WO2000006990A3 - Apparatus and methods for time-resolved spectroscopic measurements - Google Patents

Apparatus and methods for time-resolved spectroscopic measurements Download PDF

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Publication number
WO2000006990A3
WO2000006990A3 PCT/US1999/016287 US9916287W WO0006990A3 WO 2000006990 A3 WO2000006990 A3 WO 2000006990A3 US 9916287 W US9916287 W US 9916287W WO 0006990 A3 WO0006990 A3 WO 0006990A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
time
spectroscopic measurements
sample
resolved spectroscopic
Prior art date
Application number
PCT/US1999/016287
Other languages
French (fr)
Other versions
WO2000006990A2 (en
WO2000006990A9 (en
Inventor
Douglas N Modlin
Todd E French
John C Owicki
Original Assignee
Ljl Biosystems Inc
Douglas N Modlin
Todd E French
John C Owicki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ljl Biosystems Inc, Douglas N Modlin, Todd E French, John C Owicki filed Critical Ljl Biosystems Inc
Priority to AU56675/99A priority Critical patent/AU5667599A/en
Publication of WO2000006990A2 publication Critical patent/WO2000006990A2/en
Publication of WO2000006990A3 publication Critical patent/WO2000006990A3/en
Publication of WO2000006990A9 publication Critical patent/WO2000006990A9/en
Priority to US09/765,874 priority patent/US6483582B2/en
Priority to US10/445,292 priority patent/US6992761B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel

Abstract

Apparatus and method for measuring light transmitted from a sample. The apparatus may include a stage (123), a light source (103), and a detector (145). The stage (123) may be configured to hold a microplate (124) having a plurality of sample wells (126). The apparatus may be configured to take frequency-domain time-resolved measurements of one or more of luminescence lifetimes and reorientational correlation times of a luminescent analyte in the sample.
PCT/US1999/016287 1997-09-20 1999-07-26 Apparatus and methods for time-resolved spectroscopic measurements WO2000006990A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU56675/99A AU5667599A (en) 1998-07-27 1999-07-26 Apparatus and methods for time-resolved spectroscopic measurements
US09/765,874 US6483582B2 (en) 1998-07-27 2001-01-19 Apparatus and methods for time-resolved spectroscopic measurements
US10/445,292 US6992761B2 (en) 1997-09-20 2003-05-22 Broad range light detection system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9427698P 1998-07-27 1998-07-27
US60/094,276 1998-07-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/765,874 Continuation US6483582B2 (en) 1997-09-20 2001-01-19 Apparatus and methods for time-resolved spectroscopic measurements

Publications (3)

Publication Number Publication Date
WO2000006990A2 WO2000006990A2 (en) 2000-02-10
WO2000006990A3 true WO2000006990A3 (en) 2000-05-18
WO2000006990A9 WO2000006990A9 (en) 2000-07-27

Family

ID=22244191

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/016287 WO2000006990A2 (en) 1997-09-20 1999-07-26 Apparatus and methods for time-resolved spectroscopic measurements

Country Status (3)

Country Link
US (1) US6483582B2 (en)
AU (1) AU5667599A (en)
WO (1) WO2000006990A2 (en)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US6519032B1 (en) * 1998-04-03 2003-02-11 Symyx Technologies, Inc. Fiber optic apparatus and use thereof in combinatorial material science
ATE497164T1 (en) 1999-06-09 2011-02-15 Molecular Devices Inc TEST METHODS FOR MEASURING PHOSPHORYLATION
US6795189B2 (en) * 2000-06-15 2004-09-21 Packard Instrument Company Universal microplate analyzer
