WO2000000830A1 - Combined device for simultaneously conducting immunofiltration tests - Google Patents

Combined device for simultaneously conducting immunofiltration tests Download PDF

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Publication number
WO2000000830A1
WO2000000830A1 PCT/DE1999/001893 DE9901893W WO0000830A1 WO 2000000830 A1 WO2000000830 A1 WO 2000000830A1 DE 9901893 W DE9901893 W DE 9901893W WO 0000830 A1 WO0000830 A1 WO 0000830A1
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WO
WIPO (PCT)
Prior art keywords
housing
tests
pot
immunofiltration
lid
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Application number
PCT/DE1999/001893
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German (de)
French (fr)
Inventor
Peter Schneider
Uwe Alt
Original Assignee
Sension, Biologische Detektions- Und Schnelltestsysteme Gmbh
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Publication of WO2000000830A1 publication Critical patent/WO2000000830A1/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples

Definitions

  • the invention relates to a housing for holding samples for immunofiltration tests, receptor filtration tests or comparable test systems, in particular for those which are carried out using the antibody technique.
  • the object of the present invention is therefore to create a housing for the parallel and comparative execution of several immunofiltration tests.
  • a housing for carrying out several immunofiltration tests comprising at least one lid and a pot, the lid having a number of openings and the pot having a number of webs, such that in the ready-to-use state there is in each case one opening of the lid between two Webs of the pot comes to rest, fulfilled.
  • the housing it is suitable to take up samples with only a small sample volume (in the range of a few ⁇ l) and to subject them to an immunofiltration test.
  • the sample to be analyzed is applied to the surface on which the analysis is based, preferably a nitrocellulose membrane or a functionally comparable surface.
  • devices or holders are provided on the housing which make it possible to combine a plurality of housings and thus to increase the number of individual test chambers which can be used in parallel as desired.
  • these devices can e.g. Rails.
  • Every shape of the housing (with the angular as with every other) hooks are also recommended as devices or holders for combining several housings.
  • the openings of the cover narrow inwards.
  • the openings are round and narrow inwards in a conical or funnel shape.
  • the embodiment of the invention is also advantageous, in which the webs of the pot are so high that they reach approximately two thirds of the height of the pot.
  • the housing is angular or rounded, with the rectangular basic shape being particularly preferred.
  • any type of upper part of a housing, including one that is permanently connected to the lower part, is referred to here as a cover.
  • any type of lower part of a housing is referred to here as a pot.
  • the type of connection of the upper and lower part is not defined according to the invention and is therefore arbitrary.
  • FIG. 1 shows a top view of a housing
  • FIG. 2 shows a cross section through a housing
  • FIG. 3 finally shows a top view of an assembly of three housings.
  • FIG. 1 you can see the rectangular housing 1, which comprises 5 individual test chambers 2. Each individual test chamber has in the completely removable lid a round, conically narrowing opening 3 and in the pot at least one web 4. To make it easier to open and close the housing, the lid has integrated two semicircular tabs 5 with which it projects above the pot.
  • the narrowing circles 3 'of the openings show the type of constriction.
  • the openings are all the same and round.
  • the configuration of the housing in which an opening which narrows conically and / or in a funnel shape can open inwards into an edge, the edge serves for a better seal and is placed directly on the membrane or the functionally comparable surface, so that a good mechanical seal between the opening and the membrane is formed.
  • the housing is preferably tight for the absorption of liquids and plastic, but it can be made of any other materials.
  • the housing can have special insulating properties and the material of the housing parts lid and pot can be different, depending on the application of the housing.
  • FIG. 2 shows a cross section through a housing 1.
  • the lid 6 projects beyond the pot 7 on the left and right.
  • the 5 individual test chambers 2 can be seen from each other via webs 4 separated.
  • Each individual test chamber has an opening 3 in the cover 6.
  • the cover 6 has approximately the same wall thickness as the pot 7 (shown hatched), therefore it has bulges where the openings 3 narrow conically inwards.
  • An evaluation or documentation of the tests e.g. purely visual, densitometric or by automated color photography through which openings are carried out.
  • FIG. 3 shows an ensemble of 3 housings which comprises 15 individual test chambers.
  • the figure shows the casing 1 to each ⁇ wells a lid having a plurality of openings 3, a plurality of individual test chambers 2 and a plurality of fins 4.
  • the hook 8 At the edge of the housing are the hook 8 by means of which the housing can be prevented comparable with each other.
  • the hooks or rails can be made of the same material as the housing, which is particularly advantageous for production.
  • the entire housing can then be manufactured, for example, by injection molding. Several housings can be joined and released again using the hooks.
  • absorbent material with an upper end layer of nitrocellulose membrane or a comparable membrane or another material is placed in each individual test chamber, the latter having previously been treated accordingly with antibodies or other biomolecules.
  • the respective sample and other reagents relevant for the test are placed in the opening of the lid (if possible as a liquid) for each individual test chamber.
  • This mixture is then absorbed by the underlying absorbent material through the pretreated nitrocellulose membrane or another surface on which the analysis is based.
  • the pretreated nitrocellulose membrane and the reagents used result in a qualitative, semi-quantitative or, in the case of the additional use of a dosimeter, even a quantitative test system that can be optically, e.g. can be evaluated by comparing applied sample or standard solutions.
  • the invention enables the combination of any number of individual test chambers for simultaneous and parallel tests. This means that a variable number of sample or standard solutions or the combination of different test systems, e.g. to test a sample for substances to be analyzed differently, simultaneously and in parallel.

