WO2000000808A3 - Colloidal particles used in sensing arrays - Google Patents

Colloidal particles used in sensing arrays Download PDF

Info

Publication number
WO2000000808A3
WO2000000808A3 PCT/US1999/012904 US9912904W WO0000808A3 WO 2000000808 A3 WO2000000808 A3 WO 2000000808A3 US 9912904 W US9912904 W US 9912904W WO 0000808 A3 WO0000808 A3 WO 0000808A3
Authority
WO
WIPO (PCT)
Prior art keywords
conductive
conductive material
polymer
composition
organic complex
Prior art date
Application number
PCT/US1999/012904
Other languages
French (fr)
Other versions
WO2000000808A2 (en
Inventor
Nathan S Lewis
Brett J Doleman
Shawn Briglin
Erik J Severin
Original Assignee
California Inst Of Techn
Nathan S Lewis
Brett J Doleman
Shawn Briglin
Erik J Severin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Nathan S Lewis, Brett J Doleman, Shawn Briglin, Erik J Severin filed Critical California Inst Of Techn
Priority to US09/328,871 priority Critical patent/US6537498B1/en
Priority to EP99931777A priority patent/EP1084390A4/en
Priority to AU48210/99A priority patent/AU4821099A/en
Publication of WO2000000808A2 publication Critical patent/WO2000000808A2/en
Publication of WO2000000808A3 publication Critical patent/WO2000000808A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid
    • G01N27/125—Composition of the body, e.g. the composition of its sensitive layer
    • G01N27/126—Composition of the body, e.g. the composition of its sensitive layer comprising organic polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Electrochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)

Abstract

Sensor array device for detecting chemical analytes having sensors formed by separate regions of a conductive material having one composition and a non-conductive material different in composition from that material of the conductive region, and the conductive region is comprised of a nanoparticle type colloid. Each sensor operates by manifesting an electrical response path which passes through both regions of conductive and non-conductive material, where nanoparticles may have a core selected from the group of a metal, metal alloy, metal oxide, organic complex, semiconductor, superconductor or mixed inorganic/organic complex, and nonconductive materials may include ligands such as polymers, detergents, protein complexes, surfactants, radioactive groups, fluorescent moieties, oligonucleotides, alkanethiols and dendrimeric materials. Distinct embodiments of the sensing means may be based on utilizing a surface acoutic wave device, quartz microbalance, chemiresistor, conducting polymer, dye-impregnated polymer film, electrochemical gas detector, chemFET, polymer coated micromirror or a carbon black polymer composite.
PCT/US1999/012904 1995-03-27 1999-06-08 Colloidal particles used in sensing arrays WO2000000808A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US09/328,871 US6537498B1 (en) 1995-03-27 1999-06-08 Colloidal particles used in sensing arrays
EP99931777A EP1084390A4 (en) 1998-06-09 1999-06-08 Colloidal particles used in sensing arrays
AU48210/99A AU4821099A (en) 1998-06-09 1999-06-09 Colloidal particles used in sensing arrays

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8868098P 1998-06-09 1998-06-09
US60/088,680 1998-06-09
US11883399P 1999-02-05 1999-02-05
US60/118,833 1999-02-05

Publications (2)

Publication Number Publication Date
WO2000000808A2 WO2000000808A2 (en) 2000-01-06
WO2000000808A3 true WO2000000808A3 (en) 2000-03-23

Family

ID=26778943

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/012904 WO2000000808A2 (en) 1995-03-27 1999-06-08 Colloidal particles used in sensing arrays

Country Status (3)

