WO2000006249A3 - Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea - Google Patents

Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea Download PDF

Info

Publication number
WO2000006249A3
WO2000006249A3 PCT/US1999/016913 US9916913W WO0006249A3 WO 2000006249 A3 WO2000006249 A3 WO 2000006249A3 US 9916913 W US9916913 W US 9916913W WO 0006249 A3 WO0006249 A3 WO 0006249A3
Authority
WO
WIPO (PCT)
Prior art keywords
hypoglossal nerve
stimulation
sleep apnea
obstructive sleep
closed
Prior art date
Application number
PCT/US1999/016913
Other languages
French (fr)
Other versions
WO2000006249A2 (en
Inventor
Dominique Durand
Mesut Sahin
Musa A Haxhiu
Original Assignee
Univ Case Western Reserve
Dominique Durand
Mesut Sahin
Musa A Haxhiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Case Western Reserve, Dominique Durand, Mesut Sahin, Musa A Haxhiu filed Critical Univ Case Western Reserve
Priority to US09/744,640 priority Critical patent/US6587725B1/en
Priority to AU51301/99A priority patent/AU5130199A/en
Publication of WO2000006249A2 publication Critical patent/WO2000006249A2/en
Publication of WO2000006249A3 publication Critical patent/WO2000006249A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs

Abstract

This invention is a fully implanted functional electrical stimulator (20) apparatus, a method for treatment of obstructive sleep apnea that provides for both reliable detection/prediction of airway occlusion that relieves, and/or prevents same by selective, direct electrical stimulation of the hypoglossal nerve (HG). The method, and apparatus sense hypoglossal nerve electro-neurogram activity for purposes of detecting or predicting obstructive sleep apnea. The sensed hypoglossal nerve activity, itself, is used to trigger functional electrical stimulation of the hypoglossal nerve in order to improve upper airway patency. Further, an improved hypoglossal nerve stimulation electrode (10) interface (IC) is provided that allows for simultaneous hypoglossal nerve activity sensing, and stimulation by eliminating stimulation artifacts that would otherwise trigger further, erroneous stimulation.
PCT/US1999/016913 1998-07-27 1999-07-27 Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea WO2000006249A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US09/744,640 US6587725B1 (en) 1998-07-27 1999-07-27 Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea
AU51301/99A AU5130199A (en) 1998-07-27 1999-07-27 Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9426398P 1998-07-27 1998-07-27
US60/094,263 1998-07-27

Publications (2)

Publication Number Publication Date
WO2000006249A2 WO2000006249A2 (en) 2000-02-10
WO2000006249A3 true WO2000006249A3 (en) 2000-05-18

Family

ID=22244104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/016913 WO2000006249A2 (en) 1998-07-27 1999-07-27 Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea

Country Status (3)

