WO2000034781A3 - Patterned binding of functionalized microspheres for optical diffraction-based biosensors - Google Patents

Patterned binding of functionalized microspheres for optical diffraction-based biosensors Download PDF

Info

Publication number
WO2000034781A3
WO2000034781A3 PCT/US1999/027671 US9927671W WO0034781A3 WO 2000034781 A3 WO2000034781 A3 WO 2000034781A3 US 9927671 W US9927671 W US 9927671W WO 0034781 A3 WO0034781 A3 WO 0034781A3
Authority
WO
WIPO (PCT)
Prior art keywords
diffraction
analyte
functionalized microspheres
optical diffraction
binding
Prior art date
Application number
PCT/US1999/027671
Other languages
French (fr)
Other versions
WO2000034781A2 (en
Inventor
Dennis S Everhart
Rosann M Kaylor
Kevin Mcgrath
Original Assignee
Kimberly Clark Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kimberly Clark Co filed Critical Kimberly Clark Co
Priority to EP99961755A priority Critical patent/EP1137942A2/en
Priority to AU18271/00A priority patent/AU759582B2/en
Priority to CA2353535A priority patent/CA2353535C/en
Publication of WO2000034781A2 publication Critical patent/WO2000034781A2/en
Publication of WO2000034781A3 publication Critical patent/WO2000034781A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/88—Investigating the presence of flaws or contamination
    • G01N21/89—Investigating the presence of flaws or contamination in moving material, e.g. running paper or textiles
    • G01N21/892—Investigating the presence of flaws or contamination in moving material, e.g. running paper or textiles characterised by the flaw, defect or object feature examined
    • G01N21/898—Irregularities in textured or patterned surfaces, e.g. textiles, wood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4788—Diffraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00382—Stamping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

The present invention provides an inexpensive and sensitive system and method for detecting analytes present in a medium. The system comprises a diffraction enhancing element, such as functionalized microspheres, which are modified such that they are capable of binding with a target analyte. Additionally, the system comprises a polymer film, which may include a metal coating, upon which is printed a specific, predetermined pattern of analyte-specific receptors. Upon attachment of a target analyte to select areas of the polymer film, either directly or with the diffraction enhancing element, diffraction of transmitted and/or reflected light occurs via the physical dimensions and defined, precise placement of the analyte. A diffraction image is produced which can be easily seen with the eye or, optionally, with a sensing device.
PCT/US1999/027671 1998-12-11 1999-11-22 Patterned binding of functionalized microspheres for optical diffraction-based biosensors WO2000034781A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99961755A EP1137942A2 (en) 1998-12-11 1999-11-22 Patterned binding of functionalized microspheres for optical diffraction-based biosensors
AU18271/00A AU759582B2 (en) 1998-12-11 1999-11-22 Patterned binding of functionalized microspheres for optical diffraction-based biosensors
CA2353535A CA2353535C (en) 1998-12-11 1999-11-22 Patterned binding of functionalized microspheres for optical diffraction-based biosensors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/210,016 US6221579B1 (en) 1998-12-11 1998-12-11 Patterned binding of functionalized microspheres for optical diffraction-based biosensors
US09/210,016 1998-12-11

Publications (2)

Publication Number Publication Date
WO2000034781A2 WO2000034781A2 (en) 2000-06-15
WO2000034781A3 true WO2000034781A3 (en) 2000-08-17

Family

ID=22781270

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/027671 WO2000034781A2 (en) 1998-12-11 1999-11-22 Patterned binding of functionalized microspheres for optical diffraction-based biosensors

Country Status (8)

