WO2000036398A3 - Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen - Google Patents

Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen Download PDF

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Publication number
WO2000036398A3
WO2000036398A3 PCT/DE1999/003981 DE9903981W WO0036398A3 WO 2000036398 A3 WO2000036398 A3 WO 2000036398A3 DE 9903981 W DE9903981 W DE 9903981W WO 0036398 A3 WO0036398 A3 WO 0036398A3
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Prior art keywords
support
detector
molecules
optical properties
directly
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PCT/DE1999/003981
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English (en)
French (fr)
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WO2000036398A9 (de
WO2000036398A2 (de
WO2000036398A8 (de
Inventor
Annemarie Poustka
Frank Breitling
Karl-Heinz Gross
Stefan Duebel
Rainer Saffrich
Original Assignee
Deutsches Krebsforsch
Europ Lab Molekularbiolog
Annemarie Poustka
Frank Breitling
Gross Karl Heinz
Stefan Duebel
Rainer Saffrich
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Application filed by Deutsches Krebsforsch, Europ Lab Molekularbiolog, Annemarie Poustka, Frank Breitling, Gross Karl Heinz, Stefan Duebel, Rainer Saffrich filed Critical Deutsches Krebsforsch
Priority to EP99966859A priority Critical patent/EP1153282A2/de
Publication of WO2000036398A2 publication Critical patent/WO2000036398A2/de
Publication of WO2000036398A8 publication Critical patent/WO2000036398A8/de
Publication of WO2000036398A3 publication Critical patent/WO2000036398A3/de
Publication of WO2000036398A9 publication Critical patent/WO2000036398A9/de
Priority to US09/880,681 priority patent/US20020008871A1/en

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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
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    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
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Abstract

Bei einem Verfahren zur Erfassung optischer Eigenschaften, insbesondere von Lumineszenzreaktionen und Brechungsverhalten, von auf einem Träger (12) direkt oder indirekt gebundenen Molekülen (14) werden elektromagnetische Wellen, insbesondere Laserlicht (26), auf den Träger eingestrahlt. Von den Molekülen emittiertes oder gebrochenes Licht wird von einem Detektor (28) erfaßt. Während und nach dem Einstrahlen der elektromagnetischen Wellen werden Detektor und Träger relativ zueinander bewegt. Als Träger wird insbesondere ein transparenter Träger mit integrierten und von einem Detektor, insbesondere einem optoeletronischen Abtastsystem erfassbare Positionsmarkierungen (20) verwendet. Hierbei wird wenigstens eine der integrierten Positionsmarkierungen während oder nach der Relativbewegung von Träger und Detektor ausgelesen, so dass eine Zuordnung des von dem Detektor erfassten Lichts zu einem Ort auf dem Träger möglich wird. Bei einer Vorrichtung zur Durchfühnung des Verfahrens ist ein Detektor, insbesondere ein optoelektronisches Abtastsystem zur Erfassung von in dem Träger integrierten Positionsmarkierungen vorgesehen.
PCT/DE1999/003981 1998-12-14 1999-12-14 Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen WO2000036398A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99966859A EP1153282A2 (de) 1998-12-14 1999-12-14 Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen
US09/880,681 US20020008871A1 (en) 1998-12-14 2001-06-13 Method and device for detecting optical properties, especially luminescence reactions and refraction behavior of molecules which are directly or indirectly bound on a support

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19857529.7 1998-12-14
DE19857529 1998-12-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/880,681 Continuation US20020008871A1 (en) 1998-12-14 2001-06-13 Method and device for detecting optical properties, especially luminescence reactions and refraction behavior of molecules which are directly or indirectly bound on a support

Publications (4)

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WO2000036398A2 WO2000036398A2 (de) 2000-06-22
WO2000036398A8 WO2000036398A8 (de) 2000-08-17
WO2000036398A3 true WO2000036398A3 (de) 2000-10-19
WO2000036398A9 WO2000036398A9 (de) 2001-04-05

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PCT/DE1999/003981 WO2000036398A2 (de) 1998-12-14 1999-12-14 Verfahren und vorrichtungen zur erfassung optischer eigenschaften, insbesondere von lumineszenz-reaktionen und brechungsverhalten, von auf einem träger direkt oder indirekt gebundenen molekülen

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US (1) US20020008871A1 (de)
EP (1) EP1153282A2 (de)
WO (1) WO2000036398A2 (de)

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US20020008871A1 (en) 2002-01-24

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