WO1999026724A3 - Devices and methods for detecting target molecules in biological samples - Google Patents

Devices and methods for detecting target molecules in biological samples Download PDF

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Publication number
WO1999026724A3
WO1999026724A3 PCT/US1998/024918 US9824918W WO9926724A3 WO 1999026724 A3 WO1999026724 A3 WO 1999026724A3 US 9824918 W US9824918 W US 9824918W WO 9926724 A3 WO9926724 A3 WO 9926724A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
devices
biological samples
target molecules
detecting target
Prior art date
Application number
PCT/US1998/024918
Other languages
French (fr)
Other versions
WO1999026724A2 (en
Inventor
Andrew R Muir
Truett C Boles
Christopher P Adams
Original Assignee
Mosaic Technologies
Andrew R Muir
Truett C Boles
Christopher P Adams
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mosaic Technologies, Andrew R Muir, Truett C Boles, Christopher P Adams filed Critical Mosaic Technologies
Priority to EP98960365A priority Critical patent/EP1034040A2/en
Priority to AU15975/99A priority patent/AU753191B2/en
Priority to CA002311501A priority patent/CA2311501A1/en
Publication of WO1999026724A2 publication Critical patent/WO1999026724A2/en
Publication of WO1999026724A3 publication Critical patent/WO1999026724A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • C12Q1/702Specific hybridization probes for retroviruses
    • C12Q1/703Viruses associated with AIDS

Abstract

Devices and methods for detecting the presence, or absence of the presence, of at least one target molecule employing a receptacle housing a reaction chamber comprised of at least one compartment containing suitable reagents for the detection of the target molecule are disclosed. The device can be used in particular for screening donated blood or other biological fluids for the presence of contaminants. Preferably, the device comprises two or more breakable compartments separated by breakable barriers, and is associated with a collection system such as a blood bag.
PCT/US1998/024918 1997-11-25 1998-11-25 Devices and methods for detecting target molecules in biological samples WO1999026724A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP98960365A EP1034040A2 (en) 1997-11-25 1998-11-25 Devices and methods for detecting target molecules in biological samples
AU15975/99A AU753191B2 (en) 1997-11-25 1998-11-25 Devices and methods for detecting target molecules in biological samples
CA002311501A CA2311501A1 (en) 1997-11-25 1998-11-25 Devices and methods for detecting target molecules in biological samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6650897P 1997-11-25 1997-11-25
US60/066,508 1997-11-25

Publications (2)

Publication Number Publication Date
WO1999026724A2 WO1999026724A2 (en) 1999-06-03
WO1999026724A3 true WO1999026724A3 (en) 1999-09-02

Family

ID=22069936

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/024918 WO1999026724A2 (en) 1997-11-25 1998-11-25 Devices and methods for detecting target molecules in biological samples

Country Status (5)

