WO1998040023A1 - Method and apparatus for tissue ablation - Google Patents
Method and apparatus for tissue ablation Download PDFInfo
- Publication number
- WO1998040023A1 WO1998040023A1 PCT/US1998/004172 US9804172W WO9840023A1 WO 1998040023 A1 WO1998040023 A1 WO 1998040023A1 US 9804172 W US9804172 W US 9804172W WO 9840023 A1 WO9840023 A1 WO 9840023A1
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- Prior art keywords
- electrode
- temperature
- catheter
- energy
- power
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
Definitions
- This invention relates generally to the field of devices for cardiac surgery, and more specifically to devices for R-F ablation of cardiac tissue.
- the present invention is directed toward treatment of tachyarrhythmias, which are excessively fast heart rhythms.
- the present invention is directed toward treatment of tachycardias.
- R-F ablation catheters are effective to induce small lesions in heart tissue including the endocardium and inner layers of myocardium, in the immediate vicinity of the electrode.
- R-F ablation causes tissue in contact with the electrode to heat through resistance of the tissue to the induced electrical current therethrough.
- sensing when the electrode is in actual contact with the heart tissue so that the ablation procedure may begin is required.
- ablation systems of Biosense, Inc. detect wall contact through the stability of the sensed EKG. Such an approach is not completely satisfactory.
- the present invention is a system for ablating tissue within a body, the system comprising: an energy source providing a level of energy which is non damaging to the cellular structures of the body tissue, a catheter coupled to the energy source, the catheter having an electrode; the system further having means for sensing the temperature of the electrode while also sensing the amount of energy which is non damaging to the cellular structures of the body tissue (i.e. non ablative) is delivered to the electrode wherein the degree to which the electrode contacts the heart tissue (e.g. no contact, moderate contact, good contact or excellent contact) may be determined.
- the non-damaging energy delivered to the body is less than 5 Watts and the catheter has a temperature sensor positioned within the distal end.
- FIG. 2 is a sectional view of the distal end or tip of the catheter seen in FIG. 1.
- FIG. 3 illustrates a catheter tip having an electrode which is emitting energy into the blood stream and the resulting transmission of heat back into the catheter tip.
- FIG. 4 illustrates a catheter tip having an electrode in contact with heart tissue and which is emitting energy into the tissue and the resulting transmission of heat back into the catheter tip.
- FIG. 5. illustrates a system for ablating tissue according to the present invention.
- FIG. 6 illustrates the change in temperature of the tip electrode as it moves through the blood vessel and contacts heart tissue due to the delivery of a non-ablative amount of energy to the electrode.
- FIG. 7 depicts a method of determining heart wall contact of an ablation catheter by delivering an amount of power which is non-damaging to the cellular structures of the body.
- FIG. 8 illustrates the change in R-F power required for a 0.5°C temperature rise in the electrode to be maintained as the electrode is moved towards and away from contact with heart tissue.
- FIG. 9 illustrates a method of determining heart wall contact of an ablation catheter by supplying a non-damaging amount of power to the electrode to cause a pre-set rise in the temperature of the electrode.
- FIG. 10 illustrates the change in heating efficiency of the electrode as it moves into contact with the heart tissue.
- FIG. 11 depicts a method of determining heart wall contact by monitoring the heating efficiency of power supplied to the electrode.
- FIG. 12 illustrates the operation of a further embodiment of the present invention.
- FIG. 13 depicts a method of determining a heart wall contact by supplying a cyclical amount of energy to the electrode and detecting whether there is a corresponding cyclic variation of temperature in the electrode.
- FIG. 1 shows a system 10 for performing ablation on human tissue that embodies the features of the invention.
- the system 10 includes a radio frequency generator 12 that delivers radio frequency energy ("RF energy").
- RF energy radio frequency energy
- Other types of energy may also be used, such as microwave energy, heat, electrical pulses, cryothermy, and lasers.
- the specific type of energy delivered is not essential to the invention.