Country Link
US (2) US6221579B1 (en)
EP (1) EP1137942A2 (en)
KR (1) KR100794079B1 (en)
CN (1) CN1199046C (en)
AU (1) AU759582B2 (en)
CA (1) CA2353535C (en)
TW (1) TW589450B (en)
WO (1) WO2000034781A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8337775B2 (en) 2002-02-26 2012-12-25 Siemens Healthcare Diagnostics, Inc. Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3772243B2 (en) * 1996-09-25 2006-05-10 湘南デザイン株式会社 Molding method of duplicate product
US6221579B1 (en) * 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors
US6682940B2 (en) * 1999-05-04 2004-01-27 Dan A. Pankowsky Products and methods for single parameter and multiparameter phenotyping of cells
US6828157B1 (en) 1999-05-04 2004-12-07 Dan A. Pankowsky Products and methods for single parameter and multiparameter phenotyping of cells
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US6399295B1 (en) * 1999-12-17 2002-06-04 Kimberly-Clark Worldwide, Inc. Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
DE10006432A1 (en) * 2000-02-14 2001-08-16 Ganzimmun Inst Fuer Ganzheitli Method for the detection of Helicobacter pylori in stool and saliva samples
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US7033821B2 (en) * 2000-11-08 2006-04-25 Surface Logix, Inc. Device for monitoring cell motility in real-time
US7374906B2 (en) 2000-11-08 2008-05-20 Surface Logix, Inc. Biological assays using gradients formed in microfluidic systems
US6844184B2 (en) * 2000-11-08 2005-01-18 Surface Logix, Inc. Device for arraying biomolecules and for monitoring cell motility in real-time
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
US6893851B2 (en) 2000-11-08 2005-05-17 Surface Logix, Inc. Method for arraying biomolecules and for monitoring cell motility in real-time
US7033819B2 (en) 2000-11-08 2006-04-25 Surface Logix, Inc. System for monitoring cell motility in real-time
US7326563B2 (en) 2000-11-08 2008-02-05 Surface Logix, Inc. Device and method for monitoring leukocyte migration
US6864065B2 (en) * 2000-11-08 2005-03-08 Surface Logix, Inc. Assays for monitoring cell motility in real-time
US6600057B2 (en) 2000-12-29 2003-07-29 Kimberly-Clark Worldwide, Inc. Matrix metalloproteinase inhibitors
US7041787B2 (en) * 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
CN1330822C (en) * 2001-01-30 2007-08-08 宝洁公司 Coating compositions for modifying surfaces
US6620844B2 (en) 2001-02-14 2003-09-16 Newmillennium Pharmaceutical, Inc. Method for reducing blood insulin levels by reducing in vivo cathepsin L activity
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US6685885B2 (en) * 2001-06-22 2004-02-03 Purdue Research Foundation Bio-optical compact dist system
DE60231309D1 (en) * 2001-08-03 2009-04-09 Nanosphere Inc NANOPARTICLE IMAGING SYSTEM AND METHOD
EP1434994A2 (en) * 2001-09-13 2004-07-07 Axela Biosensors Inc. Method and apparatus for assay based on light diffraction
US7102752B2 (en) * 2001-12-11 2006-09-05 Kimberly-Clark Worldwide, Inc. Systems to view and analyze the results from diffraction-based diagnostics
US7098041B2 (en) * 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
US20030138570A1 (en) * 2001-12-21 2003-07-24 Kimberly-Clark Worldwide, Inc. Method to prepare diagnostic films using engraved printing cylinders such as rotogravure
US20030119209A1 (en) * 2001-12-21 2003-06-26 Kaylor Rosann Marie Diagnostic methods and devices
US7384598B2 (en) 2001-12-21 2008-06-10 Kimberly-Clark Worldwide, Inc. Diagnostic device
US20030119073A1 (en) * 2001-12-21 2003-06-26 Stephen Quirk Sensors and methods of detection for proteinase enzymes
US7244393B2 (en) * 2001-12-21 2007-07-17 Kimberly-Clark Worldwide, Inc. Diagnostic device and system
US8367013B2 (en) * 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030119203A1 (en) * 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US7365238B2 (en) 2002-02-19 2008-04-29 The Procter And Gamble Company Absorbent article having a dehydration indicator
US7214530B2 (en) * 2002-05-03 2007-05-08 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
US7223534B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7223368B2 (en) * 2002-05-03 2007-05-29 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7485453B2 (en) * 2002-05-03 2009-02-03 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7118855B2 (en) * 2002-05-03 2006-10-10 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
US7771922B2 (en) * 2002-05-03 2010-08-10 Kimberly-Clark Worldwide, Inc. Biomolecule diagnostic device
WO2004033480A2 (en) * 2002-05-21 2004-04-22 Northwestern University Peptide and protein arrays and direct-write lithographic printing of peptides and proteins