Country Link
US (1) US6251660B1 (en)
EP (1) EP1034040A2 (en)
AU (1) AU753191B2 (en)
CA (1) CA2311501A1 (en)
WO (1) WO1999026724A2 (en)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020172955A1 (en) * 1997-05-16 2002-11-21 Exact Sciences Corporation Methods for purifying DNA using immobilized capture probes
ATE335845T1 (en) * 1997-05-16 2006-09-15 Exact Sciences Corp ELECTROPHORETIC ANALYSIS OF MOLECULES USING IMMOBILIZED PROBE
GB9812768D0 (en) * 1998-06-13 1998-08-12 Zeneca Ltd Methods
EP1088105A4 (en) * 1998-06-19 2003-06-25 Exact Sciences Corp Detection of non-viral organisms with srp rna
US6780617B2 (en) 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
CA2632856C (en) 1998-06-24 2010-10-12 Chen & Chen, Llc Fluid sample testing system
US7799521B2 (en) * 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
JP3829491B2 (en) * 1998-08-27 2006-10-04 株式会社日立製作所 Probe tip, probe tip creation method, sample detection method, and sample detection device
ATE331811T1 (en) 1999-04-09 2006-07-15 Exact Sciences Corp METHOD FOR DETECTING NUCLEIC ACIDS INdicative of CANCER
US6309833B1 (en) * 1999-04-12 2001-10-30 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
US6238868B1 (en) * 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
US6531302B1 (en) * 1999-04-12 2003-03-11 Nanogen/Becton Dickinson Partnership Anchored strand displacement amplification on an electronically addressable microchip
EP1177423A4 (en) * 1999-04-12 2004-10-27 Nanogen Becton Dickinson Partn Amplification and separation of nucleic acid sequences using strand displacement amplification and bioelectronic microchip technology
US6326173B1 (en) * 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
GB2351245B (en) * 1999-06-21 2003-07-16 Univ Hull Method of controlling liquid movement in a chemical device
DE19936302A1 (en) * 1999-08-02 2001-02-15 Niels Fertig Biochip, used in probe for investigating ion channels, has substrate with opening(s) to receive cell membrane with ion channel(s)
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6919174B1 (en) * 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US7368233B2 (en) 1999-12-07 2008-05-06 Exact Sciences Corporation Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm
EP1118677A1 (en) * 2000-01-17 2001-07-25 Novartis AG Oligonucleotides useful in identifying fungicide resistant plant pathogenic fungi
US20030138774A1 (en) * 2000-01-19 2003-07-24 Jones Chris L. Methods and apparatus for separating and detecting nucleic acid
US20030207307A1 (en) * 2000-10-13 2003-11-06 Esa, Inc. Determining biochemical markers of progression and therapy monitoring and specification, therapeutic lead molecules, and target biochemical systems applied to stroke
US6641782B1 (en) * 2000-11-15 2003-11-04 Polaroid Corporation Apparatus for performing diagnostic testing
US6905816B2 (en) * 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
AU2002305941A1 (en) * 2001-03-01 2002-09-19 The Johns Hopkins University Quantitative assay for the simultaneous detection and speciation of bacterial infections
WO2002088296A1 (en) * 2001-04-26 2002-11-07 Boston Biomedica, Inc. Multichamber device and uses thereof for processing of biological samples
CA2460192C (en) 2001-09-11 2011-04-19 Iquum, Inc. Sample vessels
EP1306668B1 (en) * 2001-10-25 2008-04-09 Götec Labortechnik GmbH Chromatography column with adjustable plunger
US7776524B2 (en) * 2002-02-15 2010-08-17 Genzyme Corporation Methods for analysis of molecular events
US7582470B2 (en) * 2002-07-31 2009-09-01 Gen-Probe Incorporated Device for amplifying and detecting a target nucleic acid
US7919600B2 (en) * 2002-09-23 2011-04-05 Alcatel-Lucent Usa Inc. Compositions that reversibly gel and de-gel