Country Link
EP (1) EP1084390A4 (en)
AU (1) AU4821099A (en)
WO (1) WO2000000808A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE319080T1 (en) 1999-05-10 2006-03-15 California Inst Of Techn USE OF A SPATIO-TEMPORAL RESPONSE IN SENSOR ARRAYS FOR THE DETECTION OF ANALYTES IN FLUID
US6890715B1 (en) 1999-08-18 2005-05-10 The California Institute Of Technology Sensors of conducting and insulating composites
WO2002023134A1 (en) * 2000-04-24 2002-03-21 Lewis Nathan S Spatiotemporal and geometric optimization of sensor arrays for detecting analytes in fluids
WO2001083825A2 (en) * 2000-05-04 2001-11-08 The Center For Blood Research, Inc. Colloid compositions for solid phase biomolecular analytical systems
ATE291048T1 (en) 2000-05-18 2005-04-15 Nat Starch Chem Invest ADHESIVE ADHESIVES CONTAINING VINYL ETHER AND CARBAMAT OR UREA FUNCTIONALITY FOR SEMICONDUCTOR BOARDS
DE60124953T2 (en) 2000-10-16 2007-09-20 E.I. Du Pont De Nemours And Co., Wilmington INFRARED THERMOGRAPHIC PROCEDURE FOR SEMICONDUCTOR SEMICONDUCTORS
US6849239B2 (en) 2000-10-16 2005-02-01 E. I. Du Pont De Nemours And Company Method and apparatus for analyzing mixtures of gases
JP2004523731A (en) 2000-10-16 2004-08-05 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー Method and apparatus for analyzing a mixture of gases
ATE502296T1 (en) 2000-12-12 2011-04-15 Sony Deutschland Gmbh SELECTIVE CHEMICAL SENSORS BASED ON CHAINED NANOPARTICLE COLLECTIONS
DE10109534A1 (en) * 2001-02-28 2002-09-12 Basf Ag Method and device for the detection of fuimigants in air samples
DE60144014D1 (en) * 2001-07-19 2011-03-24 Max Planck Gesellschaft Chemical sensors made from nanoparticle-dendrimer composite materials
US7575931B2 (en) 2002-06-19 2009-08-18 E.I. Du Pont De Nemours And Company Method and apparatus for reducing a nitrogen oxide, and control thereof
US20040126286A1 (en) 2002-06-19 2004-07-01 Deruyter John C. Method and apparatus for reducing a nitrogen oxide
CN1514243A (en) * 2003-04-30 2004-07-21 成都夸常科技有限公司 Method of preceeding qualitative and lor quantitative analysis against target substance its device and marker and detecting reagent box
WO2004081571A1 (en) * 2003-03-13 2004-09-23 Chengdu Kuachang Medical Industrial Limited The detecting method and device of polypeptide, and the ligand compound comprising nanoparticles
KR100578747B1 (en) 2003-12-26 2006-05-12 한국전자통신연구원 Chemical sensors based on metal nanoparticle encapsulated by ligand mixture and sensor array
US8236246B2 (en) 2004-10-07 2012-08-07 E I Du Pont De Nemours And Company Gas sensitive apparatus
US7460958B2 (en) 2004-10-07 2008-12-02 E.I. Du Pont De Nemours And Company Computer-implemented system and method for analyzing mixtures of gases
CN100427924C (en) * 2005-11-02 2008-10-22 天津科技大学 Self-illuminating biological chip and producing and detecting method thereof
EP1790977A1 (en) * 2005-11-23 2007-05-30 SONY DEUTSCHLAND GmbH Nanoparticle/nanofiber based chemical sensor, arrays of such sensors, uses and method of fabrication thereof, and method of detecting an analyte
KR100799566B1 (en) 2005-12-08 2008-01-30 한국전자통신연구원 Metal nanoparticle chemical sensor material relatively insensitive to moisture and chemical sensor array comprising the same
WO2008088867A1 (en) 2007-01-19 2008-07-24 Cantimer Incorporated Piezoresistive microcantilever sensor and composition
US8309028B2 (en) 2007-02-02 2012-11-13 Commonwealth Scientific And Industrial Research Organisation Chemiresistor for use in conducting electrolyte solution
WO2009013754A1 (en) 2007-07-24 2009-01-29 Technion Research And Development Foundation Ltd. Chemically sensitive field effect transistors and use thereof in electronic nose devices
EP2215464B1 (en) 2007-11-20 2015-10-07 Technion Research & Development Foundation Ltd. Sensor system, use of sensor and method for sensing based on cubic nanoparticles capped with an organic coating
IL190475A0 (en) 2008-03-27 2009-02-11 Technion Res & Dev Foundation Chemical sensors based on cubic nanoparticles capped with organic coating for detecting explosives
US8443647B1 (en) * 2008-10-09 2013-05-21 Southern Illinois University Analyte multi-sensor for the detection and identification of analyte and a method of using the same
ES2582160T3 (en) 2009-01-09 2016-09-09 Technion Research & Development Foundation Ltd. Breath cancer detection comprising a set of sensors comprising coated conductive nanoparticles
WO2011148371A1 (en) 2010-05-23 2011-12-01 Technion Research And Development Foundation Ltd. Detection, staging and grading of benign and malignant tumors
US10663420B2 (en) 2012-01-03 2020-05-26 Technion R&D Foundation Ltd. Morphology engineering of conductive metallic nanoparticles capped with an organic coating
WO2013144788A1 (en) * 2012-03-26 2013-10-03 Technion Research And Development Foundation Ltd. A platform unit for combined sensing of pressure, temperature and humidity
AP2013008332A0 (en) * 2012-09-13 2015-03-31 Mintek Diagnostic probe