US7091049B2 (en) * 2002-06-26 2006-08-15 Kimberly-Clark Worldwide, Inc. Enhanced diffraction-based biosensor devices
US7867754B1 (en) * 2002-08-01 2011-01-11 Purdue Research Foundation Microarrays for analyte detection
US7508608B2 (en) * 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7441703B2 (en) * 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
WO2004019277A1 (en) * 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US20050227252A1 (en) * 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7126755B2 (en) * 2002-09-12 2006-10-24 Moon John A Method and apparatus for labeling using diffraction grating-based encoded optical identification elements
EP1535241A1 (en) * 2002-08-20 2005-06-01 Cyvera Corporation Diffraction grating-based optical identification element
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7432105B2 (en) * 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US7314763B2 (en) * 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7285424B2 (en) * 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
AU2003303950A1 (en) * 2002-09-06 2004-11-23 Derek. J. Hansford Microfabrication of polymer microparticles
CA2498933C (en) * 2002-09-12 2012-08-28 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
EP1540591A1 (en) * 2002-09-12 2005-06-15 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
CA2498913A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Assay stick comprising coded microbeads
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
WO2004025561A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
US7141414B2 (en) * 2002-09-16 2006-11-28 Hewlett-Packard Development Company, L.P. Biosensor
US7169550B2 (en) * 2002-09-26 2007-01-30 Kimberly-Clark Worldwide, Inc. Diffraction-based diagnostic devices
CA2504842A1 (en) * 2002-11-05 2004-05-21 Jingjiao Guan Self-folding polymer microparticles
US7781172B2 (en) * 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US20040106190A1 (en) * 2002-12-03 2004-06-03 Kimberly-Clark Worldwide, Inc. Flow-through assay devices
US20040121334A1 (en) * 2002-12-19 2004-06-24 Kimberly-Clark Worldwide, Inc. Self-calibrated flow-through assay devices
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US7445938B2 (en) * 2003-01-24 2008-11-04 General Dynamics Advanced Information Systems, Inc. System and method for detecting presence of analytes using gratings
US7027163B2 (en) * 2003-01-24 2006-04-11 General Dynamics Advanced Information Systems, Inc. Grating sensor
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7851209B2 (en) * 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US7795007B2 (en) 2003-09-23 2010-09-14 Wisconsin Alumni Research Foundation Detection of post-translationally modified peptides with liquid crystals
DE602004011244T2 (en) * 2003-09-23 2009-02-12 Wisconsin Alumni Research Foundation, Madison USE OF LIQUID CRYSTALS FOR THE DETECTION OF AFFINITY MICROCONTACT PRINTED BIOMOLECULES
KR100532812B1 (en) * 2003-10-06 2005-12-01 한국과학기술원 Method for fabricating a nano-biochip using the nanopattern of block copolymers
US20050112703A1 (en) * 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7713748B2 (en) * 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) * 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US7943089B2 (en) * 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
US20050136550A1 (en) * 2003-12-19 2005-06-23 Kimberly-Clark Worldwide, Inc. Flow control of electrochemical-based assay devices
US7390628B2 (en) * 2003-12-23 2008-06-24 University Of Florida Research Foundation, Inc. Microparticle-based diagnostic methods
US6981445B2 (en) * 2003-12-24 2006-01-03 Axela Biosensors Inc. Method and apparatus for micro-contact printing
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7796266B2 (en) * 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US7815854B2 (en) * 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US20050244953A1 (en) * 2004-04-30 2005-11-03 Kimberly-Clark Worldwide, Inc. Techniques for controlling the optical properties of assay devices
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
EP1789795A4 (en) * 2004-08-04 2008-12-10 Axela Inc Patterned surfaces with chemical crosslinkers for use in diffraction-based sensing
US20060093788A1 (en) * 2004-10-29 2006-05-04 Kimberly-Clark Worldwide, Inc. Disposable food preparation mats, cutting sheets, placemats, and the like
EP2194485B1 (en) 2004-11-16 2012-10-17 Illumina, Inc. Method and apparatus for reading coded microbeads
US20070121113A1 (en) * 2004-12-22 2007-05-31 Cohen David S Transmission-based optical detection systems
US7682817B2 (en) * 2004-12-23 2010-03-23 Kimberly-Clark Worldwide, Inc. Microfluidic assay devices
