WO1999013937A2 - Needleless valve - Google Patents
Needleless valve Download PDFInfo
- Publication number
- WO1999013937A2 WO1999013937A2 PCT/US1998/018068 US9818068W WO9913937A2 WO 1999013937 A2 WO1999013937 A2 WO 1999013937A2 US 9818068 W US9818068 W US 9818068W WO 9913937 A2 WO9913937 A2 WO 9913937A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plug
- rod
- valve
- fluid
- interior
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/26—Valves closing automatically on disconnecting the line and opening on reconnection thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/26—Valves closing automatically on disconnecting the line and opening on reconnection thereof
- A61M2039/262—Valves closing automatically on disconnecting the line and opening on reconnection thereof having a fluid space within the valve remaining the same upon connection and disconnection, i.e. neutral-drawback valve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/26—Valves closing automatically on disconnecting the line and opening on reconnection thereof
- A61M2039/263—Valves closing automatically on disconnecting the line and opening on reconnection thereof where the fluid space within the valve is decreasing upon disconnection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/26—Valves closing automatically on disconnecting the line and opening on reconnection thereof
- A61M2039/267—Valves closing automatically on disconnecting the line and opening on reconnection thereof having a sealing sleeve around a tubular or solid stem portion of the connector
Definitions
- the invention herein relates to valves and connectors, such as those use in medical liquid flow applications such as intravenous (IV) administration of medications. More particularly it relates to needleless valves for such applications.
- a principal example is the administration of medication or other liquids to a patient intravenously.
- the conventional practice is to insert a catheter into the patient's vein, usually through the patient's forearm, and leave the catheter in place with a portion extending out of the patient's arm and terminating in a valve (receiver) for periodic connection to the liquid source as required.
- a valve receiveriver
- receivers of valves were constructed with a resealable membrane, such as a rubber or other elastomeric plug, stretched across the inlet end of the device, closing off the IV fluid conduit.
- a resealable membrane such as a rubber or other elastomeric plug
- the physician or nurse would use a conventional hypodermic syringe with a sterile hypodermic needle which would penetrate the rubber plug and allow sterile injection of the fluid in the syringe directly into the liquid conduit or cannula.
- the elastic rubber plug Upon withdrawal of the hypodermic needle, the elastic rubber plug would resile and seal itself, maintaining the sterile condition of the interior of the system.
- Such practice has numerous disadvantages.
- hypodermic needles to break off in the plug during or before administration of the liquid, thus usually becoming lodged in the rubber plug and requiring the administrator to take time to remove the broken needle. Further, such breakage also commonly caused the loss of all or a portion of the medication or other liquid in the syringe and, of course, not properly administered to the patient.
- the fluid dispenser (usually a syringe) is fitted with a blunt nozzle rather than a hypodermic needle.
- the blunt nozzle is designed to be received into a corresponding receiver attached to the IV line or other fluid conduit.
- a hollow tubular cannula Within the receiver is normally a hollow tubular cannula, which is a fixed member forming the extended end of the fluid conduit extending into the patient's veins. Sterility of the receivers is important so that transfer of the liquid from the syringe to the cannula and IV fluid conduit can be conducted under sterile conditions.
- Needleless connectors have, for the most part, been designed with a hollow flexible plug which fits over the cannula and which has a self-sealing slit or similar closeable opening in its exterior end.
- the interior end of the plug is anchored adjacent to the downstream end of the cannula (i.e. the end leading into the IV system and the patient's arm). Since the cannula is made as a rigid elongated tube, as the nozzle of the fluid dispensing device is pushed into the receiver, it contacts that exterior end of the rubber plug and forces that end inwardly against the distal end of the cannula.
- the distal end of the cannula contacts the slit at the end of the plug and forces the slit open, so that the plug then becomes a sleeve as it is pushed inwardly along the outer surface of the cannula.
- the distal end of the cannula now being exposed, contacts the interior fluid transfer tube of the dispensing device as the nozzle of the dispensing device moves further into the receiver.
- the fluid can be transferred from the syringe directly into the cannula through which it flows onto the IV system in the patient's body.