- the system 10 also includes a steerable catheter 14 carrying a radio frequency emitting tip electrode 129.
- the system 10 operates in a monopolar mode.
- the system 10 includes a skin patch electrode that serves as an indifferent second electrode 18.
- the indifferent electrode 18 attaches to the patient's back or other exterior skin area.
- the system 10 can be operated in a bipolar mode.
- the catheter 14 carries both electrodes.
- the ablation electrode 129 and indifferent electrodes 18 are made of platinum.
- the system 10 can be used in many different environments. This specification describes the system 10 when used to provide cardiac ablation therapy.
- a physician steers the catheter 14 through a main vein or artery (typically the femoral artery) into the interior region of the heart that is to be treated.
- the physician then further manipulates the catheter 14 to place the tip electrode 129 into contact with the tissue within the heart that is targeted for ablation.
- the user directs radio frequency energy from the generator 12 into the tip electrode 129 to form a lesion on the contacted tissue.
- the catheter 14 includes a handle 20, a guide tube 22, and a tip portion, which carries the tip electrode 129.
- the handle 20 encloses a steering mechanism 26 for the catheter tip 24.
- a cable 28 extending from the rear of the handle 20 has plugs (not shown). The plugs connect the catheter 14 to the generator 12 for conveying radio frequency energy to the ablation electrode 16. The radio frequency heats the tissue to form the lesion.
- One or more steering wires 132 extend through the guide tube 22 to interconnect the steering mechanism 26 to the left and right sides of the tip 24. Rotating the steering mechanism 26 to the left pulls on the left steering wire, causing the tip having tip electrode 129 to bend to the left. Also, rotating the steering mechanism 26 to the right pulls on the right steering wire, causing the catheter tip to bend to the right. In this way, the physician steers the tip electrode 129 into contact with the tissue to be ablated.
- the generator 12 includes a radio frequency power source 30 connected through a main isolation transformer 32 to first and second conducting lines.
- the power source 30 delivers between 0 - 100 Watts of power at a frequency between 100 KHz - 1 MHz.
- the first conducting line leads to tip electrode 129.
- the second conducting line leads to the indifferent patch electrode 18.
- FIG. 2 is a sectional view of the distal end or tip of the catheter 14 seen in FIG. 1.
- Electrode 128 is electrically coupled to power source (not shown in this FIG) through conductor 129.
- electrode is a platinum alloy.
- thermistor assembly 129 Positioned within electrode is thermistor assembly 129. Although shown within electrode, thermistor may also be positioned on, adjacent to or separated from electrode. A pair of thermistor leads 131 couple to thermistor assembly and power source. Thermistor assembly is used to sense the temperature of the electrode, although other types of temperature sensors may also be used, such as a thermocouple for example.
- the degree to which the electrode contacts the heart tissue may be determined by sensing the temperature of the electrode while also sensing the amount of energy which is non damaging to the cellular structures of the body tissue (or “non-ablative" is delivered to the electrode.
- FIG. 3 illustrates a catheter tip having an electrode which is emitting energy into the blood stream and the transmission of heat back into the catheter tip.
- high frequency current is delivered to the tissue and fluids which contact the electrode. Because these tissues and fluids have some electrical resistivity, heat is generated within the tissues and fluids. This so-called resistive heating thereby causes energy in the form of heat to be transmitted back into the electrode.
- RF energy represented by dotted lines 301 is emitted from the electrode 129 of catheter 14.
- heat, represented by solid lines 302 is created in the surrounding tissues and fluids, in this case the blood stream, and partially radiated back into the electrode.
- the delivery of RF energy to the tissues or fluids of the body causes the electrode to also heat.
- the electrode is within the blood, however, less of the heat is radiated back into the electrode and more is carried away from the electrode by the blood flow 305 as compared to if the electrode was in contact with body tissue.
- FIG. 4 illustrates a catheter tip which is in contact with body tissue and which is emitting energy into tissue and the transmission of heat back into the catheter tip by the tissue.