US20070023643A1 (en) * 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US7405831B2 (en) * 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
US7910356B2 (en) * 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US7623624B2 (en) * 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
JP5815197B2 (en) * 2006-01-24 2015-11-17 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｎｏｒｔｈ Ｃａｒｏｌｉｎａ Ａｔ Ｃｈａｐｅｌ Ｈｉｌｌ System and method for detecting an image of an object using an X-ray beam having a polychromatic distribution
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
WO2007131103A2 (en) * 2006-05-03 2007-11-15 Quadraspec, Inc. Direct printing of patterned hydrophobic wells
US20080075668A1 (en) * 2006-09-27 2008-03-27 Goldstein Alan H Security Device Using Reversibly Self-Assembling Systems
KR20090086235A (en) * 2006-10-31 2009-08-11 에스알유 바이오시스템즈, 인코포레이티드 Method for blocking non-specific protein binding on a functionalized surface
US20080144899A1 (en) * 2006-11-30 2008-06-19 Manoj Varma Process for extracting periodic features from images by template matching
US7522282B2 (en) * 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
US20080230605A1 (en) * 2006-11-30 2008-09-25 Brian Weichel Process and apparatus for maintaining data integrity
KR100850364B1 (en) * 2007-01-19 2008-08-05 대한민국 A method of numberize the intensity of agglutination reaction using plate agglutination tester
US7659968B2 (en) * 2007-01-19 2010-02-09 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
WO2008118934A1 (en) * 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
WO2008150873A1 (en) * 2007-05-31 2008-12-11 Purdue Research Foundation Ultrasensitive detection of biomolecules using immunoseparation and diffractometry
GB0717637D0 (en) 2007-09-10 2007-10-17 Univ Leiden Future cardiac event biomarkers
KR100947262B1 (en) * 2008-02-28 2010-04-01 한국표준과학연구원 Detection Method Using Metallic Nano Pattern and the Apparatus Thereof
US20110201027A1 (en) * 2008-03-18 2011-08-18 Korea Research Institute Of Bioscience And Biotechnology Biosensor for detecting a trace amount of sample and production method therefor
WO2010065532A2 (en) 2008-12-01 2010-06-10 The University Of North Carolina At Chapel Hill Systems and methods for detecting an image of an object using multi-beam imaging from an x-ray beam having a polychromatic distribution
EP2398734B1 (en) * 2009-02-23 2018-07-18 The Regents of The University of California Assembly of magnetically tunable photonic crystals in nonpolar solvents
US8204174B2 (en) * 2009-06-04 2012-06-19 Nextray, Inc. Systems and methods for detecting an image of an object by use of X-ray beams generated by multiple small area sources and by use of facing sides of adjacent monochromator crystals
CA2763367C (en) * 2009-06-04 2016-09-13 Nextray, Inc. Strain matching of crystals and horizontally-spaced monochromator and analyzer crystal arrays in diffraction enhanced imaging systems and related methods
WO2011119920A2 (en) 2010-03-25 2011-09-29 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
CN101934661B (en) * 2010-08-09 2011-11-30 山东泰宝包装制品有限公司 Method for detecting surface quality of carrier before aluminizing
CA2832109C (en) 2011-06-10 2021-07-06 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
AU2012216792A1 (en) 2011-09-12 2013-03-28 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing HIV-1 proteins by broadly neutralizing antibodies
EP2586461A1 (en) 2011-10-27 2013-05-01 Christopher L. Parks Viral particles derived from an enveloped virus
EP3968026A1 (en) * 2012-03-26 2022-03-16 XCellCure, LLC Device and method for detection of analytes
ES2631608T3 (en) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Env-glycoprotein variant of HIV-1
US9982292B2 (en) * 2012-09-28 2018-05-29 Src, Inc. Detecting chemical and biological agents using textile-based sensors
US20150065381A1 (en) 2013-09-05 2015-03-05 International Aids Vaccine Initiative Methods of identifying novel hiv-1 immunogens
EP2873423B1 (en) 2013-10-07 2017-05-31 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
CN104804201B (en) * 2014-01-27 2017-12-15 中国科学院大连化学物理研究所 A kind of preparation method of polymer nano-microspheres
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
EP3072901A1 (en) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
JP6740703B2 (en) * 2016-05-16 2020-08-19 株式会社Ｊｖｃケンウッド Analysis method and analyzer
US11376588B2 (en) 2020-06-10 2022-07-05 Checkable Medical Incorporated In vitro diagnostic device
CN114295601B (en) * 2021-12-31 2024-01-30 厦门大学 Surface Raman enhancement sensing structure based on continuum bound state