- the device of this invention is configured so that a core rod forces the plug to expand during activation in a manner not possible with the prior art devices, which causes the interior volume of the plug to increase substantially from its rest (deactivated) volume and opens a flow path through the valve for the administered fluid.
- the plug Upon deactivation, the plug resiles and its interior volume returns to rest volume, closing the fluid flow path and displacing residual fluid within the valve, so that the residual fluid is expelled from the valve through its outlet into the downstream conduit or unit, purging the valve and promoting use of all of the administered fluid.
- volume decrease prevents occurrence of any partial vacuum in the valve, and in fact usually creates a transient overpressure, which also assists in purging the valve of residual fluid.
- the structure thus maintains either a positive or neutral (i.e., non-negative) pressure at all times, preventing any suctioning of blood from a patient into an attached catheter, thus avoiding clogging of the catheter by formation of clots in blood drawn into it.
- the invention involves a needleless valve comprising a tubular housing having a fluid inlet end and a fluid outlet end, a solid rod within the housing, and a hollow flexible plug within the housing and moveable along the rod, the hollow plug in response to insertion of a fluid supply nozzle into the inlet end moving in one direction along and cooperating with the rod to increase the volume of the interior of the plug and open a fluid flow path between the inlet and outlet ends, and in response to withdrawal of the fluid supply nozzle from the inlet end moving in an opposite direction along and cooperating with the rod to decrease the volume of the plug interior, close the fluid flow path between the inlet and outlet ends and cause residual fluid in the flow path to be expelled from the valve through the outlet end.
- the invention involves a needleless valve having a distal end and a proximal end, and comprising a base disposed at the proximal end and comprising a connector for fluid communication attachment to a fluid flow tube, a solid elongated fluid channeling rod extending from a proximal end joined to the base to a distal end, and a fluid flow conduit formed in the base and extending through the connector into the proximal end the rod and disposed for the fluid communication with the tube; a flexible plug having a wall forming a hollow interior bounded by an inward facing surface; the plug fitting over the rod, being sealingly attached to the base and being moveable along the rod between a first activated position and a second deactivated position; in the first activated position the rod maintaining the plug in a form with the interior having a first larger volume, with the plug withdrawn from the distal end of the rod, and creating a fluid flow path through the interior and along the rod; and in the second deactivated position the plug being
- the invention also comprises a rod for a needleless valve comprising a solid elongated core having a plurality of coaxial ribs extending outwardly therefrom.
- Ribs made be made with a uniform width so that their extended edges are straight, with continuously varying widths so that their edged form straight or curved smooth tapers, or have discontinuously varying widths, so that their edges form one or more steps over the length of each rib.
- the ribs terminate at the distal end of the rod in a hollow annular member encircling the rod.
- Figure 1 is a perspective view of the device of this invention, with the individual components thereof shown in separated relationship;
- Figure 2 is an enlarged sectional view taken on Line 2-2 of Figure 1 ;
- Figure 3 is an enlarged sectional view taken on Line 3-3 of Figure 1 ;
- Figure 4 is an enlarged sectional view taken on Line 4-4 of Figure 1 ;
- Figure 5 is a sectional view taken on Line 5-5 of Figure 4;
- Figure 6 is a sectional view taken on Line 6-6 of Figure 3;
- Figure 7 is a sectional view with the components of Figures 2, 3 and 4 shown in assembled relationship;
- Figure 8 is a view similar to Figure 7, with the valve opened by attachment of a typical Luer-Lok connector
- Figure 9 is a sectional view taken on Line 9-9 of Figure 7;
- Figure 10 is a sectional view taken on Line 10-10 of Figure 8;
- Figure 11 is a sectional view taken on Line 11-11 of Figure 8;
- Figure 12 is a perspective view of an alternative embodiment of flexible valve component
- Figure 13 is a sectional view similar to Figure 7 showing the alternative valve component in closed position;
- Figure 14 is a sectional view taken on Line 14-14 of Figure 13;
- Figure 15 is a view similar to Figure 13 showing the valve component opened by insertion of a Luer connector
- Figure 16 is a sectional view taken on Line 16-16 of Figure 15.