Abstract

The invention relates to a housing for accommodating samples for immunofiltration tests, receptor filtration tests or comparable test systems, especially for such test systems which are conducted while using antibody techniques. The housing comprises a pot and a cover which, when combined, permit the parallel accommodation of a plurality of samples.

Description

Beschreibungdescription
Kombi-Vorrichtung zur simultanen Durchführung von Immunfil- trationstestsCombination device for simultaneous immunofiltration tests
Die Erfindung betrifft ein Gehäuse zur Aufnahme von Proben für Immunfiltrationstests, Rezeptorfiltrationstests oder vergleichbarer Testsysteme, insbesondere für solche, die unter Anwendung der Antikörper-Technik durchgeführt werden.The invention relates to a housing for holding samples for immunofiltration tests, receptor filtration tests or comparable test systems, in particular for those which are carried out using the antibody technique.
Aus A. Dankwart und B.Hock: „ Immunchemischer Schnelltest zum Nachweis von Atrazin in Wasserproben und Bodenextrakten" GIT Fachzeitschrift für das Laboratorium, 37 (1993) S. 839 - 844 sind Einzelgehäuse für die Durchführung der Tests bekannt, die jedoch den Nachteil haben, daß nicht mehrere Proben nebeneinander vergleichend bestimmt werden können.From A. Dankwart and B.Hock: "Immunochemical rapid test for the detection of atrazine in water samples and soil extracts" GIT Fachzeitschrift für Laboratorium, 37 (1993) pp. 839 - 844, individual housings for carrying out the tests are known, but they have the disadvantage that several samples cannot be determined side by side.
Aufgabe der vorliegenden Erfindung ist daher die Schaffung eines Gehäuses zur parallelen und vergleichenden Durchführung mehrerer Immunfiltrationstests .The object of the present invention is therefore to create a housing for the parallel and comparative execution of several immunofiltration tests.
Diese Aufgabe wird erfindungsgemäß durch ein Gehäuse zur Durchführung mehrerer Immunfiltrationstests, zumindest einen Deckel und einen Topf umfassend, wobei der Deckel eine Anzahl von Öffnungen und der Topf eine Anzahl von Stegen aufweist, so angeordnet, daß im gebrauchsfertigen Zustand jeweils eine Öffnung des Deckels zwischen zwei Stege des Topfes zu liegen kommt, erfüllt. Weitere vorteilhafte Ausgestaltungen der Erfindung ergeben sich aus den Unteransprüchen, der Beschrei- bung und den Figuren.This object is achieved according to the invention by a housing for carrying out several immunofiltration tests, comprising at least one lid and a pot, the lid having a number of openings and the pot having a number of webs, such that in the ready-to-use state there is in each case one opening of the lid between two Webs of the pot comes to rest, fulfilled. Further advantageous embodiments of the invention result from the subclaims, the description and the figures.
Mit dem Gehäuse nach Anspruch 1 wird erreicht, daß parallel und vergleichend mehrere Immunfiltrationstests durchgeführt werden können, weil jeweils unter einer Deckelöffnung und zwischen zwei Stegen des Topfes Einzeltestkammern innerhalb des Gehäuses ausgebildet sind, in denen jeweils unabhängige Einzeltests parallel und vergleichend durchgeführt werden können. Auch die regelmäßige Durchführung von Blindtests, d.h. Tests mit standardisierten Proben, wird dadurch stark vereinfacht .With the housing according to claim 1 it is achieved that several immunofiltration tests can be carried out in parallel and in comparison, because in each case individual test chambers are formed under a cover opening and between two webs of the pot, in which independent individual tests are carried out in parallel and in a comparative manner can. This also greatly simplifies the regular execution of blind tests, ie tests with standardized samples.