- tissue such as heart tissue
- FIG. 4 illustrates a catheter tip which is in contact with tissue, such as heart tissue
- tissue such as heart tissue
- Blood transmits less heat back into the tip electrode from the emitted RF energy than does tissue. Consequently, as illustrated in this FIG., when the tip electrode contacts the heart tissue more heat 302 is delivered from the heart tissue back to the electrode as compared to when the electrode is completely surrounded by blood.
- This characteristic provides for three related methods for detecting wall contact. First, assuming constant tip temperature is maintained by the delivery of energy to the electrode, then when the amount of energy required to maintain the constant tip temperature is decreased, the tip is contacting heart tissue.
- the electrode is in contact with the heart tissue.
- the heating efficiency of transmitting energy from the electrode and the resulting transmission of heat back into the electrode is greater the closer electrode is to the wall, then by monitoring the amount of heating efficiency to increase the temperature of the tip electrode, the degree of wall contact may be detected.
- the power supplied to the electrode and the resultant temperature of the electrode are non-damaging to the cellular structures of the body.
- FIG. 5 illustrates a system for ablating tissue according to the present invention.
- the system 10 includes a RF generator 12 which is electrically coupled to electrode 128. Electrode is in catheter 14. Temperature sensor 129 is also located within the catheter and is preferably located within the electrode. Controller 500 is coupled to temperature sensor and to RF generator. Through controller, the amount of power delivered by RF generator to electrode may be controlled according to the sensor temperature of the electrode. As discussed above, this control may be aimed so that a constant power to the electrode is maintained, or a constant temperature of the tip electrode is maintained. Controller may also function to detect the heating efficiency of the power delivered to the electrode. Controller may be either a separate device or integral with the R-F generator.
- the system may further feature a second temperature sensor 529.
- the second temperature sensor would be located remote from the temperature sensor 129 but still in sensory contact with the body so that any variation in the body temperature of the patient during the ablation process may be corrected.
- Temperature sensor 529 may or may not be positioned along catheter 14. This additional temperature sensor is useful for those patients whose body temperature varies during the ablation catheterization procedure. For example, it is sometimes necessary to deliver a drug, such as isoproteronol, to mimic exercise and, in turn, induce arrhythmias. Such a drug, however, often causes the body temperature to rise 1 or 2 degree Celsius.
- system may also include display 510 to graphically output data indicating the degree to which the electrode contacts heart tissue (e.g. no contact, medium contact, etc.). Display may also provide data regarding the power delivered, electrode temperature or heating efficiency over time as further discussed below.
- an oscillator 511 is either coupled to or provided within controller 500. Oscillator is used to cyclically vary the delivered energy to the electrode at a frequency between
- FIG. 6 illustrates the change in temperature of the tip electrode as it moves through the blood and contacts heart tissue due to the delivery of a non-ablative amount of energy to tip electrode by generator.
- no energy is delivered to the electrode and the temperature of tip electrode is equal to body temperature, 37 degrees Celsius.
- tip electrode has a temperature of approx. 38 degrees Celsius due to the delivery of a non-ablative amount of energy to tip electrode by generator.
- this non-ablative amount of energy is no more than 5 Watts and is preferably less than 1 Watt.
- the amount of energy delivered to the electrode and the temperature sensed in the electrode depend on the shape and size of the electrode.
- the essential aspect of the present invention is that an non damaging amount of energy is delivered to the electrode and the temperature of the electrode is monitored. By monitoring the power delivered or the temperature created or the heating efficiency, then the degree of wall contact may be ascertained.
- the tip electrode has been moved into moderate contact with the heart tissue. As seen, due to the increased conduction of heat from tissue to tip electrode as compared to from blood to tip electrode, the temperature of the tip electrode rises.
- the tip electrode has been moved into excellent contact with the heart tissue and the temperature of the tip electrode has reached an equilibrium state at a higher temperature.