Country Link
US (1) US6587725B1 (en)
AU (1) AU5130199A (en)
WO (1) WO2000006249A2 (en)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000025859A1 (en) * 1998-10-30 2000-05-11 Aalborg University A method to control an overactive bladder
US6996435B2 (en) * 2001-11-19 2006-02-07 Neurostream Technologies Inc. Implantable signal amplifying circuit for electroneurographic recording
US7444183B2 (en) 2003-02-03 2008-10-28 Enteromedics, Inc. Intraluminal electrode apparatus and method
US8467876B2 (en) * 2003-10-15 2013-06-18 Rmx, Llc Breathing disorder detection and therapy delivery device and method
US20080161878A1 (en) * 2003-10-15 2008-07-03 Tehrani Amir J Device and method to for independently stimulating hemidiaphragms
US9259573B2 (en) * 2003-10-15 2016-02-16 Rmx, Llc Device and method for manipulating exhalation
US8265759B2 (en) * 2003-10-15 2012-09-11 Rmx, Llc Device and method for treating disorders of the cardiovascular system or heart
US20120158091A1 (en) * 2003-10-15 2012-06-21 Rmx, Llc Therapeutic diaphragm stimulation device and method
US7970475B2 (en) 2003-10-15 2011-06-28 Rmx, Llc Device and method for biasing lung volume
US8160711B2 (en) 2003-10-15 2012-04-17 Rmx, Llc Multimode device and method for controlling breathing
US20050085874A1 (en) * 2003-10-17 2005-04-21 Ross Davis Method and system for treating sleep apnea
US20050149132A1 (en) 2003-12-24 2005-07-07 Imad Libbus Automatic baroreflex modulation based on cardiac activity
US8396560B2 (en) * 2004-11-18 2013-03-12 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
US7769450B2 (en) 2004-11-18 2010-08-03 Cardiac Pacemakers, Inc. Cardiac rhythm management device with neural sensor
US7751894B1 (en) * 2004-03-04 2010-07-06 Cardiac Pacemakers, Inc. Systems and methods for indicating aberrant behavior detected by an implanted medical device
WO2005087313A1 (en) * 2004-03-18 2005-09-22 David Peter Shaw Method and apparatus for the treatment of sleep apnoea and snoring
US7371220B1 (en) 2004-06-30 2008-05-13 Pacesetter, Inc. System and method for real-time apnea/hypopnea detection using an implantable medical system
US9205261B2 (en) 2004-09-08 2015-12-08 The Board Of Trustees Of The Leland Stanford Junior University Neurostimulation methods and systems
US20060052856A1 (en) 2004-09-08 2006-03-09 Kim Daniel H Stimulation components
US20120277839A1 (en) 2004-09-08 2012-11-01 Kramer Jeffery M Selective stimulation to modulate the sympathetic nervous system
US7536227B1 (en) * 2005-01-26 2009-05-19 Pacesetter, Inc. Shielded electrode for nerve sensing
US7680538B2 (en) * 2005-03-31 2010-03-16 Case Western Reserve University Method of treating obstructive sleep apnea using electrical nerve stimulation
US9555252B2 (en) * 2005-04-25 2017-01-31 Cardiac Pacemakers, Inc. Systems for providing neural markers for sensed autonomic nervous system activity
US7640057B2 (en) * 2005-04-25 2009-12-29 Cardiac Pacemakers, Inc. Methods of providing neural markers for sensed autonomic nervous system activity
US7644714B2 (en) 2005-05-27 2010-01-12 Apnex Medical, Inc. Devices and methods for treating sleep disorders
US8036750B2 (en) * 2005-06-13 2011-10-11 Cardiac Pacemakers, Inc. System for neural control of respiration
US7672727B2 (en) * 2005-08-17 2010-03-02 Enteromedics Inc. Neural electrode treatment
US20070198066A1 (en) * 2005-11-03 2007-08-23 Greenberg Robert J Method and apparatus for visual neural stimulation
US20070144534A1 (en) * 2005-11-30 2007-06-28 Carlos Mery System to prevent airway obstruction
WO2007098202A2 (en) * 2006-02-16 2007-08-30 Imthera Medical, Inc. An rfid based apparatus, system, and method for therapeutic treatment of a patient
AU2012201366B8 (en) * 2006-02-16 2015-08-06 Imthera Medical, Inc. An RFID based apparatus, system, and method for therapeutic treatment of a patient
US20080021506A1 (en) * 2006-05-09 2008-01-24 Massachusetts General Hospital Method and device for the electrical treatment of sleep apnea and snoring
US7650189B1 (en) 2006-06-02 2010-01-19 Pacesetter, Inc. Techniques to maintain or alter upper airway patency
US7660632B2 (en) * 2006-06-30 2010-02-09 Ric Investments, Llc Method and apparatus for hypoglossal nerve stimulation
US8121692B2 (en) 2006-08-30 2012-02-21 Cardiac Pacemakers, Inc. Method and apparatus for neural stimulation with respiratory feedback
US8050765B2 (en) 2006-08-30 2011-11-01 Cardiac Pacemakers, Inc. Method and apparatus for controlling neural stimulation during disordered breathing