Bei einer bevorzugten Ausgestaltung des Gehäuses ist es geeignet, Proben mit nur geringem Probevolumen (im Bereich weniger μl) aufzunehmen und einem Immunofiltrationstest zu unterziehen. Dabei wird die zu analysierende Probe auf die der Analytik zugrunde liegende Oberfläche, bevorzugt einer Nitro- zellulosemembran oder einer funktioneil vergleichbaren Oberfläche, aufgebracht.In a preferred embodiment of the housing, it is suitable to take up samples with only a small sample volume (in the range of a few μl) and to subject them to an immunofiltration test. The sample to be analyzed is applied to the surface on which the analysis is based, preferably a nitrocellulose membrane or a functionally comparable surface.
Bevorzugt ist, daß an dem Gehäuse Vorrichtungen oder Halterungen vorgesehen sind, die es ermöglichen, mehrere Gehäuse zu kombinieren und damit die Anzahl der parallel benutzbaren Einzeltestkammern beliebig zu erhöhen. Bei einer eckigen Ausgestaltung des Gehäuses können diese Vorrichtungen z.B. Schienen sein. Bei jeder Form des Gehäuses (bei der eckigen genauso wie bei jeder anderen) empfehlen sich auch Haken als Vorrichtungen oder Halterungen zur Kombination mehrerer Gehäuse .It is preferred that devices or holders are provided on the housing which make it possible to combine a plurality of housings and thus to increase the number of individual test chambers which can be used in parallel as desired. With an angular design of the housing, these devices can e.g. Rails. With every shape of the housing (with the angular as with every other) hooks are also recommended as devices or holders for combining several housings.
Nach einer Ausgestaltung der Erfindung verengen sich die Öffnungen des Deckels nach innen hin. Nach einer weiteren Ausge- staltung der Erfindung sind die Öffnungen rund und verengen sich konisch oder trichterförmig nach innen hin.According to one embodiment of the invention, the openings of the cover narrow inwards. According to a further embodiment of the invention, the openings are round and narrow inwards in a conical or funnel shape.
Vorteilhaft ist auch die Ausgestaltung der Erfindung, bei der die Stege des Topfes so hoch sind, daß sie ca. zwei Drittel der Höhe des Topfes erreichen.The embodiment of the invention is also advantageous, in which the webs of the pot are so high that they reach approximately two thirds of the height of the pot.
Nach einer vorteilhaften Ausführungsform ist das Gehäuse ek- kig oder abgerundet ausgebildet, wobei insbesondere die rechteckige Grundform bevorzugt ist. Als Deckel wird hier in der Beschreibung und in den Schutzansprüchen jede Art von Oberteil eines Gehäuses, auch eine mit dem Unterteil unlösbar verbundene, bezeichnet.According to an advantageous embodiment, the housing is angular or rounded, with the rectangular basic shape being particularly preferred. In the description and in the claims for protection, any type of upper part of a housing, including one that is permanently connected to the lower part, is referred to here as a cover.
Als Topf wird hier entsprechend jede Art von Unterteil eines Gehäuses bezeichnet. Die Art der Verbindung von Ober- und Unterteil ist nach der Erfindung nicht festgelegt und somit beliebig.Any type of lower part of a housing is referred to here as a pot. The type of connection of the upper and lower part is not defined according to the invention and is therefore arbitrary.
Im folgenden wird die Erfindung noch anhand von Figuren, die Ausgestaltungen der Erfindung wiedergeben, weiter erläutert.In the following, the invention will be further explained with reference to figures which show configurations of the invention.
Figur 1 zeigt eine Aufsicht auf ein Gehäuse, Figur 2 zeigt einen Querschnitt durch ein Gehäuse und Figur 3 zeigt schließlich eine Aufsicht auf ein Ensemble aus drei Gehäusen.FIG. 1 shows a top view of a housing, FIG. 2 shows a cross section through a housing and FIG. 3 finally shows a top view of an assembly of three housings.
