WO1999049926A3 - Delivery of an angiogenic substance - Google Patents

Delivery of an angiogenic substance Download PDF

Info

Publication number
WO1999049926A3
WO1999049926A3 PCT/US1999/007081 US9907081W WO9949926A3 WO 1999049926 A3 WO1999049926 A3 WO 1999049926A3 US 9907081 W US9907081 W US 9907081W WO 9949926 A3 WO9949926 A3 WO 9949926A3
Authority
WO
WIPO (PCT)
Prior art keywords
angiogenic agent
agent
heart tissue
energy
angiogenic
Prior art date
Application number
PCT/US1999/007081
Other languages
French (fr)
Other versions
WO1999049926A2 (en
Inventor
Sam G Payne
Randy J Kesten
Michael Aita
Stewart Kume
Stephen B Pearce
Manuel A Javier Jr
Original Assignee
Cardiogenesis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiogenesis Corp filed Critical Cardiogenesis Corp
Priority to AU33747/99A priority Critical patent/AU3374799A/en
Publication of WO1999049926A2 publication Critical patent/WO1999049926A2/en
Publication of WO1999049926A3 publication Critical patent/WO1999049926A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/24—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor with a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00681—Aspects not otherwise provided for
    • A61B2017/00694—Aspects not otherwise provided for with means correcting for movement of or for synchronisation with the body
    • A61B2017/00703—Aspects not otherwise provided for with means correcting for movement of or for synchronisation with the body correcting for movement of heart, e.g. ECG-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00351—Heart
    • A61B2018/00392—Transmyocardial revascularisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A61M2025/0085—Multiple injection needles protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
    • A61M2025/0086—Multiple injection needles protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip the needles having bent tips, i.e. the needle distal tips are angled in relation to the longitudinal axis of the catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A61M2025/0087—Multiple injection needles protruding laterally from the distal tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
    • A61M2025/0089—Single injection needle protruding axially, i.e. along the longitudinal axis of the catheter, from the distal tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M2025/0096—Catheter tip comprising a tool being laterally outward extensions or tools, e.g. hooks or fibres

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Electromagnetism (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Using either a percutaneous, intraoperative or minimally invasive approach, an elongated member containing an angiogenic agent is guided to a heart wall and the agent is dispensed into heart tissue. The administration of the angiogenic agent can be automated and controlled so as to be synchronized with respect the cardiac cycle. The device has a distal end configured to dissect heart tissue and penetrate into the myocardium. Additional fluids or substances can be dispensed in combination with the angiogenic agent to provide visualization and site mapping. In certain embodiments, the angiogenic agent is delivered adjunctively with the administration of energy, such as laser energy of RF energy which disturbs the heart tissue sufficiently to enhance the effects of the agent. There is also disclosed a device for administering an angiogenic agent that contains the angiogenic agent and additional fluids such as a marker within a single conduit.
PCT/US1999/007081 1998-03-31 1999-03-31 Delivery of an angiogenic substance WO1999049926A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33747/99A AU3374799A (en) 1998-03-31 1999-03-31 Delivery of an angiogenic substance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5314698A 1998-03-31 1998-03-31
US09/053,146 1998-03-31

Publications (2)

Publication Number Publication Date
WO1999049926A2 WO1999049926A2 (en) 1999-10-07
WO1999049926A3 true WO1999049926A3 (en) 2000-02-10

Family

ID=21982232

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/007081 WO1999049926A2 (en) 1998-03-31 1999-03-31 Delivery of an angiogenic substance

Country Status (2)