US7714301B2 (en) 2000-10-27 2010-05-11 Molecular Devices, Inc. Instrument excitation source and calibration method
US6930314B2 (en) 2000-10-27 2005-08-16 Molecular Devices Corporation Light detection device
AU2002233598B2 (en) * 2001-02-28 2007-06-14 Ge Healthcare Niagara Inc. An imaging fluorometer for time resolved fluorescence
FI114740B (en) * 2001-04-27 2004-12-15 Wallac Oy Shield plate for imaging measuring equipment
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
DE10133273A1 (en) * 2001-07-09 2003-01-30 Bayer Cropscience Ag Device and method for the detection of photosynthesis inhibition
US6740890B1 (en) * 2001-08-15 2004-05-25 Chen-Yu Tai Time-resolved light decay measurements without using a gated detector
GB0127861D0 (en) * 2001-11-20 2002-01-16 Biotrace Ltd Absorbance monitoring
US20040057870A1 (en) * 2002-09-20 2004-03-25 Christer Isaksson Instrumentation for optical measurement of samples
GB0324784D0 (en) * 2003-10-24 2003-11-26 Biotrace Ltd Bioluminescence monitor
US7230712B2 (en) * 2003-11-03 2007-06-12 Battelle Memorial Institute Reduction of residual amplitude modulation in frequency-modulated signals
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US20070185679A1 (en) * 2004-04-01 2007-08-09 Petruno Patrick T Indicating status of a diagnostic test system
US20050221504A1 (en) * 2004-04-01 2005-10-06 Petruno Patrick T Optoelectronic rapid diagnostic test system
US8128871B2 (en) * 2005-04-22 2012-03-06 Alverix, Inc. Lateral flow assay systems and methods
US7521259B2 (en) * 2004-04-01 2009-04-21 Alverix, Inc. Assay test strips with multiple labels and reading same
US20070143035A1 (en) * 2005-12-19 2007-06-21 Petruno Patrick T Diagnostic test reader with disabling unit
US7332700B2 (en) * 2004-04-26 2008-02-19 Bruce Masato Ishimoto Photomultiplier tube with dynode modulation for photon-counting
US7796266B2 (en) 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7815854B2 (en) 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US6970241B1 (en) 2004-08-24 2005-11-29 Desa Richard J Device for enabling slow and direct measurement of fluorescence polarization
US7391512B2 (en) * 2004-12-22 2008-06-24 Avago Technologies General Ip Pte. Ltd. Integrated optoelectronic system for measuring fluorescence or luminescence emission decay
DE102005008196B4 (en) * 2005-02-22 2019-08-29 Leica Microsystems Cms Gmbh Method for detecting dark states in the spectroscopic or microscopic examination of fluorescent samples and apparatus for the spectroscopic or microscopic examination of fluorescent samples
US10041941B2 (en) * 2005-04-22 2018-08-07 Alverix, Inc. Assay test strips with multiple labels and reading same
US8632730B2 (en) * 2005-11-22 2014-01-21 Alverix, Inc. Assaying test strips having different capture reagents
US20070122914A1 (en) * 2005-11-30 2007-05-31 Curry Bo U Obtaining measurements of light transmitted through an assay test strip
KR100660519B1 (en) * 2005-12-12 2006-12-22 (주)토핀스 The testing matter photographing appratus attached three dimensional image photographing device
KR101423938B1 (en) * 2005-12-21 2014-08-06 메소 스케일 테크놀러지즈, 엘엘시 Assay apparatuses, methods and reagents
US20070188736A1 (en) * 2006-02-16 2007-08-16 Fouquet Julie E Obtaining measurement and baseline signals for evaluating assay test strips
CA2681722A1 (en) * 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
US8725477B2 (en) * 2008-04-10 2014-05-13 Schlumberger Technology Corporation Method to generate numerical pseudocores using borehole images, digital rock samples, and multi-point statistics