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3927930A (en) * 1972-07-10 1975-12-23 Polaroid Corp Light polarization employing magnetically oriented ferrite suspensions
US4453126A (en) * 1978-08-02 1984-06-05 The Hospital For Sick Children Measurement of anaesthetic gas concentration
US4644101A (en) * 1985-12-11 1987-02-17 At&T Bell Laboratories Pressure-responsive position sensor
US4737112A (en) * 1986-09-05 1988-04-12 American Telephone And Telegraph Company, At&T Bell Laboratories Anisotropically conductive composite medium
US4923739A (en) * 1987-07-30 1990-05-08 American Telephone And Telegraph Company Composite electrical interconnection medium comprising a conductive network, and article, assembly, and method
US5104210A (en) * 1989-04-24 1992-04-14 Monsanto Company Light control films and method of making
US5429975A (en) * 1993-10-25 1995-07-04 United Microelectronics Corporation Method of implanting during manufacture of ROM device
US5512882A (en) * 1991-08-07 1996-04-30 Transducer Research, Inc. Chemical sensing apparatus and methods
US5571401A (en) * 1995-03-27 1996-11-05 California Institute Of Technology Sensor arrays for detecting analytes in fluids
US5677662A (en) * 1994-01-17 1997-10-14 Hydor S.R.L. Heat-sensitive resistive compound and method for producing it and using it
US5698771A (en) * 1995-03-30 1997-12-16 The United States Of America As Represented By The United States National Aeronautics And Space Administration Varying potential silicon carbide gas sensor
US5742223A (en) * 1995-12-07 1998-04-21 Raychem Corporation Laminar non-linear device with magnetically aligned particles
US5942674A (en) * 1997-08-04 1999-08-24 Ford Global Technologies, Inc. Method for detecting oxygen partial pressure using a phase-transformation sensor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631952A (en) * 1985-08-30 1986-12-30 Chevron Research Company Resistive hydrocarbon leak detector
US5788833A (en) * 1995-03-27 1998-08-04 California Institute Of Technology Sensors for detecting analytes in fluids
CA2262018C (en) * 1996-07-29 2007-10-02 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
WO1998010289A1 (en) * 1996-09-04 1998-03-12 The Penn State Research Foundation Self-assembled metal colloid monolayers