Country Link
AU (1) AU3374799A (en)
WO (1) WO1999049926A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030377A (en) 1996-10-21 2000-02-29 Plc Medical Systems, Inc. Percutaneous transmyocardial revascularization marking system
US6685627B2 (en) 1998-10-09 2004-02-03 Swaminathan Jayaraman Modification of properties and geometry of heart tissue to influence heart function
US8715156B2 (en) 1998-10-09 2014-05-06 Swaminathan Jayaraman Modification of properties and geometry of heart tissue to influence function
US6689103B1 (en) 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
US6319230B1 (en) 1999-05-07 2001-11-20 Scimed Life Systems, Inc. Lateral needle injection apparatus and method
WO2001010315A1 (en) * 1999-08-05 2001-02-15 Cornell Research Foundation, Inc. Gene therapy platformed needle and method of administering a therapeutic solution to a heart
US6613026B1 (en) * 1999-12-08 2003-09-02 Scimed Life Systems, Inc. Lateral needle-less injection apparatus and method
US6344027B1 (en) * 1999-12-08 2002-02-05 Scimed Life Systems, Inc. Needle-less injection apparatus and method
US6241710B1 (en) * 1999-12-20 2001-06-05 Tricardia Llc Hypodermic needle with weeping tip and method of use
WO2001054605A1 (en) * 2000-01-29 2001-08-02 Plc Medical Systems, Inc. Percutaneous myocardial revascularization marking and therapeutic or diagnostic agent delivery system
US6464693B1 (en) 2000-03-06 2002-10-15 Plc Medical Systems, Inc. Myocardial revascularization
US7588554B2 (en) 2000-06-26 2009-09-15 Boston Scientific Scimed, Inc. Method and apparatus for treating ischemic tissue
CA2561565C (en) 2004-04-08 2013-11-26 Sangamo Biosciences, Inc. Methods for repression of phospholamban gene and modulating cardiac contractility
US20060064009A1 (en) * 2004-09-21 2006-03-23 Webler William E Vessel imaging devices and methods
US20070282254A1 (en) * 2006-05-16 2007-12-06 Mina Chow Needle devices and methods
JP5512653B2 (en) * 2008-04-08 2014-06-04 カロリンスカ インスティテュテット イノベーションズ エービー Medical intraluminal connection device
DE102008057255A1 (en) * 2008-08-20 2010-02-25 Friebe, Michael, Dipl.-Ing. Dr. catheter device
US10130384B2 (en) * 2014-09-23 2018-11-20 CARDINAL HEALTH SWITZERLAND 515 GmbH Catheter systems and methods for re-entry in body vessels with chronic total occlusion
DE112020006978T5 (en) 2020-03-27 2023-01-05 Japan Lifeline Co., Ltd. Drug solution injection needle and drug solution injection needle system

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150960A2 (en) * 1984-01-20 1985-08-07 Corday, Eliot, Dr. Catheter for retroinfusion of pharmacologic agents
US5431649A (en) * 1993-08-27 1995-07-11 Medtronic, Inc. Method and apparatus for R-F ablation
US5713853A (en) * 1995-06-07 1998-02-03 Interventional Innovations Corporation Methods for treating thrombosis
WO1998005307A1 (en) * 1996-08-08 1998-02-12 Localmed, Inc. Transmural drug delivery method and apparatus
EP0853921A2 (en) * 1996-12-27 1998-07-22 Eclipse Surgical Technologies, Inc. Laser assisted drug delivery
US5840059A (en) * 1995-06-07 1998-11-24 Cardiogenesis Corporation Therapeutic and diagnostic agent delivery
US5873865A (en) * 1997-02-07 1999-02-23 Eclipse Surgical Technologies, Inc. Spiral catheter with multiple guide holes

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150960A2 (en) * 1984-01-20 1985-08-07 Corday, Eliot, Dr. Catheter for retroinfusion of pharmacologic agents
US5431649A (en) * 1993-08-27 1995-07-11 Medtronic, Inc. Method and apparatus for R-F ablation
US5713853A (en) * 1995-06-07 1998-02-03 Interventional Innovations Corporation Methods for treating thrombosis
US5840059A (en) * 1995-06-07 1998-11-24 Cardiogenesis Corporation Therapeutic and diagnostic agent delivery
WO1998005307A1 (en) * 1996-08-08 1998-02-12 Localmed, Inc. Transmural drug delivery method and apparatus
EP0853921A2 (en) * 1996-12-27 1998-07-22 Eclipse Surgical Technologies, Inc. Laser assisted drug delivery
US5873865A (en) * 1997-02-07 1999-02-23 Eclipse Surgical Technologies, Inc. Spiral catheter with multiple guide holes

Also Published As

Publication number Publication date
AU3374799A (en) 1999-10-18
WO1999049926A2 (en) 1999-10-07

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