RU2440591C2 (en) 2008-04-10 2012-01-20 Шлюмбергер Текнолоджи Б.В. Method of obtaining characteristics of geological formation intersected by well
EP2269026B1 (en) * 2008-04-11 2019-06-19 Meso Scale Technologies, LLC Apparatus with plate-handling subsystem for conducting luminescence assays in multi-well plates
US8311788B2 (en) 2009-07-01 2012-11-13 Schlumberger Technology Corporation Method to quantify discrete pore shapes, volumes, and surface areas using confocal profilometry
US20110004447A1 (en) * 2009-07-01 2011-01-06 Schlumberger Technology Corporation Method to build 3D digital models of porous media using transmitted laser scanning confocal mircoscopy and multi-point statistics
DE102010052701A1 (en) * 2010-11-26 2012-05-31 Universität Konstanz Apparatus for measuring a carrier lifetime in a semiconductor substrate
CN102519017A (en) * 2011-12-28 2012-06-27 北京奥博泰科技有限公司 High color temperature continuously adjustable uniform light source device and method
US9201018B2 (en) 2013-12-23 2015-12-01 Honeywell Asca Inc. Optimized spatial resolution for a spectroscopic sensor
EP3513172B1 (en) * 2016-09-14 2022-09-14 Radiometer Medical ApS System and method for time-resolved fluoroimmunoassay detection
WO2019002689A1 (en) * 2017-06-27 2019-01-03 Thermo Fisher Scientific Oy Method of analyzing liquid samples, microplate reader and computer program
US11719638B2 (en) 2017-06-27 2023-08-08 Life Technologies Holdings Pte Ltd Method of analyzing samples, analyzing device and computer program
WO2019044969A1 (en) * 2017-09-01 2019-03-07 ウシオ電機株式会社 Microplate reader
CA3079984A1 (en) * 2017-10-31 2019-05-09 Alberta Biophotonics Inc. Optical measurement method and system
GB2569329B (en) * 2017-12-13 2021-06-09 Univ Oxford Innovation Ltd Apparatus for optical detection of contamination, radiation source, method for optical detection of contamination
CN108709163A (en) * 2018-05-16 2018-10-26 德州尧鼎光电科技有限公司 A kind of light source output Wavelength tuning device
CN108709164A (en) * 2018-05-16 2018-10-26 德州尧鼎光电科技有限公司 A kind of light source output Wavelength tuning device
US11740180B2 (en) * 2020-09-28 2023-08-29 Purdue Research Foundation Method of measuring diffusion in a medium

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808828A (en) * 1985-12-02 1989-02-28 Hitachi, Ltd. Method of and apparatus for simultaneous determination
US5323010A (en) * 1992-12-01 1994-06-21 I.S.S. (Usa) Inc. Time resolved optical array detectors and CCD cameras for frequency domain fluorometry and/or phosphorimetry
US5905571A (en) * 1995-08-30 1999-05-18 Sandia Corporation Optical apparatus for forming correlation spectrometers and optical processors

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2719214A (en) 1951-01-26 1955-09-27 Potter Edward Airport marker with flexible support
US3013467A (en) 1957-11-07 1961-12-19 Minsky Marvin Microscopy apparatus
US3423581A (en) 1966-10-26 1969-01-21 Gen Motors Corp Remote illumination apparatus
US3516736A (en) 1967-01-16 1970-06-23 Weaver Co W R Focussing objective for telescope sights
US3849654A (en) 1973-10-19 1974-11-19 H Malvin Fluorescence cuvette
US3885162A (en) 1973-10-31 1975-05-20 Contraves Goerz Corp Optical measuring apparatus
US4074939A (en) 1973-12-19 1978-02-21 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Apparatus for investigating fast chemical reactions by optical detection
DE2408646A1 (en) 1974-02-22 1975-08-28 Max Planck Gesellschaft REACTION KINETIC MEASURING DEVICE
US3932023A (en) 1974-11-18 1976-01-13 E. I. Du Pont De Nemours & Company Optical coupler for transmitting light linearly between a single point and plural points