CA2659637A1 (en) * 2006-09-19 2008-04-24 Victhom Human Bionics Inc. Method and system for the monitoring of respiratory activity and for the treatment of breathing disorders such as sleep apnea
US9744354B2 (en) 2008-12-31 2017-08-29 Cyberonics, Inc. Obstructive sleep apnea treatment devices, systems and methods
US9913982B2 (en) 2011-01-28 2018-03-13 Cyberonics, Inc. Obstructive sleep apnea treatment devices, systems and methods
US8417343B2 (en) 2006-10-13 2013-04-09 Apnex Medical, Inc. Obstructive sleep apnea treatment devices, systems and methods
US8855771B2 (en) 2011-01-28 2014-10-07 Cyberonics, Inc. Screening devices and methods for obstructive sleep apnea therapy
US9205262B2 (en) 2011-05-12 2015-12-08 Cyberonics, Inc. Devices and methods for sleep apnea treatment
US9186511B2 (en) 2006-10-13 2015-11-17 Cyberonics, Inc. Obstructive sleep apnea treatment devices, systems and methods
US20080109047A1 (en) * 2006-10-26 2008-05-08 Pless Benjamin D Apnea treatment device
WO2008070809A2 (en) * 2006-12-06 2008-06-12 Spinal Modulation, Inc. Implantable flexible circuit leads and methods of use
AU2007329252A1 (en) 2006-12-06 2008-06-12 Spinal Modulation, Inc. Hard tissue anchors and delivery devices
US9427570B2 (en) * 2006-12-06 2016-08-30 St. Jude Medical Luxembourg Holdings SMI S.A.R.L. (“SJM LUX SMI”) Expandable stimulation leads and methods of use
AU2007329253B2 (en) 2006-12-06 2014-03-27 Spinal Modulation, Inc. Delivery devices, systems and methods for stimulating nerve tissue on multiple spinal levels
US8280513B2 (en) * 2006-12-22 2012-10-02 Rmx, Llc Device and method to treat flow limitations
AU2008210504B2 (en) * 2007-01-29 2012-07-26 Spinal Modulation, Inc. Sutureless lead retention features
US7751880B1 (en) 2007-02-12 2010-07-06 Pacesetter, Inc. Shielded electrode assembly for effective nerve sensing and stimulation
US7630771B2 (en) * 2007-06-25 2009-12-08 Microtransponder, Inc. Grooved electrode and wireless microtransponder system
WO2009048581A1 (en) 2007-10-09 2009-04-16 Imthera Medical, Inc. System and method for neural stimulation
JP5538367B2 (en) * 2008-05-02 2014-07-02 メドトロニック，インコーポレイテッド Electrode lead system
US8340785B2 (en) * 2008-05-02 2012-12-25 Medtronic, Inc. Self expanding electrode cuff
EP2331201B1 (en) 2008-10-01 2020-04-29 Inspire Medical Systems, Inc. System for treating sleep apnea transvenously
BRPI0920548B8 (en) 2008-10-09 2021-06-22 Imthera Medical Inc device to control the position of a patient's tongue
EP2373378B1 (en) 2008-10-27 2017-04-26 Spinal Modulation Inc. Selective stimulation systems and signal parameters for medical conditions
US8644939B2 (en) * 2008-11-18 2014-02-04 Neurostream Technologies General Partnership Method and device for the detection, identification and treatment of sleep apnea/hypopnea
EP2358268B1 (en) * 2008-11-18 2019-03-27 MED-EL Elektromedizinische Geräte GmbH Device for detecting sleep apnea events by monitoring the internal branch of the superior laryngeal nerve
WO2010059839A2 (en) 2008-11-19 2010-05-27 Inspire Medical Systems, Inc. Method of treating sleep disordered breathing
US8515520B2 (en) 2008-12-08 2013-08-20 Medtronic Xomed, Inc. Nerve electrode
AU2010229985B2 (en) 2009-03-24 2015-09-17 Spinal Modulation, Inc. Pain management with stimulation subthreshold to paresthesia
WO2010117810A1 (en) 2009-03-31 2010-10-14 Inspire Medical Systems, Inc. Percutaneous access for systems of treating sleep-related disordered breathing
US9259569B2 (en) 2009-05-15 2016-02-16 Daniel M. Brounstein Methods, systems and devices for neuromodulating spinal anatomy
US8160712B1 (en) 2009-09-23 2012-04-17 Marcy Freed Apparatus and method for treating sleep apnea
US10751537B2 (en) 2009-10-20 2020-08-25 Nyxoah SA Arced implant unit for modulation of nerves
US9409013B2 (en) 2009-10-20 2016-08-09 Nyxoah SA Method for controlling energy delivery as a function of degree of coupling
US9415215B2 (en) 2009-10-20 2016-08-16 Nyxoah SA Methods for treatment of sleep apnea
US10806926B2 (en) * 2009-10-20 2020-10-20 Man & Science Sa Implantable electrical stimulator
US9950166B2 (en) 2009-10-20 2018-04-24 Nyxoah SA Acred implant unit for modulation of nerves
US9327110B2 (en) 2009-10-27 2016-05-03 St. Jude Medical Luxembourg Holdings SMI S.A.R.L. (“SJM LUX SMI”) Devices, systems and methods for the targeted treatment of movement disorders
JP2013509943A (en) 2009-11-10 2013-03-21 イムセラ・メディカル・インコーポレーテッド A system that adjusts the position of the patient's tongue by stimulating the hypoglossal nerve
EP2544590B1 (en) 2010-03-12 2018-02-14 Inspire Medical Systems, Inc. System for identifying a location for nerve stimulation
