WO2000015293A1 - Combined stimulation of ventral and dorsal sacral roots for control of bladder function - Google Patents
Combined stimulation of ventral and dorsal sacral roots for control of bladder function Download PDFInfo
- Publication number
- WO2000015293A1 WO2000015293A1 PCT/US1999/021049 US9921049W WO0015293A1 WO 2000015293 A1 WO2000015293 A1 WO 2000015293A1 US 9921049 W US9921049 W US 9921049W WO 0015293 A1 WO0015293 A1 WO 0015293A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- electrode
- bladder
- ventral
- sacral
- dorsal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
Definitions
- This invention relates generally to selective nerve stimulation for bladder
- urinary calculi remains a major factor leading to morbidity in spinal cord injured
- urethral or anal sphincter allows the development of techniques to selectively
- the motor impulse is
- sacral nerves are separated to isolate the ventral and dorsal roots thereof, and the
- inferior somatic nerve SI is sectioned to isolate the external sphincter on one side.
- the dorsal root of S2 is then sectioned unilaterally to isolate the sensory function
- An electrode is positioned on the S3 sacral nerve to stimulate the detrusor
- sphincter response may be
- the present invention contemplates a new technique for bladder function
- sacral motor roots and also the sacral sensory roots.
- FIG. 1 schematically illustrates the placement of electrodes for controlling the
- FIG. 2 is a graphic representation showing average voided volume from
- FIG. 3 is a graphic representation showing average voided volume when
- FIG. 4 illustrates a stimulation scheme which may be used for combined
- FIG. 1 there is shown an illustrative embodiment of the
- Kidney 10 is
- Urine is expelled from the body through bladder neck 16 and
- urethra 18 and out from urethral sphincter 20.
- Bladder 12 and sphincter 20 function
- Dorsal roots 23 are primarily sensory (afferent) to transmit sensation to spinal cord 19, while ventral roots 22
- Ventral roots 22 include nerve bundles 22a which include larger diameter
- nerve fibers and nerve bundles 22b which include smaller diameter fibers. Larger
- fibers 22a connect between spinal cord 19 and sphincter 20, while smaller fibers 22b
- Smaller fibers 22b usually carry no action potentials until the person desires
- a cuff electrode 30 can be
- Cuff electrode 30 which is preferably a self-curling spiral electrode that is biased to curl around the selected root and is described in U.S. Patent No. 4,602,624, is configured to accommodate nerves of
- the present invention also includes an additional cuff electrode 32 which is
- roots can result in the voiding of bladder contents without increasing sphincter
- a controller 34 is electrically coupled to electrodes 30 and 32 to provide
- nerve cuff electrode implanted on S2 motor roots. Either a quasitrapezoidal, balanced biphasic, 20 Hz pulse, with current amplitude set at a volume determined
- the efferent sensory stimulus was applied to the S2 dermatome
- the surface stimulus was varied to be continuous or intermittent (1 second
- FIG. 2 shows the average volume of fluid voided during a 10 second pulse
- halothane inhalation anesthesia The motor stimulus was applied by a spiral nerve
- the sensory stimulus was applied to SI, S2, or
- the intermittent surface stimulation was varied to be either 1
- Table 1 shows the average results from three trials for each stimulus pattern.
- FIG. 3 shows the
- V(ml) Average voided volume in ml
- FIG. 4 illustrates the stimulus pattern for the combined dorsal and ventral
- An intermittent pulse train 100 is applied
- pressure bladder activation can be achieved by modulating the reflexes associated
- Pulse train 100 preferably consists of pulses delivered at a frequency of 10 to
- each pulse having a nominal amplitude of less than 1 ma and a pulse
- Pulse train 100 is generated intermittently, with a
- Pulse train 102 preferably
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002343928A CA2343928A1 (en) | 1998-09-16 | 1999-09-14 | Combined stimulation of ventral and dorsal sacral roots for control of bladder function |
AU63885/99A AU758611B2 (en) | 1998-09-16 | 1999-09-14 | Combined stimulation of ventral and dorsal sacral roots for control of bladder function |
EP99951446A EP1113841A1 (en) | 1998-09-16 | 1999-09-14 | Combined stimulation of ventral and dorsal sacral roots for control of bladder function |
US09/787,244 US7142925B1 (en) | 1998-09-16 | 1999-09-14 | Combined stimulation of ventral and dorsal sacral roots for control of bladder function |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10054298P | 1998-09-16 | 1998-09-16 | |
