Pharmaceuticals, Inc. | A miniminally invasive dermal electroporation device |
US9314301B2 (en) | 2011-08-01 | 2016-04-19 | Miramar Labs, Inc. | Applicator and tissue interface module for dermatological device |
EP2564895B1 (en) * | 2011-09-05 | 2015-11-18 | Venus Concept Ltd | An improved esthetic device for beautifying skin |
CN103945786B (en) * | 2011-11-24 | 2017-03-08 | 赛诺龙医疗公司 | Safe skin care appliances for personal use and its using method |
CA2860893A1 (en) | 2012-01-13 | 2013-07-18 | Myoscience, Inc. | Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments |
EP2802278B1 (en) | 2012-01-13 | 2016-12-07 | Myoscience, Inc. | Cryogenic probe filtration system |
US9314290B2 (en) | 2012-01-13 | 2016-04-19 | Myoscience, Inc. | Cryogenic needle with freeze zone regulation |
US9017318B2 (en) | 2012-01-20 | 2015-04-28 | Myoscience, Inc. | Cryogenic probe system and method |
US9277958B2 (en) | 2012-02-22 | 2016-03-08 | Candela Corporation | Reduction of RF electrode edge effect |
US9889297B2 (en) | 2012-02-22 | 2018-02-13 | Candela Corporation | Reduction of RF electrode edge effect |
CN105919666A (en) | 2012-03-16 | 2016-09-07 | 女康乐公司 | Therapy equipment for repairing female vaginal tissue |
DE102012010262B4 (en) * | 2012-05-25 | 2014-07-03 | Albrecht Molsberger | Therapeutically applicable DC delivery device |
US20140088670A1 (en) * | 2012-09-25 | 2014-03-27 | Ines Verner Rashkovsky | Devices and methods for stimulation of hair growth |
US20140188107A1 (en) | 2012-12-31 | 2014-07-03 | Paul Joseph Weber | Methods and systems for tissue dissection and modification |
US10045761B2 (en) | 2012-12-31 | 2018-08-14 | Tdm Surgitech, Inc. | Systems, apparatus and methods for tissue dissection |
DE102013000966A1 (en) * | 2013-01-22 | 2014-07-24 | Zimmer Medizinsysteme Gmbh | Method and apparatus for continuous non-invasive measurement of tissue temperatures at different tissue depths |
US9962546B2 (en) | 2013-02-21 | 2018-05-08 | Meagan Medical, Inc. | Cutaneous field stimulation with disposable and rechargeable components |
WO2014146127A1 (en) | 2013-03-15 | 2014-09-18 | Myoscience, Inc. | Methods and systems for treatment of spasticity |
US20140350536A1 (en) | 2013-03-15 | 2014-11-27 | Myoscience, Inc. | Cryogenic Blunt Dissection Methods and Devices |
US9610112B2 (en) | 2013-03-15 | 2017-04-04 | Myoscience, Inc. | Cryogenic enhancement of joint function, alleviation of joint stiffness and/or alleviation of pain associated with osteoarthritis |
US9295512B2 (en) | 2013-03-15 | 2016-03-29 | Myoscience, Inc. | Methods and devices for pain management |
EP3437575B1 (en) | 2013-03-15 | 2021-04-21 | Edge Systems LLC | Devices and systems for treating the skin |
US9827140B2 (en) | 2013-07-17 | 2017-11-28 | William Thomas McClellan | Percutaneous blepharoplasty device and method |
WO2015013502A2 (en) | 2013-07-24 | 2015-01-29 | Miramar Labs, Inc. | Apparatus and methods for the treatment of tissue using microwave energy |
US20150342661A1 (en) * | 2013-10-09 | 2015-12-03 | Venus Concept Ltd | Integrated Treatment System |
US10130409B2 (en) | 2013-11-05 | 2018-11-20 | Myoscience, Inc. | Secure cryosurgical treatment system |
CN107206234B (en) * | 2014-07-24 | 2021-05-11 | 希纳普斯提姆有限公司 | Device and method for delivering stimulation to body tissue |
EP3795204B1 (en) | 2014-12-23 | 2023-10-25 | HydraFacial LLC | Device for treating the skin using a rollerball |
US10179229B2 (en) | 2014-12-23 | 2019-01-15 | Edge Systems Llc | Devices and methods for treating the skin using a porous member |
EP3454762B1 (en) | 2016-05-13 | 2024-04-03 | Pacira CryoTech, Inc. | Systems for locating and treating with cold therapy |
US11511110B2 (en) | 2018-06-27 | 2022-11-29 | Viveve, Inc. | Methods for treating urinary stress incontinence |
US11896823B2 (en) | 2017-04-04 | 2024-02-13 | Btl Healthcare Technologies A.S. | Method and device for pelvic floor tissue treatment |