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994015193A1 (en) * 1992-12-22 1994-07-07 Sienna Biotech, Inc. Light scatter-based immunoassay without particle self aggregation
WO1996029629A2 (en) * 1995-03-01 1996-09-26 President And Fellows Of Harvard College Microcontact printing on surfaces and derivative articles
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
WO1998027417A1 (en) * 1996-12-18 1998-06-25 Kimberly-Clark Worldwide, Inc. Biosensing devices which produce diffraction images

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4312228A (en) 1979-07-30 1982-01-26 Henry Wohltjen Methods of detection with surface acoustic wave and apparati therefor
SE434438B (en) 1980-02-21 1984-07-23 Gambro Engstrom Ab DEVICE FOR DETECTING THE EXISTENCE OF A GAS COMPONENT IN A GAS MIXTURE
US4363874A (en) 1981-08-07 1982-12-14 Miles Laboratories, Inc. Multilayer analytical element having an impermeable radiation nondiffusing reflecting layer
US4416505A (en) 1981-10-26 1983-11-22 International Business Machines Corporation Method for making holographic optical elements with high diffraction efficiencies
US4690715A (en) 1982-06-18 1987-09-01 American Telephone And Telegraph Company, At&T Bell Laboratories Modification of the properties of metals
US4534356A (en) 1982-07-30 1985-08-13 Diamond Shamrock Chemicals Company Solid state transcutaneous blood gas sensors
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
CH662421A5 (en) 1983-07-13 1987-09-30 Suisse Horlogerie Rech Lab PIEZOELECTRIC CONTAMINATION DETECTOR.
US4661235A (en) 1984-08-03 1987-04-28 Krull Ulrich J Chemo-receptive lipid based membrane transducers
US4596697A (en) 1984-09-04 1986-06-24 The United States Of America As Represented By The Secretary Of The Army Chemical sensor matrix
GB8509492D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optical assay
US5468606A (en) 1989-09-18 1995-11-21 Biostar, Inc. Devices for detection of an analyte based upon light interference
US5482830A (en) 1986-02-25 1996-01-09 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US4776944A (en) 1986-03-20 1988-10-11 Jiri Janata Chemical selective sensors utilizing admittance modulated membranes
GB8618133D0 (en) * 1986-07-24 1986-09-03 Pa Consulting Services Biosensors
US5182135A (en) 1986-08-12 1993-01-26 Bayer Aktiengesellschaft Process for improving the adherency of metallic coatings deposited without current on plastic surfaces
GB2197065A (en) * 1986-11-03 1988-05-11 Stc Plc Optical sensor device
US4837715A (en) * 1987-01-27 1989-06-06 Kimberly-Clark Corporation Method and apparatus for detecting the placement of components on absorbent articles
US4851816A (en) * 1987-02-24 1989-07-25 Helene Macias Crib death (SIDS) warning device
US4812221A (en) * 1987-07-15 1989-03-14 Sri International Fast response time microsensors for gaseous and vaporous species
US4842783A (en) * 1987-09-03 1989-06-27 Cordis Corporation Method of producing fiber optic chemical sensors incorporating photocrosslinked polymer gels
US5057560A (en) 1987-10-05 1991-10-15 Ciba-Geigy Corporation Thermotropic copolymer hydrogels from N,N-dimethylacrylamide and methoxy-ethyl (meth) acrylate