US4011451A (en) 1975-07-03 1977-03-08 Waters Associates, Incorporated Novel photometric system
US4144452A (en) 1976-07-08 1979-03-13 International Diagnostic Technology, Inc. Fluorometric system, method and test article
FR2359433A1 (en) 1976-07-23 1978-02-17 Thomson Csf ADJUSTABLE RADIATION DISTRIBUTOR GUIDED BY OPTICAL FIBER BEAMS
US4067653A (en) 1976-08-27 1978-01-10 Nasa Differential optoacoustic absorption detector
US4100416A (en) 1977-03-02 1978-07-11 Block Engineering, Inc. Serum fluorescence suppression
US4203670A (en) 1977-04-21 1980-05-20 Bromberg Nathan S System and method of fluorescence polarimetry
US4240751A (en) 1978-11-09 1980-12-23 Akzona Incorporated Method and apparatus for specific binding substances
GB2047402B (en) 1979-03-06 1983-03-09 De La Rue Thomas & Co Ltd Watermark detection
US4451149A (en) 1980-07-28 1984-05-29 Noeller Hans Guenter Polarization fluoroimmunoassay apparatus
JPS5782769A (en) 1980-11-10 1982-05-24 Hitachi Ltd Automatic analyzing device
US4485430A (en) 1981-01-22 1984-11-27 Cibie Projecteurs Complementary projector for a motor vehicle
US4397560A (en) 1981-04-23 1983-08-09 Bio-Tek Instruments, Inc. Photometer with microtray well position indicator
US4501970A (en) 1982-10-12 1985-02-26 Dynatech Laboratories Incorporated Fluorometer
JPS5970946A (en) 1982-10-15 1984-04-21 Toshiba Corp Apparatus for measuring absorbance
US4626684A (en) 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
US4704255A (en) 1983-07-15 1987-11-03 Pandex Laboratories, Inc. Assay cartridge
US4567847A (en) 1983-08-23 1986-02-04 Board Of Regents, The University Of Texas System Apparatus and method for cryopreparing biological tissue for ultrastructural analysis
EP0155528B1 (en) 1984-02-22 1989-02-01 Siemens Aktiengesellschaft Optoelectronic housing module
US4591550A (en) 1984-03-01 1986-05-27 Molecular Devices Corporation Device having photoresponsive electrode for determining analytes including ligands and antibodies
US4968148A (en) 1984-03-01 1990-11-06 Molecular Devices Corporation Single source multi-site photometric measurement system
US5500188A (en) 1984-03-01 1996-03-19 Molecular Devices Corporation Device for photoresponsive detection and discrimination
JPS6125030A (en) 1984-07-13 1986-02-03 Hitachi Ltd Fluorescence-polarization measuring apparatus
US4661770A (en) * 1984-12-18 1987-04-28 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method and apparatus for measuring minority carrier lifetime in a direct band-gap semiconductor
US4738825A (en) 1985-02-27 1988-04-19 Fisher Scientific Company Cuvette handling
US4772453A (en) 1985-03-01 1988-09-20 Lisenbee Wayne F Luminiscence measurement arrangement
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US5047215A (en) 1985-06-18 1991-09-10 Polyfiltronics, Inc. Multiwell test plate
US4948442A (en) 1985-06-18 1990-08-14 Polyfiltronics, Inc. Method of making a multiwell test plate
US4877965A (en) 1985-07-01 1989-10-31 Diatron Corporation Fluorometer
EP0213825A3 (en) 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
US4737464A (en) 1985-09-26 1988-04-12 Molecular Devices Corporation Solid-state optical assay imaging apparatus
US4873633A (en) 1985-10-18 1989-10-10 Cetus Corporation User controlled off-center light absorbance reading adjuster in a liquid handling and reaction system
US4730921A (en) 1985-10-31 1988-03-15 Genetic Systems, Inc. Photodensitometer for minimizing the refractive effects of a fluid sample
JPH0650315B2 (en) 1985-11-08 1994-06-29 株式会社日立製作所 Immunological analysis reagent and immunological analysis method
