WO1999024828A1 - Serpentine electrophoresis channel with self-correcting bends - Google Patents
Serpentine electrophoresis channel with self-correcting bends Download PDFInfo
- Publication number
- WO1999024828A1 WO1999024828A1 PCT/US1998/024202 US9824202W WO9924828A1 WO 1999024828 A1 WO1999024828 A1 WO 1999024828A1 US 9824202 W US9824202 W US 9824202W WO 9924828 A1 WO9924828 A1 WO 9924828A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- channel
- curved
- segments
- width
- channel portion
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N2030/285—Control of physical parameters of the fluid carrier electrically driven carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S366/00—Agitating
- Y10S366/03—Micromixers: variable geometry from the pathway influences mixing/agitation of non-laminar fluid flow
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69806499T DE69806499T2 (en) | 1997-11-12 | 1998-11-12 | SERPENTINE-SHAPED ELECTROFORETIC CHANNEL WITH SELF-CORRECTING CURVES |
CA002307623A CA2307623C (en) | 1997-11-12 | 1998-11-12 | Serpentine electrophoresis channel with self-correcting bends |
EP98958561A EP1031032B1 (en) | 1997-11-12 | 1998-11-12 | Serpentine electrophoresis channel with self-correcting bends |
JP2000519780A JP2001523001A (en) | 1997-11-12 | 1998-11-12 | Meandering electrophoresis channel with self-correcting bend |
AT98958561T ATE220456T1 (en) | 1997-11-12 | 1998-11-12 | SERPENTINE-SHAPED ELECTROFORETIC CHANNEL WITH SELF-CORRECTING CURVES |
AU14580/99A AU747940B2 (en) | 1997-11-12 | 1998-11-12 | Serpentine electrophoresis channel with self-correcting bends |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6510097P | 1997-11-12 | 1997-11-12 | |
US60/065,100 | 1997-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999024828A1 true WO1999024828A1 (en) | 1999-05-20 |
Family
ID=22060347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/024202 WO1999024828A1 (en) | 1997-11-12 | 1998-11-12 | Serpentine electrophoresis channel with self-correcting bends |
Country Status (8)
Country | Link |
---|---|
US (1) | US6176991B1 (en) |
EP (1) | EP1031032B1 (en) |
JP (1) | JP2001523001A (en) |
AT (1) | ATE220456T1 (en) |
AU (1) | AU747940B2 (en) |
CA (1) | CA2307623C (en) |
DE (1) | DE69806499T2 (en) |
WO (1) | WO1999024828A1 (en) |
Cited By (12)
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WO2000047985A1 (en) * | 1999-02-11 | 2000-08-17 | The Regents Of The University Of California | Apparatus and methods for high resolution separation of sample components on microfabricated channel devices |
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WO2002037092A1 (en) * | 2000-11-06 | 2002-05-10 | Dna Sciences, Inc. | Microchannel turn design |
US6596140B2 (en) | 2001-05-01 | 2003-07-22 | Applera Corporation | Multi-channel capillary electrophoresis device and method |
KR100442680B1 (en) * | 2001-05-10 | 2004-08-02 | 주식회사 디지탈바이오테크놀러지 | Apparatus for mixing fluids by micro channel |
KR100442681B1 (en) * | 2001-05-10 | 2004-08-02 | 주식회사 디지탈바이오테크놀러지 | Channel unit and apparatus for mixing fluids using the unit |
WO2004068101A2 (en) * | 2003-01-27 | 2004-08-12 | Sls Micro Technology Gmbh | Separating column, especially for a miniaturised gas chromatograph |
KR100473364B1 (en) * | 2001-10-17 | 2005-03-08 | 주식회사 디지탈바이오테크놀러지 | Microchannel apparatus for mixing liquids using microchannel and method therefor |
US8377277B2 (en) | 2008-10-22 | 2013-02-19 | General Electric Company | System and method for performing microfluidic manipulation |
EP2802415A4 (en) * | 2012-01-12 | 2015-05-20 | Fred Senftleber | Apparatus and methods for transferring materials between locations possessing different cross-sectional areas with minimal band spreading and dispersion due to unequal path-lengths |
US9539574B2 (en) | 2003-09-05 | 2017-01-10 | Caliper Life Sciences, Inc. | Analyte injection system |