US8389700B2 (en) * 2002-09-23 2013-03-05 Alcatel Lucent Agent delivery system capable of selectively releasing an agent
ES2428628T3 (en) 2002-12-12 2013-11-08 Novartis Vaccines And Diagnostics, Inc. Device and method for online blood tests using biochips
WO2004065010A2 (en) * 2003-01-21 2004-08-05 Micronics Inc. Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing
ES2604352T3 (en) * 2003-02-05 2017-03-06 Iquum, Inc. Sample Processing
US20070117092A1 (en) * 2003-04-08 2007-05-24 Daksh Sadarangani Dna analysis system
US20050003396A1 (en) * 2003-04-11 2005-01-06 Mihrimah Ozkan Biosensors having single reactant components immobilized over single electrodes and methods of making and using thereof
US20040259101A1 (en) * 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
KR101214179B1 (en) 2003-08-06 2013-01-10 더 프록터 앤드 갬블 컴퍼니 Bridged element for detection of a target substance
WO2005047881A2 (en) * 2003-11-05 2005-05-26 Exact Sciences Corporation Repetitive reversed-field affinity electrophoresis and uses therefor
JP4511914B2 (en) * 2003-12-12 2010-07-28 ベクトン・ディキンソン・アンド・カンパニー Membrane mounting method
GB0401288D0 (en) * 2004-01-21 2004-02-25 Orion Diagnostica Oy Sampling and assay device
US20050186578A1 (en) * 2004-02-20 2005-08-25 Sven Bulow Chamber array arrangement
WO2005113769A1 (en) * 2004-05-14 2005-12-01 Exact Sciences Corporation Method for stabilizing biological samples for nucleic acid analysis
AU2005253151B2 (en) * 2004-06-07 2010-08-19 Iquum, Inc. Sample multiprocessing
US20060229531A1 (en) * 2005-02-01 2006-10-12 Daniel Goldberger Blood monitoring system
US20070191716A1 (en) * 2004-09-29 2007-08-16 Daniel Goldberger Blood monitoring system
US7608042B2 (en) * 2004-09-29 2009-10-27 Intellidx, Inc. Blood monitoring system
US7514230B2 (en) * 2004-10-22 2009-04-07 Kimberly-Clark Worldwide, Inc. Detection of trichomonas
EP1920070B1 (en) 2005-05-09 2019-08-07 BioFire Diagnostics, LLC Self-contained biological analysis
WO2007011867A2 (en) * 2005-07-15 2007-01-25 Applera Corporation Fluid processing device and method
US8929086B2 (en) * 2005-09-26 2015-01-06 International Business Machines Corporation Gel package structural enhancement of compression system board connections
US7930820B2 (en) * 2005-09-26 2011-04-26 International Business Machines Corporation Method for structural enhancement of compression system board connections
KR101157174B1 (en) * 2005-11-24 2012-06-20 삼성전자주식회사 Method and apparatus for rapidly lysing cells or virus
US20070123801A1 (en) * 2005-11-28 2007-05-31 Daniel Goldberger Wearable, programmable automated blood testing system
US20080200838A1 (en) * 2005-11-28 2008-08-21 Daniel Goldberger Wearable, programmable automated blood testing system
US20080003564A1 (en) * 2006-02-14 2008-01-03 Iquum, Inc. Sample processing
US8092385B2 (en) * 2006-05-23 2012-01-10 Intellidx, Inc. Fluid access interface
GB2440749B (en) * 2006-05-26 2011-04-06 Marc Baumann Multi-dimensional analysis
WO2008012550A2 (en) 2006-07-28 2008-01-31 Diagnostics For The Real World, Ltd. Device, system and method for processing a sample
JP5266245B2 (en) * 2006-11-15 2013-08-21 バイオファイアー ダイアグノスティックス,インコーポレイテッド High density built-in biological analysis
US9102911B2 (en) 2009-05-15 2015-08-11 Biofire Diagnostics, Llc High density self-contained biological analysis
CN101970111B (en) 2007-06-21 2013-09-11 简·探针公司 Instrument and receptacles for performing processes
WO2009024773A1 (en) 2007-08-17 2009-02-26 Diagnostics For The Real World, Ltd Device, system and method for processing a sample
US20090104076A1 (en) * 2007-10-19 2009-04-23 Los Alamos National Security Llc Sample preparation cartridge and system
EP2055384A1 (en) * 2007-10-31 2009-05-06 Leukocare AG Device for identifying constituents in a fluid
