WO1999037260A1 - Plug for closing off a tear-duct - Google Patents

Plug for closing off a tear-duct Download PDF

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Publication number
WO1999037260A1
WO1999037260A1 PCT/NL1999/000023 NL9900023W WO9937260A1 WO 1999037260 A1 WO1999037260 A1 WO 1999037260A1 NL 9900023 W NL9900023 W NL 9900023W WO 9937260 A1 WO9937260 A1 WO 9937260A1
Authority
WO
WIPO (PCT)
Prior art keywords
plug
tear
broadened
duct
head
Prior art date
Application number
PCT/NL1999/000023
Other languages
French (fr)
Dutch (nl)
Inventor
Bernardus Henricus Maria Lubberman
Charles Johannes Wilhelmus Clements Vervaet
Gerrit Jan Waayman
Original Assignee
Lubberman Bernardus Henricus M
Vervaet Charles Johannes Wilhe
Gerrit Jan Waayman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lubberman Bernardus Henricus M, Vervaet Charles Johannes Wilhe, Gerrit Jan Waayman filed Critical Lubberman Bernardus Henricus M
Priority to AU19858/99A priority Critical patent/AU1985899A/en
Publication of WO1999037260A1 publication Critical patent/WO1999037260A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/1219—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices expandable in contact with liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12159—Solid plugs; being solid before insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00772—Apparatus for restoration of tear ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires

Definitions

  • the invention relates to a plug for closing off a tear-duct, which plug is provided with two extremities, with a shaft which at one of the two extremities is provided with a broadened head with a lower surface and an edge, the lower surface having at least a partially bent shape, the shaft having a broadened part which slopes in the direction of both extremities.
  • Tear-ducts serve to discharge tear-water from an eye to the nasal cavity.
  • Two tear-ducts end near each eye which ducts usually have a diameter of about 0.3 mm and are surrounded by a ring of connective tissue. Via the tear-duct opening or punctum and the tear-ducts or canaliculi tear-water is discharged to the tear- bag and from there to the nasal cavity.
  • Tear-water among others serves to discharge dust and dirt and to keep the eye clean and moist. Tear-water also contains among other the enzyme lysozyme which acts as a kind of antibiotic and which protects the eye from infections. Per day a normal eye produces about 400 drops of tear water. During sleeping the tear-water production is lower.
  • a shortage of tear-water may for instance occur as a result of excessive discharge via the tear-ducts.
  • An unfavourable composition of the tear-water may also cause these problems, for instance when too little sebaceous matter is produced and the tear-water is too watery as a result of which it evaporates more quickly.
  • Cir- cumstances which may aggravate the symptoms of dry eyes are for instance working in dry environments with a low air humidity, such as air-conditioned environments or air-planes, or working with computers.
  • Dry eyes can be prevented or at least partially be remedied by reducing the discharge of tear water via the tear-ducts by arranging a little plug in one of the tear-ducts, or in serious cases in both tear-ducts, as a result of which the discharge of tear-water is blocked.
  • Disadvantages of the known tear-duct plugs are that they are difficult to arrange and have to be arranged by an ophthalmologist or ophthalmic educated personnel.
  • the tear-duct plug known from the US patent 5.334.1 37 may in some cases move during use, and appeared not always to sufficiently close off the tear-duct.
  • the object of the invention is to provide a plug for a tear-duct, which during use remains on the same location and which sufficiently closes off the tear-duct.
  • the object of the invention is achieved with a plug of the kind mentioned in the preamble, which has said broadened head and hollow curvature, and that the edge of the broadened head is bent back in the direction of the broadened part.
  • the broadened head attaches itself firmly like a suction cup to the moist mucous membrane tissue surrounding the opening of the tear-duct.
  • the plug is durably and firmly kept in its place after insertion in the tear-duct.
  • the head of the plug known from the US patent specification does not have a bent back edge, so that no sucking effect is obtained.
  • the plug is made of a moist absorbing material which is not soluble in water, such as for instance HEMA, of which also contact lenses are made.
  • HEMA is a moist absorbing synthetic which does not irritate the eyes and mucous membranes.
  • HEMA is radio opaque so that it can be perceived with the help of for instance X-ray equipment, whereas the little plug is virtually invisible with the naked eye.
  • the HEMA is modified and substances are added for increasing the moist absorption.
  • a modified HEMA may swell with a factor 1 .4 as a result of moist absorption.
  • an inflammation inhibitor for instance heparin, may also be added to the material from which the plug is made.
  • the plug is easier to remove if at the side facing the head, the broadened part of the shaft changes with a gradual running bend into a substantially cylindrical part of the shaft.
  • the tear-duct plug is provided with a cavity which from the broadened head tapers off in the longitudinal direction of the plug.
  • the plug can be arranged or removed in a simple manner with the help of a pair of tweezers or such like tools. If, as in most cases, the tear-duct has to be completely closed off, this cavity has to be a blind cavity. If the discharge via the tear-duct has to be reduced but not entirely closed off, then a passage can be arranged contiguous to this cavity which passage continues to the extremity opposite the broadened head.
  • Figure 1 shows a plug according to the invention in perspective
  • Figure 2 shows a human eye provided with a plug in accordance with figure 1 ;
  • Figure 3 shows a cross-section of a plug along the line Ill-Ill from figure 1 ;
  • Figure 4 shows a cross-section of another embodiment of a plug according to the invention. - 4 -
  • Figure 1 shows a tear-duct plug 1 according to the invention, consisting of a shaft 2 with a broadened head 3 which serves to abut the tissue surrounding the tear- duct opening after placing the plug 1 in a tear-duct.
  • the broadened head 3 has an edge.
  • the other extremity is formed by a broadened part 4 which on the one hand shows a conical course and ends in a pointed extremity 5.
  • the broadened part 4 preferably merges with a gradual bend into a substantially cylindrical part 6 of the shaft 2.
  • the broadened head 3 is substantially dish- shaped, shows a hollow curvature 7, and the edge of the broadened head 3 is bent back in the direction of the broadened part 4, as can clearly be seen in figure 3 in which the plug 1 is shown in cross-section.
  • this hollow curvature and bending back attaches itself firmly like a suction cup to the tissue surrounding the opening or punctum 9 of the a tear-duct or canaliculus 10 to be closed off.
  • FIG 2 a part of an eye 1 1 is shown, in which the tear-duct 10, namely a lower tear-duct 12 and an upper tear-duct 1 3, are shown in dotted lines.
  • the tear- ducts 1 2, 1 3 consist of a substantially vertical part 14 of about 2 mm long and contiguous to it a substantially horizontal part 1 5 of about 8 mm long, which connects to the tear-bag 1 6.
  • a plug 1 is arranged in the lower tear-duct.
  • the broadened head 3 protrudes from the tear-duct 1 2 and abuts the tissue surrounding the tear-duct opening 9.
  • the broadened part 4 is in the tear-duct 1 2.
  • the tissue of the inner wall of the tear-duct clamps around the broadened part 4, as a result of which because of the sucking effect of the broadened head 3 the plug can less easily slide of its own accord. Because the broadened part 4 is gradually bevelled towards both extremities the plug can both be placed and removed easily.
  • the tear-duct plug 1 is made of a moist absorbing material, for instance a modified HEMA
  • the plug 1 swells after insertion in the tear-duct.
  • the factor with which the modified HEMA swells can be increased to a swell factor of about 1 .4.
  • the plug 1 in the unswollen situation immediately after insertion in the tear-duct is shown in dotted lines.
  • the same plug 1 is shown after it has swollen to its maximum size.
  • the plug 1 remains much more firmly in its place in the tear-duct 10.
  • the plug 1 further comprises a blind cylindrical cavity 1 7 which from the broadened head 3 extends in longitudinal direction of the plug 1 .
  • a blind cylindrical cavity 1 7 which from the broadened head 3 extends in longitudinal direction of the plug 1 .
  • FIG 4 another possible embodiment of a tear-duct plug according to the invention is shown in which contiguous to the cavity 17 a passage 18 is arranged which ends at the pointed extremity 5 of the plug 1 .
  • a plug can be used if the discharge of tear-water via the tear-duct should not be entirely impeded, but only partially.

Abstract

Plug (1) for closing off a tear-duct (12) which plug (1) is provided with two extremities. The plug (1) has a shaft (2) which at one of the two extremities is provided with a broadened head (3) with a lower surface and an edge. The lower surface has an at least partially bent shape. The shaft (2) comprises a broadened part (4) which slopes in the direction of both extremities. The broadened head (3) has a hollow curvature (7) and the edge of the broadened head (3) is bent back in the direction of the broadened part. The plug (1) is made of a moist absorbing material which is not soluble in water, for instance a modified HEMA, to which substances have been added for increasing the moist absorption and an inflammation inhibitor, for instance heparin.