- Figure 17 is a perspective view illustrating another embodiment of a central rod of the present invention.
- upstream and downstream will be with respect to the normal direction of fluid flow during administration of medication or other liquid through the valve of the present invention to a patient or other receiver. This is indicated in Figure 8 by the flow arrows 50 (upstream) and 52 (downstream).
- distal and proximal will be used with respect to the patient or other receiver, such that the upstream end of the device is also sometimes referred to as the distal end, while the downstream end is also sometimes referred to as the proximal end.
- FIG. 1 One embodiment of the overall device 2 is shown in Figure 1 , separated into three components: a base 4, plug 6 and housing 8.
- the principal features of each of the parts may also be seen in Figure 1.
- the base 4 consists of a connector 10 which connects the device with the fluid flow tubing or conduit 48, usually through a separate connector 94, as illustrated in Figure 8; a radial flange 12, which serves as a seat for attachment of the plug 6; and an elongated rod 14 which, as will be described below, cooperates with the plug 6 to provide the unique and desirable operating features of the present invention.
- the plug 6 has a seating gasket 16, a compressible mid-section 18 which usually folds into a configuration similar to a bellows, and, at the distal end 20, has a closeable slit or similar opening 22.
- the housing 8 has a wide diameter expansion portion 24, a coupling ring 26 which, during assembly, is bonded to the flange 12 to retain the device as a single unit and a receiving portion 28, the distal end 30 of which can be configured as shown with threads 32 to join with corresponding threads of a liquid dispenser to couple the two together.
- Figures 2, 3 and 4 show respectively the housing 8, plug 6 and base 4 in cross-section to facilitate understanding of their operations and functions.
- the base 4 is formed of the aforementioned coupler 10, flange 12 and rod 14.
- the coupler 10 is has an annular form with its inner wall 34 formed into threads or ribs 36 to allow it to be attached to a corresponding threaded end of coupler such as 94 as will be described below.
- a hollow tapered cylinder 40 Centrally disposed within the annular shaped coupler 10 is a hollow tapered cylinder 40 which has fluid flow channel 38 extending through it.
- Cylinder 40 is an extension of the flange 12 and rod 14 so that it will be desirable for the entire base unit to be molded as a single piece of rigid material, commonly plastic but also possibly of metal.
- the fluid flow conduit 38 continues as conduit 42 through the center of flange 12 and terminates as a conduit 46 within the proximal end 44 of rod 14. Fluid flowing downstream along rod 14 from the liquid dispenser 116 during activation of the device 2 thus enters the fluid conduit 46 through the openings 146, flows through aperture conduit 42 through flange 12, and on through the channel 38 into coupler 94 and eventually into tubing 48 as shown in Figure 8.
- tubing 48 may be substituted for by other devices to which the valve is to be attached, such as direct coupling to a storage, test or reaction vessel or to a measuring instrument.
- FIG. 3 A preferred embodiment of a plug 6 is shown in Figure 3.
- the plug 6 is made out of a flexible material, usually a rubber or a polymeric elastomer.
- the plug has a flange 16 which has a flat base 54 to allow it to seat against the corresponding flat distal face 56 of the flange 12 on the base 10, as shown in Figures 7 and 8.
- the most proximal section 18 may be scored with groves 58 on the interior and exterior to permit bellowing or other folding of the section as the plug is compressed and moved posteriorly during activation, as best illustrated in Figure 8.
- the flange 12 may be eliminated and other means, such as a gripping or adhesive-coated surface (not shown) provided to which the proximal end of plug 6 is secured.
- the plug 6 also has an intermediate section 60 which can be expanded, but which does not normally flex, fold or compress as extensively as section 18. Both the expansion and compression of section 18 and the expansion of section 60 contribute to the self- purging action of the device 2 as will be described below.
- the distal portion 62 of the plug 6 extends outwardly just past the tip 64 of rod 14 and normally has a somewhat thicker wall than do sections 18 and 60 to accommodate the opening and subsequent closing of slit 22 in the distal end 20 and to resist buckling of the end 20 when the unit is deactivated.