CN106596692A (en) * | 2017-01-14 | 2017-04-26 | 常州大学 | Method for detecting interaction of antibody and polypeptide through tortuous capillary electrophoresis |
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US6830729B1 (en) | 1998-05-18 | 2004-12-14 | University Of Washington | Sample analysis instrument |
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US7538237B2 (en) * | 1999-07-02 | 2009-05-26 | Kreido Laboratories | Process for high shear gas-liquid reactions |
US6471392B1 (en) * | 2001-03-07 | 2002-10-29 | Holl Technologies Company | Methods and apparatus for materials processing |
US6742774B2 (en) * | 1999-07-02 | 2004-06-01 | Holl Technologies Company | Process for high shear gas-liquid reactions |
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US6830806B2 (en) * | 2001-04-12 | 2004-12-14 | Kreido Laboratories | Methods of manufacture of electric circuit substrates and components having multiple electric characteristics and substrates and components so manufactured |
US6919058B2 (en) * | 2001-08-28 | 2005-07-19 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
US20030066624A1 (en) * | 2001-09-13 | 2003-04-10 | Holl Richard A. | Methods and apparatus for transfer of heat energy between a body surface and heat transfer fluid |
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US7005301B2 (en) * | 2002-06-10 | 2006-02-28 | Sandia National Laboratories | Piecewise uniform conduction-like flow channels and method therefor |
US20050238506A1 (en) * | 2002-06-21 | 2005-10-27 | The Charles Stark Draper Laboratory, Inc. | Electromagnetically-actuated microfluidic flow regulators and related applications |
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US20040265171A1 (en) * | 2003-06-27 | 2004-12-30 | Pugia Michael J. | Method for uniform application of fluid into a reactive reagent area |
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Citations (2)
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WO1991016966A1 (en) * | 1990-05-10 | 1991-11-14 | Pharmacia Biosensor Ab | Microfluidic structure and process for its manufacture |
WO1996004547A1 (en) * | 1994-08-01 | 1996-02-15 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis |
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DE68927019T2 (en) * | 1988-04-29 | 1997-01-23 | Beckman Instruments Inc | Cassette with a capillary detector for electrophoresis |
JPH03223674A (en) * | 1989-11-30 | 1991-10-02 | Mochida Pharmaceut Co Ltd | Reaction vessel |
EP0637996B1 (en) * | 1992-05-01 | 1997-07-23 | The Trustees Of The University Of Pennsylvania | Microfabricated detection structures |
DE59410283D1 (en) | 1993-11-11 | 2003-06-18 | Aclara Biosciences Inc | Device and method for the electrophoretic separation of fluid substance mixtures |
US5658413A (en) * | 1994-10-19 | 1997-08-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
JP3839524B2 (en) * | 1995-06-07 | 2006-11-01 | アジレント・テクノロジーズ・インク | Miniaturized total analysis system |
US5993750A (en) * | 1997-04-11 | 1999-11-30 | Eastman Kodak Company | Integrated ceramic micro-chemical plant |
US5958694A (en) * | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
-
1998
- 1998-11-12 AU AU14580/99A patent/AU747940B2/en not_active Ceased
- 1998-11-12 CA CA002307623A patent/CA2307623C/en not_active Expired - Fee Related
- 1998-11-12 US US09/191,417 patent/US6176991B1/en not_active Expired - Fee Related
- 1998-11-12 AT AT98958561T patent/ATE220456T1/en not_active IP Right Cessation
- 1998-11-12 EP EP98958561A patent/EP1031032B1/en not_active Expired - Lifetime
- 1998-11-12 DE DE69806499T patent/DE69806499T2/en not_active Expired - Lifetime
- 1998-11-12 WO PCT/US1998/024202 patent/WO1999024828A1/en active IP Right Grant