Description

Plug for closing off a tear-duct
The invention relates to a plug for closing off a tear-duct, which plug is provided with two extremities, with a shaft which at one of the two extremities is provided with a broadened head with a lower surface and an edge, the lower surface having at least a partially bent shape, the shaft having a broadened part which slopes in the direction of both extremities.
Such a plug is known from the US patent specification 5.334.1 37.
Tear-ducts serve to discharge tear-water from an eye to the nasal cavity. Two tear-ducts end near each eye which ducts usually have a diameter of about 0.3 mm and are surrounded by a ring of connective tissue. Via the tear-duct opening or punctum and the tear-ducts or canaliculi tear-water is discharged to the tear- bag and from there to the nasal cavity.
Tear-water among others serves to discharge dust and dirt and to keep the eye clean and moist. Tear-water also contains among other the enzyme lysozyme which acts as a kind of antibiotic and which protects the eye from infections. Per day a normal eye produces about 400 drops of tear water. During sleeping the tear-water production is lower.
A shortage of tear-water may for instance occur as a result of excessive discharge via the tear-ducts. An unfavourable composition of the tear-water may also cause these problems, for instance when too little sebaceous matter is produced and the tear-water is too watery as a result of which it evaporates more quickly. Cir- cumstances which may aggravate the symptoms of dry eyes are for instance working in dry environments with a low air humidity, such as air-conditioned environments or air-planes, or working with computers.
Moistening the eye is promoted by fully fluttering the eyelids. However, this - 2 - flutter reflex is reduced with some people, for instance contact lens wearers, as a result of which the symptoms of dry eyes occur earlier with these people. The symptoms of dry eyes may also occur when too little tear-water is produced. The production of tear-water decreases when getting older. Thus the tear-water production at the age of 65 is on an average 60% lower than at the age of 1 8.
By wearing contact lenses the evaporation of tear-water is accelerated. This may cause irritation or give reason for the deposit of protein or infections. Because in many quarters, for instance offices, the air humidity is kept low by means of climate control systems, more and more people, particularly wearers of contact lenses, suffer from these symptoms.
Dry eyes can be prevented or at least partially be remedied by reducing the discharge of tear water via the tear-ducts by arranging a little plug in one of the tear-ducts, or in serious cases in both tear-ducts, as a result of which the discharge of tear-water is blocked. Disadvantages of the known tear-duct plugs however are that they are difficult to arrange and have to be arranged by an ophthalmologist or ophthalmic educated personnel.
The tear-duct plug known from the US patent 5.334.1 37 may in some cases move during use, and appeared not always to sufficiently close off the tear-duct.
The object of the invention is to provide a plug for a tear-duct, which during use remains on the same location and which sufficiently closes off the tear-duct.
The object of the invention is achieved with a plug of the kind mentioned in the preamble, which has said broadened head and hollow curvature, and that the edge of the broadened head is bent back in the direction of the broadened part. With this measure it is achieved that the broadened head attaches itself firmly like a suction cup to the moist mucous membrane tissue surrounding the opening of the tear-duct. In this way the plug is durably and firmly kept in its place after insertion in the tear-duct. The head of the plug known from the US patent specification does not have a bent back edge, so that no sucking effect is obtained. - 3 -
In a preferred embodiment the plug is made of a moist absorbing material which is not soluble in water, such as for instance HEMA, of which also contact lenses are made. HEMA is a moist absorbing synthetic which does not irritate the eyes and mucous membranes. Moreover HEMA is radio opaque so that it can be perceived with the help of for instance X-ray equipment, whereas the little plug is virtually invisible with the naked eye. Preferably the HEMA is modified and substances are added for increasing the moist absorption. A modified HEMA may swell with a factor 1 .4 as a result of moist absorption. In a preferred embodiment an inflammation inhibitor, for instance heparin, may also be added to the material from which the plug is made.
The plug is easier to remove if at the side facing the head, the broadened part of the shaft changes with a gradual running bend into a substantially cylindrical part of the shaft.
Preferably the tear-duct plug is provided with a cavity which from the broadened head tapers off in the longitudinal direction of the plug. In this way it is achieved that the plug can be arranged or removed in a simple manner with the help of a pair of tweezers or such like tools. If, as in most cases, the tear-duct has to be completely closed off, this cavity has to be a blind cavity. If the discharge via the tear-duct has to be reduced but not entirely closed off, then a passage can be arranged contiguous to this cavity which passage continues to the extremity opposite the broadened head.
The invention will be elucidated on the basis of the drawing, in which:
Figure 1 shows a plug according to the invention in perspective;
Figure 2 shows a human eye provided with a plug in accordance with figure 1 ;
Figure 3 shows a cross-section of a plug along the line Ill-Ill from figure 1 ; and
Figure 4 shows a cross-section of another embodiment of a plug according to the invention. - 4 -
Figure 1 shows a tear-duct plug 1 according to the invention, consisting of a shaft 2 with a broadened head 3 which serves to abut the tissue surrounding the tear- duct opening after placing the plug 1 in a tear-duct. The broadened head 3 has an edge. The other extremity is formed by a broadened part 4 which on the one hand shows a conical course and ends in a pointed extremity 5. On the other hand the broadened part 4 preferably merges with a gradual bend into a substantially cylindrical part 6 of the shaft 2. The broadened head 3 is substantially dish- shaped, shows a hollow curvature 7, and the edge of the broadened head 3 is bent back in the direction of the broadened part 4, as can clearly be seen in figure 3 in which the plug 1 is shown in cross-section. As a result of this hollow curvature and bending back the broadened head attaches itself firmly like a suction cup to the tissue surrounding the opening or punctum 9 of the a tear-duct or canaliculus 10 to be closed off.
In figure 2 a part of an eye 1 1 is shown, in which the tear-duct 10, namely a lower tear-duct 12 and an upper tear-duct 1 3, are shown in dotted lines. The tear- ducts 1 2, 1 3 consist of a substantially vertical part 14 of about 2 mm long and contiguous to it a substantially horizontal part 1 5 of about 8 mm long, which connects to the tear-bag 1 6. To dam the discharge of tear-water via the tear- ducts 1 2, 13 in figure 2 a plug 1 is arranged in the lower tear-duct. The broadened head 3 protrudes from the tear-duct 1 2 and abuts the tissue surrounding the tear-duct opening 9. The broadened part 4 is in the tear-duct 1 2. The tissue of the inner wall of the tear-duct clamps around the broadened part 4, as a result of which because of the sucking effect of the broadened head 3 the plug can less easily slide of its own accord. Because the broadened part 4 is gradually bevelled towards both extremities the plug can both be placed and removed easily.
Because the tear-duct plug 1 is made of a moist absorbing material, for instance a modified HEMA, the plug 1 swells after insertion in the tear-duct. By means of additives the factor with which the modified HEMA swells, can be increased to a swell factor of about 1 .4. In figure 3 the plug 1 in the unswollen situation immediately after insertion in the tear-duct is shown in dotted lines. In full line the same plug 1 is shown after it has swollen to its maximum size. As a result of the - 5 - swollen size of the plug, the plug 1 remains much more firmly in its place in the tear-duct 10.
The plug 1 further comprises a blind cylindrical cavity 1 7 which from the broadened head 3 extends in longitudinal direction of the plug 1 . By means of said cavity 1 7 the plug can be placed or removed with the help of a suitable tool.
In figure 4 another possible embodiment of a tear-duct plug according to the invention is shown in which contiguous to the cavity 17 a passage 18 is arranged which ends at the pointed extremity 5 of the plug 1 . Such a plug can be used if the discharge of tear-water via the tear-duct should not be entirely impeded, but only partially.