In Figur 1 erkennt man das rechteckige Gehäuse 1, das 5 Einzeltestkammern 2 umfaßt. Jede Einzeltestkammer hat im ganz abnehmbaren Deckel eine runde, sich konisch nach innen hin verengende Öffnung 3 und im Topf zumindest einen Steg 4. Zum leichteren Öffnen und Schließen des Gehäuses hat der Deckel zwei halbrunde Laschen 5, mit denen er den Topf überragt, integriert .In Figure 1 you can see the rectangular housing 1, which comprises 5 individual test chambers 2. Each individual test chamber has in the completely removable lid a round, conically narrowing opening 3 and in the pot at least one web 4. To make it easier to open and close the housing, the lid has integrated two semicircular tabs 5 with which it projects above the pot.
Durch die kleiner werdenden Kreise 3' der Öffnungen wird die Art der Verengung gezeigt. Bei der hier gezeigten Ausführungsform sind die Öffnungen alle gleich und rund. Dies ist nur eine Ausgestaltung und die Erfindung läßt sich genauso gut mit Öffnungen im Deckel realisieren, die sich nach unten hin erweitern oder die sich weder verengen noch erweitern und die z.B. eckig sind. Ebenso möglich ist jede andere Gestaltung und jedes Design des Deckels und insbesondere die Möglichkeit, daß nicht alle Öffnungen des Deckels gleich gestal- tet sind. Besonders bevorzugt ist auch die Ausgestaltung des Gehäuses, bei der eine sich konisch und/oder trichterförmig verengende Öffnung nach innen hin in einer Kante münden kann, wobei die Kante einer besseren Abdichtung dient und direkt auf der Membran oder der funktioneil vergleichbaren Oberfläche aufsetzt, so daß ein guter mechanischer Abschluß zwischen der Öffnung und der Membran entsteht.The narrowing circles 3 'of the openings show the type of constriction. In the embodiment shown here, the openings are all the same and round. This is only one embodiment and the invention can be implemented just as well with openings in the lid that expand downwards or that neither narrow nor expand and that are, for example, angular. Any other design and design of the cover is also possible, and in particular the possibility that not all openings of the cover are of the same design. Also particularly preferred is the configuration of the housing, in which an opening which narrows conically and / or in a funnel shape can open inwards into an edge, the edge serves for a better seal and is placed directly on the membrane or the functionally comparable surface, so that a good mechanical seal between the opening and the membrane is formed.
Die Formgestaltung der Einzelteile soll den Umfang der Erfindung nicht begrenzen.The shape of the individual parts is not intended to limit the scope of the invention.
Bevorzugt ist das Gehäuse dicht für die Aufnahme von Flüssig- keiten und aus Kunststoff, es kann aber aus beliebigen anderen Materialien geschaffen sein. Das Gehäuse kann über spezielle Isoliereigenschaften verfügen und das Material der Gehäuseteile Deckel und Topf kann verschieden sein, je nach Anwendung des Gehäuses.The housing is preferably tight for the absorption of liquids and plastic, but it can be made of any other materials. The housing can have special insulating properties and the material of the housing parts lid and pot can be different, depending on the application of the housing.
Figur 2 zeigt einen Querschnitt durch ein Gehäuse 1. Zu erkennen ist oben der, wiederum vollständig abnehmbare, Deckel 6 und unten der Topf 7. Links und rechts überragt der Deckel 6 den Topf 7. Weiterhin sieht man die 5 Einzeltestkammern 2 jeweils voneinander über Stege 4 getrennt. Jede Einzeltestkammer hat eine Öffnung 3 im Deckel 6.FIG. 2 shows a cross section through a housing 1. The top 6, which is again completely removable, and the bottom of the pot 7 can be seen. The lid 6 projects beyond the pot 7 on the left and right. Furthermore, the 5 individual test chambers 2 can be seen from each other via webs 4 separated. Each individual test chamber has an opening 3 in the cover 6.
Der Deckel 6 hat ungefähr dieselbe Wandstärke wie der Topf 7 (schraffiert gezeigt) , deshalb hat er Ausbuchtungen, wo die Öffnungen 3 sich nach innen hin konisch verengen. Von oben kann eine Auswertung oder Dokumentation der Tests, z.B. rein visuell, densitometrisch oder durch automatisierte Farbphotographie, durch die Öffnungen hindurch durchgeführt werden.The cover 6 has approximately the same wall thickness as the pot 7 (shown hatched), therefore it has bulges where the openings 3 narrow conically inwards. An evaluation or documentation of the tests, e.g. purely visual, densitometric or by automated color photography through which openings are carried out.