KR20200067837A (en) * | 2017-08-29 | 2020-06-12 | 팻치미 인코포레이티드 | Microneedle treatment system |
US11134998B2 (en) | 2017-11-15 | 2021-10-05 | Pacira Cryotech, Inc. | Integrated cold therapy and electrical stimulation systems for locating and treating nerves and associated methods |
EP3870090B1 (en) | 2018-10-23 | 2023-09-27 | Aesthetics Biomedical, Inc. | Systems for inducing collagen regeneration |
FR3122826A1 (en) | 2021-05-12 | 2022-11-18 | L'oreal | METHODS AND COMPOSITIONS FOR IMPROVING SKIN |
FR3124952A1 (en) | 2021-07-09 | 2023-01-13 | L'oreal | Methods and compositions for improving the skin |
US11779389B2 (en) | 2021-08-27 | 2023-10-10 | Ilooda Co., Ltd. | Skin treatment device |
USD1016615S1 (en) | 2021-09-10 | 2024-03-05 | Hydrafacial Llc | Container for a skin treatment device |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4448198A (en) * | 1979-06-19 | 1984-05-15 | Bsd Medical Corporation | Invasive hyperthermia apparatus and method |
US6068653A (en) * | 1992-11-13 | 2000-05-30 | Scimed Life Systems, Inc. | Electrophysiology catheter device |
US5374283A (en) * | 1993-12-01 | 1994-12-20 | Flick; A. Bart | Electrical therapeutic apparatus |
DE4414807C2 (en) * | 1994-04-28 | 1996-10-02 | Willmen Hans Rainer | Electrosurgical instrument for the therapy of varices |
US5458596A (en) * | 1994-05-06 | 1995-10-17 | Dorsal Orthopedic Corporation | Method and apparatus for controlled contraction of soft tissue |
US5681308A (en) * | 1994-06-24 | 1997-10-28 | Stuart D. Edwards | Ablation apparatus for cardiac chambers |
US5588960A (en) * | 1994-12-01 | 1996-12-31 | Vidamed, Inc. | Transurethral needle delivery device with cystoscope and method for treatment of urinary incontinence |
US6430446B1 (en) * | 1995-05-05 | 2002-08-06 | Thermage, Inc. | Apparatus for tissue remodeling |
US5660836A (en) * | 1995-05-05 | 1997-08-26 | Knowlton; Edward W. | Method and apparatus for controlled contraction of collagen tissue |
US6077257A (en) * | 1996-05-06 | 2000-06-20 | Vidacare, Inc. | Ablation of rectal and other internal body structures |
US6081749A (en) * | 1997-08-13 | 2000-06-27 | Surx, Inc. | Noninvasive devices, methods, and systems for shrinking of tissues |
US5919188A (en) * | 1997-02-04 | 1999-07-06 | Medtronic, Inc. | Linear ablation catheter |
US5916213A (en) * | 1997-02-04 | 1999-06-29 | Medtronic, Inc. | Systems and methods for tissue mapping and ablation |
US5843078A (en) * | 1997-07-01 | 1998-12-01 | Sharkey; Hugh R. | Radio frequency device for resurfacing skin and method |
US6010500A (en) * | 1997-07-21 | 2000-01-04 | Cardiac Pathways Corporation | Telescoping apparatus and method for linear lesion ablation |
US6030384A (en) * | 1998-05-01 | 2000-02-29 | Nezhat; Camran | Bipolar surgical instruments having focused electrical fields |
-
1999
- 1999-02-17 US US09/251,554 patent/US6277116B1/en not_active Expired - Lifetime
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2000
- 2000-02-02 WO PCT/US2000/002778 patent/WO2000048644A2/en active IP Right Grant
- 2000-02-02 EP EP00915739A patent/EP1152701A2/en not_active Withdrawn
- 2000-02-02 AU AU36964/00A patent/AU757624B2/en not_active Ceased
- 2000-02-02 CA CA002362276A patent/CA2362276A1/en not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9095357B2 (en) | 2004-04-01 | 2015-08-04 | The General Hospital Corporation | Method and apparatus for dermatological treatment and tissue reshaping |
US9510899B2 (en) | 2004-04-01 | 2016-12-06 | The General Hospital Corporation | Method and apparatus for dermatological treatment and tissue reshaping |
Also Published As
Publication number | Publication date |
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AU3696400A (en) | 2000-09-04 |
CA2362276A1 (en) | 2000-08-24 |
WO2000048644A3 (en) | 2000-12-14 |
AU757624B2 (en) | 2003-02-27 |
WO2000048644A2 (en) | 2000-08-24 |
US6277116B1 (en) | 2001-08-21 |
EP1152701A2 (en) | 2001-11-14 |
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