Claims

- 6 -Claims
1 . Plug ( 1 ) for closing off a tear-duct (1 2), which plug ( 1 ) is provided with two extremities, with a shaft (2) which at one of the two extremities is provided with a broadened head (3) with a lower surface and an edge, the lower surface having at least a partially bent shape, the shaft (2) having a broadened part (4) which slopes in the direction of both extremities, characterized in that the broadened head has a hollow curvature (7), and that the edge of the broadened head (3) is bent back in the direction of the broadened part.
2. Plug (1 ) according to claim 1 , characterized in that the plug (1 ) is made of a moist absorbing material which is not soluble in water.
3. Plug (1 ) according to claim 2, characterized in that the plug (1 ) is made of HEMA.
4. Plug ( 1 ) according to claim 2, characterized in that the plug (1 ) is made of a modified HEMA, to which substances have been added for increasing the moist absorption.
5. Plug (1 ) according to any one of the preceding claims, characterized in that the plug (1 ) is made of a material to which an inflammation inhibitor, for instance heparin, is added.
6. Plug ( 1 ) according to any one of the preceding claims, characterized in that at the side facing the head (3) the broadened part (4) of the shaft (2) changes with a gradual running bend into a substantially cylindrical part of the shaft (2).
7. Plug (1 ) according to any one of the preceding claims, characterized in that the plug ( 1 ) is provided with a cavity (1 7) which from the broadened head tapers off in the longitudinal direction of the plug ( 1 ).
8. Plug according to claim 7, characterized in that contiguous to the cavity (1 7) a passage (18) is arranged which runs through to the extremity across the broadened head.
PCT/NL1999/000023 1998-01-22 1999-01-15 Plug for closing off a tear-duct WO1999037260A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19858/99A AU1985899A (en) 1998-01-22 1999-01-15 Plug for closing off a tear-duct

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1008090 1998-01-22
NL1008090A NL1008090C2 (en) 1998-01-22 1998-01-22 Plug for closing a tear duct.