In Figur 3 sieht man ein Ensemble aus 3 Gehäusen, das 15 Einzeltestkammern umfaßt. Die Figur zeigt zu dem Gehäuse 1 je¬ weils einen Deckel mit mehreren Öffnungen 3, mehrere Einzeltestkammern 2 und mehrere Stege 4. Am Gehäuserand befinden sich die Haken 8 mit deren Hilfe die Gehäuse miteinander ver- bunden werden können. Die Haken oder Schienen können aus demselben Material wie das Gehäuse sein, das ist insbesondere für die Herstellung günstig. Das gesamte Gehäuse läßt sich dann z.B. im Spritzgußverfahren herstellen. Über die Haken können mehrere Gehäuse zusammengefügt und wieder gelöst werden.FIG. 3 shows an ensemble of 3 housings which comprises 15 individual test chambers. The figure shows the casing 1 to each ¬ weils a lid having a plurality of openings 3, a plurality of individual test chambers 2 and a plurality of fins 4. At the edge of the housing are the hook 8 by means of which the housing can be prevented comparable with each other. The hooks or rails can be made of the same material as the housing, which is particularly advantageous for production. The entire housing can then be manufactured, for example, by injection molding. Several housings can be joined and released again using the hooks.
Bei der Durchführung der Tests wird z.B. in jede Einzeltest- kammer saugfähiges Material mit einer oberen Abschlußlage Ni- trozellulosemembran oder einer vergleichbaren Membran oder eines anderen Materials aufgelegt, wobei letztere vorher entsprechend mit Antikörpern oder anderen Biomolekülen behandelt wurde .When carrying out the tests, e.g. absorbent material with an upper end layer of nitrocellulose membrane or a comparable membrane or another material is placed in each individual test chamber, the latter having previously been treated accordingly with antibodies or other biomolecules.
Bei der Durchführung der Immunfiltrationstests wird pro Einzeltestkammer die jeweilige Probe und weitere, für den Test relevante Reagenzien über die Öffnung des Deckels (möglichst als Flüssigkeit) aufgegeben. Dieses Gemisch wird dann durch die vorbehandelte Nitrozellulosemembran oder eine andere der Analytik zugrundeliegende Oberfläche hindurch von dem darunterliegenden saugfähigen Material aufgesaugt. Aus der vorbehandelten Nitrozellulosemembran und den verwendeten Reagenzien ergibt sich ein qualitatives, semiquantitatives oder im Falle der zusätzlichen Anwendung eines Dosimeters sogar quan- titatives Testsystem, das durch Färbung der Membran optisch, z.B. durch Vergleich applizierter Probe- oder Standardlösungen, ausgewertet werden kann.When carrying out the immunofiltration tests, the respective sample and other reagents relevant for the test are placed in the opening of the lid (if possible as a liquid) for each individual test chamber. This mixture is then absorbed by the underlying absorbent material through the pretreated nitrocellulose membrane or another surface on which the analysis is based. The pretreated nitrocellulose membrane and the reagents used result in a qualitative, semi-quantitative or, in the case of the additional use of a dosimeter, even a quantitative test system that can be optically, e.g. can be evaluated by comparing applied sample or standard solutions.
Durch die Erfindung wird die Kombination beliebig vieler Ein- zeltestkammern zur gleichzeitigen und parallelen Durchführung von Tests ermöglicht. Dadurch kann eine variable Zahl an Probe- oder Standardlösungen oder auch die Kombination unterschiedlicher Testsysteme z.B. zur Testung einer Probe auf unterschiedlich zu analysierende Substanzen gleichzeitig und parallel vergleichend durchgeführt werden. The invention enables the combination of any number of individual test chambers for simultaneous and parallel tests. This means that a variable number of sample or standard solutions or the combination of different test systems, e.g. to test a sample for substances to be analyzed differently, simultaneously and in parallel.