US5268306A (en) 1988-02-29 1993-12-07 Boehringer Mannheim Gmbh Preparation of a solid phase matrix containing a bound specific binding pair
DE68907519T2 (en) 1988-05-10 1993-10-21 Amersham Int Plc Biosensors.
EP0341928A1 (en) * 1988-05-10 1989-11-15 AMERSHAM INTERNATIONAL plc Improvements relating to surface plasmon resonance sensors
GB8811919D0 (en) * 1988-05-20 1988-06-22 Amersham Int Plc Biological sensors
GB8813307D0 (en) * 1988-06-06 1988-07-13 Amersham Int Plc Biological sensors
AT390517B (en) 1988-08-04 1990-05-25 Avl Verbrennungskraft Messtech OPTICAL SENSOR AND METHOD FOR THE PRODUCTION THEREOF
EP0363504A1 (en) 1988-10-10 1990-04-18 Dräger Nederland B.V. Method of providing a substrate with a layer comprising a polyvinylbased hydrogel and a biochemically active material
SE8804074D0 (en) 1988-11-10 1988-11-10 Pharmacia Ab SENSOR UNIT AND ITS USE IN BIOSENSOR SYSTEM
SE8902043L (en) 1988-11-10 1990-05-11 Pharmacia Ab PROCEDURE CHARACTERIZES MACROMOLECULES
SE462454B (en) 1988-11-10 1990-06-25 Pharmacia Ab METHOD FOR USE IN BIOSENSORS
US5063081A (en) 1988-11-14 1991-11-05 I-Stat Corporation Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
US4895017A (en) * 1989-01-23 1990-01-23 The Boeing Company Apparatus and method for early detection and identification of dilute chemical vapors
US5096671A (en) 1989-03-15 1992-03-17 Cordis Corporation Fiber optic chemical sensors incorporating electrostatic coupling
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
GB9008261D0 (en) 1990-04-11 1990-06-13 Ares Serono Res & Dev Ltd Method of improving assay sensitivity
JPH0366384A (en) 1989-08-04 1991-03-22 Senjiyu Seiyaku Kk System for controlling release of physiologically active material
US5235238A (en) 1989-08-10 1993-08-10 Dainabot Company, Limited Electrode-separated piezoelectric crystal oscillator and method for measurement using the electrode-separated piezoelectric crystal oscillator
GB8923699D0 (en) 1989-10-20 1989-12-06 Univ Strathclyde Apparatus for assessing a particular property in a medium
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
FR2656925B1 (en) 1990-01-08 1992-05-15 Eg G MOISTURE SENSOR AND MEASUREMENT INSTALLATION COMPRISING A PLURALITY OF SUCH SENSORS.
DE4013665A1 (en) 1990-04-27 1991-10-31 Fraunhofer Ges Forschung SENSOR FOR DETECTING A SUBSTANCE IN A LIQUID
GB9019123D0 (en) 1990-09-01 1990-10-17 Fisons Plc Analytical device
US5076094A (en) 1990-10-03 1991-12-31 The United States Of America As Represented By The United States Department Of Energy Dual output acoustic wave sensor for molecular identification
US5510481A (en) 1990-11-26 1996-04-23 The Regents, University Of California Self-assembled molecular films incorporating a ligand
US5155791A (en) 1990-12-07 1992-10-13 E. I. Du Pont De Nemours And Company Hybrid optical waveguides for phase-matched nonlinear wavelength conversion
GB9102646D0 (en) 1991-02-07 1991-03-27 Fisons Plc Analytical device
DE69221758T2 (en) 1991-03-22 1998-01-02 Seiko Instr Inc Electrochemical measuring device
US5196350A (en) 1991-05-29 1993-03-23 Omnigene, Inc. Ligand assay using interference modulation