US4646214A (en) 1986-01-09 1987-02-24 Mendleski Ronald J Miniature coaxial lighting assembly
US4753501A (en) 1986-01-15 1988-06-28 The United States Of America As Represented By The Secretary Of The Air Force Fiber optic rotary switching device
US5009488A (en) 1986-02-11 1991-04-23 University Of Massachusetts Medical Center Filter accessory for an imaging microspectrofluorimeter
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
CH669851A5 (en) 1986-03-06 1989-04-14 Tecan Ag
US5206568A (en) 1986-03-26 1993-04-27 Beckman Instruments, Inc. Coordinated control of stepper motors
GB8607975D0 (en) 1986-04-01 1986-05-08 Fisons Plc Devices
US4802768A (en) 1986-04-11 1989-02-07 Sclavo, Inc. Two light source reference system for a fluorometer
GB2190195A (en) 1986-05-09 1987-11-11 Cambridge Life Sciences Microtitre plate reader
US5270788A (en) 1986-05-27 1993-12-14 Boris Cercek Apparatus for measuring polarization of bathochromically shifted fluorescence
US4758786A (en) 1986-08-06 1988-07-19 Molecular Devices Corporation Method of analyzing semiconductor systems
US4784275A (en) 1986-09-15 1988-11-15 Vanzetti Systems Inc. Verification systems for small objects
US5084246A (en) 1986-10-28 1992-01-28 Costar Corporation Multi-well test plate
US4885087A (en) 1986-11-26 1989-12-05 Kopf Henry B Apparatus for mass transfer involving biological/pharmaceutical media
US4855930A (en) 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
US4923819A (en) 1987-03-27 1990-05-08 Chimerix Corporation Time-resolved fluorescence immunoassay
US4741619A (en) 1987-05-05 1988-05-03 Molecular Devices Corporation Hydrophilic microplates for vertical beam photometry
US4826660A (en) 1987-05-07 1989-05-02 Becton, Dickinson And Company Detector assembly for analyzer instrument
US4963815A (en) 1987-07-10 1990-10-16 Molecular Devices Corporation Photoresponsive electrode for determination of redox potential
US4936682A (en) 1987-08-11 1990-06-26 Associates Of Cape Cod, Inc. Instrument for independently and kinetically measuring light transpassion through a plurality of samples
DE3879209D1 (en) 1987-08-27 1993-04-15 Polyfiltronics Ltd FILTER UNITS FOR THE PREPARATION OF BIOLOGICAL SAMPLES.
CH673534A5 (en) 1987-10-19 1990-03-15 Tecan Ag
US4979821A (en) 1988-01-27 1990-12-25 Ortho Diagnostic Systems Inc. Cuvette for receiving liquid sample
GB2215838B (en) 1988-02-12 1992-10-21 Nat Res Dev Fluorimeters
US4892409A (en) 1988-07-14 1990-01-09 Smith Harry F Photometric apparatus for multiwell plates having a positionable lens assembly
US5798083A (en) 1988-11-03 1998-08-25 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration and chemiluminescence detection
US5746974A (en) 1988-11-03 1998-05-05 Igen International, Inc. Apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence and chemiluminescence detection
GB2228081B (en) 1988-12-06 1993-07-07 Loughborough Consult Ltd A fluorimeter, and a method of carrying out a fluorescent assay of a plurality of analytes
US5020995A (en) 1989-01-18 1991-06-04 Guy Levy Surgical treatment method and instrument
WO1990009637A1 (en) 1989-02-13 1990-08-23 Research Corporation Technologies, Inc. Method and means for parallel frequency acquisition in frequency domain fluorometry
US5039219A (en) 1989-05-26 1991-08-13 Photon Technology Luminescence system and method for determining the nature of substances by measuring fluorescence and phosphorescence properties
US5480804A (en) 1989-06-28 1996-01-02 Kirin Beverage Corporation Method of and apparatus for detecting microorganisms