- the slit 22 will be terminated on the interior side of the plug 10 by a "duck bill" flange 66 which assists in causing the slit 22 to resist leakage when internal pressure is present during deactivation.
- the housing 8 is a simple rigid shell of plastic or metal, which is intended to fit over the plug 6 and attach to flange 12, thus locking gasket 16 in position, as best shown in Figures 7 and 8.
- the inner portion of coupling ring 26 of housing 8 is configured with a generally semi-circular channel 70 incorporated within it, both of which are configured to accommodate the corresponding base 72 and lip 74 of gasket 16.
- the connecting ring 26 When the connecting ring 26 is seated against the flange 12 of base 4, preferably aligned by groove 76 into which rib 78 fits, and the two are sealed together as by a conventional adhesive or by heat, ultrasonic or RF welding, the flange 16 of the plug 6 is firmly held against the flange 12 so that the plug cannot be displaced, and also to provide a firm base for subsequent return or resiling of the plug 6 upon deactivation.
- section 24 of the housing 8 is configured to have a substantially greater diameter than the deactivated rest diameter of section 18 of the plug 6, as indicated in Figure 7, creating an annular space 80 into which the portion 18 can expand as it is compressed to form the generally bellowed configuration shown in Figure 8.
- the rod 14 can have a number of different configurations, all of which are intended to cause the plug 6 to expand outwardly during activation, thus creating the expansion of the elastic plug and increase of its interior volume, so that the plug 6 upon deactivation will return or resile inwardly, decreasing its interior volume and thereby purging fluid from the fluid flow space 82 along the rod 14.
- the rod 14 can be generally described as having a solid core 84 which terminates in a blunt or rounded tip 64 and which has extending radially outwardly therefrom a plurality of ribs 86 (and perhaps also 86').
- the ribs 86 may have various configurations which will cause the plug to expand and which will prevent prolapsing of the plug during activation.
- an elongated rib may be uniform width over most of its length (with preferably a transition curve or slope at its distal end, to facilitate movement of the end 20 of plug 6 along the rod and rib), or it may have a continuously varying width, so that it has a straight or curved tapered profile, or it may have widths that vary discontinuously along its length, so that it has a stepped profile. It is preferred that for ribs in which the widths vary, either continuously or discontinuously, the widths increase from distal to proximal ends, so that no recess or shoulder is formed upon which a portion of the interior of the plug wall could become snagged, preventing or impeding return or resiling of the plug upon deactivation.
- the proximal ends of the ribs 86 may terminate in a hollow annular member 68 which serves to maintain the maximum expansion of the plug 6 during activation.
- this annular member 68 will be circular, but polygonal shapes are also usable, although polygons of less than six, and probably less than eight, sides should probably be avoided, since they may be unduly angular and tend to impede resiling of the plug upon deactivation.
- ribs 86 normally there will need to be at least three ribs 86, preferably equally spaced at 120° from each other, in order to ensure that the elastic plug 6 is stretched to form a space 82 of appropriate volume.
- ribs 86 there will be four ribs 86 in a cruciform shape as indicated in Figures 9 and 10; although a larger number of ribs, such as eight as shown in Figure 5, may also be used. It is also possible, and usually preferred, to have different numbers and lengths of ribs on the same rod 14, as illustrated in Figures 1 and 5, where the added ribs 86' are interspersed between the principal cruciform ribs 86 but are foreshortened in axial length and extend distally only as far as the length of the widest section of each rib 86.
- the added ribs help support the extended plug wall and prevent prolapse of unsupported portions of the wall and expansion increases and the wall thickness is thinned by stretching.
- eight to ten ribs are probably the maximum practical number, with four, six or eight ribs being preferred, and other numbers (both between three and ten and greater than ten) being possible.
- Use of an even number of ribs as shown in the illustrations is preferred since it is easier to mold symmetrical ribs equally spaced than to mold an asymmetric configuration as would be present with and odd number of ribs.