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3927930A (en) * 1972-07-10 1975-12-23 Polaroid Corp Light polarization employing magnetically oriented ferrite suspensions
US4453126A (en) * 1978-08-02 1984-06-05 The Hospital For Sick Children Measurement of anaesthetic gas concentration
US4644101A (en) * 1985-12-11 1987-02-17 At&T Bell Laboratories Pressure-responsive position sensor
US4737112A (en) * 1986-09-05 1988-04-12 American Telephone And Telegraph Company, At&T Bell Laboratories Anisotropically conductive composite medium
US4923739A (en) * 1987-07-30 1990-05-08 American Telephone And Telegraph Company Composite electrical interconnection medium comprising a conductive network, and article, assembly, and method
US5104210A (en) * 1989-04-24 1992-04-14 Monsanto Company Light control films and method of making
US5512882A (en) * 1991-08-07 1996-04-30 Transducer Research, Inc. Chemical sensing apparatus and methods
US5429975A (en) * 1993-10-25 1995-07-04 United Microelectronics Corporation Method of implanting during manufacture of ROM device
US5677662A (en) * 1994-01-17 1997-10-14 Hydor S.R.L. Heat-sensitive resistive compound and method for producing it and using it
US5571401A (en) * 1995-03-27 1996-11-05 California Institute Of Technology Sensor arrays for detecting analytes in fluids
US5698771A (en) * 1995-03-30 1997-12-16 The United States Of America As Represented By The United States National Aeronautics And Space Administration Varying potential silicon carbide gas sensor
US5742223A (en) * 1995-12-07 1998-04-21 Raychem Corporation Laminar non-linear device with magnetically aligned particles
US5942674A (en) * 1997-08-04 1999-08-24 Ford Global Technologies, Inc. Method for detecting oxygen partial pressure using a phase-transformation sensor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1084390A4 *

Also Published As

Publication number Publication date
EP1084390A4 (en) 2005-07-27
EP1084390A2 (en) 2001-03-21
AU4821099A (en) 2000-01-17
WO2000000808A2 (en) 2000-01-06

Similar Documents

Publication Publication Date Title
WO2000000808A3 (en) Colloidal particles used in sensing arrays
Barton et al. Screen-printed electrodes for environmental monitoring of heavy metal ions: a review
US6730212B1 (en) Sensor for chemical and biological materials
Ramanaviciene et al. Application of polypyrrole for the creation of immunosensors
Vuong et al. Hydrogen sulfide gas sensing properties of thin films derived from SnO2 sols different in grain size
US6737286B2 (en) Apparatus and method for fabricating arrays of atomic-scale contacts and gaps between electrodes and applications thereof
CN101368924B (en) A method of altering the sensitivity and/or selectivity of a chemiresistor sensor array
US20120036919A1 (en) Nanowire sensor having a nanowire and electrically conductive film
US6342347B1 (en) Electromagnetic sensor
EP2067532A1 (en) A method of producing a nanoparticle film on a substrate
WO1994022005A1 (en) Chemical switch and method for detection of chemical components
Eastman et al. Application of the solubility parameter concept to the design of chemiresistor arrays
Lanyon et al. Recessed nanoband electrodes fabricated by focused ion beam milling
KR100937260B1 (en) The Apparatus for Detecting Nano Particle Having Nano-Gap Electrode
US20160047767A1 (en) Operating imprinted thin-film electronic sensor structure
Moeller et al. Chip-based electrical detection of DNA
Avaz et al. Graphene based nanosensor for aqueous phase detection of nitroaromatics
Bruchiel‐Spanier et al. Nanoparticle‐Imprinted Polymers: Shell‐Selective Recognition of Au Nanoparticles by Imprinting Using the Langmuir–Blodgett Method
US20070235348A1 (en) Conducting polymer nanosensor
Aydın et al. A Simple and Low‐Cost Electrochemical Immunosensor for Ultrasensitive Determination of Calreticulin Biomarker in Human Serum
Ngai et al. Electrochemical sensor based on single-walled carbon nanotube/ZnO photocatalyst nanocomposite modified electrode for the determination of paracetamol
Borgwarth et al. Surface analysis by scanning electrochemical microscopy: resolution studies and applications to polymer samples
CA2777603A1 (en) Electrochemical sensor and method for the production thereof
US20040029288A1 (en) Nonlinear gold nanocluster chemical vapor sensor
Kleps et al. New micro-and nanoelectrode arrays for biomedical applications

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 1999931777

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999931777

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642