WO1998050773A2 - Microcantilever biosensor - Google Patents
Microcantilever biosensor Download PDFInfo
- Publication number
- WO1998050773A2 WO1998050773A2 PCT/US1998/009338 US9809338W WO9850773A2 WO 1998050773 A2 WO1998050773 A2 WO 1998050773A2 US 9809338 W US9809338 W US 9809338W WO 9850773 A2 WO9850773 A2 WO 9850773A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microbeam
- group
- chemical
- response
- cantilever
- Prior art date
Links
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- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/02—Analysing fluids
- G01N29/036—Analysing fluids by measuring frequency or resonance of acoustic waves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01G—WEIGHING
- G01G3/00—Weighing apparatus characterised by the use of elastically-deformable members, e.g. spring balances
- G01G3/12—Weighing apparatus characterised by the use of elastically-deformable members, e.g. spring balances wherein the weighing element is in the form of a solid body stressed by pressure or tension during weighing
- G01G3/13—Weighing apparatus characterised by the use of elastically-deformable members, e.g. spring balances wherein the weighing element is in the form of a solid body stressed by pressure or tension during weighing having piezoelectric or piezoresistive properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/025—Change of phase or condition
- G01N2291/0256—Adsorption, desorption, surface mass change, e.g. on biosensors
- G01N2291/0257—Adsorption, desorption, surface mass change, e.g. on biosensors with a layer containing at least one organic compound
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Acoustics & Sound (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Catalysts (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85275897A | 1997-05-08 | 1997-05-08 | |
US08/852,758 | 1997-05-08 | ||
US5422398A | 1998-04-02 | 1998-04-02 | |
US09/054,223 | 1998-04-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998050773A2 true WO1998050773A2 (en) | 1998-11-12 |
WO1998050773A3 WO1998050773A3 (en) | 1999-04-15 |
Family
ID=26732773
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/009338 WO1998050773A2 (en) | 1997-05-08 | 1998-05-07 | Microcantilever biosensor |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1998050773A2 (en) |
Cited By (57)
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WO2000004382A1 (en) * | 1998-07-14 | 2000-01-27 | Zyomyx, Inc. | Arrays of proteins and methods of use thereof |
WO2000004390A2 (en) * | 1998-07-14 | 2000-01-27 | Zyomyx, Inc. | Microdevices for screening biomolecules |
WO2000014539A1 (en) * | 1998-09-05 | 2000-03-16 | Aea Technology Plc | Assay of chemical binding using micro-cantilevers |
WO2000058729A2 (en) * | 1999-03-30 | 2000-10-05 | Ut-Battelle, Llc | Micromechanical antibody sensor |
WO2000075626A1 (en) * | 1999-06-08 | 2000-12-14 | Commissariat A L'energie Atomique | Platform for chemical or biological analysis with microbalances, analysis device and method using same |
WO2001033226A1 (en) * | 1999-11-03 | 2001-05-10 | International Business Machines Corporation | Cantilever sensors and transducers |
WO2002000686A2 (en) * | 2000-06-23 | 2002-01-03 | Bioelastics Research, Ltd. | Bioelastomer nanomachines and biosensors |
EP1193214A1 (en) * | 2000-09-27 | 2002-04-03 | STMicroelectronics S.r.l. | Integrated chemical microreactor, thermally insulated from detection electrodes, and manufacturing method therefor |
EP1202046A1 (en) * | 2000-10-25 | 2002-05-02 | Abb Research Ltd. | Method and apparatus for determining biological species |
GB2369436A (en) * | 2000-07-28 | 2002-05-29 | Marconi Applied Techn Ltd | Chemical sensing micro-mechanical cantilever |