US5018866A (en) 1989-09-12 1991-05-28 Packard Instrument Company Method and apparatus for performing high sensitivity fluorescence measurements
US5082628A (en) 1989-09-19 1992-01-21 Park Pharmaceuticals, Inc. Luminometer
US5198670A (en) 1989-09-29 1993-03-30 Packard Instrument Company Scintillation counting system for in-situ measurement of radioactive samples in a multiple-well plate
US5034613A (en) 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5091652A (en) 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
GB9001701D0 (en) 1990-01-25 1990-03-28 Gersan Ets Optical inspection method and apparatus
IT1239223B (en) 1990-02-20 1993-09-28 Pirelli Cavi Spa ADJUSTABLE OPTICAL CONNECTOR FOR CONNECTION OF OPTICAL FIBERS TO DISCRETE OPTICAL COMPONENTS AND SENSOR USING ONE OR MORE ADJUSTABLE CONNECTORS
US5058045A (en) 1990-03-09 1991-10-15 Ma Hsi K Battery and expansion slot changeable computer
US5169601A (en) 1990-04-27 1992-12-08 Suzuki Motor Corporation Immunological agglutination detecting apparatus with separately controlled supplementary light sources
SE9002579D0 (en) 1990-08-07 1990-08-07 Pharmacia Ab METHOD AND APPARATUS FOR CARRYING OUT BIOCHEMICAL REACTIONS
US5504337A (en) 1990-10-10 1996-04-02 Joseph R. Lakowicz Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry
FI86340C (en) 1990-10-31 1992-08-10 Labsystems Oy Procedure for conducting light
WO1992013265A1 (en) 1991-01-24 1992-08-06 The University Of Maryland Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
FR2672128B1 (en) 1991-01-28 1995-08-18 Cis Bio Int METHOD FOR MEASURING THE LUMINESCENCE EMITTED IN A LUMINESCENCE ASSAY.
US5192510A (en) 1991-01-30 1993-03-09 E. I. Du Pont De Nemours And Company Apparatus for performing fluorescent assays which separates bulk and evanescent fluorescence
US5196709A (en) 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
EP0517930B1 (en) 1991-06-08 1995-05-24 Hewlett-Packard GmbH Method and apparatus for detecting the presence and/or concentration of biomolecules
JPH06507496A (en) 1991-06-13 1994-08-25 アボツト・ラボラトリーズ Optical imaging for positioning and cell counting
US5208651A (en) 1991-07-16 1993-05-04 The Regents Of The University Of California Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes
US5289407A (en) 1991-07-22 1994-02-22 Cornell Research Foundation, Inc. Method for three dimensional optical data storage and retrieval
US5281825A (en) 1991-09-05 1994-01-25 The University Of Maryland School Of Medicine Phase fluorometry using a modulated electroluminescent lamp as a light source
US5225164A (en) 1991-09-30 1993-07-06 Astle Thomas W Microplate laboratory tray with rectilinear wells
WO1993009441A1 (en) 1991-10-31 1993-05-13 Baxter Diagnostics Inc. Specimen processing and analyzing systems with associated fluid dispensing apparatus
JPH05157684A (en) 1991-12-02 1993-06-25 Seikagaku Kogyo Co Ltd Absorptionmeter
US5670113A (en) 1991-12-20 1997-09-23 Sibia Neurosciences, Inc. Automated analysis equipment and assay method for detecting cell surface protein and/or cytoplasmic receptor function using same
US5361626A (en) 1992-01-29 1994-11-08 United States Surgical Corporation Method and apparatus for detecting leaks in sealed packages
US5635402A (en) 1992-03-05 1997-06-03 Alfano; Robert R. Technique for determining whether a cell is malignant as opposed to non-malignant using extrinsic fluorescence spectroscopy
EP0592624B1 (en) 1992-03-09 2001-09-19 Accumed International Inc. Diagnostic microbiological testing apparatus and method
US5323008A (en) 1992-03-23 1994-06-21 Diatron Corporation Fluorometer detection system