- the number of width steps may be two or three as shown or may be more, although again the small size of the device acts as a practical limitation on the number of width steps of the ribs 86 which are either feasible or desirable.
- the plug 6' is configured with an expanded downstream section 18' which substantially replaces sections 18 and 60 in the configuration described above.
- the section 18' may be somewhat bulbous or it may approximately conform to the shape of the rod 14 (shown in these Figures with an alternative form of the ribs designated as 86"), with the plug 6' having conforming hollow ribs 88.
- the operation of this alternative plug 6' is illustrated in Figures 13 and 15. In the deactivated state, shown in Figure 13, the plug is essentially in the shape shown in Figures 12 and 14.
- the bulbous section 18' with ribs 88 expands outwardly (as shown in Figures 15 and 16) into space 80 and leaves an enlarged open space 92 between the rod 14 and the interior wall surface of the plug 6'.
- the plug 6' resiles or is caused to return to the configuration shown in Figure 13.
- Coupler 94 is formed with a hollow cylindrical connector 96 which extends into the recess 98 inside coupler 10 and which is secured therein by threads 100 cooperating with ribs or threads 36 on the interior of the coupler 10.
- cylinder 40 has a tapered outer surface 102 which causes a wedging action with the interior of connector 96 as indicated at 104, such that as the connector 94 is turned and threaded into the recess 98 the cylinder 40 and connector 96 are tightly wedged together sealing against any loss of fluid.
- both cylinder 40 and connector 96 can be straight with parallel surfaces, and they can be secured together by an adhesive, such as a solvent adhesive, as shown at 97 in Figure 15.
- the design of the tapered cylinder 40 and connector 96 are such that the end 106 of cylinder 40 and the opposing surface 108 on the interior of connector 96 are closely adjacent or abutting such that the space 110 between them is minimized.
- Connection of the device of this invention to tubing 48 or any other device may be configured to be releasable or permanent, as desired.
- the connector has at its opposite end a nipple 112 to which the conventional tubing 48 is attached.
- the tubing is normally stretched slightly as indicated at 114 so that the tubing 48 is retained on the nipple 112 by the combination of the elastic resiliency of the tubing and the interference fit between the inner surface of the tubing 48 and the outer surface of the nipple 112.
- a conventional external clamp (not shown) may be placed around the circumference of the tubing 48 where it overlaps the nipple 112 and tightened to ensure good connection between the tubing and the nipple.
- various adhesives or solvents may be used to secure the tubing and nipple together. The solvents or adhesives must be selected such that they do not intrude into the fluid flow path of the device or migrate to cause unwanted adhesion elsewhere in the device.
- Activation and deactivation of the valve 2 will be best understood by comparison of Figure 7 and 8. The device in its deactivated configuration is shown in Figure 7, with the plug 6 in its "rest" or fully resiled orientation.
- Activation comprises joining of the needleless valve 2 to a liquid supply source such as a syringe or other reservoir device, partially shown at 116 in Figure 8.
- a liquid supply source such as a syringe or other reservoir device, partially shown at 116 in Figure 8.
- Connection is usually through a coupler 118 which is similar in configuration to the coupler 10 of the valve.
- Coupler 118 consists of an outer cylindrical wall 120 which has on its inner side ribs or threads 122. Aligned with the center axis of coupler 118 is nozzle 90 which extends outwardly from the end 124 of coupler 118 and which is tapered to fit into the receiving portion 126 of section 28 of the housing 8.
- the interior of nozzle 90 is an open fluid flow channel 128 which is in fluid communication with the interior 130 of liquid reservoir 116.
- the reservoir 116 is here illustrated as a conventional syringe device, with a movable piston 132 housed within a cylinder 130.
- the piston 132 is manipulated by the physician or nurse as indicated by the arrow 50 to force the liquid forward.
- Such use and operation of the fluid dispensing device 116 are conventional and need not be described further. Similarly, such devices may take many different forms, all of which are equally applicable to the present invention.