WO2002075296A1 (en) * | 2001-03-19 | 2002-09-26 | Infineon Technologies Ag | Micromechanic sensor element, electric circuit and sensor array comprising a plurality of micromechanic sensor elements |
EP1325302A2 (en) * | 2000-08-09 | 2003-07-09 | California Institute of Technology | Active nems arrays for biochemical analyses |
WO2003062135A1 (en) * | 2002-01-24 | 2003-07-31 | Cantion A/S | A sensor |
DE10209245A1 (en) * | 2002-03-04 | 2003-09-25 | Concentris Gmbh Basel | Method and device for the detection of microorganisms |
WO2003104784A1 (en) * | 2002-06-07 | 2003-12-18 | Cantion A/S | A cantilever sensor with a current shield and a method for its production |
US6682942B1 (en) | 1998-07-14 | 2004-01-27 | Zyomyx, Inc. | Microdevices for screening biomolecules |
WO2004031769A1 (en) * | 2002-10-04 | 2004-04-15 | Sony Corporation | Interaction detecting method and bioassay device, and bioassay-use substrate |
EP1536227A2 (en) * | 2003-11-25 | 2005-06-01 | Korea Institute of Science and Technology | Quantitative biopolymer detecting system using monolithic piezoelectric cantilever by resonant frequency shift, method for fabricating the same system and method for detecting biopolymer quantitatively using the same system |
EP1650564A1 (en) * | 2003-07-30 | 2006-04-26 | Riken | Mechanochemical type sensor |
WO2006046509A1 (en) * | 2004-10-27 | 2006-05-04 | Mitsubishi Chemical Corporation | Cantilever sensor, sensor system and method of detecting analyte in specimen liquid |
DE102004046685B3 (en) * | 2004-09-24 | 2006-06-29 | Concentris Gmbh | Measuring cell and method for liquid analysis |
WO2006076507A2 (en) * | 2005-01-14 | 2006-07-20 | Massachusetts Institute Of Technology | Self-activated sensor |
WO2006082668A1 (en) * | 2005-02-01 | 2006-08-10 | National University Corporation Gunma University | Biosensor and biosensor chip |
GB2432907A (en) * | 2005-12-05 | 2007-06-06 | Univ Basel | Device for detecting the characteristics of organic molecules |
WO2007072444A2 (en) * | 2005-12-23 | 2007-06-28 | Koninklijke Philips Electronics N.V. | Biosensor device |
WO2007087328A3 (en) * | 2006-01-23 | 2007-10-25 | Univ Drexel | Self-exciting, self-sensing piezoelectric cantilever sensor |
US7344678B2 (en) | 2002-11-15 | 2008-03-18 | The Regents Of The University Of California | Composite sensor membrane |
JP2008105978A (en) * | 2006-10-24 | 2008-05-08 | Japan Science & Technology Agency | Method for direct surface immobilization of saccharide, and method for detecting interaction between saccharide and protein |
US7375321B2 (en) | 2000-08-09 | 2008-05-20 | California Institute Of Technology | Dynamics bionems sensors and arrays of bionems sensor immersed in fluids |
US7671511B2 (en) | 2006-12-12 | 2010-03-02 | Concentris Gmbh | System for oscillating a micromechanical cantilever |
ITTO20080916A1 (en) * | 2008-12-09 | 2010-06-10 | St Microelectronics Srl | INTEGRATED TORSIONAL MICRO-BALANCE DEVICE IN MEMS TECHNOLOGY AND ITS MANUFACTURING PROCESS |
US7779707B2 (en) | 2004-05-24 | 2010-08-24 | Drexel University | All-electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement |
US7790440B2 (en) | 2005-02-05 | 2010-09-07 | Samsung Electronics Co., Ltd. | Sensing switch and detecting method using the same |
US7892759B2 (en) | 2007-02-16 | 2011-02-22 | Drexel University | Enhanced sensitivity of a cantilever sensor via specific bindings |
DE102007059977B4 (en) * | 2006-12-12 | 2011-03-31 | Concentris Gmbh | Device for operating a micromechanical cantilever and measuring arrangement with such a cantilever |
US7993854B2 (en) | 2007-05-30 | 2011-08-09 | Drexel University | Detection and quantification of biomarkers via a piezoelectric cantilever sensor |
US7992431B2 (en) | 2006-11-28 | 2011-08-09 | Drexel University | Piezoelectric microcantilevers and uses in atomic force microscopy |