- tip electrode is removed from excellent contact with the heart tissue and is only in good contact with heart tissue, then the conduction of heat from tissue to tip electrode is relatively decreased and the temperature correspondingly decreases, as seen at 611.
- the tip has moved to very good contact with the heart tissue and the temperature of tip has again increased.
- an ablative amount of energy is delivered to tip electrode by generator to thereby ablate tissue.
- FIG. 7 depicts a method of determining heart wall contact of an ablation catheter and ablating heart tissue using the present invention.
- a catheter is inserted into the body and preferably into a blood vessel.
- Catheter preferably has a tip electrode having a temperature sensor, the electrode and sensor are coupled to a R-F generator having a controller as discussed above.
- power which is non-damaging to the cellular structures of the body is supplied to the catheter electrode.
- the temperature of the electrode is then sensed. As discussed above the supply of energy to the electrode will cause the electrode to increase in temperature by radiative heating, although the amount of heating will vary depending upon where the electrode is located, i.e. within the blood vessel or against the heart wall.
- the catheter is moved.
- the temperature of the electrode is again detected to determine whether it has risen. Assuming a constant amount of power is supplied to the electrode, then the rise in temperature of the electrode will indicate the degree of proximity of the electrode to the heart wall. Steps 756 and 758 are iterative, i.e., they are repeated until a desired result is obtained. Once the catheter is properly located then the ablation procedure may be begun, as depicted at step 760. Of course, the ablation process as depicted includes more than simply increasing the power supplied to the electrode but is also meant to include properly locating the electrode in the specific area of the heart tissue in which the ablative procedure is to be performed.
- FIG. 8 illustrates the change in RF power required for a 0.5°C temperature rise in the electrode to be maintained over time.
- tip electrode requires 2.5 Watts to maintain a 0.5°C temperature rise. This would indicate there is no contact of the tip electrode with the heart wall.
- the RF power required has decreased to 0.1 watt. This would indicate that the tip electrode now is in very good contact with the heart wall.
- the catheter has been further moved and now requires over 0.5 watts to maintain a 0.5°C rise in electrode temperature. This would indicate only moderate contact exists between the tip electrode and the heart wall.
- the RF power requires for a 0.5°C rise in temperature has fallen to approximately 0.3 watts. As seen, this indicates there is now good contact between the heart wall and the tip electrode.
- other predetermined increases in temperature other than 0.5° C may be selected, such as 1° C. Any temperature increase which is non ablative may be used.
- FIG. 9 depicts a method of determining heart wall contact of an ablation catheter by maintaining a constant temperature rise at the catheter electrode and monitoring the required power to maintain that rise.
- the method begins at step 950 by inserting a catheter having an electrode and temperature sensor within the body, preferably within a blood vessel leading to the heart.
- an amount of power is supplied to the electrode to cause the temperture of the electrode to rise a preset amount. This preset rise in electrode temperature is no more than a temperature which is non- damaging to the cellular structures of the body.
- the catheter is moved.
- the amount of power required to maintain the electrode at the preset increase in temperature is detected. If the amount of power required is decreased, then the electrode is in better contact with tissue.
- Steps 954 and 956 are iterative and should be repeated until an acceptably low power level is required by the electrode.
- ablation procedure is begun. As discussed above in regards to FIG. 7 ablation procedure is used in the broadest possible manner and is simply intended to mean that the electrode is now in contact with tissue and a determination must be made whether the specific tissue the electrode is in contact with should be ablated.
- FIG. 10 illustrates the change in heating efficiency of the tip electrode as it moves from the blood vessel, contacts the heart tissue and the ablation process is begun.
- Heating efficiency is the rise in temperature experienced at the tip electrode as compared to the power delivered.
- the heating efficiency is very low, roughly 0.25°C/watt.
- the efficiency is increased to almost over 5°C/watt. This indicates there is very good contact between the tip electrode and the heart wall.
- the catheter has been moved and the heating efficiency is decreased now to l°C/watt. This would indicate there is only moderate contact between the tip electrode and the heart wall.
