WO2000039138A8 - Selective solvent extraction for the purification of protected nucleosides - Google Patents

Selective solvent extraction for the purification of protected nucleosides

Info

Publication number
WO2000039138A8
WO2000039138A8 PCT/US1999/030412 US9930412W WO0039138A8 WO 2000039138 A8 WO2000039138 A8 WO 2000039138A8 US 9930412 W US9930412 W US 9930412W WO 0039138 A8 WO0039138 A8 WO 0039138A8
Authority
WO
WIPO (PCT)
Prior art keywords
purification
solvent extraction
selective solvent
protected nucleosides
nucleosides
Prior art date
Application number
PCT/US1999/030412
Other languages
French (fr)
Other versions
WO2000039138A1 (en
Inventor
Raymond J Swedo
Mathias P Koljack
Romulus Gaita
Stephen F Yates
Charles Chao Wu
Original Assignee
Allied Signal Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allied Signal Inc filed Critical Allied Signal Inc
Priority to KR1020017008063A priority Critical patent/KR20010089698A/en
Priority to EP99966490A priority patent/EP1140957A1/en
Priority to JP2000591049A priority patent/JP2002540062A/en
Publication of WO2000039138A1 publication Critical patent/WO2000039138A1/en
Publication of WO2000039138A8 publication Critical patent/WO2000039138A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

A process for the purification of nucleosides, and more particularly to a selective solvent extraction method for purifying protected nucleosides. In the purification process, solid particles of protected nucleosides are selectively washed to remove undesirable polar and/or non-polar impurities, while leaving the solid particles substantially undissolved.
PCT/US1999/030412 1998-12-23 1999-12-21 Selective solvent extraction for the purification of protected nucleosides WO2000039138A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020017008063A KR20010089698A (en) 1998-12-23 1999-12-21 Selective Solvent Extraction For The Purification Of Protected Nucleosides
EP99966490A EP1140957A1 (en) 1998-12-23 1999-12-21 Selective solvent extraction for the purification of protected nucleosides
JP2000591049A JP2002540062A (en) 1998-12-23 1999-12-21 Selective solvent extraction for purification of protected nucleosides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11372498P 1998-12-23 1998-12-23
US60/113,724 1998-12-23
US09/440,335 US6414137B1 (en) 1998-12-23 1999-11-15 Selective solvent extraction for the purification of protected nucleosides
US09/440,335 1999-11-15

Publications (2)

Publication Number Publication Date
WO2000039138A1 WO2000039138A1 (en) 2000-07-06
WO2000039138A8 true WO2000039138A8 (en) 2000-11-30

Family

ID=26811393

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030412 WO2000039138A1 (en) 1998-12-23 1999-12-21 Selective solvent extraction for the purification of protected nucleosides

Country Status (5)

Country Link
US (1) US6414137B1 (en)
EP (1) EP1140957A1 (en)
JP (1) JP2002540062A (en)
KR (1) KR20010089698A (en)
WO (1) WO2000039138A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2381367A1 (en) * 2001-04-12 2002-10-12 Hironori Komatsu Method for purifying 5'-protected 2'-deoxypurine nucleosides
ATE275574T1 (en) * 2001-05-15 2004-09-15 Mitsui Chemicals Inc METHOD FOR PURIFYING 5'-PROTECTED THYMIDINES
CN100424091C (en) 2002-06-05 2008-10-08 三井化学株式会社 Method for purifying protected 2'-deoxycytidines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984298A (en) * 1970-12-28 1976-10-05 Haber Instruments, Incorporated Electromolecular propulsion in semiconductive media
DK0644196T3 (en) 1993-09-17 1998-07-27 Novartis Ag TTTr as a protecting group in nucleotide synthesis
WO1995018137A1 (en) * 1993-12-30 1995-07-06 Genta Incorporated Improved process for the purification of oligomers

Also Published As

Publication number Publication date
EP1140957A1 (en) 2001-10-10
US6414137B1 (en) 2002-07-02
KR20010089698A (en) 2001-10-08
JP2002540062A (en) 2002-11-26
WO2000039138A1 (en) 2000-07-06

Similar Documents

Publication Publication Date Title
GB2334460B (en) Process and system for recovering glycol from glycol/brine streams
WO2004101437A3 (en) Process for producing 1, 3-propanediol
WO2002018663A8 (en) Selective recovery of aluminium, cobalt and platinum values from a spent catalyst composition
AU2003248067A1 (en) Organic porous article having selective adsorption ability for boron, and boron removing module and ultra-pure water production apparatus using the same
AU2097199A (en) Methods to remove metals from water
CA2563483A1 (en) Removal of nitrogen containing compounds from tobacco
AU1715500A (en) Method, apparatus, and agent for removing contaminants from wastewater
WO2001048155A3 (en) Method using filtration aids for the separation of virus vectors from nucleic acids and other cellular contaminants
DE60029057D1 (en) Process for separating, removing and recovering gas components
ZA973243B (en) Process for removing oxygenated contaminants from hydrocarbon streams.
ZA200005520B (en) Thermal swing adsorption process for the removal of dinitrogen oxide, hydrocarbons and other trace impurities from air.
CA2409127A1 (en) Process for treating a lipophilic fluid
AU7876200A (en) Method for purifying acetone
HK1049803A1 (en) Process for purifying and reusing solvent used to remove extractables
WO2000039138A8 (en) Selective solvent extraction for the purification of protected nucleosides
AU2002211430A1 (en) Apparatus and process for extracting and recovering metals from aqueous solutions
MY119738A (en) Process for the purification of an alkanolamine
AU2556801A (en) Method for the selective removal of metals from concentrated metal-containing streams
MXPA02012829A (en) Method of reducing formation of precipitates in solvent recovery system.
AU7610300A (en) Process for extracting copper values from copper-containing ores
WO2003011775A3 (en) Method and installation for treating liquids, especially for purifying contaminated water, using a perforated cylinder station
CA2185443A1 (en) Method for the separation and purification of fullerenes
AU2001259113A1 (en) Apparatus and method for separating and purifying polynucleotides
WO2003085109A3 (en) Method and apparatus for extracting nucleic acids from a complex mixture
MXPA03002707A (en) Adsorptive separation process for recovery of two paraffin products.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP KR

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: C1

Designated state(s): JP KR

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

WR Later publication of a revised version of an international search report
WWE Wipo information: entry into national phase

Ref document number: 1999966490

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1020017008063

Country of ref document: KR

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 591049

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1020017008063

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 1999966490

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1999966490

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1020017008063

Country of ref document: KR