US60/100,542 | 1998-09-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000015293A1 true WO2000015293A1 (en) | 2000-03-23 |
Family
ID=22280289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/021049 WO2000015293A1 (en) | 1998-09-16 | 1999-09-14 | Combined stimulation of ventral and dorsal sacral roots for control of bladder function |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1113841A1 (en) |
AU (1) | AU758611B2 (en) |
CA (1) | CA2343928A1 (en) |
WO (1) | WO2000015293A1 (en) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001060445A2 (en) * | 2000-02-17 | 2001-08-23 | Neurodan A/S | Methods and implantable systems for neural sensing and nerve stimulation |
WO2001089629A1 (en) * | 2000-05-26 | 2001-11-29 | Consejo Superior De Investigaciones Científicas | Sacral root stimulating system by means of a radio-frequency powered implant |
WO2010069317A1 (en) * | 2008-12-19 | 2010-06-24 | Neurodan A/S | Bursts of electrical pulses in the treatment of pelvic disorders by electrical nerve stimulation |
US7813803B2 (en) | 2005-06-09 | 2010-10-12 | Medtronic, Inc. | Regional therapies for treatment of pain |
US7890176B2 (en) | 1998-07-06 | 2011-02-15 | Boston Scientific Neuromodulation Corporation | Methods and systems for treating chronic pelvic pain |
US9452287B2 (en) | 2013-01-21 | 2016-09-27 | Cala Health, Inc. | Devices and methods for controlling tremor |
US9802041B2 (en) | 2014-06-02 | 2017-10-31 | Cala Health, Inc. | Systems for peripheral nerve stimulation to treat tremor |
US10765856B2 (en) | 2015-06-10 | 2020-09-08 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation to treat tremor with detachable therapy and monitoring units |
US10814130B2 (en) | 2016-07-08 | 2020-10-27 | Cala Health, Inc. | Dry electrodes for transcutaneous nerve stimulation |
US11331480B2 (en) | 2017-04-03 | 2022-05-17 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder |
US11344722B2 (en) | 2016-01-21 | 2022-05-31 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder |
US11596785B2 (en) | 2015-09-23 | 2023-03-07 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation in the finger or hand to treat hand tremors |
US11857778B2 (en) | 2018-01-17 | 2024-01-02 | Cala Health, Inc. | Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation |
US11890468B1 (en) | 2019-10-03 | 2024-02-06 | Cala Health, Inc. | Neurostimulation systems with event pattern detection and classification |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3870051A (en) * | 1972-04-27 | 1975-03-11 | Nat Res Dev | Urinary control |
US4569351A (en) * | 1984-12-20 | 1986-02-11 | University Of Health Sciences/The Chicago Medical School | Apparatus and method for stimulating micturition and certain muscles in paraplegic mammals |
US4602624A (en) | 1984-10-11 | 1986-07-29 | Case Western Reserve University | Implantable cuff, method of manufacture, and method of installation |
US4607639A (en) | 1984-05-18 | 1986-08-26 | Regents Of The University Of California | Method and system for controlling bladder evacuation |
US4608985A (en) | 1984-10-11 | 1986-09-02 | Case Western Reserve University | Antidromic pulse generating wave form for collision blocking |
EP0245547A1 (en) * | 1986-05-12 | 1987-11-19 | The Regents Of The University Of California | Electronic control system for controlling pelvic viscera via neuro-electrical stimulation |
US5199430A (en) | 1991-03-11 | 1993-04-06 | Case Western Reserve University | Micturitional assist device |
US5370670A (en) * | 1993-12-13 | 1994-12-06 | Thomas Jefferson University | Detrusor myoplasty and neuromuscular electrical stimulation of the urinary bladder |
-
1999
- 1999-09-14 CA CA002343928A patent/CA2343928A1/en not_active Abandoned
- 1999-09-14 AU AU63885/99A patent/AU758611B2/en not_active Ceased
- 1999-09-14 WO PCT/US1999/021049 patent/WO2000015293A1/en not_active Application Discontinuation
- 1999-09-14 EP EP99951446A patent/EP1113841A1/en not_active Withdrawn
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3870051A (en) * | 1972-04-27 | 1975-03-11 | Nat Res Dev | Urinary control |
US4607639A (en) | 1984-05-18 | 1986-08-26 | Regents Of The University Of California | Method and system for controlling bladder evacuation |
US4602624A (en) | 1984-10-11 | 1986-07-29 | Case Western Reserve University | Implantable cuff, method of manufacture, and method of installation |
US4608985A (en) | 1984-10-11 | 1986-09-02 | Case Western Reserve University | Antidromic pulse generating wave form for collision blocking |