- 1998-11-12 JP JP2000519780A patent/JP2001523001A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1991016966A1 (en) * | 1990-05-10 | 1991-11-14 | Pharmacia Biosensor Ab | Microfluidic structure and process for its manufacture |
WO1996004547A1 (en) * | 1994-08-01 | 1996-02-15 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6913679B1 (en) | 1999-02-11 | 2005-07-05 | The Regents Of The University Of California | Apparatus and methods for high resolution separation of sample components on microfabricated channel devices |
JP2002536662A (en) * | 1999-02-11 | 2002-10-29 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Apparatus and method for high resolution separation of sample components on microfabricated channel device |
WO2000047985A1 (en) * | 1999-02-11 | 2000-08-17 | The Regents Of The University Of California | Apparatus and methods for high resolution separation of sample components on microfabricated channel devices |
AU768109B2 (en) * | 1999-02-11 | 2003-12-04 | Regents Of The University Of California, The | Apparatus and methods for high resolution separation of sample components on microfabricated channel devices |
US6733730B1 (en) | 1999-04-26 | 2004-05-11 | Sandia Corporation | Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems |
WO2000065337A1 (en) * | 1999-04-26 | 2000-11-02 | Sandia Corporation | Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems |
US6270641B1 (en) | 1999-04-26 | 2001-08-07 | Sandia Corporation | Method and apparatus for reducing sample dispersion in turns and junctions of microchannel systems |
WO2002037092A1 (en) * | 2000-11-06 | 2002-05-10 | Dna Sciences, Inc. | Microchannel turn design |
US6596140B2 (en) | 2001-05-01 | 2003-07-22 | Applera Corporation | Multi-channel capillary electrophoresis device and method |
US7112266B2 (en) | 2001-05-01 | 2006-09-26 | Applera Corporation | Multi channel capillary electrophoresis device and method |
KR100442680B1 (en) * | 2001-05-10 | 2004-08-02 | 주식회사 디지탈바이오테크놀러지 | Apparatus for mixing fluids by micro channel |
KR100442681B1 (en) * | 2001-05-10 | 2004-08-02 | 주식회사 디지탈바이오테크놀러지 | Channel unit and apparatus for mixing fluids using the unit |
KR100473364B1 (en) * | 2001-10-17 | 2005-03-08 | 주식회사 디지탈바이오테크놀러지 | Microchannel apparatus for mixing liquids using microchannel and method therefor |
WO2004068101A2 (en) * | 2003-01-27 | 2004-08-12 | Sls Micro Technology Gmbh | Separating column, especially for a miniaturised gas chromatograph |
WO2004068101A3 (en) * | 2003-01-27 | 2004-12-16 | Sls Micro Technology Gmbh | Separating column, especially for a miniaturised gas chromatograph |
US9539574B2 (en) | 2003-09-05 | 2017-01-10 | Caliper Life Sciences, Inc. | Analyte injection system |
US8377277B2 (en) | 2008-10-22 | 2013-02-19 | General Electric Company | System and method for performing microfluidic manipulation |
EP2802415A4 (en) * | 2012-01-12 | 2015-05-20 | Fred Senftleber | Apparatus and methods for transferring materials between locations possessing different cross-sectional areas with minimal band spreading and dispersion due to unequal path-lengths |
CN106596692A (en) * | 2017-01-14 | 2017-04-26 | 常州大学 | Method for detecting interaction of antibody and polypeptide through tortuous capillary electrophoresis |
CN106596692B (en) * | 2017-01-14 | 2018-12-28 | 常州大学 | A kind of method of tortuous capillary electrophoresis detection antibody polypeptides interaction |
Also Published As
Publication number | Publication date |
---|---|
DE69806499T2 (en) | 2003-02-27 |
US6176991B1 (en) | 2001-01-23 |
ATE220456T1 (en) | 2002-07-15 |
DE69806499D1 (en) | 2002-08-14 |
AU1458099A (en) | 1999-05-31 |
CA2307623A1 (en) | 1999-05-20 |
CA2307623C (en) | 2004-03-16 |
JP2001523001A (en) | 2001-11-20 |
AU747940B2 (en) | 2002-05-30 |
EP1031032A1 (en) | 2000-08-30 |
EP1031032B1 (en) | 2002-07-10 |
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