WO2011143233A2 (en) 2010-05-10 2011-11-17 Spinal Modulation, Inc. Methods, systems and devices for reducing migration
US20140194793A1 (en) * 2010-05-14 2014-07-10 Kai Medical, Inc. Systems and methods for non-contact multiparameter vital signs monitoring, apnea therapy, apnea diagnosis, and snore therapy
US8825164B2 (en) 2010-06-11 2014-09-02 Enteromedics Inc. Neural modulation devices and methods
CN102198010B (en) 2010-09-29 2015-11-25 张湘民 Embedded type tongue pulling device, towing plate, draught line, tractor and method
US9457186B2 (en) * 2010-11-15 2016-10-04 Bluewind Medical Ltd. Bilateral feedback
EP2691149B1 (en) 2011-03-28 2019-02-27 Med-El Elektromedizinische Geraete GmbH System for treating apnea using evoked swallow
US9980645B1 (en) * 2011-06-21 2018-05-29 Case Western Reserve University High-contact density electrode and fabrication technique for an implantable cuff design
US8583240B2 (en) 2011-07-18 2013-11-12 Marcy L. Freed Device and method for treating dysphagia with electrical stimulation
EP2741813B1 (en) 2011-08-11 2022-03-09 Inspire Medical Systems, Inc. System for selecting a stimulation protocol based on sensed respiratory effort
US8934992B2 (en) 2011-09-01 2015-01-13 Inspire Medical Systems, Inc. Nerve cuff
WO2013046038A2 (en) 2011-09-30 2013-04-04 Adi Mashiach Apparatus and methods for feedback-based nerve modulation
EP3739250B1 (en) 2012-01-26 2023-03-29 MED-EL Elektromedizinische Geräte GmbH Neural monitoring systems for treating pharyngeal disorders
EP2849838B1 (en) * 2012-05-15 2021-11-17 Imthera Medical, Inc. Stimulation of a hypoglossal nerve for controlling the position of a patient's tongue
US9907967B2 (en) 2012-07-26 2018-03-06 Adi Mashiach Transcutaneous power conveyance device
US10052097B2 (en) 2012-07-26 2018-08-21 Nyxoah SA Implant unit delivery tool
US11253712B2 (en) 2012-07-26 2022-02-22 Nyxoah SA Sleep disordered breathing treatment apparatus
WO2014016694A2 (en) 2012-07-26 2014-01-30 Adi Mashiach Internal resonance matching between an implanted device and an external device
US9788779B2 (en) * 2013-03-14 2017-10-17 Flint Hills Scientific, L.L.C. Seizure detection based on work level excursion
WO2015004540A2 (en) 2013-06-17 2015-01-15 Adi Mashiach Dynamic modification of modulation throughout a therapy period
US9757560B2 (en) 2013-11-19 2017-09-12 The Cleveland Clinic Foundation System and method for treating obstructive sleep apnea
US20170143960A1 (en) * 2014-01-07 2017-05-25 Invicta Medical, Inc. Predicting an onset of apnea
US11383083B2 (en) 2014-02-11 2022-07-12 Livanova Usa, Inc. Systems and methods of detecting and treating obstructive sleep apnea
AU2015294336B2 (en) * 2014-07-22 2017-12-07 Imthera Medical, Inc. Method for adjusting a system for stimulating a hypoglossal nerve
WO2016033245A1 (en) 2014-08-26 2016-03-03 Rmx, Llc Devices and methods for reducing intrathoracic pressure
EP3271008A1 (en) 2015-03-19 2018-01-24 Inspire Medical Systems, Inc. Stimulation for treating sleep disordered breathing
AU2018316277B2 (en) 2017-08-11 2023-12-07 Inspire Medical Systems, Inc. Cuff electrode
WO2019172603A1 (en) * 2018-03-05 2019-09-12 주식회사 바이랩 Sleep apnea treatment apparatus and method
CA3096130A1 (en) 2018-06-01 2019-12-05 Zennea Technologies Inc. Method and device for treating sleep related breathing disorders
US11771899B2 (en) 2018-07-10 2023-10-03 The Cleveland Clinic Foundation System and method for treating obstructive sleep apnea
US20200281522A1 (en) 2019-03-06 2020-09-10 Medtronic Xomed, LLC System and method for improved obstructive sleep apnea diagnostic for implantable devices
CN109907934A (en) * 2019-04-15 2019-06-21 上海交通大学医学院附属第九人民医院 Tongue training aids
JP2022531411A (en) 2019-05-02 2022-07-06 トゥウェルブ メディカル インコーポレイテッド Systems and methods to improve sleep-disordered breathing using closed-loop feedback
US11266838B1 (en) * 2019-06-21 2022-03-08 Rmx, Llc Airway diagnostics utilizing phrenic nerve stimulation device and method
US11420061B2 (en) 2019-10-15 2022-08-23 Xii Medical, Inc. Biased neuromodulation lead and method of using same
US11491324B2 (en) 2019-10-16 2022-11-08 Invicta Medical, Inc. Adjustable devices for treating sleep apnea, and associated systems and methods
CA3200092A1 (en) 2020-11-04 2022-05-12 Invicta Medical, Inc. Implantable electrodes with remote power delivery for treating sleep apnea, and associated systems and methods
US11691010B2 (en) 2021-01-13 2023-07-04 Xii Medical, Inc. Systems and methods for improving sleep disordered breathing

