WO1999051299A3 - Radioactive composition for fabrication of implanted device - Google Patents

Radioactive composition for fabrication of implanted device Download PDF

Info

Publication number
WO1999051299A3
WO1999051299A3 PCT/US1999/005036 US9905036W WO9951299A3 WO 1999051299 A3 WO1999051299 A3 WO 1999051299A3 US 9905036 W US9905036 W US 9905036W WO 9951299 A3 WO9951299 A3 WO 9951299A3
Authority
WO
WIPO (PCT)
Prior art keywords
radioactivable
isotope
composition
beneficiated
isotopic
Prior art date
Application number
PCT/US1999/005036
Other languages
French (fr)
Other versions
WO1999051299A2 (en
Inventor
Stanley Satz
Original Assignee
Bionucleonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/038,560 external-priority patent/US6187037B1/en
Application filed by Bionucleonics Inc filed Critical Bionucleonics Inc
Priority to CA002323440A priority Critical patent/CA2323440A1/en
Priority to JP2000542068A priority patent/JP2003518392A/en
Priority to AU50784/99A priority patent/AU5078499A/en
Priority to KR1020007010154A priority patent/KR20010041861A/en
Priority to EP99935270A priority patent/EP1284684A2/en
Publication of WO1999051299A2 publication Critical patent/WO1999051299A2/en
Publication of WO1999051299A3 publication Critical patent/WO1999051299A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1002—Intraluminal radiation therapy

Abstract

Disclosed are radioactivable compositions, preferably metal alloy compositions containing a metal having shape memory characteristics, and at least one radioactivable isotope comprising a lanthanide series element or mixtures of lanthanide series of elements or other suitable isotope. The radioactivable isotope is present in sufficient concentration (relative to other components of the composition) to deliver an effective radiation dose to a target tissue to achieve a specified therapeutic objective. One of the more advantageous and useful applications for this composition is the formation of medical devices for the treatment of coronary artery disease and the abatement of proliferation of cancer cells. In one of the preferred embodiments of this invention, a radioactivable isotope is incorporated, by isotopic beneficiated combination, with a matrix material such as a nickel/titanium alloy (e.g. Nitinol metal alloys), or by isotopic beneficiated combination with a biodegradable organic naturally occurring or synthetic polymer so as to form a solid solution; and, the resultant alloy or solid solution, thereafter, formed into a stent, or other suitable form, for selective and targeted delivery of therapeutic and effective amounts of low dosage forms of radiation (principally beta particles) to a specific site or tissue within the human body.
PCT/US1999/005036 1998-03-11 1999-03-10 Radioactive composition for fabrication of implanted device WO1999051299A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002323440A CA2323440A1 (en) 1998-03-11 1999-03-10 Radioactivable composition suitable for fabrication of implantable medical devices
JP2000542068A JP2003518392A (en) 1998-03-11 1999-03-10 Radioactivatable compositions suitable for the manufacture of implantable medical devices
AU50784/99A AU5078499A (en) 1998-03-11 1999-03-10 Radioactivable composition suitable for fabrication of implantable medical devices
KR1020007010154A KR20010041861A (en) 1998-03-11 1999-03-10 Radioactivable composition suitable for fabrication of implantable medical devices
EP99935270A EP1284684A2 (en) 1998-03-11 1999-03-10 Radioactivable composition suitable for fabrication of implantable medical devices

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/038,560 1998-03-11
US09/038,560 US6187037B1 (en) 1998-03-11 1998-03-11 Metal stent containing radioactivatable isotope and method of making same
US13859498A 1998-08-22 1998-08-22
US09/138,594 1998-08-22

Publications (2)

Publication Number Publication Date
WO1999051299A2 WO1999051299A2 (en) 1999-10-14
WO1999051299A3 true WO1999051299A3 (en) 2002-11-14

Family

ID=26715320

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/005036 WO1999051299A2 (en) 1998-03-11 1999-03-10 Radioactive composition for fabrication of implanted device

Country Status (5)

Country Link
EP (1) EP1284684A2 (en)
JP (1) JP2003518392A (en)
KR (1) KR20010041861A (en)
AU (1) AU5078499A (en)
WO (1) WO1999051299A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19953636A1 (en) * 1999-11-09 2001-05-23 Karlsruhe Forschzent Neutron-activated radioactive material comprising rare earth compound, preferably thulium oxide, in matrix, e.g. of polymer, useful in medicine, e.g. for producing restenosis-preventing stents
AU1660901A (en) * 1999-11-18 2001-05-30 Howard L. Schrayer Device for the inhibition of cellular proliferation
EP1232770A1 (en) 2001-02-15 2002-08-21 AEA Technology QSA GmbH Radioactive capsule seed
EP1232769A1 (en) * 2001-02-15 2002-08-21 AEA Technology QSA GmbH Capsule seed manufactured with Pd-103
US7018371B2 (en) 2001-05-07 2006-03-28 Xoft, Inc. Combination ionizing radiation and radiosensitizer delivery devices and methods for inhibiting hyperplasia
US6537195B2 (en) 2001-05-07 2003-03-25 Xoft, Microtube, Inc. Combination x-ray radiation and drug delivery devices and methods for inhibiting hyperplasia
JP4886939B2 (en) * 2001-07-19 2012-02-29 真也 岡崎 Iodine-releasing therapeutic material and stent for in-vivo placement
US8945207B2 (en) 2010-12-20 2015-02-03 Graftcraft I Göteborg Ab Removable stent and method of production
CA2820405C (en) 2010-12-20 2017-10-24 Graftcraft I Goteborg Ab Removable stent and method of production
KR101550370B1 (en) 2013-12-26 2015-09-07 한국원자력의학원 Method for recovering damaged chondrocyte using low-dose radiation
AU2016229667A1 (en) * 2015-03-12 2017-07-13 Nextbiomedical Co., Ltd. Stent having functional material coated on cell space thereof
US11798700B2 (en) 2018-03-26 2023-10-24 The University Of British Columbia Systems, apparatus and methods for separating actinium, radium, and thorium

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795286A (en) * 1996-08-15 1998-08-18 Cathco, Inc. Radioisotope impregnated sheet of biocompatible material for preventing scar tissue formation
US5843163A (en) * 1996-06-06 1998-12-01 Wall; William H. Expandable stent having radioactive treatment means
US5865720A (en) * 1997-03-06 1999-02-02 Scimed Life Systems, Inc. Expandable and retrievable radiation delivery system
US5919126A (en) * 1997-07-07 1999-07-06 Implant Sciences Corporation Coronary stent with a radioactive, radiopaque coating

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843163A (en) * 1996-06-06 1998-12-01 Wall; William H. Expandable stent having radioactive treatment means
US5795286A (en) * 1996-08-15 1998-08-18 Cathco, Inc. Radioisotope impregnated sheet of biocompatible material for preventing scar tissue formation
US5865720A (en) * 1997-03-06 1999-02-02 Scimed Life Systems, Inc. Expandable and retrievable radiation delivery system
US5919126A (en) * 1997-07-07 1999-07-06 Implant Sciences Corporation Coronary stent with a radioactive, radiopaque coating

Also Published As

Publication number Publication date
WO1999051299A2 (en) 1999-10-14
AU5078499A (en) 1999-10-25
KR20010041861A (en) 2001-05-25
EP1284684A2 (en) 2003-02-26
JP2003518392A (en) 2003-06-10

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