US5418136A (en) 1991-10-01 1995-05-23 Biostar, Inc. Devices for detection of an analyte based upon light interference
US5304293A (en) 1992-05-11 1994-04-19 Teknekron Sensor Development Corporation Microsensors for gaseous and vaporous species
ATE146882T1 (en) 1992-09-14 1997-01-15 Siemens Ag GAS SENSOR
US5402075A (en) 1992-09-29 1995-03-28 Prospects Corporation Capacitive moisture sensor
CA2108705A1 (en) 1992-11-06 1994-05-07 Richard Barner Biologically recognizing layers on new ti02 waveguide for biosensors
US5351548A (en) 1992-12-02 1994-10-04 Walbro Corporation Capacitive pressure sensor
GB2273772A (en) 1992-12-16 1994-06-29 Granta Lab Ltd Detection of macromolecules utilising light diffraction
CA2154444A1 (en) 1993-01-21 1994-08-04 John F. W. Keana Chemical functionalization of surfaces
US5327225A (en) 1993-01-28 1994-07-05 The Center For Innovative Technology Surface plasmon resonance sensor
US5430815A (en) 1993-02-05 1995-07-04 Raychem Corporation Optical fiber water sensor
US5280548A (en) 1993-03-11 1994-01-18 Boc Health Care, Inc. Emission based fiber optic sensors for pH and carbon dioxide analysis
DE4310142A1 (en) 1993-03-29 1994-10-06 Boehringer Mannheim Gmbh Immunologically active conjugates and a process for their preparation
US5658443A (en) 1993-07-23 1997-08-19 Matsushita Electric Industrial Co., Ltd. Biosensor and method for producing the same
US5512131A (en) 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US5352582A (en) 1993-10-28 1994-10-04 Hewlett-Packard Company Holographic based bio-assay
US5455475A (en) 1993-11-01 1995-10-03 Marquette University Piezoelectric resonant sensor using the acoustoelectric effect
US5527711A (en) 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
CA2187616A1 (en) 1994-04-15 1995-10-26 Hoechst Celanese Corporation Biocompatible coated article
US5514501A (en) 1994-06-07 1996-05-07 The United States Of America As Represented By The Secretary Of Commerce Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5489988A (en) 1995-01-03 1996-02-06 Motorola Environmental sensor and method therefor
FR2730810B1 (en) * 1995-02-21 1997-03-14 Thomson Csf HIGHLY SELECTIVE CHEMICAL SENSOR
US5736257A (en) * 1995-04-25 1998-04-07 Us Navy Photoactivatable polymers for producing patterned biomolecular assemblies
US6020047A (en) 1996-09-04 2000-02-01 Kimberly-Clark Worldwide, Inc. Polymer films having a printed self-assembling monolayer
US6221579B1 (en) * 1998-12-11 2001-04-24 Kimberly-Clark Worldwide, Inc. Patterned binding of functionalized microspheres for optical diffraction-based biosensors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994015193A1 (en) * 1992-12-22 1994-07-07 Sienna Biotech, Inc. Light scatter-based immunoassay without particle self aggregation
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
WO1996029629A2 (en) * 1995-03-01 1996-09-26 President And Fellows Of Harvard College Microcontact printing on surfaces and derivative articles
WO1998027417A1 (en) * 1996-12-18 1998-06-25 Kimberly-Clark Worldwide, Inc. Biosensing devices which produce diffraction images