Publications (1)

Publication Number Publication Date
WO1999037260A1 true WO1999037260A1 (en) 1999-07-29

Family

ID=19766388

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1999/000023 WO1999037260A1 (en) 1998-01-22 1999-01-15 Plug for closing off a tear-duct

Country Status (3)

Country Link
AU (1) AU1985899A (en)
NL (1) NL1008090C2 (en)
WO (1) WO1999037260A1 (en)

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FR2813522A1 (en) * 2000-09-06 2002-03-08 Alain Fouere Lachrymal drain implant, is located and held in place by its external screw thread, and completes lachrymal path
FR2834446A1 (en) * 2002-01-08 2003-07-11 Ioltechnologie Production EXPANDING MEATIC NAIL
WO2008094989A2 (en) 2007-01-31 2008-08-07 Alcon Research, Ltd. Punctal plugs and methods of delivering therapeutic agents
WO2010101758A1 (en) 2009-03-03 2010-09-10 Alcon Research, Ltd. Peri-corneal drug delivery device
WO2011094170A1 (en) 2010-01-27 2011-08-04 Alcon Research, Ltd. Pulsatile peri-corneal drug delivery device
US8691265B2 (en) 2006-03-31 2014-04-08 Mati Therapeutics, Inc. Drug delivery methods, structures, and compositions for nasolacrimal system
US9132088B2 (en) 2008-04-30 2015-09-15 Mati Therapeutics Inc. Composite lacrimal insert and related methods
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US9216108B2 (en) 2008-02-18 2015-12-22 Mati Therapeutics Inc. Lacrimal implants and related methods
US9445944B2 (en) 2007-09-07 2016-09-20 Mati Therapeutics Inc. Lacrimal implants and related methods
US9463114B2 (en) 2004-04-15 2016-10-11 Mati Therapeutics Inc. Punctal plug with active agent
US9610271B2 (en) 2011-08-29 2017-04-04 Mati Therapeutics Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9949942B2 (en) 2008-05-09 2018-04-24 Mati Therapeutics Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
US10238535B2 (en) 2009-02-23 2019-03-26 Mati Therapeutics Inc. Lacrimal implants and related methods
US11141312B2 (en) 2007-09-07 2021-10-12 Mati Therapeutics Inc. Lacrimal implant detection

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Publication number Priority date Publication date Assignee Title
FR2813522A1 (en) * 2000-09-06 2002-03-08 Alain Fouere Lachrymal drain implant, is located and held in place by its external screw thread, and completes lachrymal path
FR2834446A1 (en) * 2002-01-08 2003-07-11 Ioltechnologie Production EXPANDING MEATIC NAIL
WO2003057101A1 (en) * 2002-01-08 2003-07-17 Ioltechnologie-Production Expanding punctum plug
US9463114B2 (en) 2004-04-15 2016-10-11 Mati Therapeutics Inc. Punctal plug with active agent
US9180045B2 (en) 2004-07-02 2015-11-10 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device
US10610407B2 (en) 2004-07-02 2020-04-07 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such delivery device
US9820884B2 (en) 2004-07-02 2017-11-21 Mati Therapeutics Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such delivery device
US10383817B2 (en) 2006-03-31 2019-08-20 Mati Therapeutics Inc. Nasolacrimal drainage system implants for drug therapy
US11406592B2 (en) 2006-03-31 2022-08-09 Mati Therapeutics Inc. Drug delivery methods, structures, and compositions for nasolacrimal system
US10300014B2 (en) 2006-03-31 2019-05-28 Mati Therapeutics Inc. Nasolacrimal drainage system implants for drug therapy
US9168222B2 (en) 2006-03-31 2015-10-27 Mati Therapeutics Inc. Nasolacrimal drainage system implants for drug therapy
US8691265B2 (en) 2006-03-31 2014-04-08 Mati Therapeutics, Inc. Drug delivery methods, structures, and compositions for nasolacrimal system
US10874606B2 (en) 2006-03-31 2020-12-29 Mati Therapeutics Inc. Nasolacrimal drainage system implants for drug therapy
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AU1985899A (en) 1999-08-09

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