- the tapered nozzle 90 interacts with the inner surface 136 of the receiver section 126 of the housing to create a wedging action similar to that described above between the connectors 94 and 10, thus forming a mechanically tight connection.
- the front end 138 of coupler 118 comes into contact with distal end surface 20 of plug 6 and forces the plug 6 to compress in the downstream or proximal direction, thus causing the slit 22 to contact the tip 64 of rod 14 and be forced open as it passes over and around the tip 64, as best illustrated in Figure 11.
- the compressive movement of the rest of the plug 6 caused by the forward motion of the nozzle 90 causes the other portions of the plug 6 to move along corresponding sections of the rod 14 and ribs 86 (and 86', if present), thus forcing the wall of the plug 6 to be stretched and expanded outwardly, substantially increasing the interior volume of the plug 6 and creating the space 82 through which the fluid can flow along the surfaces of rod 14 and ribs 86.
- the liquid can flow freely from the liquid reservoir or supply device 116 through the nozzle 90 and the now-opened slit 22, along and adjacent to the outer surfaces of the rod 14 and ribs-86 (through the elongated V-shaped spaces 82 formed by adjacent ribs 86, the rod 14, and the inner surface of the plug 6, and on through the openings 146 and into the conduits 46, 42 and 38 , on through the channel 140 in the nipple 112 and into the interior 142 of tubing 48, and subsequently to the patient or other receiver.
- this activated configuration is stable and can be maintained for as long as the physician, nurse or other user wishes to continue dispensing the liquid. It can also, of course, be maintained for an extended period of time without human supervision or control, where the reservoir or liquid supply device 116 is mechanically or electrically operated and provides a continuous or intermittent flow of fluid through the valve 2 to the patient or receiver.
- the flexible plug merely slid along the outside of the tubular cannula. Since the cannula had a uniform diameter, the plug remained strongly compressed over substantially all of its length, being stretched or expanded only at the distal tip, and then only by the minimal amount necessary to open the end slit and allow the end of the hollow cannula to protrude into the nozzle of the fluid dispensing device As the nozzle of the dispensing device was subsequently withdrawn and the plug allowed to resile back in the distal direction along the outer surface of the cannula and closed over the open end of the cannula, a partial vacuum was created in the cannula This in turn commonly resulted in liquid being withdrawn from the patient or receiver and pulled by suction back into the catheter to which the cannula of the prior art device was connected Where the receiver was a human patient, the fluid drawn back into the cannula would usually consist in whole or in part of venous blood The blood thus retained in the cannula would thereafter often congeal
- Figure 8 illustrates the improvement of the present invention in which such creation of partial vacuum is entirely avoided and the self-purging property of the device is illustrated
- the plug by being stretched to increase the interior volume during activation, resiles and decreases that volume during deactivation, so that the contraction of the plug wall into the space 82 (essentially eliminating space 82) displaces substantially all residual fluid remaining within the valve upon deactivation, and forces it to be expelled through the exit conduits
- the resiling of the plug wall often creates a transient overpressure which also assists in expulsion of the residual fluid Since the plug ultimately resiles back to its rest configuration the overpressure decreases to neutral pressure
- the center member of this device is solid rod 14 rather than an open cannula, the end 20 of resiling plug 6 passes over distal end 64 of rod 14 and slit 22 closes before the decrease in interior volume, and therefore purging action of the resiling plug, is completed Consequently, unlike in the prior art valves, no negative pressure is formed by the movement
- the return and closing action of the plug 6 will be adequately accomplished entirely by the resiliency of the elastic material forming the plug, such that no outside biasing or urging of the plug is necessary.
- an inert gas 144 such as nitrogen or argon, preferably under pressure.
- the compressed gas 144 acts on the outside surface of the plug 6 and as the volume of chamber 80 begins to increase (and space 82 decrease), the pressure of the expanding gas supplements the normal resiliency of the plug 6 material, causing the device to purge itself more quickly and completely.
- the device of the present invention with its variable volume flow path formed by the interaction of the center rod and ribs and the expanding and contracting interior dimension of the plug, employs a unique self-purging and pressure generating action that causes essentially all of the fluid to be forced into the receiver or patient This not only keeps the valve from being clogged by return flow of blood or other receiver fluid, but also ensures that substantially all of the dosage of the fluid intended for the patient or receiver is, in fact, administered, with no signficant amounts retained or lost within the valve structure itself
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98944635A EP1044033B1 (en) | 1997-09-15 | 1998-08-31 | Needleless valve |
JP2000511546A JP4184597B2 (en) | 1997-09-15 | 1998-08-31 | Needleless valve |
IL13505798A IL135057A0 (en) | 1997-09-15 | 1998-08-31 | Needleless valve |
DE69841178T DE69841178D1 (en) | 1997-09-15 | 1998-08-31 | NEEDLE VALVE |
DK98944635T DK1044033T3 (en) | 1997-09-15 | 1998-08-31 | Needless valve |
AU92132/98A AU747578B2 (en) | 1997-09-15 | 1998-08-31 | Needleless valve |
BR9812460-9A BR9812460A (en) | 1997-09-15 | 1998-08-31 | "needle-free valve" |
KR1020007002690A KR100540861B1 (en) | 1997-09-15 | 1998-08-31 | Needless valve |
AT98944635T ATE443536T1 (en) | 1997-09-15 | 1998-08-31 | NEEDLELESS VALVE |
CA002303084A CA2303084C (en) | 1997-09-15 | 1998-08-31 | Needleless valve |
NZ503168A NZ503168A (en) | 1997-09-15 | 1998-08-31 | Needleless valve providing a positive self-purging effect upon deactivation |
HK01102733.7A HK1032209A1 (en) | 1997-09-15 | 2001-04-18 | Needleless valve |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/929,919 US6029946A (en) | 1997-09-15 | 1997-09-15 | Needleless valve |
US08/929,919 | 1997-09-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999013937A2 true WO1999013937A2 (en) | 1999-03-25 |
WO1999013937A3 WO1999013937A3 (en) | 1999-06-03 |
Family
ID=25458690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/018068 WO1999013937A2 (en) | 1997-09-15 | 1998-08-31 | Needleless valve |
Country Status (18)
Country | Link |
---|---|
US (5) | US6029946A (en) |
EP (1) | EP1044033B1 (en) |
JP (1) | JP4184597B2 (en) |
KR (1) | KR100540861B1 (en) |
CN (1) | CN1270533A (en) |
AT (1) | ATE443536T1 (en) |
AU (1) | AU747578B2 (en) |
BR (1) | BR9812460A (en) |
CA (1) | CA2303084C (en) |
CY (1) | CY1109674T1 (en) |
DE (1) | DE69841178D1 (en) |
DK (1) | DK1044033T3 (en) |
ES (1) | ES2331939T3 (en) |
HK (1) | HK1032209A1 (en) |
IL (1) | IL135057A0 (en) |
NZ (2) | NZ503168A (en) |
PT (1) | PT1044033E (en) |
WO (1) | WO1999013937A2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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WO2013188103A1 (en) * | 2012-06-15 | 2013-12-19 | B. Braun Medical, Inc. | Self-priming, anti-free flow valve for infusion pumps |
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1998
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- 1998-08-31 AU AU92132/98A patent/AU747578B2/en not_active Expired
- 1998-08-31 JP JP2000511546A patent/JP4184597B2/en not_active Expired - Lifetime
- 1998-08-31 ES ES98944635T patent/ES2331939T3/en not_active Expired - Lifetime
- 1998-08-31 NZ NZ503168A patent/NZ503168A/en not_active IP Right Cessation
- 1998-08-31 DK DK98944635T patent/DK1044033T3/en active
- 1998-08-31 WO PCT/US1998/018068 patent/WO1999013937A2/en active IP Right Grant
- 1998-08-31 KR KR1020007002690A patent/KR100540861B1/en not_active IP Right Cessation
- 1998-08-31 PT PT98944635T patent/PT1044033E/en unknown
- 1998-08-31 CN CN98809128A patent/CN1270533A/en active Pending
- 1998-08-31 DE DE69841178T patent/DE69841178D1/en not_active Expired - Lifetime
- 1998-08-31 AT AT98944635T patent/ATE443536T1/en active
- 1998-08-31 IL IL13505798A patent/IL135057A0/en not_active IP Right Cessation
- 1998-08-31 EP EP98944635A patent/EP1044033B1/en not_active Expired - Lifetime
- 1998-08-31 CA CA002303084A patent/CA2303084C/en not_active Expired - Lifetime
-
2000
- 2000-01-10 US US09/480,373 patent/US6290206B1/en not_active Expired - Lifetime
-
2001
- 2001-04-18 HK HK01102733.7A patent/HK1032209A1/en not_active IP Right Cessation
- 2001-07-23 US US09/911,133 patent/US6541802B2/en not_active Expired - Lifetime
-
2003
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-
2005
- 2005-01-10 US US11/032,826 patent/US20050121638A1/en not_active Abandoned
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2009
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2292296A1 (en) * | 2009-09-08 | 2011-03-09 | Asset Medikal Tasarim Sanayi Ve Ticaret Anonim Sirketi | Swabbable needleless valve |
CN104114225A (en) * | 2012-02-15 | 2014-10-22 | 株式会社Jms | Cover for male member |
WO2013188103A1 (en) * | 2012-06-15 | 2013-12-19 | B. Braun Medical, Inc. | Self-priming, anti-free flow valve for infusion pumps |
US8758307B2 (en) | 2012-06-15 | 2014-06-24 | B. Braun Medical Inc. | Self-priming, anti-free flow valve for infusion pumps |
US9320859B2 (en) | 2012-06-15 | 2016-04-26 | B. Braun Medical Inc. | Self-priming, anti-free flow valve for infusion pumps |
US9320858B2 (en) | 2012-06-15 | 2016-04-26 | B. Braun Medical Inc. | Self-priming, anti-free flow valve for infusion pumps |
US9320860B2 (en) | 2012-06-15 | 2016-04-26 | B. Braun Medical Inc. | Self-priming, anti-free flow valve for infusion pumps |
EP3170529A1 (en) * | 2013-03-18 | 2017-05-24 | Becton, Dickinson and Company | Multiple-use intravenous catheter assembly septum and septum actuator |
WO2023172391A1 (en) * | 2022-03-08 | 2023-09-14 | B. Braun Medical Inc. | Needle-free connector |
Also Published As
Publication number | Publication date |
---|---|
KR100540861B1 (en) | 2006-01-12 |
NZ503168A (en) | 2002-12-20 |
US20050121638A1 (en) | 2005-06-09 |
JP2001516626A (en) | 2001-10-02 |
ES2331939T3 (en) | 2010-01-20 |
US6541802B2 (en) | 2003-04-01 |
US6840501B2 (en) | 2005-01-11 |
EP1044033B1 (en) | 2009-09-23 |
IL135057A0 (en) | 2001-05-20 |
JP4184597B2 (en) | 2008-11-19 |
BR9812460A (en) | 2000-09-19 |
CA2303084A1 (en) | 1999-03-25 |
US20010045539A1 (en) | 2001-11-29 |
CA2303084C (en) | 2008-07-15 |
KR20010015585A (en) | 2001-02-26 |
AU747578B2 (en) | 2002-05-16 |
US6290206B1 (en) | 2001-09-18 |
US20030183795A1 (en) | 2003-10-02 |
ATE443536T1 (en) | 2009-10-15 |
PT1044033E (en) | 2009-11-19 |
HK1032209A1 (en) | 2001-07-13 |
NZ529166A (en) | 2005-07-29 |
EP1044033A2 (en) | 2000-10-18 |
US6029946A (en) | 2000-02-29 |
CN1270533A (en) | 2000-10-18 |
DE69841178D1 (en) | 2009-11-05 |
CY1109674T1 (en) | 2014-08-13 |
AU9213298A (en) | 1999-04-05 |
WO1999013937A3 (en) | 1999-06-03 |
DK1044033T3 (en) | 2010-01-11 |
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