US4569351A (en) * | 1984-12-20 | 1986-02-11 | University Of Health Sciences/The Chicago Medical School | Apparatus and method for stimulating micturition and certain muscles in paraplegic mammals |
EP0245547A1 (en) * | 1986-05-12 | 1987-11-19 | The Regents Of The University Of California | Electronic control system for controlling pelvic viscera via neuro-electrical stimulation |
US5199430A (en) | 1991-03-11 | 1993-04-06 | Case Western Reserve University | Micturitional assist device |
US5370670A (en) * | 1993-12-13 | 1994-12-06 | Thomas Jefferson University | Detrusor myoplasty and neuromuscular electrical stimulation of the urinary bladder |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7890176B2 (en) | 1998-07-06 | 2011-02-15 | Boston Scientific Neuromodulation Corporation | Methods and systems for treating chronic pelvic pain |
US7996089B2 (en) | 2000-02-17 | 2011-08-09 | Neurodan A/S | Methods and implantable systems for neural sensing and nerve stimulation |
WO2001060445A3 (en) * | 2000-02-17 | 2002-04-18 | Neurodan As | Methods and implantable systems for neural sensing and nerve stimulation |
US7403821B2 (en) | 2000-02-17 | 2008-07-22 | Neurodan A/S | Method and implantable systems for neural sensing and nerve stimulation |
WO2001060445A2 (en) * | 2000-02-17 | 2001-08-23 | Neurodan A/S | Methods and implantable systems for neural sensing and nerve stimulation |
ES2164017A2 (en) * | 2000-05-26 | 2002-02-01 | Consejo Superior Investigacion | Sacral root stimulating system by means of a radio-frequency powered implant |
WO2001089629A1 (en) * | 2000-05-26 | 2001-11-29 | Consejo Superior De Investigaciones Científicas | Sacral root stimulating system by means of a radio-frequency powered implant |
US7813803B2 (en) | 2005-06-09 | 2010-10-12 | Medtronic, Inc. | Regional therapies for treatment of pain |
US7890166B2 (en) | 2005-06-09 | 2011-02-15 | Medtronic, Inc. | Regional therapies for treatment of pain |
US8244360B2 (en) | 2005-06-09 | 2012-08-14 | Medtronic, Inc. | Regional therapies for treatment of pain |
WO2010069317A1 (en) * | 2008-12-19 | 2010-06-24 | Neurodan A/S | Bursts of electrical pulses in the treatment of pelvic disorders by electrical nerve stimulation |
US9452287B2 (en) | 2013-01-21 | 2016-09-27 | Cala Health, Inc. | Devices and methods for controlling tremor |
US10850090B2 (en) | 2013-01-21 | 2020-12-01 | Cala Health, Inc. | Devices and methods for controlling tremor |
US10625074B2 (en) | 2013-01-21 | 2020-04-21 | Cala Health, Inc. | Devices and methods for controlling tremor |
US10179238B2 (en) | 2014-06-02 | 2019-01-15 | Cala Health, Inc. | Systems for peripheral nerve stimulation |
US10905879B2 (en) | 2014-06-02 | 2021-02-02 | Cala Health, Inc. | Methods for peripheral nerve stimulation |
US10561839B2 (en) | 2014-06-02 | 2020-02-18 | Cala Health, Inc. | Systems for peripheral nerve stimulation |
US10173060B2 (en) | 2014-06-02 | 2019-01-08 | Cala Health, Inc. | Methods for peripheral nerve stimulation |
US10549093B2 (en) | 2014-06-02 | 2020-02-04 | Cala Health, Inc. | Method for peripheral nerve stimulation |
US10960207B2 (en) | 2014-06-02 | 2021-03-30 | Cala Health, Inc. | Systems for peripheral nerve stimulation |
US9802041B2 (en) | 2014-06-02 | 2017-10-31 | Cala Health, Inc. | Systems for peripheral nerve stimulation to treat tremor |
US10765856B2 (en) | 2015-06-10 | 2020-09-08 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation to treat tremor with detachable therapy and monitoring units |
US11596785B2 (en) | 2015-09-23 | 2023-03-07 | Cala Health, Inc. | Systems and methods for peripheral nerve stimulation in the finger or hand to treat hand tremors |
US11344722B2 (en) | 2016-01-21 | 2022-05-31 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder |
US11918806B2 (en) | 2016-01-21 | 2024-03-05 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation of the leg |
US10814130B2 (en) | 2016-07-08 | 2020-10-27 | Cala Health, Inc. | Dry electrodes for transcutaneous nerve stimulation |
US11331480B2 (en) | 2017-04-03 | 2022-05-17 | Cala Health, Inc. | Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder |
US11857778B2 (en) | 2018-01-17 | 2024-01-02 | Cala Health, Inc. | Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation |
US11890468B1 (en) | 2019-10-03 | 2024-02-06 | Cala Health, Inc. | Neurostimulation systems with event pattern detection and classification |
Also Published As
Publication number | Publication date |
---|---|
EP1113841A1 (en) | 2001-07-11 |
AU758611B2 (en) | 2003-03-27 |
CA2343928A1 (en) | 2000-03-23 |
AU6388599A (en) | 2000-04-03 |
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