US8753290B2 (en) * 2009-03-27 2014-06-17 Intellectual Inspiration, Llc Fluid transfer system and method
JP2013506846A (en) * 2009-10-02 2013-02-28 ライフ テクノロジーズ コーポレーション Sample preparation device and method
KR101314221B1 (en) * 2009-12-09 2013-10-02 한국전자통신연구원 Diagnostic kit for respiratory disease
EP2593769B2 (en) 2010-07-14 2023-08-30 Qiagen GmbH New liquid processing device
WO2012007503A1 (en) * 2010-07-14 2012-01-19 Qiagen Gmbh New storage, collection or isolation device
WO2012007502A1 (en) 2010-07-14 2012-01-19 Qiagen Gmbh Device for isolation and/or purification of biomolecules
EP2678664B1 (en) 2011-02-24 2019-08-07 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
US9766207B2 (en) 2011-11-04 2017-09-19 Bio-Rad Laboratories, Inc. Affinity methods and compositions employing electronic control of pH
US9234875B2 (en) 2011-11-04 2016-01-12 Bio-Rad Laboratories, Inc. Simultaneous purification of cell components
JP6430253B2 (en) 2011-11-05 2018-11-28 プレジデント アンド フェローズ オブ ハーバード カレッジ Nucleic acid-based linkers for detecting and measuring interactions
CN106591103B (en) 2011-12-01 2021-06-04 吉纳普赛斯股份有限公司 System and method for efficient electronic sequencing and detection
EP2814597A4 (en) 2012-02-15 2015-10-28 Bio Rad Laboratories Electronic control of ph and ionic strength
US9321012B2 (en) 2012-04-04 2016-04-26 Bio-Rad Laboratories, Inc. Electronic protein fractionation
EP2879581B1 (en) * 2012-08-02 2017-12-06 Siemens Healthcare Diagnostics Inc. Biological liquid collection vessels
EP2893029B1 (en) * 2012-09-04 2017-09-27 Becton, Dickinson and Company Bacterial pre-concentration and detection technique
KR101533363B1 (en) * 2012-12-05 2015-07-03 대한민국(관리부서 : 농림축산식품부 농림축산검역본부) A Bio Probe for Detecting Novel Swine-Origin H1N1 Influenza and Method for Diagnosing Novel Swine-Origin H1N1 Influenza Using the Same
CA2991918A1 (en) * 2014-07-11 2016-01-14 Advanced Theranostics Inc. Point of care polymerase chain reaction device for disease detection
US9145581B1 (en) * 2014-10-17 2015-09-29 Daniel Lai Rapid nucleic acid extraction method and apparatus
US11198900B2 (en) 2014-12-06 2021-12-14 Children's Medical Center Corporation Nucleic acid-based linkers for detecting and measuring interactions
EP3249404B1 (en) * 2015-01-22 2019-10-02 NEC Solution Innovators, Ltd. Target analysis apparatus and target analysis method
WO2016196824A1 (en) 2015-06-02 2016-12-08 Children's Medical Center Corporation Nucleic acid complexes for screening barcoded compounds
WO2017117666A1 (en) 2016-01-08 2017-07-13 Advanced Theranostics Inc. Fully integrated, stand-alone, point-of-care device to detect target nucleic acids
US11713483B2 (en) 2016-02-09 2023-08-01 Children's Medical Center Corporation Method for detection of analytes via polymer complexes
US10919037B2 (en) 2016-03-23 2021-02-16 Children's Medical Center Corporation Systems and apparatus for detecting compounds in human biological samples
GB201703383D0 (en) 2017-03-02 2017-04-19 Gargle Tech Ltd Testing for particulates
JP2018163079A (en) * 2017-03-27 2018-10-18 大研医器株式会社 Examination structure
CN108654138B (en) * 2017-04-01 2023-06-16 四川大学 Centrifugal force micro-fluid extraction device and extraction method thereof
US11591636B2 (en) 2017-11-20 2023-02-28 Children's Medical Center Corporation Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids
US10830672B2 (en) * 2018-02-13 2020-11-10 Hangzhou Biotest Biotech Co., Ltd. Apparatus for collecting liquid sample
US11680877B2 (en) 2018-09-05 2023-06-20 Hero Scientific Ltd. Testing for particulates
WO2022098878A1 (en) * 2020-11-06 2022-05-12 Aftab Alam Method, device, and kit for collecting and processing a biological sample
WO2022149135A2 (en) 2021-01-06 2022-07-14 Hero Scientific Ltd. Filtration sampling devices