JP2561367Y2 (en) 1992-04-03 1998-01-28 東亞医用電子株式会社 Sample suction and discharge device
US5401465A (en) 1992-05-05 1995-03-28 Chiron Corporation Luminometer with reduced sample crosstalk
US5319436A (en) 1992-05-28 1994-06-07 Packard Instrument Company, Inc. Microplate farming wells with transparent bottom walls for assays using light measurements
US5470754A (en) 1992-06-01 1995-11-28 The Coca-Cola Company Method and system for sampling and determining the presence of compounds
US5357095A (en) 1992-07-16 1994-10-18 Schiapparelli Biosystems, Inc. Reagent bottle identification and reagent monitoring system for a chemical analyzer
US5290521A (en) 1992-09-04 1994-03-01 Destefano Jr Albert M Lab-top work station
US5736410A (en) 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5355215A (en) 1992-09-30 1994-10-11 Environmental Research Institute Of Michigan Method and apparatus for quantitative fluorescence measurements
US5825617A (en) 1992-10-02 1998-10-20 Teletransactions, Inc. Workslate computer having modular device docking stations on horizontal and vertical side portions
JP3305322B2 (en) 1992-11-06 2002-07-22 バイオログ，インコーポレーテッド Liquid and suspension analyzers
JP2575270B2 (en) 1992-11-10 1997-01-22 浜松ホトニクス株式会社 Method for determining base sequence of nucleic acid, method for detecting single molecule, apparatus therefor and method for preparing sample
US5315015A (en) 1992-11-10 1994-05-24 Hoffmann-La Roche Inc. Compounds having improved fluorescence in fluorescence polarization immunoassays and immunoassays utilizing same
US5445935A (en) 1992-11-23 1995-08-29 Royer; Catherine A. Quantitative detection of macromolecules with fluorescent oligonucleotides
US5418371A (en) 1993-02-01 1995-05-23 Aslund; Nils R. D. Apparatus for quantitative imaging of multiple fluorophores using dual detectors
US5459300A (en) 1993-03-03 1995-10-17 Kasman; David H. Microplate heater for providing uniform heating regardless of the geometry of the microplates
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5317485A (en) 1993-06-04 1994-05-31 American Surgical Technologies Corporation Connector and method for coupling an end of a light-transmitting conduit
JPH08501882A (en) 1993-07-09 1996-02-27 マイクロスキャン、インコーポレイテッド Liquid dispensing device and method
GB9314991D0 (en) 1993-07-20 1993-09-01 Sandoz Ltd Mechanical device
US5436718A (en) 1993-07-30 1995-07-25 Biolumin Corporation Mutli-functional photometer with movable linkage for routing optical fibers
US5766875A (en) 1993-07-30 1998-06-16 Molecular Devices Corporation Metabolic monitoring of cells in a microplate reader
CA2169292C (en) 1993-08-12 2010-11-23 E. Edward Baetge Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
US5537343A (en) 1993-09-02 1996-07-16 Elonex Technologies, Inc. Digital assistant system having a host computer with a docking bay and a moveable heat sink for cooling a docked module
US5541113A (en) 1993-09-22 1996-07-30 Beckman Instruments, Inc. Method for detecting an analyte using an electrochemical luminescent transition metal label
JPH07113872A (en) 1993-10-13 1995-05-02 Shigeo Baba Method and apparatus for measuring beta emitter
FI96452C (en) 1994-01-26 1996-06-25 Pekka Haenninen Method for excitation of dyes
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5491343A (en) 1994-03-25 1996-02-13 Brooker; Gary High-speed multiple wavelength illumination source, apparatus containing the same, and applications thereof to methods of irradiating luminescent samples and of quantitative luminescence ratio microscopy
