WO2000038579B1 - Device and method for safe location and marking of a cavity and sentinel lymph nodes - Google Patents

Device and method for safe location and marking of a cavity and sentinel lymph nodes

Info

Publication number
WO2000038579B1
WO2000038579B1 PCT/US1999/030619 US9930619W WO0038579B1 WO 2000038579 B1 WO2000038579 B1 WO 2000038579B1 US 9930619 W US9930619 W US 9930619W WO 0038579 B1 WO0038579 B1 WO 0038579B1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
microparticles
node
cavity
sentinel
Prior art date
Application number
PCT/US1999/030619
Other languages
French (fr)
Other versions
WO2000038579A3 (en
WO2000038579A2 (en
WO2000038579A9 (en
Inventor
D Laksen Sirimanne
Natalie V Fawzi
Douglas S Sutton
Gail S Lebovic
Stanley R Conston
Peter M Wilson
Anne B Morrissey
Mary Elizabeth Bush
Original Assignee
Vivant Medical Inc
D Laksen Sirimanne
Natalie V Fawzi
Douglas S Sutton
Gail S Lebovic
Stanley R Conston
Peter M Wilson
Anne B Morrissey
Mary Elizabeth Bush
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/285,329 external-priority patent/US6356782B1/en
Application filed by Vivant Medical Inc, D Laksen Sirimanne, Natalie V Fawzi, Douglas S Sutton, Gail S Lebovic, Stanley R Conston, Peter M Wilson, Anne B Morrissey, Mary Elizabeth Bush filed Critical Vivant Medical Inc
Priority to CA2356890A priority Critical patent/CA2356890C/en
Priority to US09/869,282 priority patent/US9669113B1/en
Priority to AU25924/00A priority patent/AU774994B2/en
Priority to EP99968528A priority patent/EP1152696B1/en
Priority to AT99968528T priority patent/ATE280537T1/en
Priority to DE69921508T priority patent/DE69921508T2/en
Priority to PCT/US2000/018394 priority patent/WO2001008578A1/en
Priority to AU60702/00A priority patent/AU6070200A/en
Publication of WO2000038579A2 publication Critical patent/WO2000038579A2/en
Publication of WO2000038579A3 publication Critical patent/WO2000038579A3/en
Publication of WO2000038579B1 publication Critical patent/WO2000038579B1/en
Publication of WO2000038579A9 publication Critical patent/WO2000038579A9/en
Priority to US12/777,710 priority patent/US9492570B2/en
Priority to US13/604,111 priority patent/US20130066195A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00535—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
    • A61B2017/00539—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated hydraulically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3966—Radiopaque markers visible in an X-ray image
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3987—Applicators for implanting markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3995—Multi-modality markers

Abstract

Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

Claims

AMENDED CLAIMS
[received by the International Bureau on 13 October 2000 (13.10.00); original claims 68, 72 and 73 amended; new claim 226 added; remaining claims unchanged (2 pages)]
65. A composition for locating a sentinel node comprising nontoxic, non-radioactive microparticles configured to migrate from an insertion site to a lymph node in less than 3 hours and said microparticles being noninvasively detectable.
66. The composition of claim 65 and further including a visible dye wherein said dye renders the lymph node detectable under direct visualization.
67. The composition of claim 65 and further including carbon particles.
68. The composition of claim 65 wherein at least some of said microparticles are configured to migrate from the insertion site to a lymph node in 5 to 20 minutes.
69. The composition of claim 65 wherein said microparticles are echogenic.
70. The composition of claim 65 wherein said microparticles are radiopaque.
71. The composition of claim 69 wherein said microparticles are hollow.
72. The composition of claim 71 wherein said hollow microparticles are filled with air, C02, nitrogen, or a fluorinated gas.
73. The composition of claim 65 wherein said microparticles contain silicon or a silicon compound.
74. The composition of claim 73 wherein said microparticles contain silicone.
75. The composition of claim 73 wherein said microparticles contain Si02.
76. The composition of claim 65 wherein a diameter of said microparticles is between 0.05 microns and 5 microns.
76
225. The process of claim 224 wherein said placing step comprises inserting a tube containing the at least one marker into the hole created by the needle and pushing the marker out of the tube and into the filler body.
226. The delivery device of claim 94 wherein said ejector first position is fitted to carry the marking device in contact with the cannula.
11
PCT/US1999/030619 1998-12-24 1999-12-23 Device and method for safe location and marking of a cavity and sentinel lymph nodes WO2000038579A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA2356890A CA2356890C (en) 1998-12-24 1999-12-23 Device and method for safe location and marking of a cavity and sentinel lymph nodes
US09/869,282 US9669113B1 (en) 1998-12-24 1999-12-23 Device and method for safe location and marking of a biopsy cavity
AU25924/00A AU774994B2 (en) 1998-12-24 1999-12-23 Device and method for safe location and marking of a cavity and sentinel lymph nodes
EP99968528A EP1152696B1 (en) 1998-12-24 1999-12-23 Device and method for safe location and marking of a cavity and sentinel lymph nodes
AT99968528T ATE280537T1 (en) 1998-12-24 1999-12-23 DEVICE AND METHOD FOR SAFE LOCATION AND MARKING OF A CAVITY AND SENTINAL LYMPH NODES
DE69921508T DE69921508T2 (en) 1998-12-24 1999-12-23 DEVICE AND METHOD FOR THE SAFE LOCALIZATION AND MARKING OF A CAVE AND SENTINELL LYMPHOTIC NODES
AU60702/00A AU6070200A (en) 1999-07-30 2000-07-03 Device and method for safe location and marking of a cavity and sentinel lymph nodes
PCT/US2000/018394 WO2001008578A1 (en) 1999-07-30 2000-07-03 Device and method for safe location and marking of a cavity and sentinel lymph nodes
US12/777,710 US9492570B2 (en) 1998-12-24 2010-05-11 Device and method for safe location and marking of a biopsy cavity
US13/604,111 US20130066195A1 (en) 1998-12-24 2012-09-05 Device and method for safe location and marking of a cavity and sentinel lymph nodes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22061898A 1998-12-24 1998-12-24
US09/220,618 1998-12-24
US09/285,329 US6356782B1 (en) 1998-12-24 1999-04-02 Subcutaneous cavity marking device and method
US09/285,329 1999-04-02
US09/347,185 1999-07-02
US09/347,185 US6371904B1 (en) 1998-12-24 1999-07-02 Subcutaneous cavity marking device and method

