WO2000004364A3 - Evanescent field illumination devices and methods - Google Patents

Evanescent field illumination devices and methods Download PDF

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Publication number
WO2000004364A3
WO2000004364A3 PCT/US1999/016057 US9916057W WO0004364A3 WO 2000004364 A3 WO2000004364 A3 WO 2000004364A3 US 9916057 W US9916057 W US 9916057W WO 0004364 A3 WO0004364 A3 WO 0004364A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
illumination devices
field illumination
evanescent field
devices
Prior art date
Application number
PCT/US1999/016057
Other languages
French (fr)
Other versions
WO2000004364A2 (en
WO2000004364A8 (en
WO2000004364A9 (en
Inventor
Douglas N Modlin
Original Assignee
Ljl Biosystems Inc
Douglas N Modlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1998/014575 external-priority patent/WO1999004228A2/en
Priority claimed from US09/160,533 external-priority patent/US6097025A/en
Application filed by Ljl Biosystems Inc, Douglas N Modlin filed Critical Ljl Biosystems Inc
Priority to AU49990/99A priority Critical patent/AU4999099A/en
Publication of WO2000004364A2 publication Critical patent/WO2000004364A2/en
Publication of WO2000004364A3 publication Critical patent/WO2000004364A3/en
Priority to US09/759,711 priority patent/US20030205681A1/en
Publication of WO2000004364A8 publication Critical patent/WO2000004364A8/en
Publication of WO2000004364A9 publication Critical patent/WO2000004364A9/en
Priority to US10/445,292 priority patent/US6992761B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)

Abstract

Devices and methods are disclosed comprising providing a sample holder (41) having a plurality of sample wells (44). Inner (46) and outer (48) surfaces of at least one well are configured for total internal reflection of incident light (i).
PCT/US1999/016057 1997-09-20 1999-07-15 Evanescent field illumination devices and methods WO2000004364A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU49990/99A AU4999099A (en) 1998-07-15 1999-07-15 Evanescent field illumination devices and methods
US09/759,711 US20030205681A1 (en) 1998-07-22 2001-01-12 Evanescent field illumination devices and methods
US10/445,292 US6992761B2 (en) 1997-09-20 2003-05-22 Broad range light detection system

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
USPCT/US98/14575 1998-07-15
PCT/US1998/014575 WO1999004228A2 (en) 1997-07-16 1998-07-15 Light detection device
US9383898P 1998-07-22 1998-07-22
US60/093,838 1998-07-22
US09/160,533 US6097025A (en) 1997-10-31 1998-09-24 Light detection device having an optical-path switching mechanism
US09/160,533 1998-09-24

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/160,533 Continuation US6097025A (en) 1997-07-16 1998-09-24 Light detection device having an optical-path switching mechanism

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/759,711 Continuation US20030205681A1 (en) 1997-09-20 2001-01-12 Evanescent field illumination devices and methods

Publications (4)

Publication Number Publication Date
WO2000004364A2 WO2000004364A2 (en) 2000-01-27
WO2000004364A3 true WO2000004364A3 (en) 2000-09-08
WO2000004364A8 WO2000004364A8 (en) 2001-03-01
WO2000004364A9 WO2000004364A9 (en) 2001-06-28

Family

ID=27377585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/016057 WO2000004364A2 (en) 1997-09-20 1999-07-15 Evanescent field illumination devices and methods

Country Status (2)

Country Link
AU (1) AU4999099A (en)
WO (1) WO2000004364A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
WO2000075167A2 (en) 1999-06-09 2000-12-14 Ljl Biosystems, Inc. Phosphorylation assays
US6486947B2 (en) * 1998-07-22 2002-11-26 Ljl Biosystems, Inc. Devices and methods for sample analysis
JP3783826B2 (en) * 2000-01-17 2006-06-07 横河電機株式会社 Biochip reader
EP1354064A2 (en) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
JP2006254838A (en) * 2005-03-18 2006-09-28 Toppan Printing Co Ltd Detection chip and method for detecting substance using the same
DE202008009859U1 (en) * 2007-12-21 2009-03-05 Berthold Technologies Gmbh & Co. Kg Device for the optional measurement of in particular luminescence and / or fluorescence radiation
US9709504B2 (en) 2008-04-23 2017-07-18 Molecular Fingerprint Sweden Ab Optical sensor unit for evanescence wave spectroscopy
FI20095064A0 (en) 2009-01-26 2009-01-26 Wallac Oy Apparatus and method for controlling the measuring head of an optical measuring instrument
FI20095061A0 (en) 2009-01-26 2009-01-26 Wallac Oy Master module for an optical measuring instrument

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4979821A (en) * 1988-01-27 1990-12-25 Ortho Diagnostic Systems Inc. Cuvette for receiving liquid sample
US5341215A (en) * 1991-06-08 1994-08-23 Hewlett-Packard Company Method and apparatus for detecting the presence and/or concentration of biomolecules
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5738825A (en) * 1993-07-20 1998-04-14 Balzers Aktiengesellschaft Optical biosensor matrix
US5750410A (en) * 1994-08-26 1998-05-12 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of and apparatus for immune analysis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4979821A (en) * 1988-01-27 1990-12-25 Ortho Diagnostic Systems Inc. Cuvette for receiving liquid sample
US5341215A (en) * 1991-06-08 1994-08-23 Hewlett-Packard Company Method and apparatus for detecting the presence and/or concentration of biomolecules
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5738825A (en) * 1993-07-20 1998-04-14 Balzers Aktiengesellschaft Optical biosensor matrix
US5750410A (en) * 1994-08-26 1998-05-12 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of and apparatus for immune analysis

Also Published As

Publication number Publication date
AU4999099A (en) 2000-02-07
WO2000004364A2 (en) 2000-01-27
WO2000004364A8 (en) 2001-03-01
WO2000004364A9 (en) 2001-06-28

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