US8083916B2 (en) | 2004-07-19 | 2011-12-27 | Stmicroelectronics S.R.L. | Detection device having increased detection rate, and method for quick detection of biological molecules |
US8171795B1 (en) | 2006-01-23 | 2012-05-08 | Drexel University | Self-exciting, self-sensing piezoelectric cantilever sensor for detection of airborne analytes directly in air |
US8236508B2 (en) | 2008-01-29 | 2012-08-07 | Drexel University | Detecting and measuring live pathogens utilizing a mass detection device |
US8241569B2 (en) | 2007-11-23 | 2012-08-14 | Drexel University | Lead-free piezoelectric ceramic films and a method for making thereof |
US8286486B2 (en) | 2006-05-10 | 2012-10-16 | Drexel University | Molecular control of surface coverage |
US8372139B2 (en) | 2001-02-14 | 2013-02-12 | Advanced Bio Prosthetic Surfaces, Ltd. | In vivo sensor and method of making same |
US8456150B2 (en) | 2007-02-01 | 2013-06-04 | Drexel University | Hand-held phase-shift detector for sensor applications |
US8481335B2 (en) | 2006-11-27 | 2013-07-09 | Drexel University | Specificity and sensitivity enhancement in cantilever sensing |
US8479585B2 (en) | 2010-09-08 | 2013-07-09 | Micropen Technologies Corporation | Pressure sensing or force generating device |
US8512947B2 (en) | 2007-02-16 | 2013-08-20 | Drexel University | Detection of nucleic acids using a cantilever sensor |
US8562546B2 (en) | 2008-05-16 | 2013-10-22 | Drexel University | System and method for evaluating tissue |
DE10333972B4 (en) * | 2003-07-25 | 2014-04-10 | Robert Bosch Gmbh | Method for producing a sensor for biochemical measurements |
US8722427B2 (en) | 2009-10-08 | 2014-05-13 | Drexel University | Determination of dissociation constants using piezoelectric microcantilevers |
US8741663B2 (en) | 2008-03-11 | 2014-06-03 | Drexel University | Enhanced detection sensitivity with piezoelectric sensors |
US8927259B2 (en) | 2006-11-28 | 2015-01-06 | Drexel University | Piezoelectric microcantilever sensors for biosensing |
US9012810B2 (en) | 2001-12-20 | 2015-04-21 | Stmicroelectronics, Inc. | Heating element for microfluidic and micromechanical applications |
WO2017052950A1 (en) * | 2015-09-25 | 2017-03-30 | Intel Corporation | Integrated molecular sensor system |
US10329396B2 (en) * | 2015-07-14 | 2019-06-25 | Nanosniff Technologies Pvt. Ltd. | Process for immobilizing one or more receptor biomolecules on one or more solid surfaces |
US10899607B2 (en) | 2014-08-13 | 2021-01-26 | University Of South Carolina | III-V nitride resonate based photoacoustic sensor |
DE102021107254A1 (en) | 2021-03-23 | 2022-09-29 | digid GmbH | Digital sensor device for detecting an analyte in a sample |
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US4789804A (en) * | 1985-09-17 | 1988-12-06 | Seiko Instruments & Electronics Ltd. | Analytical device and method utilizing a piezoelectric crystal biosensor |
US4906440A (en) * | 1986-09-09 | 1990-03-06 | The United States Of America As Represented By The Secretary Of The Air Force | Sensor for detecting chemicals |
US5209119A (en) * | 1990-12-12 | 1993-05-11 | Regents Of The University Of Minnesota | Microdevice for sensing a force |
WO1994005414A1 (en) * | 1992-08-31 | 1994-03-17 | The Regents Of The University Of California | Microfabricated reactor |
EP0657737A2 (en) * | 1993-12-13 | 1995-06-14 | Hewlett-Packard Company | Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques |
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US5589136A (en) * | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
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-
1998
- 1998-05-07 WO PCT/US1998/009338 patent/WO1998050773A2/en active Application Filing
Patent Citations (10)
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