- the catheter has been further moved and the heating efficiency is increased to roughly 4°C/watt. This would indicate there is good contact between the electrode and the heart wall.
- the RF ablation process may be begin as illustrated. As illustrated the RF ablation process has a constant heating efficiency assuming the contact of the electrode to the tissue is constant. Thus using this method the degree of wall contact of the electrode can be monitored during the R-F ablation.
- FIG. 11 depicts a method of determining heart wall contact by measuring the change in heating efficiency of the tip electrode.
- a catheter is inserted into the body, preferably a blood vessel leading to the heart.
- power is supplied to the electrode. The amount of power supplied is preferably within a range which would not cause damage to the cellular structures of the body.
- the temperature of the electrode is detected.
- the heating efficiency of the power supplied to the electrode is determined.
- the catheter is moved through the blood vessel, preferably towards contact with the heart wall tissue.
- Steps 88 and 90 are iterative and should be repeated until the desired heating efficiency is attained.
- the ablation procedure may be begun.
- FIG. 12 illustrates the operation of further embodiment of the present invention.
- the temperature of the patient's body may vary during the ablation process. This may provide problems with indicating the quality of wall contact of the tip electrode.
- this problem is overcome through the use of a cyclic delivery of non-damaging amount of RF energy to the tip electrode and the corresponding sensing of the temperature in the tip electrode.
- a cycle of RF energy between 0-0.2 watts is delivered to the electrode.
- the electrode temperature undergoes a slight change in temperature as illustrated at 850.
- the sensed electrode temperature will also undergo a cyclic variation as illustrated at 854.
- phase shift between the sensed temperature of the electrode and the delivery of the RF energy while any contact is maintained. This phase shift will result from the lag in time of the power being delivered to the tissue, the tissue heating, and the radiation of the tissue heat back into the tip electrode and the sensing of this heat by the temperature sensor. If the electrode is further moved and only moderate contact is made between the tip electrode and the heart tissue, then the amplitude of the temperature variation of the electrode will decrease as seen at 860. Once good or better contact is satisfactorily achieved, then the amplitude of the temperature variation at the tip electrode will increase again as illustrated at 862.
- FIG. 13 depicts a method of determining heart wall contact through the use of a cyclic delivery of a non-damaging amount of energy to the electrode and the corresponding sensing of the temperature variation in the tip electrode.
- the catheter having a tip electrode is inserted into the body, preferably a blood vessel lead to the heart.
- an amount of power which is non-damaging to the cellular structures of the body is supplied to the electrode in a cyclic or oscillatory manner.
- the temperature of the tip electrode is detected.
- Steps 85 and 87 are iterative and should be repeated until a temperature variation in the electrode which is in a cycle corresponding to the power supplied and which also shows a sufficient amplitute of temperature variance is achieved.
- the ablation process is begun.
Abstract
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Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98907712A EP0967924A1 (en) | 1997-03-12 | 1998-03-04 | Method and apparatus for tissue ablation |
JP53961898A JP2001514557A (en) | 1997-03-12 | 1998-03-04 | Methods and devices for tissue resection |
Applications Claiming Priority (2)
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US08/815,819 | 1997-03-12 | ||
US08/815,819 US6063078A (en) | 1997-03-12 | 1997-03-12 | Method and apparatus for tissue ablation |
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WO1998040023A1 true WO1998040023A1 (en) | 1998-09-17 |
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PCT/US1998/004172 WO1998040023A1 (en) | 1997-03-12 | 1998-03-04 | Method and apparatus for tissue ablation |
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US (1) | US6063078A (en) |
EP (1) | EP0967924A1 (en) |
JP (1) | JP2001514557A (en) |
WO (1) | WO1998040023A1 (en) |
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Also Published As
Publication number | Publication date |
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US6063078A (en) | 2000-05-16 |
EP0967924A1 (en) | 2000-01-05 |
JP2001514557A (en) | 2001-09-11 |
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