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/347,185 Continuation-In-Part US6371904B1 (en) 1998-12-24 1999-07-02 Subcutaneous cavity marking device and method

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09/869,282 A-371-Of-International US9669113B1 (en) 1998-12-24 1999-12-23 Device and method for safe location and marking of a biopsy cavity
US12/777,710 Continuation US9492570B2 (en) 1998-12-24 2010-05-11 Device and method for safe location and marking of a biopsy cavity
US13/604,111 Continuation US20130066195A1 (en) 1998-12-24 2012-09-05 Device and method for safe location and marking of a cavity and sentinel lymph nodes

Publications (4)

Publication Number Publication Date
WO2000038579A2 WO2000038579A2 (en) 2000-07-06
WO2000038579A3 WO2000038579A3 (en) 2000-12-21
WO2000038579B1 true WO2000038579B1 (en) 2001-01-18
WO2000038579A9 WO2000038579A9 (en) 2001-09-13

Family

ID=27396810

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030619 WO2000038579A2 (en) 1998-12-24 1999-12-23 Device and method for safe location and marking of a cavity and sentinel lymph nodes

Country Status (8)

Country Link
US (2) US6371904B1 (en)
EP (3) EP2174596B1 (en)
AT (2) ATE280537T1 (en)
AU (1) AU774994B2 (en)
CA (2) CA2715331C (en)
DE (2) DE69921508T2 (en)
ES (1) ES2340584T3 (en)
WO (1) WO2000038579A2 (en)

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US9427186B2 (en) 2009-12-04 2016-08-30 Endomagnetics Ltd. Magnetic probe apparatus
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US9586059B2 (en) 2004-07-23 2017-03-07 Varian Medical Systems, Inc. User interface for guided radiation therapy

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WO2000038579A3 (en) 2000-12-21
US9492570B2 (en) 2016-11-15
DE69921508D1 (en) 2004-12-02
ES2340584T3 (en) 2010-06-07
CA2715331A1 (en) 2000-07-06
EP1491147B1 (en) 2010-03-10
EP1152696A2 (en) 2001-11-14
AU774994B2 (en) 2004-07-15
EP1152696B1 (en) 2004-10-27
EP1491147A1 (en) 2004-12-29
EP2174596A1 (en) 2010-04-14
WO2000038579A2 (en) 2000-07-06
DE69942132D1 (en) 2010-04-22
WO2000038579A9 (en) 2001-09-13
US6371904B1 (en) 2002-04-16
ATE280537T1 (en) 2004-11-15
CA2356890C (en) 2010-12-07
ATE460116T1 (en) 2010-03-15
CA2715331C (en) 2016-01-12
DE69921508T2 (en) 2006-02-09
CA2356890A1 (en) 2000-07-06
AU2592400A (en) 2000-07-31
US20100234726A1 (en) 2010-09-16

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