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3217710A (en) * 1963-03-25 1965-11-16 Abbott Lab Blood collection and sampling apparatus provided with separable coupling means
WO1986000704A1 (en) * 1984-07-17 1986-01-30 International Health Services Method and apparatus for filtering particulate matter from fluids of biomedical interest and examining same
EP0397424A2 (en) * 1989-05-08 1990-11-14 Biotrack, Inc. Multiple analysis system
DE9417612U1 (en) * 1994-11-03 1995-01-05 Kloth Bernd Sampling device
WO1995015681A1 (en) * 1993-12-09 1995-06-15 Baxter International Inc. Method and device for testing blood units for viral contamination
US5591573A (en) * 1995-04-10 1997-01-07 Alpha Therapeutic Corporation Method and system for testing blood samples
WO1997047967A1 (en) * 1996-06-14 1997-12-18 Sarnoff Corporation Automated nucleic acid isolation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766064A (en) 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay employing polyether and diagnostic kit
US5034428A (en) 1986-06-19 1991-07-23 Board Of Regents Of The University Of Washington Immobilized biomolecules and method of making same
US4829098A (en) 1986-06-19 1989-05-09 Washington Research Foundation Immobilized biomolecules and method of making same
US5310650A (en) 1986-09-29 1994-05-10 Abbott Laboratoires Method and device for improved reaction kinetics in nucleic acid hybridizations
CA2006845C (en) 1988-12-29 1998-08-25 Joong M. Cho Expression of proteinaceous sweeteners in yeast
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5188615A (en) * 1990-11-19 1993-02-23 Habley Medical Technology Corp. Mixing vial
US5762876A (en) 1991-03-05 1998-06-09 Molecular Tool, Inc. Automatic genotype determination
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5482836A (en) 1993-01-14 1996-01-09 The Regents Of The University Of California DNA purification by triplex-affinity capture and affinity capture electrophoresis
US5610287A (en) 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
AU694187B2 (en) 1994-02-07 1998-07-16 Beckman Coulter, Inc. Ligase/polymerase-mediated genetic bit analysis TM of single nucleotide polymorphisms and its use in genetic analysis
EP0671626B1 (en) 1994-03-08 2000-01-12 Zeptosens AG Device and method for combined bioaffinity assay and electrophoretic separation
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US5955268A (en) 1996-04-26 1999-09-21 Abbott Laboratories Method and reagent for detecting multiple nucleic acid sequences in a test sample
US6203978B1 (en) 1996-05-31 2001-03-20 Du Vergier Ltd. Capture of single stranded nucleic acids

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3217710A (en) * 1963-03-25 1965-11-16 Abbott Lab Blood collection and sampling apparatus provided with separable coupling means
WO1986000704A1 (en) * 1984-07-17 1986-01-30 International Health Services Method and apparatus for filtering particulate matter from fluids of biomedical interest and examining same
EP0397424A2 (en) * 1989-05-08 1990-11-14 Biotrack, Inc. Multiple analysis system
WO1995015681A1 (en) * 1993-12-09 1995-06-15 Baxter International Inc. Method and device for testing blood units for viral contamination
DE9417612U1 (en) * 1994-11-03 1995-01-05 Kloth Bernd Sampling device
US5591573A (en) * 1995-04-10 1997-01-07 Alpha Therapeutic Corporation Method and system for testing blood samples
WO1997047967A1 (en) * 1996-06-14 1997-12-18 Sarnoff Corporation Automated nucleic acid isolation

Also Published As

Publication number Publication date
EP1034040A2 (en) 2000-09-13
AU753191B2 (en) 2002-10-10
WO1999026724A2 (en) 1999-06-03
US6251660B1 (en) 2001-06-26
CA2311501A1 (en) 1999-06-03
AU1597599A (en) 1999-06-15

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