US5557398A (en) 1994-04-15 1996-09-17 Molecular Devices Corporation Photometric device
US5487872A (en) 1994-04-15 1996-01-30 Molecular Device Corporation Ultraviolet radiation transparent multi-assay plates
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5515864A (en) 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5959738A (en) 1994-07-25 1999-09-28 Molecular Devices Corporation Determination of light absorption pathlength in a vertical-beam photometer
US5750410A (en) 1994-08-26 1998-05-12 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of and apparatus for immune analysis
US5589351A (en) 1994-12-06 1996-12-31 Nps Pharmaceuticals, Inc. Fluorescence detection apparatus
EP0746865B1 (en) 1994-12-08 2003-03-26 Molecular Dynamics, Inc. Fluorescence imaging system employing a macro scanning objective
US5592289A (en) 1995-01-09 1997-01-07 Molecular Dynamics Self-aligning mechanism for positioning analyte receptacles
US5595710A (en) 1995-05-25 1997-01-21 Intelligent Medical Imaging, Inc. Medical slide holder
US5604130A (en) 1995-05-31 1997-02-18 Chiron Corporation Releasable multiwell plate cover
US5620894A (en) 1995-06-16 1997-04-15 Glaxo Wellcome Inc. Apparatus for automated biological cell harvesting
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5679310A (en) 1995-07-11 1997-10-21 Polyfiltronics, Inc. High surface area multiwell test plate
US5663545A (en) 1995-08-23 1997-09-02 Ljl Biosystems Inc. Labware identification system
US5633724A (en) 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
FI954512A0 (en) 1995-09-22 1995-09-22 Labsystems Oy Plattbaerare
US5641633A (en) 1995-11-15 1997-06-24 Becton, Dickinson And Company Fluorescence polarization detection of nucleic acids
US5670375A (en) 1996-02-21 1997-09-23 Biomerieux Vitek, Inc. Sample card transport method for biological sample testing machine
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
AT1406U1 (en) 1996-05-31 1997-04-25 Slt Labinstruments Gmbh FLUOROMETER
US5741554A (en) 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
US5780857A (en) 1996-10-04 1998-07-14 Wallac Oy Apparatus for imaging biochemical samples on substrates
JP3830167B2 (en) 1996-11-27 2006-10-04 マックス−プランク−ゲゼルシャフト ツル フェルデルング デァ ヴィッセンシャフテン エー．フォオ．，ベルリン Method and apparatus for determining a predetermined property of a target particle in a sample medium
DE19704732A1 (en) 1997-02-07 1998-08-13 Stratec Elektronik Gmbh Luminescence measurement device
US6020591A (en) 1997-07-11 2000-02-01 Imra America, Inc. Two-photon microscopy with plane wave illumination
US6071748A (en) 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6097025A (en) 1997-10-31 2000-08-01 Ljl Biosystems, Inc. Light detection device having an optical-path switching mechanism
ATE303598T1 (en) 1998-07-31 2005-09-15 Tecan Trading Ag MAGNETIC SEPARATOR
EP0993916B1 (en) 1998-10-15 2004-02-25 Tecan Trading AG Robot gripper
EP0995555A1 (en) 1998-10-15 2000-04-26 Tecan AG Robot arm
CH698240B1 (en) 1998-11-17 2009-06-30 Tecan Trading Ag A method for weighing sample tubes, feeding and workstation.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808828A (en) * 1985-12-02 1989-02-28 Hitachi, Ltd. Method of and apparatus for simultaneous determination
US5323010A (en) * 1992-12-01 1994-06-21 I.S.S. (Usa) Inc. Time resolved optical array detectors and CCD cameras for frequency domain fluorometry and/or phosphorimetry
US5905571A (en) * 1995-08-30 1999-05-18 Sandia Corporation Optical apparatus for forming correlation spectrometers and optical processors

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