Claims

Patentansprüche claims
I.Gehäuse zur Durchführung von Immunfiltrationstests, zumindest einen Deckel und einen Topf umfassend, wobei der Dek- kel eine Anzahl von Öffnungen und der Topf eine Anzahl von Stegen aufweist, so angeordnet, daß im gebrauchsfertigem Zustand jeweils eine Öffnung des Deckels zwischen zwei Stege des Topfes zu liegen kommt.I. Housing for carrying out immunofiltration tests, comprising at least one lid and a pot, the lid having a number of openings and the pot having a number of webs, arranged such that in the ready-to-use state, an opening of the lid between two webs of the Comes to rest.
2. Gehäuse nach Anspruch 1, das Vorrichtungen umfaßt, die eine Verbindung mehrerer Gehäuse zu einem größeren Ensemble ermöglicht.2. Housing according to claim 1, comprising devices which enables a connection of several housings to a larger ensemble.
3. Gehäuse nach Anspruch 2, bei dem die Vorrichtungen Haken oder Schienen sind.3. Housing according to claim 2, wherein the devices are hooks or rails.
4. Gehäuse nach einem der vorstehenden Ansprüche, bei dem die Öffnungen des Deckels sich nach innen hin verengen.4. Housing according to one of the preceding claims, wherein the openings of the cover narrow towards the inside.
5. Gehäuse nach einem der vorstehenden Ansprüche, bei dem die Stege des Topfes über zwei Drittel der Höhe des Topfes erreichen.5. Housing according to one of the preceding claims, in which the webs of the pot reach over two thirds of the height of the pot.
6. Gehäuse nach einem der vorstehenden Ansprüche, das eine rechteckige oder abgerundete Form hat.6. Housing according to one of the preceding claims, which has a rectangular or rounded shape.
7. Gehäuse nach einem der vorstehenden Ansprüche, bei dem die Öffnungen des Deckels rund sind. 7. Housing according to one of the preceding claims, wherein the openings of the cover are round.
PCT/DE1999/001893 1998-06-29 1999-06-29 Combined device for simultaneously conducting immunofiltration tests WO2000000830A1 (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1327885A1 (en) * 2001-08-17 2003-07-16 Shanghai Health Digit Limited A kit for the simultaneous diagnosis of a plurality of infectious diseases and a method for preparation of it
EP1327885A4 (en) * 2001-08-17 2004-04-21 Shanghai Health Digit Ltd A kit for the simultaneous diagnosis of a plurality of infectious diseases and a method for preparation of it

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