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MRKSICH M ET AL: "PATTERNING SELF-ASSEMBLED MONOLAYERS USING MICROCONTACT PRINTING: A NEW TECHNOLOGY FOR BIOSENSORS", TIBTECH,GB,CAMBRIDGE, vol. 13, 1 June 1995 (1995-06-01), pages 228 - 235, XP002060826 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8337775B2 (en) 2002-02-26 2012-12-25 Siemens Healthcare Diagnostics, Inc. Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces

Also Published As

Publication number Publication date
TW589450B (en) 2004-06-01
EP1137942A2 (en) 2001-10-04
CA2353535A1 (en) 2000-06-15
AU1827100A (en) 2000-06-26
KR20010090881A (en) 2001-10-19
CN1350641A (en) 2002-05-22
AU759582B2 (en) 2003-04-17
WO2000034781A2 (en) 2000-06-15
US20010004526A1 (en) 2001-06-21
CA2353535C (en) 2012-01-17
US6221579B1 (en) 2001-04-24
KR100794079B1 (en) 2008-01-10
US6573040B2 (en) 2003-06-03
CN1199046C (en) 2005-04-27

Similar Documents

Publication Publication Date Title
WO2000034781A3 (en) Patterned binding of functionalized microspheres for optical diffraction-based biosensors
WO2001044813A3 (en) Use of wicking agent to eliminate wash steps for optical diffraction-based biosensors
CA2274456A1 (en) Biosensing devices which produce diffraction images
ATE392617T1 (en) PATTERNED DEPOSITION OF ANTIBODY BINDING PROTEINS FOR OPTICAL DIFFRACTION BASED BIOSENSORS
EP1456660B1 (en) Methods to view and analyze the results from diffraction-based diagnostics
WO2001071322A3 (en) Method and apparatus for multiple-analyte assay
US7102752B2 (en) Systems to view and analyze the results from diffraction-based diagnostics
WO2003023400A3 (en) Method and apparatus for assay based on light diffraction
CA2007532A1 (en) Threshold ligand-receptor assay
WO2001071344A3 (en) Immunochromatographic assay method and apparatus
IL136978A0 (en) Method comprising capture molecule fixed on disc surface
ATE195189T1 (en) COMPACT DEVICE FOR MAKING AN IMAGE OF THE SURFACE TOPOLOGY OF OBJECTS AND METHOD FOR MAKING THE DEVICE
DK0747706T3 (en) Adduct protection assay
EP1324042A3 (en) Detection and/or quantication method of a target molecule by a binding with a capture molecule fixed on the surface of a disc
CA2286141A1 (en) Reflectivity measuring apparatus and method
Goh et al. Label-free monitoring of multiple biomolecular binding interactions in real-time with diffraction-based sensing
WO2001081921A3 (en) Use of ink-jet printing to produce diffraction-based biosensors
WO2001069248A3 (en) An immunoassay diagnostic probe and its use
EP1420252A3 (en) Detection and/or quantification method of a target molecule by binding with a capture molecule fixed on the surface of a disc
CA2309599A1 (en) Improvements in or relating to displacement assays
WO2005054857A3 (en) Optical sensor with nanoparticle-transfer
Schmid et al. Biosensors for Analysis of Pesticides in Water(Biosensoren zur Analytik von Pflanzenschutzmitteln in Wasser)
HAYES A Neural Network for Moving Light Display Trajectory Prediction

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 99816140.3

Country of ref document: CN

ENP Entry into the national phase

Ref document number: 2000 18271

Country of ref document: AU

Kind code of ref document: A

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2353535

Country of ref document: CA

Ref document number: 2353535

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1999961755

Country of ref document: EP

Ref document number: IN/PCT/2001/794/CHE

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 1020017007234

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/005907

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 18271/00

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 1999961755

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1020017007234

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 18271/00

Country of ref document: AU

WWR Wipo information: refused in national office

Ref document number: 1020017007234

Country of ref document: KR