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4830008A (en) * 1987-04-24 1989-05-16 Meer Jeffrey A Method and system for treatment of sleep apnea
US5540732A (en) * 1994-09-21 1996-07-30 Medtronic, Inc. Method and apparatus for impedance detecting and treating obstructive airway disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4830008A (en) * 1987-04-24 1989-05-16 Meer Jeffrey A Method and system for treatment of sleep apnea
US5540732A (en) * 1994-09-21 1996-07-30 Medtronic, Inc. Method and apparatus for impedance detecting and treating obstructive airway disorders

Also Published As

Publication number Publication date
AU5130199A (en) 2000-02-21
US6587725B1 (en) 2003-07-01
WO2000006249A2 (en) 2000-02-10

Similar Documents

Publication Publication Date Title
WO2000006249A3 (en) Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea
EP0706808B1 (en) Apparatus for synchronized treatment of obstructive sleep apnea
EP1087815B1 (en) Cardiac activity algorithm activation of a neurostimulator
EP0702978B1 (en) Apparatus for treating obstructive sleep apnea
US8594785B2 (en) Neurostimulation system and method for measuring patient activity
EP1308181A3 (en) Vestibular stimulation system and method
EP0702977B1 (en) Apparatus for detecting and treating obstructive airway disorders
US4830008A (en) Method and system for treatment of sleep apnea
WO2003086531A3 (en) Method and apparatus for the treatment of sleep apnea using biventricular pacing
DE69927438D1 (en) Active implantable medical device for the treatment of sleep apnea by electrostimulation
US20080058893A1 (en) Deep Brain Stimulation System
US20120123499A1 (en) Therapy Control Using Relative Motion Between Sensors
WO2004093982A1 (en) Neurostimulation for treatment of sleep apnea
SE9901056D0 (en) Sensor system
WO2001060445A8 (en) Methods and implantable systems for neural sensing and nerve stimulation
EP1306104A3 (en) Apparatus for treatment of sleep apnea by electrical stimulation
WO2005062829A3 (en) Skull-mounted electrical stimulation system and method for treating patients
WO2001097906A3 (en) Apparatus for treatment of mood and/or anxiety disorders by electrical brain stimulation and/or drug infusion
WO2008005903A3 (en) Method and apparatus for hypoglossal nerve stimulation
WO2002026317A8 (en) Method and apparatus for treating obesity by electrical stimulation of the gastrointestinal tract using sensed activity
WO2002089655A3 (en) Submucosal gastric implant device and method
US11890479B2 (en) Selection of parameters for electrical stimulation
US8781587B2 (en) Detecting and treatment of sleep apnea
CN116018085A (en) Analysis of ECAP signals
US8359097B2 (en) Method of detecting sleep apnea and treatment thereof

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 09744640

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase