WO1999009416A3 - Method of drug selection - Google Patents

Method of drug selection Download PDF

Info

Publication number
WO1999009416A3
WO1999009416A3 PCT/GB1998/002504 GB9802504W WO9909416A3 WO 1999009416 A3 WO1999009416 A3 WO 1999009416A3 GB 9802504 W GB9802504 W GB 9802504W WO 9909416 A3 WO9909416 A3 WO 9909416A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligopeptide
construction
amino acids
components
oligopeptides
Prior art date
Application number
PCT/GB1998/002504
Other languages
French (fr)
Other versions
WO1999009416A2 (en
Inventor
Henry R Wolfe
Original Assignee
Nycomed Imaging As
Cockbain Julian
Henry R Wolfe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging As, Cockbain Julian, Henry R Wolfe filed Critical Nycomed Imaging As
Priority to EP98939765A priority Critical patent/EP1005655A2/en
Priority to AU88168/98A priority patent/AU8816898A/en
Priority to CA002300903A priority patent/CA2300903A1/en
Priority to JP2000510029A priority patent/JP2001516029A/en
Publication of WO1999009416A2 publication Critical patent/WO1999009416A2/en
Publication of WO1999009416A3 publication Critical patent/WO1999009416A3/en
Priority to NO20000811A priority patent/NO20000811L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • G01N2333/245—Escherichia (G)

Abstract

Method of selecting a candidate drug compound comprising generating from a starting oligopeptide a plurality of oligopeptides having single site amino acid modifications which lead to a change in the ratio of binding affinity of said oligopeptide to a receptor to biological reponse of said binding, identification of components in the oligopeptide responsible for secondary structure and replacement of said components with non-natural amino acids, construction of combinatorial libraries based on the use of sets of amino acids for the modification sites identified and the construction of further libraries based upon oligopeptides produced in the first library having the desired binding activity. Drug candidates are selected from the identified members of the libraries.
PCT/GB1998/002504 1997-08-20 1998-08-20 Method of drug selection WO1999009416A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP98939765A EP1005655A2 (en) 1997-08-20 1998-08-20 Method of drug selection
AU88168/98A AU8816898A (en) 1997-08-20 1998-08-20 Method of drug selection
CA002300903A CA2300903A1 (en) 1997-08-20 1998-08-20 Method of drug selection
JP2000510029A JP2001516029A (en) 1997-08-20 1998-08-20 How to choose a drug
NO20000811A NO20000811L (en) 1997-08-20 2000-02-18 Procedure for drug selection

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5685997P 1997-08-20 1997-08-20
GBGB9717652.3A GB9717652D0 (en) 1997-08-20 1997-08-20 Method
GB9717652.3 1997-08-20

Publications (2)

Publication Number Publication Date
WO1999009416A2 WO1999009416A2 (en) 1999-02-25
WO1999009416A3 true WO1999009416A3 (en) 1999-10-21

Family

ID=10817781

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/GB1998/002504 WO1999009416A2 (en) 1997-08-20 1998-08-20 Method of drug selection
PCT/GB1998/002510 WO1999009417A2 (en) 1997-08-20 1998-08-20 Method of drug selection

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/002510 WO1999009417A2 (en) 1997-08-20 1998-08-20 Method of drug selection

Country Status (7)

Country Link
EP (1) EP1005655A2 (en)
JP (1) JP2001516029A (en)
AU (2) AU8816898A (en)
CA (1) CA2300903A1 (en)
GB (1) GB9717652D0 (en)
NO (1) NO20000811L (en)
WO (2) WO1999009416A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9809776D0 (en) * 1998-05-07 1998-07-08 Nycomed Imaging As Method
GB9809782D0 (en) * 1998-05-07 1998-07-08 Nycomed Imaging As Method
GB9809780D0 (en) * 1998-05-07 1998-07-08 Nycomed Imaging As Method
US8779090B2 (en) 2007-02-26 2014-07-15 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of heart failure and other disorders
CA2707840A1 (en) 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
US10166279B2 (en) 2013-02-20 2019-01-01 Bergen Teknologioverføring Vaccine
WO2020039387A1 (en) * 2018-08-24 2020-02-27 Vestlandets Innovasjonsselskap As (Vis) Heat-stable enterotoxins mutants as antidiarrheal vaccine antigens

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0267802A2 (en) * 1986-11-14 1988-05-18 Genetic Systems Corporation Synthetic antigen for the detection of aids-related disease
US4965343A (en) * 1988-01-28 1990-10-23 Hoffmann-La Roche Inc. Method of peptide synthesis
EP0418617A1 (en) * 1989-08-31 1991-03-27 Mitsubishi Petrochemical Co., Ltd. Method for preparing human osteocalcin
EP0529075A1 (en) * 1990-04-09 1993-03-03 Asahi Glass Company Ltd. Hybrid calcitonin
US5432018A (en) * 1990-06-20 1995-07-11 Affymax Technologies N.V. Peptide library and screening systems
WO1996040186A1 (en) * 1995-06-07 1996-12-19 Connective Therapeutics, Inc. Relaxin-like factor and methods and uses thereof
WO1997000267A1 (en) * 1995-06-16 1997-01-03 Pence Conformationally-restricted combinatorial library composition and method
WO1997022617A1 (en) * 1995-12-18 1997-06-26 Praecis Pharmaceuticals Incorporated Methods for identifying compounds that bind to a target

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0267802A2 (en) * 1986-11-14 1988-05-18 Genetic Systems Corporation Synthetic antigen for the detection of aids-related disease
US4965343A (en) * 1988-01-28 1990-10-23 Hoffmann-La Roche Inc. Method of peptide synthesis
EP0418617A1 (en) * 1989-08-31 1991-03-27 Mitsubishi Petrochemical Co., Ltd. Method for preparing human osteocalcin
EP0529075A1 (en) * 1990-04-09 1993-03-03 Asahi Glass Company Ltd. Hybrid calcitonin
US5432018A (en) * 1990-06-20 1995-07-11 Affymax Technologies N.V. Peptide library and screening systems
WO1996040186A1 (en) * 1995-06-07 1996-12-19 Connective Therapeutics, Inc. Relaxin-like factor and methods and uses thereof
WO1997000267A1 (en) * 1995-06-16 1997-01-03 Pence Conformationally-restricted combinatorial library composition and method
WO1997022617A1 (en) * 1995-12-18 1997-06-26 Praecis Pharmaceuticals Incorporated Methods for identifying compounds that bind to a target

Also Published As

Publication number Publication date
EP1005655A2 (en) 2000-06-07
WO1999009417A3 (en) 1999-08-12
NO20000811D0 (en) 2000-02-18
NO20000811L (en) 2000-04-12
GB9717652D0 (en) 1997-10-22
WO1999009417A2 (en) 1999-02-25
WO1999009416A2 (en) 1999-02-25
JP2001516029A (en) 2001-09-25
AU8816898A (en) 1999-03-08
WO1999009417A9 (en) 1999-05-27
AU8817398A (en) 1999-03-08
CA2300903A1 (en) 1999-02-25

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